Test systems in drug discovery for hazard identification and risk assessment of human drug-induced liver injury

Measurement of β-oxidation capacity of biological samples by respirometry: a review of principles and substrates

(2016) Edward Ojuka et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

A multicenter assessment of single-cell models aligned to standard measures of cell health for prediction of acute hepatotoxicity

(2016) Rowena L. Sison-Young et al.   ARCHIVES OF TOXICOLOGY

The Rat microRNA body atlas; Evaluation of the microRNA content of rat organs through deep sequencing and characterization of pancreas enriched miRNAs as biomarkers of pancreatic toxicity in the rat and dog

(2016) Aaron Smith et al.   BMC GENOMICS

Primary-like human hepatocytes genetically engineered to obtain proliferation competence display hepatic differentiation characteristics in monolayer and organotypical spheroid cultures

(2016) Natalie Herzog et al.   CELL BIOLOGY INTERNATIONAL

Liver immunology and its role in inflammation and homeostasis

(2016) Mark W Robinson et al.   Cellular & Molecular Immunology

Classification of Cholestatic and Necrotic Hepatotoxicants Using Transcriptomics on Human Precision-Cut Liver Slices

(2016) Suresh Vatakuti et al.   CHEMICAL RESEARCH IN TOXICOLOGY

New Approaches to Investigate Drug-Induced Hypersensitivity

(2016) Monday O. Ogese et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Advances in Predictive Toxicology for Discovery Safety through High Content Screening

(2016) Mikael Persson et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Stem cell-derived models to improve mechanistic understanding and prediction of human drug-induced liver injury

(2016) Christopher Goldring et al.   HEPATOLOGY

Identification of the Additional Mitochondrial Liabilities of 2-Hydroxyflutamide When Compared With its Parent Compound, Flutamide in HepG2 Cells

(2016) Amy L. Ball et al.   TOXICOLOGICAL SCIENCES

A combined in vitro approach to improve the prediction of mitochondrial toxicants

(2016) Julie Eakins et al.   TOXICOLOGY IN VITRO

A novel cell-based assay for the evaluation of immune- and inflammatory-related gene expression as biomarkers for the risk assessment of drug-induced liver injury

(2016) Shingo Oda et al.   TOXICOLOGY LETTERS

Assessing Concordance of Drug-Induced Transcriptional Response in Rodent Liver and Cultured Hepatocytes

(2016) Jeffrey J. Sutherland et al.   PLoS Computational Biology

Effects of mid-respiratory chain inhibition on mitochondrial function in vitro and in vivo

(2016) Ashley J. Broom et al.   Toxicology Research

Biomarkers in DILI: One More Step Forward

(2016) Mercedes Robles-Díaz et al.   Frontiers in Pharmacology

Hepatic 3D spheroid models for the detection and study of compounds with cholestatic liability

(2016) Delilah F. G. Hendriks et al.   Scientific Reports

Towards depersonalized abacavir therapy

(2015) Dean J. Naisbitt et al.   AIDS

Toxicology Strategies for Drug Discovery: Present and Future

(2015) Eric A. G. Blomme et al.   CHEMICAL RESEARCH IN TOXICOLOGY

The application of engineered liver tissues for novel drug discovery

(2015) Christine Lin et al.   Expert Opinion on Drug Discovery

Development of novel tools for thein vitroinvestigation of drug-induced liver injury

(2015) Jian Jiang et al.   Expert Opinion on Drug Metabolism & Toxicology

Characterization of amoxicillin- and clavulanic acid-specific T cells in patients with amoxicillin-clavulanate-induced liver injury

(2015) Seung-Hyun Kim et al.   HEPATOLOGY

Treatment of PD-1−/−mice with amodiaquine and anti-CTLA4 leads to liver injury similar to idiosyncratic liver injury in patients

(2015) Imir G. Metushi et al.   HEPATOLOGY

Drug-induced allergic hepatitis develops in mice when myeloid-derived suppressor cells are depleted prior to halothane treatment

(2015) Mala Chakraborty et al.   HEPATOLOGY

Activation of Flucloxacillin-Specific CD8+ T-Cells With the Potential to Promote Hepatocyte Cytotoxicity in a Mouse Model

(2015) Ryan Nattrass et al.   TOXICOLOGICAL SCIENCES

Comparative Proteomic Characterization of 4 Human Liver-Derived Single Cell Culture Models Reveals Significant Variation in the Capacity for Drug Disposition, Bioactivation, and Detoxication

(2015) Rowena L. C. Sison-Young et al.   TOXICOLOGICAL SCIENCES

The utility of HepG2 cells to identify direct mitochondrial dysfunction in the absence of cell death

(2015) Laleh Kamalian et al.   TOXICOLOGY IN VITRO

Development and use of in vitro alternatives to animal testing by the pharmaceutical industry 1980–2013

(2015) Jen-Yin Goh et al.   Toxicology Research

High-Content Analysis/Screening for Predictive Toxicology: Application to Hepatotoxicity and Genotoxicity

(2014) Mikael Persson et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Toward predictive models for drug-induced liver injury in humans: are we there yet?

