Screening out irrelevant cell-based models of disease

Microfluidics for cell-based high throughput screening platforms—A review

(2016) Guansheng Du et al.   ANALYTICA CHIMICA ACTA

The role of microenvironment and immunity in drug response in leukemia

(2016) Emyr Bakker et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Induced pluripotent stem cells: at the heart of cardiovascular precision medicine

(2016) Ian Y. Chen et al.   Nature Reviews Cardiology

Evolution of strategies to improve preclinical cardiac safety testing

(2016) Gary Gintant et al.   NATURE REVIEWS DRUG DISCOVERY

Pluripotent stem cells in disease modelling and drug discovery

(2016) Yishai Avior et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Generation of stem cell-derived β-cells from patients with type 1 diabetes

(2016) Jeffrey R. Millman et al.   Nature Communications

DIC image reconstruction using an energy minimization framework to visualize optical path length distribution

(2016) Krisztian Koos et al.   Scientific Reports

When Quality Beats Quantity: Decision Theory, Drug Discovery, and the Reproducibility Crisis

(2016) Jack W. Scannell et al.   PLoS One

A non-inheritable maternal Cas9-based multiple-gene editing system in mice

(2016) Takayuki Sakurai et al.   Scientific Reports

Drug Discovery Goes Three-Dimensional: Goodbye to Flat High-Throughput Screening?

(2015) Richard M. Eglen et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Three-Dimensional Cell Culture Assays: Are They More Predictive of In Vivo Efficacy than 2D Monolayer Cell-Based Assays?

(2015) Sitta Sittampalam et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Overcoming Obstacles in the Implementation of Factorial Design for Assay Optimization

(2015) Robert Shaw et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Micro 3D cell culture systems for cellular behavior studies: Culture matrices, devices, substrates, and in-situ sensing methods

(2015) Jonghoon Choi et al.   Biotechnology Journal

A 3D-microtissue-based phenotypic screening of radiation resistant tumor cells with synchronized chemotherapeutic treatment

(2015) Nataša Anastasov et al.   BMC CANCER

Prospective Derivation of a Living Organoid Biobank of Colorectal Cancer Patients

(2015) Marc van de Wetering et al.   CELL

Microfluidic 3D cell culture: from tools to tissue models

(2015) Vincent van Duinen et al.   CURRENT OPINION IN BIOTECHNOLOGY

The impact of CRISPR–Cas9 on target identification and validation

(2015) Jonathan D. Moore   DRUG DISCOVERY TODAY

A novel 3D high-content assay identifies compounds that prevent fibroblast invasion into tissue surrogates

(2015) Carsten Wenzel et al.   EXPERIMENTAL CELL RESEARCH

Life in 3D is never flat: 3D models to optimise drug delivery

(2015) Kathleen A. Fitzgerald et al.   JOURNAL OF CONTROLLED RELEASE

Cyclic stretch of embryonic cardiomyocytes increases proliferation, growth, and expression while repressing Tgf-β signaling

(2015) Indroneal Banerjee et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Nanomagnetic levitation three-dimensional cultures of breast and colorectal cancers

(2015) Harvey L. Bumpers et al.   JOURNAL OF SURGICAL RESEARCH

A four-organ-chip for interconnected long-term co-culture of human intestine, liver, skin and kidney equivalents

(2015) Ilka Maschmeyer et al.   LAB ON A CHIP

Involvement of hepatic stellate cell cytoglobin in acute hepatocyte damage through the regulation of CYP2E1-mediated xenobiotic metabolism

(2015) Yuga Teranishi et al.   LABORATORY INVESTIGATION

Identification of anti-tumour biologics using primary tumour models, 3-D phenotypic screening and image-based multi-parametric profiling

(2015) Alan M. Sandercock et al.   Molecular Cancer

Patient-centric trials for therapeutic development in precision oncology

(2015) Andrew V. Biankin et al.   NATURE

A novel multiple-stage antimalarial agent that inhibits protein synthesis

(2015) Beatriz Baragaña et al.   NATURE

Axitinib effectively inhibits BCR-ABL1(T315I) with a distinct binding conformation

(2015) Tea Pemovska et al.   NATURE

Correlating chemical sensitivity and basal gene expression reveals mechanism of action

(2015) Matthew G Rees et al.   Nature Chemical Biology

Small airway-on-a-chip enables analysis of human lung inflammation and drug responses in vitro

