Dynamic imaging of adaptive stress response pathway activation for prediction of drug induced liver injury

A transcriptomics data-driven gene space accurately predicts liver cytopathology and drug-induced liver injury

(2017) Pekka Kohonen et al.   Nature Communications

High-content imaging-based BAC-GFP toxicity pathway reporters to assess chemical adversity liabilities

(2016) Steven Wink et al.   ARCHIVES OF TOXICOLOGY

p21(WAF1) Mediates Cell-Cycle Inhibition, Relevant to Cancer Suppression and Therapy

(2016) Wafik S. El-Deiry   CANCER RESEARCH

DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans

(2016) Minjun Chen et al.   DRUG DISCOVERY TODAY

Endoplasmic Reticulum Stress Induction and ERK1/2 Activation Contribute to Nefazodone-Induced Toxicity in Hepatic Cells

(2016) Zhen Ren et al.   TOXICOLOGICAL SCIENCES

Drug-induced liver injury: Interactions between drug properties and host factors

(2015) Minjun Chen et al.   JOURNAL OF HEPATOLOGY

Antioxidant responses and cellular adjustments to oxidative stress

(2015) Cristina Espinosa-Diez et al.   Redox Biology

Dose-Response Analysis Using R

(2015) Christian Ritz et al.   PLoS One

A 3D in vitro model of differentiated HepG2 cell spheroids with improved liver-like properties for repeated dose high-throughput toxicity studies

(2014) Sreenivasa C. Ramaiahgari et al.   ARCHIVES OF TOXICOLOGY

Clozapine-Induced Cardiotoxicity: Role of Oxidative Stress, Tumour Necrosis Factor Alpha and NF-κβ

(2014) Basel A. Abdel-Wahab et al.   Cardiovascular Toxicology

Quantitative High Content Imaging of Cellular Adaptive Stress Response Pathways in Toxicity for Chemical Safety Assessment

(2014) Steven Wink et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Drug-Induced Endoplasmic Reticulum and Oxidative Stress Responses Independently Sensitize Toward TNFα-Mediated Hepatotoxicity

(2014) Lisa Fredriksson et al.   TOXICOLOGICAL SCIENCES

Expression patterns of cell cycle proteins in the livers of rats treated with hepatocarcinogens for 28 days

(2013) Atsunori Yafune et al.   ARCHIVES OF TOXICOLOGY

Sterile inflammation in the liver and pancreas

(2013) Rafaz Hoque et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

A Correlation Between the In Vitro Drug Toxicity of Drugs to Cell Lines That Express Human P450s and Their Propensity to Cause Liver Injury in Humans

(2013) Frida Gustafsson et al.   TOXICOLOGICAL SCIENCES

Utilization of Causal Reasoning of Hepatic Gene Expression in Rats to Identify Molecular Pathways of Idiosyncratic Drug-Induced Liver Injury

(2013) Daphna Laifenfeld et al.   TOXICOLOGICAL SCIENCES

Evaluation of the use of imaging parameters for the detection of compound-induced hepatotoxicity in 384-well cultures of HepG2 cells and cryopreserved primary human hepatocytes

(2013) Helen Garside et al.   TOXICOLOGY IN VITRO

Peroxiredoxin III and Sulfiredoxin Together Protect Mice from Pyrazole-Induced Oxidative Liver Injury

(2012) Soo Han Bae et al.   ANTIOXIDANTS & REDOX SIGNALING

Role of sulfiredoxin as a regulator of peroxiredoxin function and regulation of its expression

(2012) Woojin Jeong et al.   FREE RADICAL BIOLOGY AND MEDICINE

Enhancement by novel anti-methicillin-resistant Staphylococcus aureus compound HT61 of the activity of neomycin, gentamicin, mupirocin and chlorhexidine: in vitro and in vivo studies

(2012) Y. Hu et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Use of Micropatterned Cocultures to Detect Compounds That Cause Drug-Induced Liver Injury in Humans

(2012) Salman R. Khetani et al.   TOXICOLOGICAL SCIENCES

Nrf2 activation prevents cadmium-induced acute liver injury

(2012) Kai C. Wu et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Real-time concurrent monitoring of apoptosis, cytosolic calcium, and mitochondria permeability transition for hypermulticolor high-content screening of drug-induced mitochondrial dysfunction-mediated hepatotoxicity

(2012) Jae-Ah Kim et al.   TOXICOLOGY LETTERS

Perturbations in Ataxia Telangiectasia Mutant Signaling Pathways After Drug-Induced Acute Liver Failure and Their Reversal During Rescue of Animals by Cell Therapy

(2011) Sriram Bandi et al.   AMERICAN JOURNAL OF PATHOLOGY

Improved structure, function and compatibility for CellProfiler: modular high-throughput image analysis software

(2011) Lee Kamentsky et al.   BIOINFORMATICS

FDA-approved drug labeling for the study of drug-induced liver injury

(2011) Minjun Chen et al.   DRUG DISCOVERY TODAY

Protein and its function based on a subcellular localization

(2011) Jana Ćmielová et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Does endoplasmic reticulum stress participate in APD-induced hepatic metabolic dysregulation?

(2011) Emilie Lauressergues et al.   NEUROPHARMACOLOGY

A flexible R package for nonnegative matrix factorization

(2010) Renaud Gaujoux et al.   BMC BIOINFORMATICS

Concerted action of sulfiredoxin and peroxiredoxin I protects against alcohol-induced oxidative injury in mouse liver

(2010) Soo Han Bae et al.   HEPATOLOGY

Trovafloxacin Enhances TNF-Induced Inflammatory Stress and Cell Death Signaling and Reduces TNF Clearance in a Murine Model of Idiosyncratic Hepatotoxicity

(2009) Patrick J. Shaw et al.   TOXICOLOGICAL SCIENCES

Synergistic drug–cytokine induction of hepatocellular death as an in vitro approach for the study of inflammation-associated idiosyncratic drug hepatotoxicity

(2009) Benjamin D. Cosgrove et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Hug Tightly and Say Goodbye: Role of Endothelial ICAM-1 in Leukocyte Transmigration

(2008) Arshad Rahman et al.   ANTIOXIDANTS & REDOX SIGNALING

Cellular Imaging Predictions of Clinical Drug-Induced Liver Injury

(2008) Jinghai J. Xu et al.   TOXICOLOGICAL SCIENCES

Nrf2 signaling: An adaptive response pathway for protection against environmental toxic insults

(2007) W OSBURN et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH