Hepatic lipotoxicity and the pathogenesis of nonalcoholic steatohepatitis: The central role of nontriglyceride fatty acid metabolites

Lipolysis Control: The Plot Thickens

(2010) Dawn L. Brasaemle   Cell Metabolism

Increased fructose consumption is associated with fibrosis severity in patients with nonalcoholic fatty liver disease

(2010) Manal F. Abdelmalek et al.   HEPATOLOGY

Shotgun lipidomics of neutral lipids as an enabling technology for elucidation of lipid-related diseases

(2009) Richard W. Gross et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

In SituLipidomic Analysis of Nonalcoholic Fatty Liver by Cluster TOF-SIMS Imaging

(2009) Delphine Debois et al.   ANALYTICAL CHEMISTRY

Lysophosphatidylcholine Activates a Novel PKD2-Mediated Signaling Pathway That Controls Monocyte Migration

(2009) Mingqi Tan et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

A Sweet Path to Insulin Resistance Through PGC-1β

(2009) Carlos Hernandez et al.   Cell Metabolism

Reactive Oxygen Species Enhance Insulin Sensitivity

(2009) Kim Loh et al.   Cell Metabolism

Role of Insulin Resistance and Lipotoxicity in Non-Alcoholic Steatohepatitis

(2009) Kenneth Cusi   Clinics in Liver Disease

Saturated with fat: new perspectives on lipotoxicity

(2009) Jeanne Garbarino et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Toll-like receptor signaling links dietary fatty acids to the metabolic syndrome

(2009) Michael B Fessler et al.   CURRENT OPINION IN LIPIDOLOGY

The farnesoid X receptor (FXR) as a new target in non-alcoholic steatohepatitis

(2009) B. Cariou   DIABETES & METABOLISM

Inherited susceptibility to non-alcoholic fatty liver disease

(2009) R. J. F. Loos et al.   DIABETOLOGIA

Perilipin Is Present in Islets of Langerhans and Protects against Lipotoxicity When Overexpressed in the β-Cell Line INS-1

(2009) Jörgen Borg et al.   ENDOCRINOLOGY

Hedgehog-Mediated Epithelial-to-Mesenchymal Transition and Fibrogenic Repair in Nonalcoholic Fatty Liver Disease

(2009) Wing–Kin Syn et al.   GASTROENTEROLOGY

Prediction of Non-Alcoholic Fatty Liver Disease and Liver Fat Using Metabolic and Genetic Factors

(2009) Anna Kotronen et al.   GASTROENTEROLOGY

Differential expression of lumican and fatty acid binding protein-1: New insights into the histologic spectrum of nonalcoholic fatty liver disease

(2009) Michael Charlton et al.   HEPATOLOGY

Lipidomic dissection of nonalcoholic steatohepatitis: Moving beyond foie gras to fat traffic

(2009) Nathan M. Bass   HEPATOLOGY

Importance of changes in adipose tissue insulin resistance to histological response during thiazolidinedione treatment of patients with nonalcoholic steatohepatitis

(2009) Amalia Gastaldelli et al.   HEPATOLOGY

Toll-like receptor 4 is involved in the development of fructose-induced hepatic steatosis in mice

(2009) Astrid Spruss et al.   HEPATOLOGY

Abnormal hepatic energy homeostasis in type 2 diabetes

(2009) Julia Szendroedi et al.   HEPATOLOGY

What's in a NAme?

(2009) Elizabeth M. Brunt   HEPATOLOGY

The plasma lipidomic signature of nonalcoholic steatohepatitis

(2009) Puneet Puri et al.   HEPATOLOGY

Adipokines in liver diseases

(2009) Fabio Marra et al.   HEPATOLOGY

Advances in adipose tissue metabolism

(2009) M Lafontan   INTERNATIONAL JOURNAL OF OBESITY

Accelerated Fatty Acid Oxidation in Muscle Averts Fasting-induced Hepatic Steatosis in SJL/J Mice

(2009) Hong-Ping Guan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deorphanization of GPR109B as a Receptor for the β-Oxidation Intermediate 3-OH-octanoic Acid and Its Role in the Regulation of Lipolysis

(2009) Kashan Ahmed et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Non-coding RNAgadd7Is a Regulator of Lipid-induced Oxidative and Endoplasmic Reticulum Stress

(2009) Rita T. Brookheart et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hepatic Lipid Partitioning and Liver Damage in Nonalcoholic Fatty Liver Disease

(2009) Zheng Zheng Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipotoxicity: Why do saturated fatty acids cause and monounsaturates protect against it?

