MITOsym®: A Mechanistic, Mathematical Model of Hepatocellular Respiration and Bioenergetics

Linking physiology to toxicity using DILIsym®, a mechanistic mathematical model of drug-induced liver injury

(2013) Lisl K. M. Shoda et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Combined in vivo and in silico investigations of activation of glycolysis in contracting skeletal muscle

(2012) J. P. J. Schmitz et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Effects of a glucokinase activator on hepatic intermediary metabolism: study with13C-isotopomer-based metabolomics

(2012) Itzhak Nissim et al.   BIOCHEMICAL JOURNAL

Assessment of drug-induced mitochondrial dysfunction via altered cellular respiration and acidification measured in a 96-well platform

(2012) Sashi Nadanaciva et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

In vitro to in vivo extrapolation and species response comparisons for drug-induced liver injury (DILI) using DILIsym™: a mechanistic, mathematical model of DILI

(2012) Brett A. Howell et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Mechanisms of Hepatocellular Toxicity Associated with Dronedarone—A Comparison to Amiodarone

(2012) Andrea Felser et al.   TOXICOLOGICAL SCIENCES

Assessing mitochondrial dysfunction in cells

(2011) Martin D. Brand et al.   BIOCHEMICAL JOURNAL

Susceptibility to simvastatin-induced toxicity is partly determined by mitochondrial respiration and phosphorylation state of Akt

(2011) Peter J. Mullen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mitochondrial Energetics, pH Regulation, and Ion Dynamics: A Computational-Experimental Approach

(2011) An-Chi Wei et al.   BIOPHYSICAL JOURNAL

Mitochondrial membrane potential probes and the proton gradient: a practical usage guide

(2011) Seth W. Perry et al.   BIOTECHNIQUES

Bioenergetic characterization of mouse podocytes

(2010) Yoshifusa Abe et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The role of CYP3A4 in amiodarone-associated toxicity on HepG2 cells

(2010) Anja Zahno et al.   BIOCHEMICAL PHARMACOLOGY

Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity

(2010) F. Weinberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Establishment and characterization of a novel method for evaluating gluconeogenesis using hepatic cell lines, H4IIE and HepG2

(2009) Takashi Okamoto et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Advances in measuring cellular bioenergetics using extracellular flux

(2008) David A. Ferrick et al.   DRUG DISCOVERY TODAY

In Vitro Assessment of Mitochondrial Dysfunction and Cytotoxicity of Nefazodone, Trazodone, and Buspirone

(2008) James A. Dykens et al.   TOXICOLOGICAL SCIENCES

Identification of metabolic fluxes in hepatic cells from transient13C-labeling experiments: Part II. Flux estimation

(2007) Klaus Maier et al.   BIOTECHNOLOGY AND BIOENGINEERING