(2014) Minjun Chen et al.   Biomarkers in Medicine

Mechanisms of drug-induced liver injury

(2014) Camilla Stephens et al.   Current Opinion in Allergy and Clinical Immunology

Mitochondrial toxicity assessment in industry – a decade of technology development and insight

(2014) Yvonne Will et al.   Expert Opinion on Drug Metabolism & Toxicology

Competency of different cell models to predict human hepatotoxic drugs

(2014) M José Gómez-Lechón et al.   Expert Opinion on Drug Metabolism & Toxicology

Human drug-induced liver injury severity is highly associated with dual inhibition of liver mitochondrial function and bile salt export pump

(2014) Michael D. Aleo et al.   HEPATOLOGY

Inflammatory cytokines promote the retrodifferentiation of tumor-derived hepatocyte-like cells to progenitor cells

(2014) Hélène Dubois-Pot-Schneider et al.   HEPATOLOGY

Involvement of immune- and inflammatory-related factors in flucloxacillin-induced liver injury in mice

(2014) Shohei Takai et al.   JOURNAL OF APPLIED TOXICOLOGY

PPAR agonists reduce steatosis in oleic acid-overloaded HepaRG cells

(2014) Alexandra Rogue et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Fialuridine Induces Acute Liver Failure in Chimeric TK-NOG Mice: A Model for Detecting Hepatic Drug Toxicity Prior to Human Testing

(2014) Dan Xu et al.   PLOS MEDICINE

MicroRNAs as potential circulating biomarkers of drug-induced liver injury: key current and future issues for translation to humans

(2014) Robert James Hornby et al.   Expert Review of Clinical Pharmacology

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME

(2013) Patricio Godoy et al.   ARCHIVES OF TOXICOLOGY

The broadening spectrum of mitochondrial disease: Shifts in the diagnostic paradigm

(2013) Christina Liang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Detection of anti-isoniazid and anti-cytochrome P450 antibodies in patients with isoniazid-induced liver failure

(2013) Imir G. Metushi et al.   HEPATOLOGY

Drug-induced liver injury in obesity

(2013) Bernard Fromenty   JOURNAL OF HEPATOLOGY

Isoniazid-induced liver injury and immune response in mice

(2013) Imir G. Metushi et al.   Journal of Immunotoxicology

Biliary Proliferative Lesions in the Sprague-Dawley Rat

(2013) James R. Hailey et al.   TOXICOLOGIC PATHOLOGY

A high content screening assay to predict human drug-induced liver injury during drug discovery

(2013) Mikael Persson et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Preclinical Strategy to Reduce Clinical Hepatotoxicity Using in Vitro Bioactivation Data for >200 Compounds

(2012) Melanie Z. Sakatis et al.   CHEMICAL RESEARCH IN TOXICOLOGY

In Vitro Approach to Assess the Potential for Risk of Idiosyncratic Adverse Reactions Caused by Candidate Drugs

(2012) Richard A. Thompson et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Role of immune reactions in drug-induced liver injury (DILI)

(2012) Cynthia Ju et al.   DRUG METABOLISM REVIEWS

Human leukocyte antigen (HLA)-B*57:01-restricted activation of drug-specific T cells provides the immunological basis for flucloxacillin-induced liver injury

(2012) Manal M. Monshi et al.   HEPATOLOGY

Assessment of drug-induced mitochondrial dysfunction via altered cellular respiration and acidification measured in a 96-well platform

(2012) Sashi Nadanaciva et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

In vitro validation of drug-induced phospholipidosis

(2012) Sora Park et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Leveraging models of cell regulation and GWAS data in integrative network-based association studies

(2012) Andrea Califano et al.   NATURE GENETICS

Mitochondrial membrane potential probes and the proton gradient: a practical usage guide

(2011) Seth W. Perry et al.   BIOTECHNIQUES

Pentoxifylline aggravates fatty liver in obese and diabetic ob/ob mice by increasing intestinal glucose absorption and activating hepatic lipogenesis

(2011) J Massart et al.   BRITISH JOURNAL OF PHARMACOLOGY

Is Toxicogenomics a More Reliable and Sensitive Biomarker than Conventional Indicators from Rats To Predict Drug-Induced Liver Injury in Humans?

(2011) Min Zhang et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Animal models of idiosyncratic drug-induced liver injury—Current status

(2011) Robert A. Roth et al.   CRITICAL REVIEWS IN TOXICOLOGY

Central role of mitochondria in drug-induced liver injury

(2011) Dominique Pessayre et al.   DRUG METABOLISM REVIEWS

HLA-DQA1*02:01 Is a Major Risk Factor for Lapatinib-Induced Hepatotoxicity in Women With Advanced Breast Cancer

(2011) Colin F. Spraggs et al.   JOURNAL OF CLINICAL ONCOLOGY

Managing the challenge of chemically reactive metabolites in drug development

(2011) B. Kevin Park et al.   NATURE REVIEWS DRUG DISCOVERY

Evaluation of Drugs With Specific Organ Toxicities in Organ-Specific Cell Lines

(2011) Zhiwu Lin et al.   TOXICOLOGICAL SCIENCES

The potential of cytokines as safety biomarkers for drug-induced liver injury

(2010) Hugh G. Laverty et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Drug-induced toxicity on mitochondria and lipid metabolism: Mechanistic diversity and deleterious consequences for the liver

(2010) Karima Begriche et al.   JOURNAL OF HEPATOLOGY

Admission levels and early changes in serum interleukin-10 are predictive of poor outcome in acute liver failure and decompensated cirrhosis

(2010) P. A. Berry et al.   LIVER INTERNATIONAL

Predicting safety toleration of pharmaceutical chemical leads: Cytotoxicity correlations to exploratory toxicity studies☆

(2010) John W. Benbow et al.   TOXICOLOGY LETTERS

Fulminant Liver Failure After Vancomycin in a Sulfasalazine-Induced DRESS Syndrome: Fatal Recurrence After Liver Transplantation

(2009) M. Mennicke et al.   AMERICAN JOURNAL OF TRANSPLANTATION

A Zone Classification System for Risk Assessment of Idiosyncratic Drug Toxicity Using Daily Dose and Covalent Binding

(2009) S. Nakayama et al.   DRUG METABOLISM AND DISPOSITION

Evaluation of the Potential for Drug-Induced Liver Injury Based on in Vitro Covalent Binding to Human Liver Proteins

(2009) T. Usui et al.   DRUG METABOLISM AND DISPOSITION

Cytokine and autoantibody patterns in acute liver failure

(2009) Jinze Li et al.   Journal of Immunotoxicology

HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin

(2009) Ann K Daly et al.   NATURE GENETICS

Drug-induced liver injury following positive drug rechallenge

(2009) Julie I. Papay et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Sensitivity of Liver Injury in Heterozygous Sod2 Knockout Mice Treated with Troglitazone or Acetaminophen

(2009) Kazunori Fujimoto et al.   TOXICOLOGIC PATHOLOGY

Underlying mitochondrial dysfunction triggers flutamide-induced oxidative liver injury in a mouse model of idiosyncratic drug toxicity

(2009) Rohini Kashimshetty et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Can In Vitro Metabolism-Dependent Covalent Binding Data in Liver Microsomes Distinguish Hepatotoxic from Nonhepatotoxic Drugs? An Analysis of 18 Drugs with Consideration of Intrinsic Clearance and Daily Dose

(2008) R. Scott Obach et al.   CHEMICAL RESEARCH IN TOXICOLOGY

The in-depth evaluation of suspected mitochondrial disease

(2008) Richard H. Haas et al.   MOLECULAR GENETICS AND METABOLISM

Cellular Imaging Predictions of Clinical Drug-Induced Liver Injury

(2008) Jinghai J. Xu et al.   TOXICOLOGICAL SCIENCES

Selection of cytotoxicity markers for the screening of new chemical entities in a pharmaceutical context: A preliminary study using a multiplexing approach

(2008) H.H.J. Gerets et al.   TOXICOLOGY IN VITRO

Comparison of four different colorimetric and fluorometric cytotoxicity assays in a zebrafish liver cell line

(2008) Stephanie K Bopp et al.   BMC Pharmacology & Toxicology