High-content imaging-based BAC-GFP toxicity pathway reporters to assess chemical adversity liabilities

Activation of the Nrf2 response by intrinsic hepatotoxic drugs correlates with suppression of NF-κB activation and sensitizes toward TNFα-induced cytotoxicity

(2015) Bram Herpers et al.   ARCHIVES OF TOXICOLOGY

Pink1 protects cortical neurons from thapsigargin-induced oxidative stress and neuronal apoptosis

(2015) Lin Li et al.   BIOSCIENCE REPORTS

Proteostasis control by the unfolded protein response

(2015) Claudio Hetz et al.   NATURE CELL BIOLOGY

Transcriptomics hit the target: Monitoring of ligand-activated and stress response pathways for chemical testing

(2015) Alice Limonciel et al.   TOXICOLOGY IN VITRO

Quantitative High Content Imaging of Cellular Adaptive Stress Response Pathways in Toxicity for Chemical Safety Assessment

(2014) Steven Wink et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Dephosphorylation Enables the Recruitment of 53BP1 to Double-Strand DNA Breaks

(2014) Dong-Hyun Lee et al.   MOLECULAR CELL

Drug-Induced Endoplasmic Reticulum and Oxidative Stress Responses Independently Sensitize Toward TNFα-Mediated Hepatotoxicity

(2014) Lisa Fredriksson et al.   TOXICOLOGICAL SCIENCES

The adverse outcome pathway concept: A pragmatic tool in toxicology

(2013) Mathieu Vinken   TOXICOLOGY

Evaluation of the use of imaging parameters for the detection of compound-induced hepatotoxicity in 384-well cultures of HepG2 cells and cryopreserved primary human hepatocytes

(2013) Helen Garside et al.   TOXICOLOGY IN VITRO

A high content screening assay to predict human drug-induced liver injury during drug discovery

(2013) Mikael Persson et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

The Predicted Molecular Weight of Nrf2: It Is What It Is Not

(2012) Alexandria Lau et al.   ANTIOXIDANTS & REDOX SIGNALING

An overview of transcriptional regulation in response to toxicological insult

(2012) Paul Jennings et al.   ARCHIVES OF TOXICOLOGY

Gene regulatory network of unfolded protein response genes in endoplasmic reticulum stress

(2012) Sayuri Takayanagi et al.   CELL STRESS & CHAPERONES

Automated Analysis of NF-κB Nuclear Translocation Kinetics in High-Throughput Screening

(2012) Zi Di et al.   PLoS One

Improved structure, function and compatibility for CellProfiler: modular high-throughput image analysis software

(2011) Lee Kamentsky et al.   BIOINFORMATICS

Diclofenac inhibits tumor necrosis factor-α-induced nuclear factor-κB activation causing synergistic hepatocyte apoptosis

(2011) Lisa Fredriksson et al.   HEPATOLOGY

Spatial Dynamics of DNA Damage Response Protein Foci along the Ion Trajectory of High-LET Particles

(2011) Guanghua Du et al.   RADIATION RESEARCH

The ToxTracker Assay: Novel GFP Reporter Systems that Provide Mechanistic Insight into the Genotoxic Properties of Chemicals

(2011) Giel Hendriks et al.   TOXICOLOGICAL SCIENCES

Evaluation of Drugs With Specific Organ Toxicities in Organ-Specific Cell Lines

(2011) Zhiwu Lin et al.   TOXICOLOGICAL SCIENCES

Cell-specific elevation of NRF2 and sulfiredoxin-1 as markers of oxidative stress in the lungs of idiopathic pulmonary fibrosis and non-specific interstitial pneumonia

(2010) WITOLD MAZUR et al.   APMIS

A flexible R package for nonnegative matrix factorization

(2010) Renaud Gaujoux et al.   BMC BIOINFORMATICS

Adverse outcome pathways: A conceptual framework to support ecotoxicology research and risk assessment

(2010) Gerald T. Ankley et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Phototoxicity of Hoechst 33342 in time-lapse fluorescence microscopy

(2010) Martin Purschke et al.   PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES

The future of drug safety testing: expanding the view and narrowing the focus

(2009) James L. Stevens et al.   DRUG DISCOVERY TODAY

Neuroprotective Effects of the Triterpenoid, CDDO Methyl Amide, a Potent Inducer of Nrf2-Mediated Transcription

(2009) Lichuan Yang et al.   PLoS One

BAC TransgeneOmics: a high-throughput method for exploration of protein function in mammals

(2008) Ina Poser et al.   NATURE METHODS