The unfolded protein response: controlling cell fate decisions under ER stress and beyond

Cofactor-mediated conformational control in the bifunctional kinase/RNase Ire1

(2011) Alexei V Korennykh et al.   BMC BIOLOGY

Protein homeostasis networks in physiology and disease

(2011) Claudio Hetz et al.   CURRENT OPINION IN CELL BIOLOGY

Protein folding stress in neurodegenerative diseases: a glimpse into the ER

(2011) Soledad Matus et al.   CURRENT OPINION IN CELL BIOLOGY

The unfolded protein response transducer IRE1α prevents ER stress-induced hepatic steatosis

(2011) Kezhong Zhang et al.   EMBO JOURNAL

Peptides derived from the bifunctional kinase/RNase enzyme IRE1α modulate IRE1α activity and protect cells from endoplasmic reticulum stress

(2011) Marion Bouchecareilh et al.   FASEB JOURNAL

The signalling from endoplasmic reticulum-resident bZIP transcription factors involved in diverse cellular physiology

(2011) R. Asada et al.   JOURNAL OF BIOCHEMISTRY

Attenuation of yeast UPR is essential for survival and is mediated byIRE1kinase

(2011) Aditi Chawla et al.   JOURNAL OF CELL BIOLOGY

A CHOP-regulated microRNA controls rhodopsin expression

(2011) Shannon Behrman et al.   JOURNAL OF CELL BIOLOGY

Homeostatic adaptation to endoplasmic reticulum stress depends on Ire1 kinase activity

(2011) Claudia Rubio et al.   JOURNAL OF CELL BIOLOGY

Selective Abrogation of BiP/GRP78 Blunts Activation of NF- B through the ATF6 Branch of the UPR: Involvement of C/EBP  and mTOR-Dependent Dephosphorylation of Akt

(2011) S. Nakajima et al.   MOLECULAR AND CELLULAR BIOLOGY

The eIF2 kinase PERK and the integrated stress response facilitate activation of ATF6 during endoplasmic reticulum stress

(2011) Brian F. Teske et al.   MOLECULAR BIOLOGY OF THE CELL

Membrane aberrancy and unfolded proteins activate the endoplasmic reticulum stress sensor Ire1 in different ways

(2011) Thanyarat Promlek et al.   MOLECULAR BIOLOGY OF THE CELL

Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity

(2011) Suneng Fu et al.   NATURE

Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress

(2011) Ira Tabas et al.   NATURE CELL BIOLOGY

p38 MAPK–mediated regulation of Xbp1s is crucial for glucose homeostasis

(2011) Jaemin Lee et al.   NATURE MEDICINE

Regulation of glucose homeostasis through a XBP-1–FoxO1 interaction

(2011) Yingjiang Zhou et al.   NATURE MEDICINE

The Unfolded Protein Response: Integrating Stress Signals Through the Stress Sensor IRE1α

(2011) Claudio Hetz et al.   PHYSIOLOGICAL REVIEWS

Selective activation of the transcription factor ATF6 mediates endoplasmic reticulum proliferation triggered by a membrane protein

(2011) J. Maiuolo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dual and opposing roles of the unfolded protein response regulated by IRE1  and XBP1 in proinsulin processing and insulin secretion

(2011) A.-H. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Translational Pausing Ensures Membrane Targeting and Cytoplasmic Splicing of XBP1u mRNA

(2011) K. Yanagitani et al.   SCIENCE

Selective Inhibition of a Regulatory Subunit of Protein Phosphatase 1 Restores Proteostasis

(2011) P. Tsaytler et al.   SCIENCE

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

Unfolded Proteins Are Ire1-Activating Ligands That Directly Induce the Unfolded Protein Response

(2011) B. M. Gardner et al.   SCIENCE

Modulating stress responses by the UPRosome: A matter of life and death

(2011) Ute Woehlbier et al.   TRENDS IN BIOCHEMICAL SCIENCES

Amyotrophic Lateral Sclerosis Pathogenesis: A Journey Through the Secretory Pathway

(2010) Melissa Nassif et al.   ANTIOXIDANTS & REDOX SIGNALING

SUMO modification regulates the transcriptional activity of XBP1

(2010) Hui Chen et al.   BIOCHEMICAL JOURNAL

Regulation of unfolded protein response modulator XBP1s by acetylation and deacetylation

(2010) Feng-Ming Wang et al.   BIOCHEMICAL JOURNAL

Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease

(2010) Gökhan S. Hotamisligil   CELL

Luminal Domain of ATF6 Alone Is Sufficient for Sensing Endoplasmic Reticulum Stress and Subsequent Transport to the Golgi Apparatus

(2010) Yoshimi Sato et al.   CELL STRUCTURE AND FUNCTION

Endoplasmic reticulum stress-sensing mechanisms in yeast and mammalian cells

(2010) Yukio Kimata et al.   CURRENT OPINION IN CELL BIOLOGY

Regulation of innate immunity by signaling pathways emerging from the endoplasmic reticulum

(2010) Fabio Martinon et al.   CURRENT OPINION IN IMMUNOLOGY

XBP1 Controls Maturation of Gastric Zymogenic Cells by Induction of MIST1 and Expansion of the Rough Endoplasmic Reticulum

(2010) Won Jae Huh et al.   GASTROENTEROLOGY

The unfolded protein response in familial amyotrophic lateral sclerosis

(2010) L. Wang et al.   HUMAN MOLECULAR GENETICS

Bifunctional Apoptosis Regulator (BAR), an Endoplasmic Reticulum (ER)-associated E3 Ubiquitin Ligase, Modulates BI-1 Protein Stability and Function in ER Stress

(2010) Juan Rong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of basal cellular physiology by the homeostatic unfolded protein response

(2010) D. Thomas Rutkowski et al.   JOURNAL OF CELL BIOLOGY

Wolfram syndrome 1 gene negatively regulates ER stress signaling in rodent and human cells

(2010) Sonya G. Fonseca et al.   JOURNAL OF CLINICAL INVESTIGATION

Induction of Liver Steatosis and Lipid Droplet Formation in ATF6α-Knockout Mice Burdened with Pharmacological Endoplasmic Reticulum Stress

(2010) Keisuke Yamamoto et al.   MOLECULAR BIOLOGY OF THE CELL

Autophagy and the Integrated Stress Response

(2010) Guido Kroemer et al.   MOLECULAR CELL

TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages

(2010) Fabio Martinon et al.   NATURE IMMUNOLOGY

A regulatory subunit of phosphoinositide 3-kinase increases the nuclear accumulation of X-box–binding protein-1 to modulate the unfolded protein response

(2010) Jonathon N Winnay et al.   NATURE MEDICINE

The regulatory subunits of PI3K, p85α and p85β, interact with XBP-1 and increase its nuclear translocation

(2010) Sang Won Park et al.   NATURE MEDICINE

Mitochondria and cell death: outer membrane permeabilization and beyond

(2010) Stephen W. G. Tait et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

IRE1α Disruption Causes Histological Abnormality of Exocrine Tissues, Increase of Blood Glucose Level, and Decrease of Serum Immunoglobulin Level

(2010) Takao Iwawaki et al.   PLoS One

Calcineurin Interacts with PERK and Dephosphorylates Calnexin to Relieve ER Stress in Mammals and Frogs

(2010) Mariana Bollo et al.   PLoS One

Insulin/IGF-1 signaling mutants reprogram ER stress response regulators to promote longevity

(2010) S. Henis-Korenblit et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mammalian endoplasmic reticulum stress sensor IRE1 signals by dynamic clustering

(2010) H. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Crucial Role for RACK1 in the Regulation of Glucose-Stimulated IRE1  Activation in Pancreatic   Cells

