Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models

Analyzing the Mechanisms Behind Macrolide Antibiotic-Induced Liver Injury Using Quantitative Systems Toxicology Modeling

(2019) Jeffrey L. Woodhead et al.   PHARMACEUTICAL RESEARCH

A Bioreactor Technology for Modeling Fibrosis in Human and Rodent Precision‐Cut Liver Slices

(2019) Hannah L. Paish et al.   HEPATOLOGY

Isolation and propagation of primary human cholangiocyte organoids for the generation of bioengineered biliary tissue

(2019) Olivia C. Tysoe et al.   Nature Protocols

Dynamic imaging of adaptive stress response pathway activation for prediction of drug induced liver injury

(2018) Steven Wink et al.   ARCHIVES OF TOXICOLOGY

Generation of Hepatic Stellate Cells from Human Pluripotent Stem Cells Enables In Vitro Modeling of Liver Fibrosis

(2018) Mar Coll et al.   Cell Stem Cell

Application of in Vitro T Cell Assay Using Human Leukocyte Antigen-Typed Healthy Donors for the Assessment of Drug Immunogenicity

(2018) Toru Usui et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Liver ‘organ on a chip’

(2018) Colin H. Beckwitt et al.   EXPERIMENTAL CELL RESEARCH

Endoplasmic reticulum stress precedes oxidative stress in antibiotic-induced cholestasis and cytotoxicity in human hepatocytes

(2018) Audrey Burban et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondria in non-alcoholic fatty liver disease

(2018) Inês C.M. Simões et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

A transgenic mouse model for HLA-B*57:01–linked abacavir drug tolerance and reactivity

(2018) Marco Cardone et al.   JOURNAL OF CLINICAL INVESTIGATION

Farnesoid X Receptor Agonists Obeticholic Acid and Chenodeoxycholic Acid Increase Bile Acid Efflux in Sandwich-Cultured Human Hepatocytes: Functional Evidence and Mechanisms

(2018) Cen Guo et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Drug-Induced Alterations of Mitochondrial DNA Homeostasis in Steatotic and Nonsteatotic HepaRG Cells

(2018) Dounia Le Guillou et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Serious Liver Injury Associated with Macitentan: A Case Report

(2018) Thao T. Tran et al.   PHARMACOTHERAPY

Prediction of Drug-Induced Hepatotoxicity Using Long-Term Stable Primary Hepatic 3D Spheroid Cultures in Chemically Defined Conditions

(2018) Sabine U Vorrink et al.   TOXICOLOGICAL SCIENCES

Comparison of Hepatic 2D Sandwich Cultures and 3D Spheroids for Long-term Toxicity Applications: A Multicenter Study

(2018) Catherine C Bell et al.   TOXICOLOGICAL SCIENCES

Metabolomics profiling of steatosis progression in HepaRG ® cells using sodium valproate

(2018) Matthias Cuykx et al.   TOXICOLOGY LETTERS

Inter-individual differences in the susceptibility of primary human hepatocytes towards drug-induced cholestasis are compound and time dependent

(2018) Céline Parmentier et al.   TOXICOLOGY LETTERS

Can BSEP Inhibition Testing In Drug Discovery And Development Reduce Liver Injury Risk? - An International Transporter Consortium Perspective

(2018) J Gerry Kenna et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Trovafloxacin-induced liver injury: lack in regulation of inflammation by inhibition of nucleotide release and neutrophil movement

(2018) Giulio Giustarini et al.   TOXICOLOGICAL SCIENCES

The utility of HepaRG cells for bioenergetic investigation and detection of drug-induced mitochondrial toxicity

(2018) Laleh Kamalian et al.   TOXICOLOGY IN VITRO

Human hepatic 3D spheroids as a model for steatosis and insulin resistance

(2018) Mikael Kozyra et al.   Scientific Reports

Long-Term Expansion of Functional Mouse and Human Hepatocytes as 3D Organoids

(2018) Huili Hu et al.   CELL

Inflammatory Cytokine TNFα Promotes the Long-Term Expansion of Primary Hepatocytes in 3D Culture

(2018) Weng Chuan Peng et al.   CELL

Today’s Challenges to De-Risk and Predict Drug Safety in Human “Mind-the-Gap”

(2018) Richard J Weaver et al.   TOXICOLOGICAL SCIENCES

Quantitative Systems Toxicology Analysis of In Vitro Mechanistic Assays Reveals Importance of Bile Acid Accumulation and Mitochondrial Dysfunction in TAK-875-induced Liver Injury

(2018) Diane M Longo et al.   TOXICOLOGICAL SCIENCES

Navigating tissue chips from development to dissemination: A pharmaceutical industry perspective

(2017) Lorna Ewart et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Test systems in drug discovery for hazard identification and risk assessment of human drug-induced liver injury

(2017) Richard J. Weaver et al.   Expert Opinion on Drug Metabolism & Toxicology

Endogenous and xenobiotic metabolic stability of primary human hepatocytes in long-term 3D spheroid cultures revealed by a combination of targeted and untargeted metabolomics

(2017) Sabine U. Vorrink et al.   FASEB JOURNAL

Association of Liver Injury From Specific Drugs, or Groups of Drugs, With Polymorphisms in HLA and Other Genes in a Genome-Wide Association Study

(2017) Paola Nicoletti et al.   GASTROENTEROLOGY

Identification of drug- and drug-metabolite immune responses originating from both naive and memory T cells

(2017) Andrew Gibson et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Minocycline hepatotoxicity: Clinical characterization and identification of HLA-B∗ 35:02 as a risk factor

(2017) Thomas Jacob Urban et al.   JOURNAL OF HEPATOLOGY

Development and characterization of cholangioids from normal and diseased human cholangiocytes as an in vitro model to study primary sclerosing cholangitis

(2017) Lorena Loarca et al.   LABORATORY INVESTIGATION

Directed differentiation of human induced pluripotent stem cells into functional cholangiocyte-like cells

(2017) Fotios Sampaziotis et al.   Nature Protocols

Measures of BSEP Inhibition In Vitro Are Not Useful Predictors of DILI

(2017) Rosa Chan et al.   TOXICOLOGICAL SCIENCES

Characterization of Drug-Specific Signaling Between Primary Human Hepatocytes and Immune Cells

(2017) Monday O. Ogese et al.   TOXICOLOGICAL SCIENCES

From the Cover: MechanisticInsights in Cytotoxic and Cholestatic Potential of the Endothelial Receptor Antagonists Using HepaRG Cells

(2017) Matthew Gibson Burbank et al.   TOXICOLOGICAL SCIENCES

Maintenance of high quality rat precision cut liver slices during culture to study hepatotoxic responses: Acetaminophen as a model compound

(2017) Anne Granitzny et al.   TOXICOLOGY IN VITRO

The Liver Toxicity Knowledge Base (LKTB) and drug-induced liver injury (DILI) classification for assessment of human liver injury

(2017) Shraddha Thakkar et al.   Expert Review of Gastroenterology & Hepatology

Donor-Dependent and Other Nondefined Factors have Greater Influence on the Hepatic Phenotype than the Starting Cell Type in Induced Pluripotent Stem Cell Derived Hepatocyte-Like Cells

(2017) James A. Heslop et al.   Stem Cells Translational Medicine

An In Vitro Human Liver Model by iPSC-Derived Parenchymal and Non-parenchymal Cells

(2017) Yuta Koui et al.   Stem Cell Reports

Real-time in vivo imaging reveals localised Nrf2 stress responses associated with direct and metabolism-dependent drug toxicity

(2017) Shiva S. Forootan et al.   Scientific Reports

Evidence-based selection of training compounds for use in the mechanism-based integrated prediction of drug-induced liver injury in man

(2016) Sanja Dragovic et al.   ARCHIVES OF TOXICOLOGY

High-content imaging-based BAC-GFP toxicity pathway reporters to assess chemical adversity liabilities

