Prediction of Liver Injury Induced by Chemicals in Human With a Multiparametric Assay on Isolated Mouse Liver Mitochondria

In vitro-in vivocorrelation for intrinsic clearance for CP-409,092 and sumatriptan: a case study to predict thein vivoclearance for compounds metabolized by monoamine oxidase

(2011) Amin Kamel et al.   XENOBIOTICA

Fatal myocardial infarction during nilotinib treatment in a 60-year-old male patient

(2010) Yolanda B. Brauchli et al.   ACTA ONCOLOGICA

Polymerase γ Gene POLG determines the risk of sodium valproate-induced liver toxicity

(2010) Joanna D. Stewart et al.   HEPATOLOGY

Drug-induced toxicity on mitochondria and lipid metabolism: Mechanistic diversity and deleterious consequences for the liver

(2010) Karima Begriche et al.   JOURNAL OF HEPATOLOGY

Use of Human Cancer Cell Lines Mitochondria to Explore the Mechanisms of BH3 Peptides and ABT-737-Induced Mitochondrial Membrane Permeabilization

(2010) Nelly Buron et al.   PLoS One

Potential estrogenic effect(s) of parabens at the prepubertal stage of a postnatal female rat model

(2010) Thuy T.B. Vo et al.   REPRODUCTIVE TOXICOLOGY

Multiple mechanisms underlying troglitazone-induced mitochondrial permeability transition

(2010) Takuya Okuda et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Cardiotoxicity induced by tyrosine kinase inhibitors

(2009) George S. Orphanos et al.   ACTA ONCOLOGICA

Sunitinib-Induced Cardiotoxicity Is Mediated by Off-Target Inhibition of AMP-Activated Protein Kinase

(2009) Risto Kerkela et al.   CTS-Clinical and Translational Science

Current Concepts of Mechanisms in Drug-Induced Hepatotoxicity

(2009) Stefan Russmann et al.   CURRENT MEDICINAL CHEMISTRY

Mitochondrial Tubulopathy in Tenofovir Disoproxil Fumarate-Treated Rats

(2009) Dirk Lebrecht et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

The Natural History of Drug-Induced Liver Injury

(2009) Einar Björnsson   SEMINARS IN LIVER DISEASE

Troglitazone, but not rosiglitazone, damages mitochondrial DNA and induces mitochondrial dysfunction and cell death in human hepatocytes

(2009) Lyudmila I. Rachek et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The relationship between diphenylamine structure and NSAIDs-induced hepatocytes injury

(2009) Yan Li et al.   TOXICOLOGY LETTERS

The heterozygous Sod2+/− mouse: modeling the mitochondrial role in drug toxicity

(2008) Urs A. Boelsterli et al.   DRUG DISCOVERY TODAY

Drug-induced liver injury through mitochondrial dysfunction: mechanisms and detection during preclinical safety studies

(2008) Gilles Labbe et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Effect of the Multitargeted Tyrosine Kinase Inhibitors Imatinib, Dasatinib, Sunitinib, and Sorafenib on Mitochondrial Function in Isolated Rat Heart Mitochondria and H9c2 Cells

(2008) Yvonne Will et al.   TOXICOLOGICAL SCIENCES

In Vitro Assessment of Mitochondrial Dysfunction and Cytotoxicity of Nefazodone, Trazodone, and Buspirone

(2008) James A. Dykens et al.   TOXICOLOGICAL SCIENCES