(2010) Y. Qiu et al.   Science Signaling

BiP Binding to the ER-Stress Sensor Ire1 Tunes the Homeostatic Behavior of the Unfolded Protein Response

(2010) David Pincus et al.   PLOS BIOLOGY

HSP72 Protects Cells from ER Stress-induced Apoptosis via Enhancement of IRE1α-XBP1 Signaling through a Physical Interaction

(2010) Sanjeev Gupta et al.   PLOS BIOLOGY

IRE1α Kinase Activation Modes Control Alternate Endoribonuclease Outputs to Determine Divergent Cell Fates

(2009) Dan Han et al.   CELL

Activation of mammalian IRE1α upon ER stress depends on dissociation of BiP rather than on direct interaction with unfolded proteins

(2009) Daisuke Oikawa et al.   EXPERIMENTAL CELL RESEARCH

XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy

(2009) C. Hetz et al.   GENES & DEVELOPMENT

Hepatic Bax Inhibitor-1 Inhibits IRE1α and Protects from Obesity-associated Insulin Resistance and Glucose Intolerance

(2009) Béatrice Bailly-Maitre et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulated Ire1-dependent decay of messenger RNAs in mammalian cells

(2009) Julie Hollien et al.   JOURNAL OF CELL BIOLOGY

Cotranslational Targeting of XBP1 Protein to the Membrane Promotes Cytoplasmic Splicing of Its Own mRNA

(2009) Kota Yanagitani et al.   MOLECULAR CELL

BAX Inhibitor-1 Is a Negative Regulator of the ER Stress Sensor IRE1α

(2009) Fernanda Lisbona et al.   MOLECULAR CELL

Fine-Tuning of the Unfolded Protein Response: Assembling the IRE1α Interactome

(2009) Claudio Hetz et al.   MOLECULAR CELL

Adaptive suppression of the ATF4–CHOP branch of the unfolded protein response by toll-like receptor signalling

(2009) Connie W. Woo et al.   NATURE CELL BIOLOGY

A role for motoneuron subtype–selective ER stress in disease manifestations of FALS mice

(2009) Smita Saxena et al.   NATURE NEUROSCIENCE

Divergent Effects of PERK and IRE1 Signaling on Cell Viability

(2009) Jonathan H. Lin et al.   PLoS One

Regulation of PERK Signaling and Leukemic Cell Survival by a Novel Cytosolic Isoform of the UPR Regulator GRP78/BiP

(2009) Min Ni et al.   PLoS One

In vitro reconstitution of ER-stress induced ATF6 transport in COPII vesicles

(2009) A. J. Schindler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability

(2009) T. Iwawaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ER Stress Controls Iron Metabolism Through Induction of Hepcidin

(2009) C. Vecchi et al.   SCIENCE

IRE1β Inhibits Chylomicron Production by Selectively Degrading MTP mRNA

(2008) Jahangir Iqbal et al.   Cell Metabolism

ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1

(2008) H. Nishitoh et al.   GENES & DEVELOPMENT

AIP1 Is Critical in Transducing IRE1-mediated Endoplasmic Reticulum Stress Response

(2008) Dianhong Luo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CBF/NF-Y controls endoplasmic reticulum stress induced transcription through recruitment of both ATF6(N) and TBP

(2008) Rong Luo et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The unfolded protein response signals through high-order assembly of Ire1

(2008) Alexei V. Korennykh et al.   NATURE

The Role of IRE1α in the Degradation of Insulin mRNA in Pancreatic β-Cells

(2008) Kathryn L. Lipson et al.   PLoS One

Regulation of Hepatic Lipogenesis by the Transcription Factor XBP1

(2008) A.-H. Lee et al.   SCIENCE

Activating transcription factor 4

(2007) Kurosh Ameri et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The unfolded protein response of B-lymphocytes: PERK-independent development of antibody-secreting cells

(2007) Jennifer N. Gass et al.   MOLECULAR IMMUNOLOGY