(2016) Steven Wink et al.   ARCHIVES OF TOXICOLOGY

Live-cell imaging approaches for the investigation of xenobiotic-induced oxidant stress

(2016) Phillip A. Wages et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Novel 3D Culture Systems for Studies of Human Liver Function and Assessments of the Hepatotoxicity of Drugs and Drug Candidates

(2016) Volker M. Lauschke et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Evaluation of multiple mechanism-based toxicity endpoints in primary cultured human hepatocytes for the identification of drugs with clinical hepatotoxicity: Results from 152 marketed drugs with known liver injury profiles

(2016) Jie Zhang et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Quality guidelines for oral drug candidates: dose, solubility and lipophilicity

(2016) Martin K. Bayliss et al.   DRUG DISCOVERY TODAY

Screening out irrelevant cell-based models of disease

(2016) Peter Horvath et al.   NATURE REVIEWS DRUG DISCOVERY

Mechanisms for Hepatobiliary Toxicity in Rats Treated with an Antagonist of Melanin Concentrating Hormone Receptor 1 (MCHR1)

(2016) Monicah A. Otieno et al.   TOXICOLOGICAL SCIENCES

Detection of Primary T Cell Responses to Drugs and Chemicals in HLA-Typed Volunteers: Implications for the Prediction of Drug Immunogenicity

(2016) Lee Faulkner et al.   TOXICOLOGICAL SCIENCES

From the Cover: Characterization of Isoniazid-Specific T-Cell Clones in Patients with anti-Tuberculosis Drug-Related Liver and Skin Injury

(2016) Toru Usui et al.   TOXICOLOGICAL SCIENCES

Application of a Mechanistic Model to Evaluate Putative Mechanisms of Tolvaptan Drug-Induced Liver Injury and Identify Patient Susceptibility Factors

(2016) Jeffrey L. Woodhead et al.   TOXICOLOGICAL SCIENCES

A combined in vitro approach to improve the prediction of mitochondrial toxicants

(2016) Julie Eakins et al.   TOXICOLOGY IN VITRO

Drug-induced cholestasis risk assessment in sandwich-cultured human hepatocytes

(2016) Marlies Oorts et al.   TOXICOLOGY IN VITRO

A novel cell-based assay for the evaluation of immune- and inflammatory-related gene expression as biomarkers for the risk assessment of drug-induced liver injury

(2016) Shingo Oda et al.   TOXICOLOGY LETTERS

Rho-kinase/myosin light chain kinase pathway plays a key role in the impairment of bile canaliculi dynamics induced by cholestatic drugs

(2016) Ahmad Sharanek et al.   Scientific Reports

Assessing Concordance of Drug-Induced Transcriptional Response in Rodent Liver and Cultured Hepatocytes

(2016) Jeffrey J. Sutherland et al.   PLoS Computational Biology

Key Challenges and Opportunities Associated with the Use of In Vitro Models to Detect Human DILI: Integrated Risk Assessment and Mitigation Plans

(2016) Franck A. Atienzar et al.   Biomed Research International

Oxidative stress during acetaminophen hepatotoxicity: Sources, pathophysiological role and therapeutic potential

(2016) Kuo Du et al.   Redox Biology

Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease

(2016) Catherine C. Bell et al.   Scientific Reports

Hepatic 3D spheroid models for the detection and study of compounds with cholestatic liability

(2016) Delilah F. G. Hendriks et al.   Scientific Reports

Drug-induced fatty liver disease: An overview of pathogenesis and management

(2015) Sanjaya Satapathy et al.   Annals of Hepatology

The Role of Endoplasmic Reticulum Stress in Human Pathology

(2015) Scott A. Oakes et al.   Annual Review of Pathology-Mechanisms of Disease

Toxicophore exploration as a screening technology for drug design and discovery: techniques, scope and limitations

(2015) Pankaj Kumar Singh et al.   ARCHIVES OF TOXICOLOGY

High-content screening technology for studying drug-induced hepatotoxicity in cell models

