Hepatic 3D spheroid models for the detection and study of compounds with cholestatic liability

Mechanistic evaluation of primary human hepatocyte culture using global proteomic analysis reveals a selective dedifferentiation profile

(2016) James A. Heslop et al.   ARCHIVES OF TOXICOLOGY

Drug-induced cholestasis risk assessment in sandwich-cultured human hepatocytes

(2016) Marlies Oorts et al.   TOXICOLOGY IN VITRO

Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease

(2016) Catherine C. Bell et al.   Scientific Reports

Comparative Localization and Functional Activity of the Main Hepatobiliary Transporters in HepaRG Cells and Primary Human Hepatocytes

(2015) Pamela Bachour-El Azzi et al.   TOXICOLOGICAL SCIENCES

Different Dose-Dependent Mechanisms Are Involved in Early Cyclosporine A-Induced Cholestatic Effects in HepaRG Cells

(2014) Ahmad Sharanek et al.   TOXICOLOGICAL SCIENCES

Role of Bile Acids in Liver Injury and Regeneration following Acetaminophen Overdose

(2013) Bharat Bhushan et al.   AMERICAN JOURNAL OF PATHOLOGY

Proteome-wide analyses of human hepatocytes during differentiation and dedifferentiation

(2013) Cliff Rowe et al.   HEPATOLOGY

An updated review on drug-induced cholestasis: Mechanisms and investigation of physicochemical properties and pharmacokinetic parameters

(2013) Kyunghee Yang et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

A Multifactorial Approach to Hepatobiliary Transporter Assessment Enables Improved Therapeutic Compound Development

(2013) Ryan E. Morgan et al.   TOXICOLOGICAL SCIENCES

A Correlation Between the In Vitro Drug Toxicity of Drugs to Cell Lines That Express Human P450s and Their Propensity to Cause Liver Injury in Humans

(2013) Frida Gustafsson et al.   TOXICOLOGICAL SCIENCES

3D Organotypic Cultures of Human HepaRG Cells: A Tool for In Vitro Toxicity Studies

(2013) Patrina Gunness et al.   TOXICOLOGICAL SCIENCES

Hepatocyte-based in vitro model for assessment of drug-induced cholestasis

(2013) Sagnik Chatterjee et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Multi-cell type human liver microtissues for hepatotoxicity testing

(2012) S. Messner et al.   ARCHIVES OF TOXICOLOGY

Oxidative stress plays a major role in chlorpromazine-induced cholestasis in human HepaRG cells

(2012) Sébastien Anthérieu et al.   HEPATOLOGY

Drug-induced cholestasis

(2011) Manmeet S. Padda et al.   HEPATOLOGY

Human liver cell spheroids in extended perfusion bioreactor culture for repeated-dose drug testing

(2011) Rui M. Tostões et al.   HEPATOLOGY

Sandwich-cultured hepatocytes: anin vitromodel to evaluate hepatobiliary transporter-based drug interactions and hepatotoxicity

(2010) Brandon Swift* et al.   DRUG METABOLISM REVIEWS

Nuclear receptors as drug targets in cholestasis and drug-induced hepatotoxicity

(2010) Gernot Zollner et al.   PHARMACOLOGY & THERAPEUTICS

Interference with Bile Salt Export Pump Function Is a Susceptibility Factor for Human Liver Injury in Drug Development

(2010) Ryan E. Morgan et al.   TOXICOLOGICAL SCIENCES

HepaRG human hepatic cell line utility as a surrogate for primary human hepatocytes in drug metabolism assessment in vitro

(2010) Marc Lübberstedt et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

The future of drug safety testing: expanding the view and narrowing the focus

(2009) James L. Stevens et al.   DRUG DISCOVERY TODAY

An In Vitro Assay to Assess Transporter-Based Cholestatic Hepatotoxicity Using Sandwich-Cultured Rat Hepatocytes

(2009) J. H. Ansede et al.   DRUG METABOLISM AND DISPOSITION

High performance liquid chromatography–tandem mass spectrometry for the determination of bile acid concentrations in human plasma

(2009) Xiaoqiang Xiang et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Transcriptional regulation of the AP-1 and Nrf2 target gene sulfiredoxin

(2009) Francesc X. Soriano et al.   MOLECULES AND CELLS

Case series of liver failure associated with rosiglitazone and pioglitazone

(2009) James S. Floyd et al.   PHARMACOEPIDEMIOLOGY AND DRUG SAFETY

Bile Acid Sulfation: A Pathway of Bile Acid Elimination and Detoxification

(2009) Yazen Alnouti   TOXICOLOGICAL SCIENCES