Analyzing the Mechanisms Behind Macrolide Antibiotic-Induced Liver Injury Using Quantitative Systems Toxicology Modeling

SOLITAIRE-IV: A Randomized, Double-Blind, Multicenter Study Comparing the Efficacy and Safety of Intravenous-to-Oral Solithromycin to Intravenous-to-Oral Moxifloxacin for Treatment of Community-Acquired Bacterial Pneumonia

(2016) Thomas M. File et al.   CLINICAL INFECTIOUS DISEASES

Efficacy and safety of oral solithromycin versus oral moxifloxacin for treatment of community-acquired bacterial pneumonia: a global, double-blind, multicentre, randomised, active-controlled, non-inferiority trial (SOLITAIRE-ORAL)

(2016) Carlos M Barrera et al.   LANCET INFECTIOUS DISEASES

Application of a Mechanistic Model to Evaluate Putative Mechanisms of Tolvaptan Drug-Induced Liver Injury and Identify Patient Susceptibility Factors

(2016) Jeffrey L. Woodhead et al.   TOXICOLOGICAL SCIENCES

Macrolide Antibiotics and the Risk of Cardiac Arrhythmias

(2014) Richard K. Albert et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Efficacy and Safety of Long-Term Antibiotics (Macrolides) for the Treatment of Chronic Rhinosinusitis

(2014) Anders Cervin et al.   CURRENT ALLERGY AND ASTHMA REPORTS

MITOsym®: A Mechanistic, Mathematical Model of Hepatocellular Respiration and Bioenergetics

(2014) Y. Yang et al.   PHARMACEUTICAL RESEARCH

Exploring BSEP inhibition-mediated toxicity with a mechanistic model of drug-induced liver injury

(2014) Jeffrey L. Woodhead et al.   Frontiers in Pharmacology

Linking physiology to toxicity using DILIsym®, a mechanistic mathematical model of drug-induced liver injury

(2013) Lisl K. M. Shoda et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Risk of Acute Liver Injury Associated with the Use of Moxifloxacin and Other Oral Antimicrobials: A Retrospective, Population-Based Cohort Study

(2013) James A. Kaye et al.   PHARMACOTHERAPY

In vitro to in vivo extrapolation and species response comparisons for drug-induced liver injury (DILI) using DILIsym™: a mechanistic, mathematical model of DILI

(2012) Brett A. Howell et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Hepatic safety of antibiotics used in primary care

(2011) R. J. Andrade et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Role of cAMP-responsive Element-binding Protein (CREB)-regulated Transcription Coactivator 3 (CRTC3) in the Initiation of Mitochondrial Biogenesis and Stress Response in Liver Cells

(2011) Tin Aung Than et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hepatobiliary transporter expression and post-operative jaundice in patients undergoing partial hepatectomy

(2011) Gerwin A. Bernhardt et al.   LIVER INTERNATIONAL

Azithromycin-induced liver injury: Table 1

(2010) Alissa M. Lockwood et al.   AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY

Molecular Characterization of Off-Target Activities of Telithromycin: a Potential Role for Nicotinic Acetylcholine Receptors

(2010) D. Bertrand et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Telithromycin-associated hepatotoxicity: Clinical spectrum and causality assessment of 42 cases

(2008) Allen D. Brinker et al.   HEPATOLOGY