(2015) Laia Tolosa et al.   ARCHIVES OF TOXICOLOGY

Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver

(2015) Meritxell Huch et al.   CELL

The Role of CD8 T Cells in Amodiaquine-Induced Liver Injury in PD1–/– Mice Cotreated with Anti-CTLA-4

(2015) Alastair Mak et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Toxicology Strategies for Drug Discovery: Present and Future

(2015) Eric A. G. Blomme et al.   CHEMICAL RESEARCH IN TOXICOLOGY

The application of engineered liver tissues for novel drug discovery

(2015) Christine Lin et al.   Expert Opinion on Drug Discovery

Development of novel tools for thein vitroinvestigation of drug-induced liver injury

(2015) Jian Jiang et al.   Expert Opinion on Drug Metabolism & Toxicology

Immunological basis in the pathogenesis of intrahepatic cholestasis of pregnancy

(2015) Spencer P Larson et al.   Expert Review of Clinical Immunology

Monocyte-derived hepatocyte-like cells for causality assessment of idiosyncratic drug-induced liver injury

(2015) Andreas Benesic et al.   GUT

Characterization of amoxicillin- and clavulanic acid-specific T cells in patients with amoxicillin-clavulanate-induced liver injury

(2015) Seung-Hyun Kim et al.   HEPATOLOGY

Treatment of PD-1−/−mice with amodiaquine and anti-CTLA4 leads to liver injury similar to idiosyncratic liver injury in patients

(2015) Imir G. Metushi et al.   HEPATOLOGY

Bile salt export pump-reactive antibodies form a polyclonal, multi-inhibitory response in antibody-induced bile salt export pump deficiency

(2015) Jan Stindt et al.   HEPATOLOGY

Promiscuous T-cell responses to drugs and drug-haptens

(2015) Fiazia S. Yaseen et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Assessing drug safety in human tissues — what are the barriers?

(2015) Anthony Holmes et al.   NATURE REVIEWS DRUG DISCOVERY

Nonclinical safety testing of biopharmaceuticals – Addressing current challenges of these novel and emerging therapies

(2015) Frank R. Brennan et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Cellular Accumulation and Toxic Effects of Bile Acids in Cyclosporine A-Treated HepaRG Hepatocytes

(2015) Ahmad Sharanek et al.   TOXICOLOGICAL SCIENCES

Comparative Proteomic Characterization of 4 Human Liver-Derived Single Cell Culture Models Reveals Significant Variation in the Capacity for Drug Disposition, Bioactivation, and Detoxication

(2015) Rowena L. C. Sison-Young et al.   TOXICOLOGICAL SCIENCES

Trovafloxacin-induced replication stress sensitizes HepG2 cells to tumor necrosis factor-alpha-induced cytotoxicity mediated by extracellular signal-regulated kinase and ataxia telangiectasia and Rad3-related

(2015) Kevin M. Beggs et al.   TOXICOLOGY

Mechanistic review of drug-induced steatohepatitis

(2015) Justin D. Schumacher et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Bile acid-induced necrosis in primary human hepatocytes and in patients with obstructive cholestasis

(2015) Benjamin L. Woolbright et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Minimizing DILI risk in drug discovery — A screening tool for drug candidates

(2015) S. Schadt et al.   TOXICOLOGY IN VITRO

The utility of HepG2 cells to identify direct mitochondrial dysfunction in the absence of cell death

(2015) Laleh Kamalian et al.   TOXICOLOGY IN VITRO

A testing strategy to predict risk for drug-induced liver injury in humans using high-content screen assays and the ‘rule-of-two’ model

(2014) Minjun Chen et al.   ARCHIVES OF TOXICOLOGY

Human Hepatocarcinoma Functional Liver Cell-4 Cell Line Exhibits High Expression of Drug-Metabolizing Enzymes in Three-Dimensional Culture

(2014) Ryuji Kato et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Human drug-induced liver injury severity is highly associated with dual inhibition of liver mitochondrial function and bile salt export pump