(2015) Kambez H Benam et al.   NATURE METHODS

Preclinical target validation using patient-derived cells

(2015) Aled M. Edwards et al.   NATURE REVIEWS DRUG DISCOVERY

Organs-on-chips at the frontiers of drug discovery

(2015) Eric W. Esch et al.   NATURE REVIEWS DRUG DISCOVERY

High-throughput functional genomics using CRISPR–Cas9

(2015) Ophir Shalem et al.   NATURE REVIEWS GENETICS

Automated multi-parameter measurement of cardiomyocytes dynamics with digital holographic microscopy

(2015) Benjamin Rappaz et al.   OPTICS EXPRESS

Contributions of microbiome and mechanical deformation to intestinal bacterial overgrowth and inflammation in a human gut-on-a-chip

(2015) Hyun Jung Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Challenges of Precision Oncology Drug Development and Implementation

(2015) Simon J. Hollingsworth et al.   Public Health Genomics

Developing predictive assays: The phenotypic screening “rule of 3”

(2015) Fabien Vincent et al.   Science Translational Medicine

High Throughput Measurement of Ca++Dynamics in Human Stem Cell-Derived Cardiomyocytes by Kinetic Image Cytometery: A Cardiac Risk Assessment Characterization Using a Large Panel of Cardioactive and Inactive Compounds

(2015) Hua Rong Lu et al.   TOXICOLOGICAL SCIENCES

Bioprinting for cancer research

(2015) Stephanie Knowlton et al.   TRENDS IN BIOTECHNOLOGY

Self-organizing human cardiac microchambers mediated by geometric confinement

(2015) Zhen Ma et al.   Nature Communications

Predicting clinical response to anticancer drugs using an ex vivo platform that captures tumour heterogeneity

(2015) Biswanath Majumder et al.   Nature Communications

Drug screen in patient cells suggests quinacrine to be repositioned for treatment of acute myeloid leukemia

(2015) A Eriksson et al.   Blood Cancer Journal

Constructive remodeling of a synthetic endothelial extracellular matrix

(2015) Sewoon Han et al.   Scientific Reports

Distinctive Behaviors of Druggable Proteins in Cellular Networks

(2015) Costas Mitsopoulos et al.   PLoS Computational Biology

Micro 3D cell culture systems for cellular behavior studies: Culture matrices, devices, substrates, and in-situ sensing methods

(2015) Jonghoon Choi et al.   Biotechnology Journal

Rewriting the blueprint of life by synthetic genomics and genome engineering

(2015) Narayana Annaluru et al.   GENOME BIOLOGY

A new age in functional genomics using CRISPR/Cas9 in arrayed library screening

(2015) Alexander Agrotis et al.   Frontiers in Genetics

Peptide Hydrogels – Versatile Matrices for 3D Cell Culture in Cancer Medicine

(2015) Peter Worthington et al.   Frontiers in Oncology

A microfluidic shear device that accommodates parallel high and low stress zones within the same culturing chamber

(2014) X. Zhang et al.   Biomicrofluidics

Enhancing Reproducibility in Cancer Drug Screening: How Do We Move Forward?

(2014) C. Hatzis et al.   CANCER RESEARCH

Human Stem Cell-Derived Cardiomyocytes in Cellular Impedance Assays: Bringing Cardiotoxicity Screening to the Front Line

(2014) Matthew F. Peters et al.   Cardiovascular Toxicology

Pilot Clinical Trial of Hedgehog Pathway Inhibitor GDC-0449 (Vismodegib) in Combination with Gemcitabine in Patients with Metastatic Pancreatic Adenocarcinoma

(2014) E. J. Kim et al.   CLINICAL CANCER RESEARCH

Digital Holographic Microscopy: A Quantitative Label-Free Microscopy Technique for Phenotypic Screening

(2014) Benjamin Rappaz et al.   COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

3D high-content screening for the identification of compounds that target cells in dormant tumor spheroid regions

(2014) Carsten Wenzel et al.   EXPERIMENTAL CELL RESEARCH

The proteasome inhibitor bortezomib reduced cholesterol accumulation in fibroblasts from Niemann-Pick type C patients carrying missense mutations

