CYP17A1 Maintains the Survival of Glioblastomas by Regulating SAR1-Mediated Endoplasmic Reticulum Health and Redox Homeostasis

Sex differences in GBM revealed by analysis of patient imaging, transcriptome, and survival data

(2019) Wei Yang et al.   Science Translational Medicine

Interplay between the unfolded protein response and reactive oxygen species: a dynamic duo

(2018) Rengin Ozgur et al.   JOURNAL OF EXPERIMENTAL BOTANY

Dehydroepiandrosterone Induces Temozolomide Resistance Through Modulating Phosphorylation and Acetylation of Sp1 in Glioblastoma

(2018) Wen-Bin Yang et al.   MOLECULAR NEUROBIOLOGY

Females have the survival advantage in glioblastoma

(2018) Quinn T Ostrom et al.   NEURO-ONCOLOGY

Neurosteroid allopregnanolone inhibits glutamate release from rat cerebrocortical nerve terminals

(2018) Yi Chang et al.   SYNAPSE

Steroid 17-hydroxylase and 17,20-lyase deficiencies, genetic and pharmacologic

(2017) Richard J. Auchus   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

CYP17A1 inhibitor abiraterone, an anti-prostate cancer drug, also inhibits the 21-hydroxylase activity of CYP21A2

(2017) Jana Malikova et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Upregulation of CYP17A1 by Sp1-mediated DNA demethylation confers temozolomide resistance through DHEA-mediated protection in glioma

(2017) J-Y Chuang et al.   Oncogenesis

Specificity protein 1-modulated superoxide dismutase 2 enhances temozolomide resistance in glioblastoma, which is independent of O 6 -methylguanine-DNA methyltransferase

(2017) Kwang-Yu Chang et al.   Redox Biology

Specificity of anti-prostate cancer CYP17A1 inhibitors on androgen biosynthesis

(2016) Sameer S. Udhane et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

New Insights into Protein Hydroxylation and Its Important Role in Human Diseases

(2016) Giada Zurlo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

The hunt for a selective 17,20 lyase inhibitor; learning lessons from nature

(2016) Ian M. Bird et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

An independently validated nomogram for individualized estimation of survival among patients with newly diagnosed glioblastoma: NRG Oncology RTOG 0525 and 0825

(2016) Haley Gittleman et al.   NEURO-ONCOLOGY

Protein Hydroxylation Catalyzed by 2-Oxoglutarate-dependent Oxygenases

(2015) Suzana Markolovic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The diverse chemistry of cytochrome P450 17A1 (P450c17, CYP17A1)

(2015) Francis K. Yoshimoto et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

COPII-Dependent ER Export: A Critical Component of Insulin Biogenesis and β-Cell ER Homeostasis

(2015) Jingye Fang et al.   MOLECULAR ENDOCRINOLOGY

Alu RNA regulates the cellular pool of active ribosomes by targeted delivery of SRP9/14 to 40S subunits

(2015) Elena Ivanova et al.   NUCLEIC ACIDS RESEARCH

Dietary omega-3 fatty acids modulate the eicosanoid profile in man primarily via the CYP-epoxygenase pathway

(2014) Robert Fischer et al.   JOURNAL OF LIPID RESEARCH

Optimal Translational Termination Requires C4 Lysyl Hydroxylation of eRF1

(2014) Tianshu Feng et al.   MOLECULAR CELL

Neurosteroid interactions with synaptic and extrasynaptic GABAA receptors: regulation of subunit plasticity, phasic and tonic inhibition, and neuronal network excitability

(2013) Chase Matthew Carver et al.   PSYCHOPHARMACOLOGY

The purpose of the HIF-1/PHD feedback loop: To limit mTOR-induced HIF-1α

(2011) Zoya N. Demidenko et al.   CELL CYCLE

Neuroprotective Actions of Neurosteroids

(2011) Kinga K. Borowicz et al.   Frontiers in Endocrinology

The Neurosteroid Allopregnanolone Modulates Specific Functions in Central and Peripheral Glial Cells

(2011) Alessandro Faroni et al.   Frontiers in Endocrinology

Molecular characterization of the endoplasmic reticulum: Insights from proteomic studies

(2010) Xuequn Chen et al.   PROTEOMICS