(2014) Michael D. Aleo et al.   HEPATOLOGY

High-throughput Assays for Superoxide and Hydrogen Peroxide

(2014) Jacek Zielonka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Negative Regulation by PD-L1 during Drug-Specific Priming of IL-22-Secreting T Cells and the Influence of PD-1 on Effector T Cell Function

(2014) A. Gibson et al.   JOURNAL OF IMMUNOLOGY

Development of a novel mouse model of amodiaquine-induced liver injury with a delayed onset

(2014) Imir G. Metushi et al.   Journal of Immunotoxicology

Microfluidic organs-on-chips

(2014) Sangeeta N Bhatia et al.   NATURE BIOTECHNOLOGY

MITOsym®: A Mechanistic, Mathematical Model of Hepatocellular Respiration and Bioenergetics

(2014) Y. Yang et al.   PHARMACEUTICAL RESEARCH

Drug-Induced Endoplasmic Reticulum and Oxidative Stress Responses Independently Sensitize Toward TNFα-Mediated Hepatotoxicity

(2014) Lisa Fredriksson et al.   TOXICOLOGICAL SCIENCES

Different Dose-Dependent Mechanisms Are Involved in Early Cyclosporine A-Induced Cholestatic Effects in HepaRG Cells

(2014) Ahmad Sharanek et al.   TOXICOLOGICAL SCIENCES

Quantification of biliary excretion and sinusoidal excretion of 5(6)-carboxy-2′,7′-dichlorofluorescein (CDF) in cultured hepatocytes isolated from Sprague Dawley, Wistar and Mrp2-deficient Wistar (TR−) rats

(2014) L.C.J. Ellis et al.   TOXICOLOGY IN VITRO

Fialuridine Induces Acute Liver Failure in Chimeric TK-NOG Mice: A Model for Detecting Hepatic Drug Toxicity Prior to Human Testing

(2014) Dan Xu et al.   PLOS MEDICINE

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME

(2013) Patricio Godoy et al.   ARCHIVES OF TOXICOLOGY

ER stress-induced cell death mechanisms

(2013) Renata Sano et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

In Vitro Methods to Support Transporter Evaluation in Drug Discovery and Development

(2013) K L R Brouwer et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Detection of anti-isoniazid and anti-cytochrome P450 antibodies in patients with isoniazid-induced liver failure

(2013) Imir G. Metushi et al.   HEPATOLOGY

Hybridin silicomodels for drug-induced liver injury using chemical descriptors andin vitrocell-imaging information

(2013) Xiang-Wei Zhu et al.   JOURNAL OF APPLIED TOXICOLOGY

Pharmacogenomics of severe cutaneous adverse reactions and drug-induced liver injury

(2013) Nahoko Kaniwa et al.   JOURNAL OF HUMAN GENETICS

HLA Haplotype Determines Hapten or p-i T Cell Reactivity to Flucloxacillin

(2013) N. Wuillemin et al.   JOURNAL OF IMMUNOLOGY

In Silico Physicochemical Parameter Predictions

(2013) Mark C. Wenlock et al.   MOLECULAR PHARMACEUTICS

Early Identification of Clinically Relevant Drug Interactions With the Human Bile Salt Export Pump (BSEP/ABCB11)

(2013) Jenny M. Pedersen et al.   TOXICOLOGICAL SCIENCES

Validation of a HTS-amenable assay to detect drug-induced mitochondrial toxicity in the absence and presence of cell death

(2013) Rachel Swiss et al.   TOXICOLOGY IN VITRO

A high content screening assay to predict human drug-induced liver injury during drug discovery

(2013) Mikael Persson et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Drug induced phospholipidosis: An acquired lysosomal storage disorder

(2012) James A. Shayman et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Preclinical Strategy to Reduce Clinical Hepatotoxicity Using in Vitro Bioactivation Data for >200 Compounds

(2012) Melanie Z. Sakatis et al.   CHEMICAL RESEARCH IN TOXICOLOGY

In Vitro Approach to Assess the Potential for Risk of Idiosyncratic Adverse Reactions Caused by Candidate Drugs