(2009) Christopher J Nolan et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Differential effect of oleic and palmitic acid on lipid accumulation and apoptosis in cultured hepatocytes

(2009) Matteo Ricchi et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Dietary sucrose is essential to the development of liver injury in the methionine-choline-deficient model of steatohepatitis

(2009) Michael K. Pickens et al.   JOURNAL OF LIPID RESEARCH

Adoption of PERILIPIN as a unifying nomenclature for the mammalian PAT-family of intracellular lipid storage droplet proteins: TABLE 1.

(2009) Alan R. Kimmel et al.   JOURNAL OF LIPID RESEARCH

Dietary fructose and intestinal barrier: potential risk factor in the pathogenesis of nonalcoholic fatty liver disease

(2009) Astrid Spruss et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Rats selectively bred for low aerobic capacity have reduced hepatic mitochondrial oxidative capacity and susceptibility to hepatic steatosis and injury

(2009) John P. Thyfault et al.   JOURNAL OF PHYSIOLOGY-LONDON

Genetic differences in oxidative stress and inflammatory responses to diet-induced obesity do not alter liver fibrosis in mice

(2009) Wing-Kin Syn et al.   LIVER INTERNATIONAL

Another way to get rid of fat

(2009) Rudolf Zechner et al.   NATURE

Autophagy regulates lipid metabolism

(2009) Rajat Singh et al.   NATURE

AdPLA ablation increases lipolysis and prevents obesity induced by high-fat feeding or leptin deficiency

(2009) Kathy Jaworski et al.   NATURE MEDICINE

PPARγ activation in adipocytes is sufficient for systemic insulin sensitization

(2009) Shigeki Sugii et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The skinny on fat: lipolysis and fatty acid utilization in adipocytes

(2009) Maryam Ahmadian et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The lowering of hepatic fatty acid uptake improves liver function and insulin sensitivity without affecting hepatic fat content in humans

(2008) Sara Rigazio et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Beyond triglyceride synthesis: the dynamic functional roles of MGAT and DGAT enzymes in energy metabolism

(2008) Yuguang Shi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The Adventures of Sonic Hedgehog in Development and Repair. II. Sonic hedgehog and liver development, inflammation, and cancer

(2008) Alessia Omenetti et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Severe NAFLD with hepatic necroinflammatory changes in mice fed trans fats and a high-fructose corn syrup equivalent

(2008) Laura H. Tetri et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Obstructive Sleep Apnea, Insulin Resistance, and Steatohepatitis in Severe Obesity

(2008) Vsevolod Y. Polotsky et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Cytochrome P450 omega hydroxylase (CYP4) function in fatty acid metabolism and metabolic diseases

(2008) James P. Hardwick   BIOCHEMICAL PHARMACOLOGY

Chanarin–Dorfman syndrome: Deficiency in CGI-58, a lipid droplet-bound coactivator of lipase

(2008) Tomohiro Yamaguchi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Hepatic Insulin Resistance Is Sufficient to Produce Dyslipidemia and Susceptibility to Atherosclerosis

(2008) Sudha B. Biddinger et al.   Cell Metabolism

FXR: a metabolic regulator and cell protector

(2008) Yan-Dong Wang et al.   CELL RESEARCH

Hepatic triglyceride synthesis and nonalcoholic fatty liver disease

(2008) Steve S Choi et al.   CURRENT OPINION IN LIPIDOLOGY

Skeletal Muscle-Specific Deletion of Lipoprotein Lipase Enhances Insulin Signaling in Skeletal Muscle but Causes Insulin Resistance in Liver and Other Tissues

(2008) H. Wang et al.   DIABETES

Glycerolipid Metabolism and Signaling in Health and Disease

(2008) Marc Prentki et al.   ENDOCRINE REVIEWS

Minireview: Lipid Droplets in Lipogenesis and Lipolysis

(2008) Nicole A. Ducharme et al.   ENDOCRINOLOGY

SREBPs: physiology and pathophysiology of the SREBP family

(2008) Hitoshi Shimano   FEBS Journal

Mechanism of Mitochondrial Glutathione-Dependent Hepatocellular Susceptibility to TNF Despite NF-κB Activation

(2008) Montserrat Marí et al.   GASTROENTEROLOGY

Hepatotoxicity of fast food?