(2014) Judit Macías-Vidal et al.   FEBS Journal

Tissue-culture light sheet fluorescence microscopy (TC-LSFM) allows long-term imaging of three-dimensional cell cultures under controlled conditions

(2014) Francesco Pampaloni et al.   Integrative Biology

Therapeutic Targeting of Integrin αvβ6 in Breast Cancer

(2014) Kate M. Moore et al.   JNCI-Journal of the National Cancer Institute

Immunocompetent 3D Model of Human Upper Airway for Disease Modeling and In Vitro Drug Evaluation

(2014) Helen Harrington et al.   MOLECULAR PHARMACEUTICS

CRISPR-mediated direct mutation of cancer genes in the mouse liver

(2014) Wen Xue et al.   NATURE

CRISPR-Cas systems for editing, regulating and targeting genomes

(2014) Jeffry D Sander et al.   NATURE BIOTECHNOLOGY

Microfluidic organs-on-chips

(2014) Sangeeta N Bhatia et al.   NATURE BIOTECHNOLOGY

3D bioprinting of tissues and organs

(2014) Sean V Murphy et al.   NATURE BIOTECHNOLOGY

The discovery of first-in-class drugs: origins and evolution

(2014) Jörg Eder et al.   NATURE REVIEWS DRUG DISCOVERY

Phenotypic screening in cancer drug discovery — past, present and future

(2014) John G. Moffat et al.   NATURE REVIEWS DRUG DISCOVERY

Three-dimensional organotypic culture: experimental models of mammalian biology and disease

(2014) Eliah R. Shamir et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Ultra High Content Image Analysis and Phenotype Profiling of 3D Cultured Micro-Tissues

(2014) Zi Di et al.   PLoS One

The new frontier of genome engineering with CRISPR-Cas9

(2014) J. A. Doudna et al.   SCIENCE

Emerging Viral Diseases: Confronting Threats with New Technologies

(2014) H. D. Marston et al.   Science Translational Medicine

Characterization of the molecular mechanisms underlying increased ischemic damage in the aldehyde dehydrogenase 2 genetic polymorphism using a human induced pluripotent stem cell model system

(2014) A. D. Ebert et al.   Science Translational Medicine

Liver zonation: Novel aspects of its regulation and its impact on homeostasis

(2014) Rolf Gebhardt   WORLD JOURNAL OF GASTROENTEROLOGY

Human-induced pluripotent stem cell-derived cardiomyocytes exhibit temporal changes in phenotype

(2013) Christine Y. Ivashchenko et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

A review of microfabrication and hydrogel engineering for micro-organs on chips

(2013) Marine Verhulsel et al.   BIOMATERIALS

Intravital FLIM-FRET Imaging Reveals Dasatinib-Induced Spatial Control of Src in Pancreatic Cancer

(2013) M. Nobis et al.   CANCER RESEARCH

High-resolution deep imaging of live cellular spheroids with light-sheet-based fluorescence microscopy

(2013) Francesco Pampaloni et al.   CELL AND TISSUE RESEARCH

Integration of Chemical and RNAi Multiparametric Profiles Identifies Triggers of Intracellular Mycobacterial Killing

(2013) Varadharajan Sundaramurthy et al.   Cell Host & Microbe

Human iPSC-Based Modeling of Late-Onset Disease via Progerin-Induced Aging

(2013) Justine D. Miller et al.   Cell Stem Cell

Screening Drug-Induced Arrhythmia Using Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes and Low-Impedance Microelectrode Arrays

(2013) E. G. Navarrete et al.   CIRCULATION

Drug Screening Using a Library of Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes Reveals Disease-Specific Patterns of Cardiotoxicity

(2013) Ping Liang et al.   CIRCULATION

Genome editing of human pluripotent stem cells to generate human cellular disease models

(2013) K. Musunuru   Disease Models & Mechanisms

iPSC-derived β cells model diabetes due to glucokinase deficiency

(2013) Haiqing Hua et al.   JOURNAL OF CLINICAL INVESTIGATION

HB-EGF affects astrocyte morphology, proliferation, differentiation, and the expression of intermediate filament proteins

(2013) Till B. Puschmann et al.   JOURNAL OF NEUROCHEMISTRY

A novel three-dimensional stromal-based model forin vitrochemotherapy sensitivity testing of leukemia cells

