Evidence-based selection of training compounds for use in the mechanism-based integrated prediction of drug-induced liver injury in man

A multicenter assessment of single-cell models aligned to standard measures of cell health for prediction of acute hepatotoxicity

(2016) Rowena L. Sison-Young et al.   ARCHIVES OF TOXICOLOGY

The HepaRG cell line, a superior in vitro model to L-02, HepG2 and hiHeps cell lines for assessing drug-induced liver injury

(2016) Yu Wu et al.   CELL BIOLOGY AND TOXICOLOGY

Inter-donor variability of phase I/phase II metabolism of three reference drugs in cryopreserved primary human hepatocytes in suspension and monolayer

(2016) Shalenie P. den Braver-Sewradj et al.   TOXICOLOGY IN VITRO

Characterization of cytochrome P450 isoforms involved in sequential two-step bioactivation of diclofenac to reactive p-benzoquinone imines

(2016) Michiel W. den Braver et al.   TOXICOLOGY LETTERS

Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease

(2016) Catherine C. Bell et al.   Scientific Reports

Acetaminophen: Dose-Dependent Drug Hepatotoxicity and Acute Liver Failure in Patients

(2015) Hartmut Jaeschke   DIGESTIVE DISEASES

Comparative Proteomic Characterization of 4 Human Liver-Derived Single Cell Culture Models Reveals Significant Variation in the Capacity for Drug Disposition, Bioactivation, and Detoxication

(2015) Rowena L. C. Sison-Young et al.   TOXICOLOGICAL SCIENCES

Characterizing the mechanism of thiazolidinedione-induced hepatotoxicity: An in vitro model in mitochondria

(2015) Dan Hu et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Expression and Function of mARC: Roles in Lipogenesis and Metabolic Activation of Ximelagatran

(2015) Etienne P. A. Neve et al.   PLoS One

Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria

(2014) Hannah R. Bridges et al.   BIOCHEMICAL JOURNAL

Human NAD(P)H:quinone Oxidoreductase 1 (NQO1)-Mediated Inactivation of Reactive Quinoneimine Metabolites of Diclofenac and Mefenamic Acid

(2014) Galvin Vredenburg et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Systems Pharmacology Modeling Predicts Delayed Presentation and Species Differences in Bile Acid–Mediated Troglitazone Hepatotoxicity

(2014) K Yang et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Fialuridine Induces Acute Liver Failure in Chimeric TK-NOG Mice: A Model for Detecting Hepatic Drug Toxicity Prior to Human Testing

(2014) Dan Xu et al.   PLOS MEDICINE

Metabolism and Disposition of Acetaminophen: Recent Advances in Relation to Hepatotoxicity and Diagnosis

(2013) Mitchell R. McGill et al.   PHARMACEUTICAL RESEARCH

A Multifactorial Approach to Hepatobiliary Transporter Assessment Enables Improved Therapeutic Compound Development

(2013) Ryan E. Morgan et al.   TOXICOLOGICAL SCIENCES

AMAP, the alleged non-toxic isomer of acetaminophen, is toxic in rat and human liver

(2012) Mackenzie Hadi et al.   ARCHIVES OF TOXICOLOGY

Human leukocyte antigen (HLA)-B*57:01-restricted activation of drug-specific T cells provides the immunological basis for flucloxacillin-induced liver injury

(2012) Manal M. Monshi et al.   HEPATOLOGY

Programmed necrosis: putting the pieces together

(2012) Maria Papatriantafyllou   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Staurosporine Induces Necroptotic Cell Death under Caspase-Compromised Conditions in U937 Cells

(2012) Zsuzsanna A. Dunai et al.   PLoS One

Proteomic Analysis of Acetaminophen-Induced Changes in Mitochondrial Protein Expression Using Spectral Counting

(2011) Brendan D. Stamper et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Diclofenac inhibits tumor necrosis factor-α-induced nuclear factor-κB activation causing synergistic hepatocyte apoptosis

(2011) Lisa Fredriksson et al.   HEPATOLOGY

Acetaminophen hepatotoxicity and repair: the role of sterile inflammation and innate immunity

(2011) Hartmut Jaeschke et al.   LIVER INTERNATIONAL

Hepatotoxicity Associated with Metformin Therapy in Treatment of Type 2 Diabetes Mellitus with Nonalcoholic Fatty Liver Disease

(2010) Catherine J Cone et al.   ANNALS OF PHARMACOTHERAPY

Necroptosis as an alternative form of programmed cell death

(2010) Dana E Christofferson et al.   CURRENT OPINION IN CELL BIOLOGY

Molecular mechanisms of necroptosis: an ordered cellular explosion

(2010) Peter Vandenabeele et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Dabigatran etexilate versus warfarin as the oral anticoagulant of choice? A review of clinical data

(2010) Terry K.W. Ma et al.   PHARMACOLOGY & THERAPEUTICS

Interference with Bile Salt Export Pump Function Is a Susceptibility Factor for Human Liver Injury in Drug Development

(2010) Ryan E. Morgan et al.   TOXICOLOGICAL SCIENCES

Updated study on risk of cholestatic liver disease and flucloxacillin

(2009) Lin Li et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

A novel pregnane X receptor and S14-mediated lipogenic pathway in human hepatocyte

(2009) Amélie Moreau et al.   HEPATOLOGY

Histological patterns in drug-induced liver disease

(2009) R Ramachandran et al.   JOURNAL OF CLINICAL PATHOLOGY

HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin

(2009) Ann K Daly et al.   NATURE GENETICS

Case series of liver failure associated with rosiglitazone and pioglitazone

(2009) James S. Floyd et al.   PHARMACOEPIDEMIOLOGY AND DRUG SAFETY

Capture Compound Mass Spectrometry Sheds Light on the Molecular Mechanisms of Liver Toxicity of Two Parkinson Drugs

(2009) Jenny J. Fischer et al.   TOXICOLOGICAL SCIENCES

Proteomic analysis of protein tyrosine nitration after ischemia reperfusion injury: Mitochondria as the major target

(2008) Bin Liu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Bioactivation of Diclofenacin Vitroandin Vivo: Correlation to Electrochemical Studies

(2008) Kim G. Madsen et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Electrochemical Oxidation of Troglitazone: Identification and Characterization of the Major Reactive Metabolite in Liver Microsomes

(2008) Kim G. Madsen et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Drug-induced liver injury through mitochondrial dysfunction: mechanisms and detection during preclinical safety studies

(2008) Gilles Labbe et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

In Vitro Assessment of Mitochondrial Dysfunction and Cytotoxicity of Nefazodone, Trazodone, and Buspirone

(2008) James A. Dykens et al.   TOXICOLOGICAL SCIENCES

Prediction of drug-induced liver injury in humans by using in vitro methods: The case of ximelagatran

(2007) Kerstin Kenne et al.   TOXICOLOGY IN VITRO