(2008) G. Marchesini et al.   GUT

Fast-food-based hyper-alimentation can induce rapid and profound elevation of serum alanine aminotransferase in healthy subjects

(2008) S. Kechagias et al.   GUT

The lysosomal-mitochondrial axis in free fatty acid-induced hepatic lipotoxicity

(2008) ZhengZheng Li et al.   HEPATOLOGY

Adiponectin gene polymorphisms modulate acute adiponectin response to dietary fat: Possible pathogenetic role in NASH

(2008) Giovanni Musso et al.   HEPATOLOGY

Beyond insulin resistance: Innate immunity in nonalcoholic steatohepatitis

(2008) Jacquelyn J. Maher et al.   HEPATOLOGY

Prevention of free fatty acid-induced hepatic lipotoxicity by 18β-glycyrrhetinic acid through lysosomal and mitochondrial pathways

(2008) Xudong Wu et al.   HEPATOLOGY

Inhibition of apolipoprotein B100 secretion by lipid-induced hepatic endoplasmic reticulum stress in rodents

(2008) Tsuguhito Ota et al.   JOURNAL OF CLINICAL INVESTIGATION

Insulin sensitivity: modulation by nutrients and inflammation

(2008) Simon Schenk et al.   JOURNAL OF CLINICAL INVESTIGATION

Fructose consumption as a risk factor for non-alcoholic fatty liver disease

(2008) Xiaosen Ouyang et al.   JOURNAL OF HEPATOLOGY

Inhibition of stearoyl CoA desaturase activity induces hypercholesterolemia in the cholesterol-fed hamster

(2008) Catherine A. Major et al.   JOURNAL OF LIPID RESEARCH

Blocking VLDL secretion causes hepatic steatosis but does not affect peripheral lipid stores or insulin sensitivity in mice

(2008) Kaori Minehira et al.   JOURNAL OF LIPID RESEARCH

Thematic Review Series: Glycerolipids.DGAT enzymes and triacylglycerol biosynthesis

(2008) Chi-Liang Eric Yen et al.   JOURNAL OF LIPID RESEARCH

Hepatic steatosis rather than visceral adiposity is more closely associated with insulin resistance in the early stage of obesity

(2008) Taro Wasada et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes

(2008) Adilson Guilherme et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Molecular Mechanisms and Therapeutic Targets in Steatosis and Steatohepatitis

(2008) N. Anderson et al.   PHARMACOLOGICAL REVIEWS

Bioactive lipids in metabolic syndrome

(2008) Koji Nagao et al.   PROGRESS IN LIPID RESEARCH

Recent insights into hepatic lipid metabolism in non-alcoholic fatty liver disease (NAFLD)

(2008) G MUSSO et al.   PROGRESS IN LIPID RESEARCH

Abnormalities of Lipid Metabolism in Nonalcoholic Fatty Liver Disease

(2008) Onpan Cheung et al.   SEMINARS IN LIVER DISEASE

Role of Fatty Acids in the Pathogenesis of Obesity and Fatty Liver: Impact of Bariatric Surgery

(2008) Elizabeth Verna et al.   SEMINARS IN LIVER DISEASE

Molecular Mechanisms of Lipotoxicity in Nonalcoholic Fatty Liver Disease

(2008) Harmeet Malhi et al.   SEMINARS IN LIVER DISEASE

Mechanisms of Disease Progression in Nonalcoholic Fatty Liver Disease

(2008) Janice Jou et al.   SEMINARS IN LIVER DISEASE

Location, location: protein trafficking and lipolysis in adipocytes

(2008) James G. Granneman et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Control of lipolysis by natriuretic peptides and cyclic GMP

(2008) Max Lafontan et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Role of peroxisome proliferators-activated receptors in the pathogenesis and treatment of nonalcoholic fatty liver disease

(2008) Eric R Kallwitz et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Activation and Dysregulation of the Unfolded Protein Response in Nonalcoholic Fatty Liver Disease

(2007) Puneet Puri et al.   GASTROENTEROLOGY

Alterations in Adipose Tissue and Hepatic Lipid Kinetics in Obese Men and Women With Nonalcoholic Fatty Liver Disease

(2007) Elisa Fabbrini et al.   GASTROENTEROLOGY

Lipid accumulation in non-adipose tissue and lipotoxicity

(2007) N.A. van Herpen et al.   PHYSIOLOGY & BEHAVIOR