In vitro to in vivo extrapolation and species response comparisons for drug-induced liver injury (DILI) using DILIsym™: a mechanistic, mathematical model of DILI

Bottom-up modeling and simulation of tacrolimus clearance: prospective investigation of blood cell distribution, sex and CYP3A5 expression as covariates and assessment of study power

(2011) Hisakazu Ohtani et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

In Vivo-In Vitro-In Silico Pharmacokinetic Modelling in Drug Development

(2011) Olavi Pelkonen et al.   CLINICAL PHARMACOKINETICS

In Vitro–In Vivo Extrapolation of Clearance: Modeling Hepatic Metabolic Clearance of Highly Bound Drugs and Comparative Assessment with Existing Calculation Methods

(2011) Patrick Poulin et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Silencing Glycogen Synthase Kinase-3β Inhibits Acetaminophen Hepatotoxicity and Attenuates JNK Activation and Loss of Glutamate Cysteine Ligase and Myeloid Cell Leukemia Sequence 1

(2010) Mie Shinohara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Antioxidative and hepatoprotective effects of magnolol on acetaminophen-induced liver damage in rats

(2009) Yung-Hsiang Chen et al.   ARCHIVES OF PHARMACAL RESEARCH

Novel mechanisms of protection against acetaminophen hepatotoxicity in mice by glutathione and N-acetylcysteine

(2009) Chieko Saito et al.   HEPATOLOGY

Children’s toxicology from bench to bed - Liver Injury (3): Oxidative stress and anti-oxidant systems in liver of patients with wilson disease

(2009) Hironori Nagasaka et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Bacterial- and Viral-Induced Inflammation Increases Sensitivity to Acetaminophen Hepatotoxicity

(2009) Jane F. Maddox et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

Sensitivity of Liver Injury in Heterozygous Sod2 Knockout Mice Treated with Troglitazone or Acetaminophen

(2009) Kazunori Fujimoto et al.   TOXICOLOGIC PATHOLOGY

Mechanism of protection by metallothionein against acetaminophen hepatotoxicity

(2009) Chieko Saito et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Hepatic Mrp4 induction following acetaminophen exposure is dependent on Kupffer cell function

(2008) Sarah N. Campion et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Th1/Th2 cytokine balance as a determinant of acetaminophen-induced liver injury

(2008) Yasuhiro Masubuchi et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Clinical relevance of predictive physiologically based pharmacokinetic methods

(2008) Simon Thomas   Expert Opinion on Drug Discovery

Deletion of Apoptosis Signal-Regulating Kinase 1 Attenuates Acetaminophen-Induced Liver Injury by Inhibiting c-Jun N-Terminal Kinase Activation

(2008) Hayato Nakagawa et al.   GASTROENTEROLOGY

Role of JNK Translocation to Mitochondria Leading to Inhibition of Mitochondria Bioenergetics in Acetaminophen-induced Liver Injury

(2008) Naoko Hanawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of the Thiophene Ring of Methapyrilene as a Novel Bioactivation-Dependent Hepatic Toxicophore

(2008) E. E. Graham et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Applications of Physiologically Based Absorption Models in Drug Discovery and Development

(2008) Neil Parrott et al.   MOLECULAR PHARMACEUTICS

Acquired Resistance to Acetaminophen Hepatotoxicity is Associated with Induction of Multidrug Resistance-Associated Protein 4 (Mrp4) in Proliferating Hepatocytes

(2008) Lauren M. Aleksunes et al.   TOXICOLOGICAL SCIENCES