(2012) Richard A. Thompson et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Oxidative stress plays a major role in chlorpromazine-induced cholestasis in human HepaRG cells

(2012) Sébastien Anthérieu et al.   HEPATOLOGY

Human leukocyte antigen (HLA)-B*57:01-restricted activation of drug-specific T cells provides the immunological basis for flucloxacillin-induced liver injury

(2012) Manal M. Monshi et al.   HEPATOLOGY

Computational Prediction of Metabolism: Sites, Products, SAR, P450 Enzyme Dynamics, and Mechanisms

(2012) Johannes Kirchmair et al.   Journal of Chemical Information and Modeling

In vitro to in vivo extrapolation and species response comparisons for drug-induced liver injury (DILI) using DILIsym™: a mechanistic, mathematical model of DILI

(2012) Brett A. Howell et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

The Generation, Detection, and Effects of Reactive Drug Metabolites

(2012) Andrew V. Stachulski et al.   MEDICINAL RESEARCH REVIEWS

The unfolded protein response: controlling cell fate decisions under ER stress and beyond

(2012) Claudio Hetz   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Development of In Vitro Culture Methods to Characterize Primary T-Cell Responses to Drugs

(2012) Lee Faulkner et al.   TOXICOLOGICAL SCIENCES

Prediction of Liver Injury Induced by Chemicals in Human With a Multiparametric Assay on Isolated Mouse Liver Mitochondria

(2012) Mathieu Porceddu et al.   TOXICOLOGICAL SCIENCES

Mitochondrial bioenergetics and drug-induced toxicity in a panel of mouse embryonic fibroblasts with mitochondrial DNA single nucleotide polymorphisms

(2012) Claudia V. Pereira et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

A high-throughput dual parameter assay for assessing drug-induced mitochondrial dysfunction provides additional predictivity over two established mitochondrial toxicity assays

(2012) James Hynes et al.   TOXICOLOGY IN VITRO

A transgenic mouse model for monitoring oxidative stress

(2012) Daisuke Oikawa et al.   Scientific Reports

In silico analysis of HLA associations with drug-induced liver injury: use of a HLA-genotyped DNA archive from healthy volunteers

(2012) Ana Alfirevic et al.   Genome Medicine

Modeling Drug- and Chemical-Induced Hepatotoxicity with Systems Biology Approaches

(2012) Sudin Bhattacharya et al.   Frontiers in Physiology

Structural Alert/Reactive Metabolite Concept as Applied in Medicinal Chemistry to Mitigate the Risk of Idiosyncratic Drug Toxicity: A Perspective Based on the Critical Examination of Trends in the Top 200 Drugs Marketed in the United States

(2011) Antonia F. Stepan et al.   CHEMICAL RESEARCH IN TOXICOLOGY

A generic operational strategy to qualify translational safety biomarkers

(2011) Katja Matheis et al.   DRUG DISCOVERY TODAY

FDA-approved drug labeling for the study of drug-induced liver injury

(2011) Minjun Chen et al.   DRUG DISCOVERY TODAY

Genetic association studies in drug-induced liver injury

(2011) Ann K. Daly et al.   DRUG METABOLISM REVIEWS

The contribution of endoplasmic reticulum stress to liver diseases

(2011) Lily Dara et al.   HEPATOLOGY

Drug-induced cholestasis

(2011) Manmeet S. Padda et al.   HEPATOLOGY

Diclofenac inhibits tumor necrosis factor-α-induced nuclear factor-κB activation causing synergistic hepatocyte apoptosis

(2011) Lisa Fredriksson et al.   HEPATOLOGY

Global Profiling of Reactive Oxygen and Nitrogen Species in Biological Systems

(2011) Jacek Zielonka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HLA-DQA1*02:01 Is a Major Risk Factor for Lapatinib-Induced Hepatotoxicity in Women With Advanced Breast Cancer

(2011) Colin F. Spraggs et al.   JOURNAL OF CLINICAL ONCOLOGY

Managing the challenge of chemically reactive metabolites in drug development

(2011) B. Kevin Park et al.   NATURE REVIEWS DRUG DISCOVERY

Amiodarone Exposure During Modest Inflammation Induces Idiosyncrasy-like Liver Injury in Rats: Role of Tumor Necrosis Factor-alpha

