Endogenous and xenobiotic metabolic stability of primary human hepatocytes in long-term 3D spheroid cultures revealed by a combination of targeted and untargeted metabolomics

Engineered Liver Platforms for Different Phases of Drug Development

(2017) Brenton R. Ware et al.   TRENDS IN BIOTECHNOLOGY

Strategies for large-scale targeted metabolomics quantification by liquid chromatography-mass spectrometry

(2016) Juntuo Zhou et al.   ANALYST

Improving global feature detectabilities through scan range splitting for untargeted metabolomics by high-performance liquid chromatography-Orbitrap mass spectrometry

(2016) Christina Ranninger et al.   ANALYTICA CHIMICA ACTA

Influence of Mass Resolving Power in Orbital Ion-Trap Mass Spectrometry-Based Metabolomics

(2016) Lukáš Najdekr et al.   ANALYTICAL CHEMISTRY

A multicenter assessment of single-cell models aligned to standard measures of cell health for prediction of acute hepatotoxicity

(2016) Rowena L. Sison-Young et al.   ARCHIVES OF TOXICOLOGY

Novel 3D Culture Systems for Studies of Human Liver Function and Assessments of the Hepatotoxicity of Drugs and Drug Candidates

(2016) Volker M. Lauschke et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Massive rearrangements of cellular MicroRNA signatures are key drivers of hepatocyte dedifferentiation

(2016) Volker M. Lauschke et al.   HEPATOLOGY

The Importance of Patient-Specific Factors for Hepatic Drug Response and Toxicity

(2016) Volker Lauschke et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A metabolomics cell-based approach for anticipating and investigating drug-induced liver injury

(2016) Juan Carlos García- Cañaveras et al.   Scientific Reports

Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease

(2016) Catherine C. Bell et al.   Scientific Reports

Toward Merging Untargeted and Targeted Methods in Mass Spectrometry-Based Metabolomics and Lipidomics

(2015) Tomas Cajka et al.   ANALYTICAL CHEMISTRY

Evolution of Orbitrap Mass Spectrometry Instrumentation

(2015) Shannon Eliuk et al.   Annual Review of Analytical Chemistry

Phenotypic and functional analyses show stem cell-derived hepatocyte-like cells better mimic fetal rather than adult hepatocytes

(2015) Melissa Baxter et al.   JOURNAL OF HEPATOLOGY

Metabolomics analysis of the toxicity pathways of triphenyl phosphate in HepaRG cells and comparison to oxidative stress mechanisms caused by acetaminophen

(2015) Nele Van den Eede et al.   TOXICOLOGY IN VITRO

Cell-Type-Resolved Quantitative Proteomics of Murine Liver

(2014) S. Babak Azimifar et al.   Cell Metabolism

Vitamin B12–dependent taurine synthesis regulates growth and bone mass

(2014) Pablo Roman-Garcia et al.   JOURNAL OF CLINICAL INVESTIGATION

A cocktail approach for assessing the in vitro activity of human cytochrome P450s: An overview of current methodologies

(2014) Dany Spaggiari et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Comparative metabolome analysis of cultured fetal and adult hepatocytes in humans

(2014) Su-Ryang Kim et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Temporal metabolomic responses of cultured HepG2 liver cells to high fructose and high glucose exposures

(2014) John K. Meissen et al.   Metabolomics

Clinical development success rates for investigational drugs

(2014) Michael Hay et al.   NATURE BIOTECHNOLOGY

Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework

(2014) David Cook et al.   NATURE REVIEWS DRUG DISCOVERY

Pharmacometabolomics of Statin Response

(2013) R M Krauss et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Incidence, Presentation, and Outcomes in Patients With Drug-Induced Liver Injury in the General Population of Iceland

(2013) Einar S. Björnsson et al.   GASTROENTEROLOGY

Proteome-wide analyses of human hepatocytes during differentiation and dedifferentiation

(2013) Cliff Rowe et al.   HEPATOLOGY

Identification of small molecules for human hepatocyte expansion and iPS differentiation

(2013) Jing Shan et al.   Nature Chemical Biology

Metabolomic signatures in lipid-loaded HepaRGs reveal pathways involved in steatotic progression

(2013) Meredith V. Brown et al.   Obesity

Acridone Derivative 8a Induces Oxidative Stress-Mediated Apoptosis in CCRF-CEM Leukemia Cells: Application of Metabolomics in Mechanistic Studies of Antitumor Agents

(2013) Yini Wang et al.   PLoS One

Pharmaceutical toxicology: Designing studies to reduce animal use, while maximizing human translation

(2013) Kathryn L. Chapman et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Nuclear Receptors HNF4α and LRH-1 Cooperate in RegulatingCyp7a1 in Vivo

(2012) Serkan Kir et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Suggested guidelines for the diagnosis and management of urea cycle disorders

(2012) Johannes Häberle et al.   Orphanet Journal of Rare Diseases

Comparison between a high-resolution single-stage Orbitrap and a triple quadrupole mass spectrometer for quantitative analyses of drugs

(2012) Hugues Henry et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Nuclear receptor PXR, transcriptional circuits and metabolic relevance

(2011) Chibueze A. Ihunnah et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Human liver cell spheroids in extended perfusion bioreactor culture for repeated-dose drug testing

(2011) Rui M. Tostões et al.   HEPATOLOGY

Metabolomic Profile of Hepatitis C Virus-Infected Hepatocytes

(2011) Barbara Roe et al.   PLoS One

The Secret Life of NAD+: An Old Metabolite Controlling New Metabolic Signaling Pathways

(2010) Riekelt H. Houtkooper et al.   ENDOCRINE REVIEWS

Drug-induced acute liver failure: Results of a U.S. multicenter, prospective study

(2010) Adrian Reuben et al.   HEPATOLOGY

PharmGKB very important pharmacogene: SLCO1B1

(2010) Connie Oshiro et al.   Pharmacogenetics and Genomics

Aetiology and outcome of acute liver failure

(2010) Ravi Marudanayagam et al.   HPB

Constitutive androstane receptor transcriptionally activates human CYP1A1 and CYP1A2 genes through a common regulatory element in the 5′-flanking region

(2009) Kouichi Yoshinari et al.   BIOCHEMICAL PHARMACOLOGY

Stable Expression, Activity, and Inducibility of Cytochromes P450 in Differentiated HepaRG Cells

(2009) S. Antherieu et al.   DRUG METABOLISM AND DISPOSITION

Regulation of cytochrome P450 2C9 expression in primary cultures of human hepatocytes

(2009) Jasminder Sahi et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

The Small Molecule GMX1778 Is a Potent Inhibitor of NAD+ Biosynthesis: Strategy for Enhanced Therapy in Nicotinic Acid Phosphoribosyltransferase 1-Deficient Tumors

(2009) M. Watson et al.   MOLECULAR AND CELLULAR BIOLOGY

Metabolomic Profiling of Drug Responses in Acute Myeloid Leukaemia Cell Lines

(2009) Stefano Tiziani et al.   PLoS One

Dexamethasone controls aryl hydrocarbon receptor (AhR)-mediated CYP1A1 and CYP1A2 expression and activity in primary cultures of human hepatocytes

(2008) Radim Vrzal et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Evaluation of HepaRG Cells as an in Vitro Model for Human Drug Metabolism Studies

(2008) K. P. Kanebratt et al.   DRUG METABOLISM AND DISPOSITION