(2013) Omar S. Aljitawi et al.   LEUKEMIA & LYMPHOMA

A cellular model for sporadic ALS using patient-derived induced pluripotent stem cells

(2013) Matthew F. Burkhardt et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Inconsistency in large pharmacogenomic studies

(2013) Benjamin Haibe-Kains et al.   NATURE

canSAR: updated cancer research and drug discovery knowledgebase

(2013) Krishna C. Bulusu et al.   NUCLEIC ACIDS RESEARCH

Phase II Study of Dasatinib (BMS-354825) in Patients With Metastatic Adenocarcinoma of the Pancreas

(2013) C. E. Chee et al.   ONCOLOGIST

Identification and Rescue of  -Synuclein Toxicity in Parkinson Patient-Derived Neurons

(2013) C. Y. Chung et al.   SCIENCE

Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells

(2013) Ophir Shalem et al.   SCIENCE

Genetic Screens in Human Cells Using the CRISPR-Cas9 System

(2013) Tim Wang et al.   SCIENCE

Multiplex Genome Engineering Using CRISPR/Cas Systems

(2013) L. Cong et al.   SCIENCE

Phenotypic Profiling of Structural Cardiotoxins In Vitro Reveals Dependency on Multiple Mechanisms of Toxicity

(2013) Amy Pointon et al.   TOXICOLOGICAL SCIENCES

The development of a 3D immunocompetent model of human skin

(2013) David Y S Chau et al.   Biofabrication

Individualized Systems Medicine Strategy to Tailor Treatments for Patients with Chemorefractory Acute Myeloid Leukemia

(2013) T. Pemovska et al.   Cancer Discovery

High Content Analysis of Primary Macrophages Hosting Proliferating Leishmania Amastigotes: Application to Anti-leishmanial Drug Discovery

(2013) Nathalie Aulner et al.   PLoS Neglected Tropical Diseases

Accurate Prediction of Drug-Induced Liver Injury Using Stem Cell-Derived Populations

(2013) Dagmara Szkolnicka et al.   Stem Cells Translational Medicine

Presenilin-1 L166P Mutant Human Pluripotent Stem Cell–Derived Neurons Exhibit Partial Loss of γ-Secretase Activity in Endogenous Amyloid-β Generation

(2012) Philipp Koch et al.   AMERICAN JOURNAL OF PATHOLOGY

Label-Free Cytotoxicity Screening Assay by Digital Holographic Microscopy

(2012) Jonas Kühn et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Bi-specific TCR-anti CD3 redirected T-cell targeting of NY-ESO-1- and LAGE-1-positive tumors

(2012) Emmet McCormack et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Host Cell Autophagy Activated by Antibiotics Is Required for Their Effective Antimycobacterial Drug Action

(2012) Jwa-Jin Kim et al.   Cell Host & Microbe

Computation as the Mechanistic Bridge Between Precision Medicine and Systems Therapeutics

(2012) J Hansen et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Synthetic 3D multicellular systems for drug development

(2012) Markus Rimann et al.   CURRENT OPINION IN BIOTECHNOLOGY

Oxygen concentration modulates the differentiation of muscle stem cells toward myogenic and adipogenic fates

(2012) Zoe Redshaw et al.   DIFFERENTIATION

Discovery of small molecule cancer drugs: Successes, challenges and opportunities

(2012) Swen Hoelder et al.   Molecular Oncology

Systematic identification of genomic markers of drug sensitivity in cancer cells

(2012) Mathew J. Garnett et al.   NATURE

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

(2012) Jordi Barretina et al.   NATURE

BioImageXD: an open, general-purpose and high-throughput image-processing platform

(2012) Pasi Kankaanpää et al.   NATURE METHODS

Use of Reprogrammed Cells to Identify Therapy for Respiratory Papillomatosis

(2012) Hang Yuan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Phenotypic Characterization of Prostate Cancer LNCaP Cells Cultured within a Bioengineered Microenvironment

(2012) Shirly Sieh et al.   PLoS One

Conditionally reprogrammed cells represent a stem-like state of adult epithelial cells

(2012) F. A. Suprynowicz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Designing Cell-Compatible Hydrogels for Biomedical Applications

(2012) D. Seliktar   SCIENCE

Prevention of β-amyloid induced toxicity in human iPS cell-derived neurons by inhibition of Cyclin-dependent kinases and associated cell cycle events

