Glycine-based treatment ameliorates NAFLD by modulating fatty acid oxidation, glutathione synthesis, and the gut microbiome

Nitro-fatty acids protect against steatosis and fibrosis during development of nonalcoholic fatty liver disease in mice

(2019) Oren Rom et al.   EBioMedicine

Assessing the causal association of glycine with risk of cardio-metabolic diseases

(2019) Laura B. L. Wittemans et al.   Nature Communications

Molecular phenomics and metagenomics of hepatic steatosis in non-diabetic obese women

(2018) Lesley Hoyles et al.   NATURE MEDICINE

Mechanisms of NAFLD development and therapeutic strategies

(2018) Scott L. Friedman et al.   NATURE MEDICINE

Emerging therapeutic potential of glycine in cardiometabolic diseases

(2018) Oren Rom et al.   CURRENT OPINION IN LIPIDOLOGY

A spotlight on pathogenesis, interactions and novel therapeutic options in NAFLD

(2018) Ramy Younes et al.   Nature Reviews Gastroenterology & Hepatology

Association of serum glycine levels with metabolic syndrome in an elderly Chinese population

(2018) Xianghui Li et al.   Nutrition & Metabolism

Altered amino acid concentrations in NAFLD: Impact of obesity and insulin resistance

(2017) Melania Gaggini et al.   HEPATOLOGY

Atherogenicity of amino acids in the lipid-laden macrophage model system in vitro and in atherosclerotic mice: a key role for triglyceride metabolism

(2017) Oren Rom et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Personal model‐assisted identification of NAD + and glutathione metabolism as intervention target in NAFLD

(2017) Adil Mardinoglu et al.   Molecular Systems Biology

Plasma amino acid profile associated with fatty liver disease and co-occurrence of metabolic risk factors

(2017) Minoru Yamakado et al.   Scientific Reports

Glycine prevents metabolic steatohepatitis in diabetic KK-Ay mice through modulation of hepatic innate immunity

(2016) Shiori Takashima et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Acrolein increases macrophage atherogenicity in association with gut microbiota remodeling in atherosclerotic mice: protective role for the polyphenol-rich pomegranate juice

(2016) Oren Rom et al.   ARCHIVES OF TOXICOLOGY

Noninvasive Detection of Nonalcoholic Steatohepatitis Using Clinical Markers and Circulating Levels of Lipids and Metabolites

(2016) You Zhou et al.   Clinical Gastroenterology and Hepatology

Glycine supplementation during calorie restriction accelerates fat loss and protects against further muscle loss in obese mice

(2016) Marissa K. Caldow et al.   CLINICAL NUTRITION

Metabolomics in Prediabetes and Diabetes: A Systematic Review and Meta-analysis

(2016) Marta Guasch-Ferré et al.   DIABETES CARE

Comparison of Gene Expression Patterns Between Mouse Models of Nonalcoholic Fatty Liver Disease and Liver Tissues From Patients

(2016) Andreas Teufel et al.   GASTROENTEROLOGY

Persistent Nonalcoholic Fatty Liver Disease Increases Risk for Carotid Atherosclerosis

(2016) Dong Hyun Sinn et al.   GASTROENTEROLOGY

Liver PPARα is crucial for whole-body fatty acid homeostasis and is protective against NAFLD

(2016) Alexandra Montagner et al.   GUT

Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes

(2016) Zobair M. Younossi et al.   HEPATOLOGY

A diet-induced animal model of non-alcoholic fatty liver disease and hepatocellular cancer

(2016) Amon Asgharpour et al.   JOURNAL OF HEPATOLOGY

Perinatal Lead Exposure Alters Gut Microbiota Composition and Results in Sex-specific Bodyweight Increases in Adult Mice

(2016) Jianfeng Wu et al.   TOXICOLOGICAL SCIENCES

The Intestinal Microbiota in Metabolic Disease

(2016) Anni Woting et al.   Nutrients

Dysbiosis gut microbiota associated with inflammation and impaired mucosal immune function in intestine of humans with non-alcoholic fatty liver disease

(2015) Weiwei Jiang et al.   Scientific Reports

Plasma Glycine and Risk of Acute Myocardial Infarction in Patients With Suspected Stable Angina Pectoris

(2015) Yunpeng Ding et al.   Journal of the American Heart Association

Seven weeks of Western diet in apolipoprotein-E-deficient mice induce metabolic syndrome and non-alcoholic steatohepatitis with liver fibrosis