(2011) Jingtao Lu et al.   TOXICOLOGICAL SCIENCES

Differential Disposition of Chenodeoxycholic Acid versus Taurocholic Acid in Response to Acute Troglitazone Exposure in Rat Hepatocytes

(2011) Tracy L. Marion et al.   TOXICOLOGICAL SCIENCES

Translating Clinical Findings into Knowledge in Drug Safety Evaluation - Drug Induced Liver Injury Prediction System (DILIps)

(2011) Zhichao Liu et al.   PLoS Computational Biology

Risk assessment and mitigation strategies for reactive metabolites in drug discovery and development

(2010) Richard A. Thompson et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Building a Tiered Approach to In Vitro Predictive Toxicity Screening: A Focus on Assays with In Vivo Relevance

(2010) James McKim Jr.   COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

A Comparison of Whole Genome Gene Expression Profiles of HepaRG Cells and HepG2 Cells to Primary Human Hepatocytes and Human Liver Tissues

(2010) S. N. Hart et al.   DRUG METABOLISM AND DISPOSITION

Sandwich-cultured hepatocytes: anin vitromodel to evaluate hepatobiliary transporter-based drug interactions and hepatotoxicity

(2010) Brandon Swift* et al.   DRUG METABOLISM REVIEWS

Hepatic lipotoxicity and the pathogenesis of nonalcoholic steatohepatitis: The central role of nontriglyceride fatty acid metabolites

(2010) Brent A. Neuschwander-Tetri   HEPATOLOGY

Human leucocyte antigen class II genotype in susceptibility and resistance to co-amoxiclav-induced liver injury

(2010) Peter T. Donaldson et al.   JOURNAL OF HEPATOLOGY

A genome-wide study identifies HLA alleles associated with lumiracoxib-related liver injury

(2010) Jonathan B Singer et al.   NATURE GENETICS

Contribution of High Basolateral Bile Salt Efflux to the Lack of Hepatotoxicity in Rat in Response to Drugs Inducing Cholestasis in Human

(2010) Katalin Jemnitz et al.   TOXICOLOGICAL SCIENCES

Interference with Bile Salt Export Pump Function Is a Susceptibility Factor for Human Liver Injury in Drug Development

(2010) Ryan E. Morgan et al.   TOXICOLOGICAL SCIENCES

Oxidative stress is important in the pathogenesis of liver injury induced by sulindac and lipopolysaccharide cotreatment

(2010) Wei Zou et al.   TOXICOLOGY

Fulminant Liver Failure After Vancomycin in a Sulfasalazine-Induced DRESS Syndrome: Fatal Recurrence After Liver Transplantation

(2009) M. Mennicke et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Screening for the Drug-Phospholipid Interaction: Correlation to Phospholipidosis

(2009) Juha-Matti Alakoskela et al.   ChemMedChem

Drug-Induced Liver Injury Network (DILIN) Prospective Study

(2009) Robert J. Fontana et al.   DRUG SAFETY

Bile acids: regulation of synthesis

(2009) John Y. L. Chiang   JOURNAL OF LIPID RESEARCH

HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin

(2009) Ann K Daly et al.   NATURE GENETICS

Trovafloxacin Enhances TNF-Induced Inflammatory Stress and Cell Death Signaling and Reduces TNF Clearance in a Murine Model of Idiosyncratic Hepatotoxicity

(2009) Patrick J. Shaw et al.   TOXICOLOGICAL SCIENCES

Bile acids: Chemistry, physiology, and pathophysiology

(2009) Maria J Monte et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Coordinated induction of drug transporters and phase I and II metabolism in human liver slices

(2008) P. Olinga et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Gene Expression Profiles in Livers from Diclofenac-Treated Rats Reveal Intestinal Bacteria-Dependent and -Independent Pathways Associated with Liver Injury

(2008) X. Deng et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS