Human hepatic 3D spheroids as a model for steatosis and insulin resistance

Recent Insights into the Pathogenesis of Nonalcoholic Fatty Liver Disease

(2018) Juan Pablo Arab et al.   Annual Review of Pathology-Mechanisms of Disease

Pyruvate dehydrogenase kinase 4 mediates lipogenesis and contributes to the pathogenesis of nonalcoholic steatohepatitis

(2018) Ming Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Non-alcoholic fatty liver disease (NAFLD) models in drug discovery

(2017) Banumathi K. Cole et al.   Expert Opinion on Drug Discovery

Endogenous and xenobiotic metabolic stability of primary human hepatocytes in long-term 3D spheroid cultures revealed by a combination of targeted and untargeted metabolomics

(2017) Sabine U. Vorrink et al.   FASEB JOURNAL

Microengineered cultures containing human hepatic stellate cells and hepatocytes for drug development

(2017) Matthew D. Davidson et al.   Integrative Biology

Divergent effects of glucose and fructose on hepatic lipogenesis and insulin signaling

(2017) Samir Softic et al.   JOURNAL OF CLINICAL INVESTIGATION

Liver inflammation and fibrosis

(2017) Yukinori Koyama et al.   JOURNAL OF CLINICAL INVESTIGATION

Inhibiting poly ADP-ribosylation increases fatty acid oxidation and protects against fatty liver disease

(2017) Karim Gariani et al.   JOURNAL OF HEPATOLOGY

Lipid droplets and liver disease: from basic biology to clinical implications

(2017) Nina L. Gluchowski et al.   Nature Reviews Gastroenterology & Hepatology

Three-dimensional perfused human in vitro model of non-alcoholic fatty liver disease

(2017) Tomasz Kostrzewski et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Obesity

(2017) Pedro González-Muniesa et al.   Nature Reviews Disease Primers

Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes

(2016) Zobair M. Younossi et al.   HEPATOLOGY

The pathogenesis of insulin resistance: integrating signaling pathways and substrate flux

(2016) Varman T. Samuel et al.   JOURNAL OF CLINICAL INVESTIGATION

Gene expression profiling in human precision cut liver slices in response to the FXR agonist obeticholic acid

(2016) Noortje Ijssennagger et al.   JOURNAL OF HEPATOLOGY

The Sweet Path to Metabolic Demise: Fructose and Lipid Synthesis

(2016) Mark A. Herman et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Long-term exposure to abnormal glucose levels alters drug metabolism pathways and insulin sensitivity in primary human hepatocytes

(2016) Matthew D. Davidson et al.   Scientific Reports

Investigating Nonalcoholic Fatty Liver Disease in a Liver-on-a-Chip Microfluidic Device

(2016) Manuele Gori et al.   PLoS One

Long noncoding RNA MALAT1 promotes hepatic steatosis and insulin resistance by increasing nuclear SREBP-1c protein stability

(2016) Caifeng Yan et al.   Scientific Reports

Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease

(2016) Catherine C. Bell et al.   Scientific Reports

Hepatic 3D spheroid models for the detection and study of compounds with cholestatic liability

(2016) Delilah F. G. Hendriks et al.   Scientific Reports

Challenges and opportunities in drug and biomarker development for nonalcoholic steatohepatitis: Findings and recommendations from an American Association for the Study of Liver Diseases-U.S. Food and Drug Administration Joint Workshop

(2015) Arun J. Sanyal et al.   HEPATOLOGY

Nonalcoholic fatty liver disease, metabolic risk factors, and hepatocellular carcinoma: An open question

(2015) Letiția Adela Maria Streba   WORLD JOURNAL OF GASTROENTEROLOGY

Genetic Factors in the Pathogenesis of Nonalcoholic Fatty Liver and Steatohepatitis

(2015) Paola Dongiovanni et al.   Biomed Research International

Nonalcoholic Steatohepatitis: A Search for Factual Animal Models

(2015) Sheila Cristina L. Sanches et al.   Biomed Research International

Nonalcoholic fatty liver disease

(2015) Elizabeth M. Brunt et al.   Nature Reviews Disease Primers

Mouse Models of Diet-Induced Nonalcoholic Steatohepatitis Reproduce the Heterogeneity of the Human Disease

(2015) Mariana Verdelho Machado et al.   PLoS One

Obesity

(2014) Tony Scully   NATURE

Lipids in health and disease

(2014) Joshua Finkelstein et al.   NATURE

Association between serum free fatty acid levels and nonalcoholic fatty liver disease: a cross-sectional study

(2014) Juanwen Zhang et al.   Scientific Reports

In Vitro and in Vivo Models of Non-Alcoholic Fatty Liver Disease (NAFLD)

(2013) Giridhar Kanuri et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The burden of liver disease in Europe: A review of available epidemiological data

(2013) Martin Blachier et al.   JOURNAL OF HEPATOLOGY

Non-Alcoholic Fatty Liver Disease (NAFLD) and Its Connection with Insulin Resistance, Dyslipidemia, Atherosclerosis and Coronary Heart Disease

(2013) Melania Gaggini et al.   Nutrients

Fat Depots, Free Fatty Acids, and Dyslipidemia

(2013) Jon Ebbert et al.   Nutrients

Profiling the Impact of Medium Formulation on Morphology and Functionality of Primary Hepatocytes in vitro

(2013) Leonard J. Nelson et al.   Scientific Reports

Systematic review: the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults

(2011) G. Vernon et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Physiologic action of glucagon on liver glucose metabolism

(2011) C. J. Ramnanan et al.   DIABETES OBESITY & METABOLISM

Human liver cell spheroids in extended perfusion bioreactor culture for repeated-dose drug testing

(2011) Rui M. Tostões et al.   HEPATOLOGY

Diacylglycerol-mediated insulin resistance

(2010) Derek M Erion et al.   NATURE MEDICINE

Pioglitazone, Vitamin E, or Placebo for Nonalcoholic Steatohepatitis

(2010) Arun J. Sanyal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Dietary fructose and the metabolic syndrome

(2008) Abigale Miller et al.   CURRENT OPINION IN GASTROENTEROLOGY

Pck1 Gene Silencing in the Liver Improves Glycemia Control, Insulin Sensitivity, and Dyslipidemia in db/db Mice

(2008) A. G. Gomez-Valades et al.   DIABETES