(2015) Robert Schierwagen et al.   Scientific Reports

HTSeq--a Python framework to work with high-throughput sequencing data

(2014) S. Anders et al.   BIOINFORMATICS

Shiny-phyloseq: Web application for interactive microbiome analysis with provenance tracking

(2014) P. J. McMurdie et al.   BIOINFORMATICS

Trimmomatic: a flexible trimmer for Illumina sequence data

(2014) Anthony M. Bolger et al.   BIOINFORMATICS

Fattyaciddesaturase 1gene polymorphisms control human hepatic lipid composition

(2014) Libo Wang et al.   HEPATOLOGY

Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease

(2014) Changtao Jiang et al.   JOURNAL OF CLINICAL INVESTIGATION

Glycine treatment decreases proinflammatory cytokines and increases interferon-γ in patients with Type 2 diabetes

(2014) M. Cruz et al.   JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION

Alterations of the human gut microbiome in liver cirrhosis

(2014) Nan Qin et al.   NATURE

Metabolic make-up of NASH: from fat and sugar to amino acids

(2014) Silvia Sookoian et al.   Nature Reviews Gastroenterology & Hepatology

Obesity accelerates epigenetic aging of human liver

(2014) S. Horvath et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-scale metabolic modelling of hepatocytes reveals serine deficiency in patients with non-alcoholic fatty liver disease

(2014) Adil Mardinoglu et al.   Nature Communications

Glycine metabolism in animals and humans: implications for nutrition and health

(2013) Weiwei Wang et al.   AMINO ACIDS

Fecal Microbiome and Volatile Organic Compound Metabolome in Obese Humans With Nonalcoholic Fatty Liver Disease

(2013) Maitreyi Raman et al.   Clinical Gastroenterology and Hepatology

Enhanced Lipid Oxidation and Maintenance of Muscle Insulin Sensitivity Despite Glucose Intolerance in a Diet-Induced Obesity Mouse Model

(2013) Karin E. Trajcevski et al.   PLoS One

A Tripeptide Diapin Effectively Lowers Blood Glucose Levels in Male Type 2 Diabetes Mice by Increasing Blood Levels of Insulin and GLP-1

(2013) Jifeng Zhang et al.   PLoS One

Histopathological algorithm and scoring system for evaluation of liver lesions in morbidly obese patients

(2012) Pierre Bedossa et al.   HEPATOLOGY

Characterization of gut microbiomes in nonalcoholic steatohepatitis (NASH) patients: A connection between endogenous alcohol and NASH

(2012) Lixin Zhu et al.   HEPATOLOGY

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

(2012) Guangchuang Yu et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

Dietary Leucine - An Environmental Modifier of Insulin Resistance Acting on Multiple Levels of Metabolism

(2011) Yazmin Macotela et al.   PLoS One

Identification, Replication, and Functional Fine-Mapping of Expression Quantitative Trait Loci in Primary Human Liver Tissue

(2011) Federico Innocenti et al.   PLoS Genetics

Metagenomic biomarker discovery and explanation

(2011) Nicola Segata et al.   GENOME BIOLOGY

Glutathione Synthesis Is Diminished in Patients With Uncontrolled Diabetes and Restored by Dietary Supplementation With Cysteine and Glycine

(2010) R. V. Sekhar et al.   DIABETES CARE

Differential expression of liver and kidney proteins in a mouse model for primary hyperoxaluria type I

(2010) Juan R. Hernández-Fernaud et al.   FEBS Journal

Comparing morphometric, biochemical, and visual measurements of macrovesicular steatosis of liver☆☆☆

(2010) Mei Li et al.   HUMAN PATHOLOGY

Hepatic Gene Expression of Caucasian and African-American Patients with Obesity-Related Non-Alcoholic Fatty Liver Disease

(2010) Maria Stepanova et al.   OBESITY SURGERY

Introducing mothur: Open-Source, Platform-Independent, Community-Supported Software for Describing and Comparing Microbial Communities

(2009) P. D. Schloss et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and Lean Humans and Contributes to Insulin Resistance

(2009) Christopher B. Newgard et al.   Cell Metabolism

Fast UniFrac: facilitating high-throughput phylogenetic analyses of microbial communities including analysis of pyrosequencing and PhyloChip data

(2009) Micah Hamady et al.   ISME Journal

Accurate determination of microbial diversity from 454 pyrosequencing data

(2009) Christopher Quince et al.   NATURE METHODS

FORWARD SELECTION OF EXPLANATORY VARIABLES

(2008) F. Guillaume Blanchet et al.   ECOLOGY