(2012) Xiaohong Xu et al.   Stem Cell Research

Hybrid printing of mechanically and biologically improved constructs for cartilage tissue engineering applications

(2012) Tao Xu et al.   Biofabrication

Development of High Content Imaging Methods for Cell Death Detection in Human Pluripotent Stem Cell-Derived Cardiomyocytes

(2012) Maxime Mioulane et al.   Journal of Cardiovascular Translational Research

High throughput measurement of Ca2+ dynamics for drug risk assessment in human stem cell-derived cardiomyocytes by kinetic image cytometry

(2012) Fabio Cerignoli et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Muscle on a chip: In vitro contractility assays for smooth and striated muscle

(2012) Anna Grosberg et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

An Image-Based High-Content Screening Assay for Compounds Targeting Intracellular Leishmania donovani Amastigotes in Human Macrophages

(2012) Jair L. Siqueira-Neto et al.   PLoS Neglected Tropical Diseases

Systems Pharmacology: Network Analysis to Identify Multiscale Mechanisms of Drug Action

(2011) Shan Zhao et al.   Annual Review of Pharmacology and Toxicology

Cell adhesion on an artificial extracellular matrix using aptamer-functionalized PEG hydrogels

(2011) Niancao Chen et al.   BIOMATERIALS

How can we improve our understanding of cardiovascular safety liabilities to develop safer medicines?

(2011) HG Laverty et al.   BRITISH JOURNAL OF PHARMACOLOGY

Epigenetic Memory and Preferential Lineage-Specific Differentiation in Induced Pluripotent Stem Cells Derived from Human Pancreatic Islet Beta Cells

(2011) Ori Bar-Nur et al.   Cell Stem Cell

Drug evaluation in cardiomyocytes derived from human induced pluripotent stem cells carrying a long QT syndrome type 2 mutation

(2011) Elena Matsa et al.   EUROPEAN HEART JOURNAL

Stochastic modeling and identification of emergent behaviors of an Endothelial Cell population in angiogenic pattern formation

(2011) Levi Wood et al.   INTERNATIONAL JOURNAL OF ROBOTICS RESEARCH

Why is the partial oxygen pressure of human tissues a crucial parameter? Small molecules and hypoxia

(2011) Aude Carreau et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

A first step towards practical single cell proteomics: a microfluidic antibody capture chip with TIRF detection

(2011) Ali Salehi-Reyhani et al.   LAB ON A CHIP

A living system on a chip

(2011) Monya Baker   NATURE

Donor cell type can influence the epigenome and differentiation potential of human induced pluripotent stem cells

(2011) Kitai Kim et al.   NATURE BIOTECHNOLOGY

High-throughput analysis of single hematopoietic stem cell proliferation in microfluidic cell culture arrays

(2011) Véronique Lecault et al.   NATURE METHODS

How were new medicines discovered?

(2011) David C. Swinney et al.   NATURE REVIEWS DRUG DISCOVERY

Phase II failures: 2008–2010

(2011) John Arrowsmith   NATURE REVIEWS DRUG DISCOVERY

Human Engineered Heart Tissue as a Versatile Tool in Basic Research and Preclinical Toxicology

(2011) Sebastian Schaaf et al.   PLoS One

Single-Cell Mass Cytometry of Differential Immune and Drug Responses Across a Human Hematopoietic Continuum

(2011) S. C. Bendall et al.   SCIENCE

From 3D cell culture to organs-on-chips

(2011) Dongeun Huh et al.   TRENDS IN CELL BIOLOGY

Oxygen matters: tissue culture oxygen levels affect mitochondrial function and structure as well as responses to HIV viroproteins

(2011) L M Tiede et al.   Cell Death & Disease

A Screen against Leishmania Intracellular Amastigotes: Comparison to a Promastigote Screen and Identification of a Host Cell-Specific Hit

(2011) Geraldine De Muylder et al.   PLoS Neglected Tropical Diseases

Live Cell in Vitro and in Vivo Imaging Applications: Accelerating Drug Discovery

(2011) Beverley Isherwood et al.   Pharmaceutics

The beautiful cell: high-content screening in drug discovery

(2010) Marc Bickle   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Identification of Human Ether-à-go-go Related Gene Modulators by Three Screening Platforms in an Academic Drug-Discovery Setting

(2010) Xi-Ping Huang et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

A Model for Neural Development and Treatment of Rett Syndrome Using Human Induced Pluripotent Stem Cells

(2010) Maria C.N. Marchetto et al.   CELL

Development of a Drug Screening Platform Based on Engineered Heart Tissue

(2010) Arne Hansen et al.   CIRCULATION RESEARCH

The distributed genome hypothesis as a rubric for understanding evolutionin situduring chronic bacterial biofilm infectious processes

(2010) Garth D. Ehrlich et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

Pancreatic cancer organotypic cultures

(2010) Fieke E.M. Froeling et al.   JOURNAL OF BIOTECHNOLOGY

A Chemical Screen Identifies Novel Compounds That Overcome Glial-Mediated Inhibition of Neuronal Regeneration

(2010) L. C. Usher et al.   JOURNAL OF NEUROSCIENCE

Optimization of microfluidic single cell trapping for long-term on-chip culture

(2010) Stefan Kobel et al.   LAB ON A CHIP

A microfluidic device for a pharmacokinetic–pharmacodynamic (PK–PD) model on a chip

(2010) Jong Hwan Sung et al.   LAB ON A CHIP

Alzheimer's disease: clinical trials and drug development

(2010) Francesca Mangialasche et al.   LANCET NEUROLOGY

Development of a quantitative 96-well method to image glycogen storage in primary rat hepatocytes

(2010) James Pilling et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

High-Content Phenotypic Profiling of Drug Response Signatures across Distinct Cancer Cells

(2010) P. D. Caie et al.   MOLECULAR CANCER THERAPEUTICS

Chemical genetics of Plasmodium falciparum

(2010) W. Armand Guiguemde et al.   NATURE

Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro

(2010) Jason R. Spence et al.   NATURE

Three-dimensional tissue culture based on magnetic cell levitation

(2010) Glauco R. Souza et al.   Nature Nanotechnology

Psoriasin (S100A7) associates with integrin β6 subunit and is required for αvβ6-dependent carcinoma cell invasion

(2010) M R Morgan et al.   ONCOGENE

Bioartificial matrices for therapeutic vascularization

(2010) Edward A. Phelps et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE

A Microfabricated Scaffold Induces the Spheroid Formation of Human Bone Marrow-Derived Mesenchymal Progenitor Cells and Promotes Efficient Adipogenic Differentiation

(2010) Yoshitaka Miyagawa et al.   TISSUE ENGINEERING PART A

Microfluidic compartmentalized co-culture platform for CNS axon myelination research

(2009) Jaewon Park et al.   BIOMEDICAL MICRODEVICES

An open-access microfluidic model for lung-specific functional studies at an air-liquid interface

(2009) Divya D. Nalayanda et al.   BIOMEDICAL MICRODEVICES

Port-a-Patch and Patchliner: High Fidelity Electrophysiology for Secondary Screening and Safety Pharmacology

(2009) Niels Fertig et al.   COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

Alzheimer's disease: new approaches to drug discovery

(2009) Maria L Bolognesi et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Micro and nano-scale in vitro 3D culture system for cardiac stem cells

(2009) Hossein Hosseinkhani et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Droplet microfluidic technology for single-cell high-throughput screening

(2009) E. Brouzes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer

(2009) K. P. Olive et al.   SCIENCE

Profiling distinct mechanisms of tumour invasion for drug discovery: imaging adhesion, signalling and matrix turnover

(2008) Neil O. Carragher   CLINICAL & EXPERIMENTAL METASTASIS

Cellular Sources of Extracellular Matrix in Hepatic Fibrosis

(2008) Rebecca G. Wells   Clinics in Liver Disease

The role of matrix stiffness in regulating cell behavior

(2008) Rebecca G. Wells   HEPATOLOGY

Induced pluripotent stem cells from a spinal muscular atrophy patient

(2008) Allison D. Ebert et al.   NATURE

Comparison of 3D and 2D tumor models reveals enhanced HER2 activation in 3D associated with an increased response to trastuzumab

(2008) M Pickl et al.   ONCOGENE

Integrated microfluidic bioprocessor for single-cell gene expression analysis

(2008) N. M. Toriello et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induced Pluripotent Stem Cells Generated from Patients with ALS Can Be Differentiated into Motor Neurons

(2008) J. T. Dimos et al.   SCIENCE