The P2X7 Receptor in Inflammatory Diseases: Angel or Demon?

Synthesis and in vitro characterization of a P2X7 radioligand [ 123 I]TZ6019 and its response to neuroinflammation in a mouse model of Alzheimer disease

(2018) Hongjun Jin et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Discovery and pharmacological evaluation of a novel series of adamantyl cyanoguanidines as P2X 7 receptor antagonists

(2017) James O'Brien-Brown et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

P2X7 receptor in the hippocampus is involved in gp120-induced cognitive dysfunction

(2017) Y. Liu et al.   GENETICS AND MOLECULAR RESEARCH

High expression of P2X7R is an independent postoperative indicator of poor prognosis in colorectal cancer

(2017) Fei Qian et al.   HUMAN PATHOLOGY

The P2X7 Receptor in Infection and Inflammation

(2017) Francesco Di Virgilio et al.   IMMUNITY

Mast Cells Are Crucial for Induction of Group 2 Innate Lymphoid Cells and Clearance of Helminth Infections

(2017) Chikako Shimokawa et al.   IMMUNITY

Inflammatory early events associated to the role of P2X7 receptor in acute murine toxoplasmosis

(2017) Gladys Corrêa et al.   IMMUNOBIOLOGY

The ectonucleotidases CD39 and CD73: Novel checkpoint inhibitor targets

(2017) Bertrand Allard et al.   IMMUNOLOGICAL REVIEWS

Purinergic P2X7 receptor mediates acetaldehyde-induced hepatic stellate cells activation via PKC-dependent GSK3β pathway

(2017) Xiaojuan Wu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

CD39 limits P2X7 receptor inflammatory signaling and attenuates sepsis-induced liver injury

(2017) Luiz Eduardo Baggio Savio et al.   JOURNAL OF HEPATOLOGY

Virus-Triggered ATP Release Limits Viral Replication through Facilitating IFN-β Production in a P2X7-Dependent Manner

(2017) Chengfei Zhang et al.   JOURNAL OF IMMUNOLOGY

4-Methyl-6,7-dihydro-4H-triazolo[4,5-c]pyridine-Based P2X7 Receptor Antagonists: Optimization of Pharmacokinetic Properties Leading to the Identification of a Clinical Candidate

(2017) Michael A. Letavic et al.   JOURNAL OF MEDICINAL CHEMISTRY

Purinergic signaling during intestinal inflammation

(2017) Maria Serena Longhi et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Brain ureido degenerative protein modifications are associated with neuroinflammation and proteinopathy in Alzheimer’s disease with cerebrovascular disease

(2017) Xavier Gallart-Palau et al.   Journal of Neuroinflammation

The P2X7 receptor antagonist, oxidized adenosine triphosphate, ameliorates renal ischemia-reperfusion injury by expansion of regulatory T cells

(2017) Tai Yeon Koo et al.   KIDNEY INTERNATIONAL

Purinergic signaling in kidney disease

(2017) Robert I. Menzies et al.   KIDNEY INTERNATIONAL

Evaluation of P2X7 receptor expression in peripheral lymphocytes and immune profile from patients with indeterminate form of Chagas disease

(2017) Viviane do Carmo Gonçalves Souza et al.   MICROBIAL PATHOGENESIS

Purinergic Antagonism Prevents Mitochondrial Dysfunction and Behavioral Deficits Associated with Dopaminergic Toxicity Induced by 6-OHDA in Rats

(2017) Saket Kumar et al.   NEUROCHEMICAL RESEARCH

Potentiation of hepatic stellate cell activation by extracellular ATP is dependent on P2X7R-mediated NLRP3 inflammasome activation

(2017) Shuang Jiang et al.   PHARMACOLOGICAL RESEARCH

P2X7 receptor-pannexin 1 interaction mediates extracellular alpha-synuclein-induced ATP release in neuroblastoma SH-SY5Y cells

(2017) Anna Wilkaniec et al.   Purinergic Signalling

Potential role of P2X7R in esophageal squamous cell carcinoma proliferation

(2017) André A Santos et al.   Purinergic Signalling

Repression of acetaminophen-induced hepatotoxicity by a combination of celastrol and brilliant blue G

(2017) Heba A. Abdelaziz et al.   TOXICOLOGY LETTERS

Th2 and Th1 Responses: Clear and Hidden Sides of Immunity Against Intestinal Helminths

(2017) Alba Cortés et al.   TRENDS IN PARASITOLOGY

Contribution of the Purinergic Receptor P2X7 to Development of Lung Immunopathology during Influenza Virus Infection

(2017) Victor H. Leyva-Grado et al.   mBio

Hyperthermia and associated changes in membrane fluidity potentiate P2X7 activation to promote tumor cell death

(2017) Paola de Andrade Mello et al.   Oncotarget

P2X7 receptor and NLRP3 inflammasome activation in head and neck cancer

(2017) Ju Young Bae et al.   Oncotarget

P2X7 receptor drives Th1 cell differentiation and controls the follicular helper T cell population to protect against Plasmodium chabaudi malaria

(2017) Érika Machado de Salles et al.   PLoS Pathogens

P2X1, P2X4, and P2X7 Receptor Knock Out Mice Expose Differential Outcome of Sepsis Induced by α-Haemolysin Producing Escherichia coli

(2017) Anne-Sofie Greve et al.   Frontiers in Cellular and Infection Microbiology

Purinergic Signalling: Therapeutic Developments

(2017) Geoffrey Burnstock   Frontiers in Pharmacology

Modulation of P2X7 Receptor during Inflammation in Multiple Sclerosis

(2017) Susanna Amadio et al.   Frontiers in Immunology

The P2X7 Receptor Mediates Toxoplasma gondii Control in Macrophages through Canonical NLRP3 Inflammasome Activation and Reactive Oxygen Species Production

(2017) Aline Cristina Abreu Moreira-Souza et al.   Frontiers in Immunology

NOD-Like Receptor P3 Inflammasome Controls Protective Th1/Th17 Immunity against Pulmonary Paracoccidioidomycosis

(2017) Claudia Feriotti et al.   Frontiers in Immunology

P2X7 Receptor in Bone Marrow-Derived Cells Aggravates Tuberculosis Caused by Hypervirulent Mycobacterium bovis

(2017) Caio César Barbosa Bomfim et al.   Frontiers in Immunology

Multifaceted Effects of Extracellular Adenosine Triphosphate and Adenosine in the Tumor–Host Interaction and Therapeutic Perspectives

(2017) Paola de Andrade Mello et al.   Frontiers in Immunology

Hyperglycemia-induced Renal P2X7 Receptor Activation Enhances Diabetes-related Injury

(2017) Robert I. Menzies et al.   EBioMedicine

Alzheimer's Disease and the Amyloid-β Peptide

(2017) M. Paul Murphy et al.   JOURNAL OF ALZHEIMERS DISEASE

Systemic blockade of P2X7 receptor protects against sepsis-induced intestinal barrier disruption

(2017) Xiuwen Wu et al.   Scientific Reports

Association of IFN-γ and P2X7 Receptor Gene Polymorphisms in Susceptibility to Tuberculosis Among Iranian Patients

(2016) Mahdi Shamsi et al.   ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA

Deletion of P2X7 attenuates hyperoxia-induced acute lung injury via inflammasome suppression

(2016) Lakshmi Galam et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

P2X7 from j774 murine macrophages acts as a scavenger receptor for bacteria but not yeast

(2016) Gabriela Pérez-Flores et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Purinergic Signaling and the Immune Response in Sepsis: A Review

(2016) Carola Ledderose et al.   CLINICAL THERAPEUTICS

P2X7 1513 A>C Polymorphism Confers Increased Risk of Extrapulmonary Tuberculosis: A Meta-analysis of Case-Control Studies

(2016) Mohammed Y. Areeshi et al.   CURRENT GENOMICS

P2X7 receptor antagonists: a patent review (2010–2015)

(2016) Jin-Hee Park et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

The purinergic receptor P2X7 role in control of Dengue virus-2 infection and cytokine/chemokine production in infected human monocytes

(2016) Gladys Corrêa et al.   IMMUNOBIOLOGY

P2X7 receptor-dependent tuning of gut epithelial responses to infection

(2016) Szu-Wei Huang et al.   IMMUNOLOGY AND CELL BIOLOGY

The P2X7 Receptor Involved in gp120-Induced Cell Injury in BV2 Microglia

(2016) Qiang Chen et al.   INFLAMMATION

The new sepsis consensus definitions (Sepsis-3): the good, the not-so-bad, and the actually-quite-pretty

(2016) Mervyn Singer   INTENSIVE CARE MEDICINE

Targeting of the P2X7 receptor in pancreatic cancer and stellate cells

(2016) Andrea Giannuzzo et al.   INTERNATIONAL JOURNAL OF CANCER

P2X7 receptor as a novel drug delivery system to increase the entrance of hydrophilic drugs into cells during photodynamic therapy

(2016) Paulo Anastácio Furtado Pacheco et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Shock wave-induced ATP release from osteosarcoma U2OS cells promotes cellular uptake and cytotoxicity of methotrexate

(2016) Baochang Qi et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

A Critical Role for P2X7Receptor–Induced VCAM-1 Shedding and Neutrophil Infiltration during Acute Lung Injury

(2016) Amarjit Mishra et al.   JOURNAL OF IMMUNOLOGY

Potent Suppressive Effects of 1-Piperidinylimidazole Based Novel P2X7 Receptor Antagonists on Cancer Cell Migration and Invasion

(2016) Jin-Hee Park et al.   JOURNAL OF MEDICINAL CHEMISTRY

P2X7 receptor knockout prevents streptozotocin-induced type 1 diabetes in mice

(2016) Flávia Sarmento Vieira et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Early P2X7R-related astrogliosis in autoimmune encephalomyelitis

(2016) Tomasz Grygorowicz et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Inhibiting purinergic P2X7 receptors with the antagonist brilliant blue G is neuroprotective in an intranigral lipopolysaccharide animal model of Parkinson's disease

(2016) Xin-Hong Wang et al.   Molecular Medicine Reports

P2X7 Receptor Signaling Contributes to Sepsis-Associated Brain Dysfunction

(2016) Luiz Eduardo Baggio Savio et al.   MOLECULAR NEUROBIOLOGY

Contraction of intestinal effector T cells by retinoic acid-induced purinergic receptor P2X7

(2016) S Hashimoto-Hill et al.   Mucosal Immunology

Extracellular purines, purinergic receptors and tumor growth

(2016) F Di Virgilio et al.   ONCOGENE

The role of the P2X7 receptor in murine cutaneous leishmaniasis: aspects of inflammation and parasite control

(2016) Vanessa Ribeiro Figliuolo et al.   Purinergic Signalling

Genetically dissecting P2rx7 expression within the central nervous system using conditional humanized mice

(2016) Michael W. Metzger et al.   Purinergic Signalling

Increased expression of NTPDases 2 and 3 in mesenteric endothelial cells during schistosomiasis favors leukocyte adhesion through P2Y1 receptors

(2016) Suellen Darc Santos Oliveira et al.   VASCULAR PHARMACOLOGY

P2X7 targeting inhibits growth of human mesothelioma

(2016) Francesca Amoroso et al.   Oncotarget

Human iNKT Cells Promote Protective Inflammation by Inducing Oscillating Purinergic Signaling in Monocyte-Derived DCs

(2016) Xuequn Xu et al.   Cell Reports

Danger signals, inflammasomes, and the intricate intracellular lives of chlamydiae

(2016) Matthew A. Pettengill et al.   Biomedical Journal

Purinergic signaling in infection and autoimmune disease

(2016) Luiz Eduardo Baggio Savio et al.   Biomedical Journal

Purinergic signaling in schistosomal infection

(2016) Claudia Lucia Martins Silva   Biomedical Journal

Purinergic signaling during Porphyromonas gingivalis infection

(2016) Cássio Luiz Coutinho Almeida-da-Silva et al.   Biomedical Journal

P2X7R-Panx1 Complex Impairs Bone Mechanosignaling under High Glucose Levels Associated with Type-1 Diabetes

(2016) Zeynep Seref-Ferlengez et al.   PLoS One

Extracellular ATP mediates inflammatory responses in colitis via P2 × 7 receptor signaling

(2016) Ping Wan et al.   Scientific Reports

Purinergic receptors in tubulointerstitial inflammatory cells: a pathophysiological mechanism of salt-sensitive hypertension

(2015) M. Franco et al.   Acta Physiologica

Emerging role of P2X7 receptors in CNS health and disease

(2015) Manju Tewari et al.   AGEING RESEARCH REVIEWS

P2X7 receptor inhibition protects against ischemic acute kidney injury in mice

(2015) Yanli Yan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Understanding the roles of the P2X7 receptor in solid tumour progression and therapeutic perspectives

(2015) Sébastien Roger et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Genetic and Pharmacological Inactivation of the Purinergic P2RX7 Receptor Dampens Inflammation but Increases Tumor Incidence in a Mouse Model of Colitis-Associated Cancer

(2015) P. Hofman et al.   CANCER RESEARCH

P2X7 receptor predicts postoperative cancer-specific survival of patients with clear-cell renal cell carcinoma

(2015) Zheng Liu et al.   CANCER SCIENCE

P2RX7 sensitizes Mac-1/ICAM-1-dependent leukocyte-endothelial adhesion and promotes neurovascular injury during septic encephalopathy

(2015) Huan Wang et al.   CELL RESEARCH

Single Nucleotide Polymorphisms inP2X7Gene Are Associated with Serum Immunoglobulin G Responses toMycobacterium tuberculosisin Tuberculosis Patients

(2015) Jiangdong Wu et al.   DISEASE MARKERS

Extracellular ATP protects against sepsis through macrophage P2X7 purinergic receptors by enhancing intracellular bacterial killing

(2015) Balázs Csóka et al.   FASEB JOURNAL

CD39 improves survival in microbial sepsis by attenuating systemic inflammation

(2015) Balázs Csóka et al.   FASEB JOURNAL

Interaction of Chlamydiae with human macrophages

(2015) Jo-Ana Herweg et al.   FEBS Journal

Ceramide-CD300f binding suppresses experimental colitis by inhibiting ATP-mediated mast cell activation

(2015) Toshihiro Matsukawa et al.   GUT

A rare P2X7 variant Arg307Gln with absent pore formation function protects against neuroinflammation in multiple sclerosis

(2015) Ben J. Gu et al.   HUMAN MOLECULAR GENETICS

Caspase-11 Requires the Pannexin-1 Channel and the Purinergic P2X7 Pore to Mediate Pyroptosis and Endotoxic Shock

(2015) Dahai Yang et al.   IMMUNITY

Lipopolysaccharide Induces Alveolar Macrophage Necrosis via CD14 and the P2X7 Receptor Leading to Interleukin-1α Release

(2015) Jargalsaikhan Dagvadorj et al.   IMMUNITY

Safety and Efficacy of an Oral Inhibitor of the Purinergic Receptor P2X7 in Adult Patients with Moderately to Severely Active Crohnʼs Disease

(2015) Alexander Eser et al.   INFLAMMATORY BOWEL DISEASES

Blockage of P2X7 attenuates acute lung injury in mice by inhibiting NLRP3 inflammasome

(2015) Shuang Wang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

P2X7 receptor as predictor gene for glioma radiosensitivity and median survival

(2015) Marina P. Gehring et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Involvement of purinergic system in the release of cytokines by macrophages exposed to glioma-conditioned medium

(2015) Letícia Scussel Bergamin et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Variation in Glucose Homeostasis Traits Associated WithP2RX7Polymorphisms in Mice and Humans

(2015) Jennifer N. Todd et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

A Dual Role for P2X7 Receptor during Porphyromonas gingivalis Infection

(2015) E.S. Ramos-Junior et al.   JOURNAL OF DENTAL RESEARCH

The P2X7 Receptor Contributes to the Development of the Exacerbated Inflammatory Response Associated with Sepsis

(2015) Patricia Texeira Santana et al.   Journal of Innate Immunity

Inhibition of the purinergic P2X7 receptor improves renal perfusion in angiotensin-II-infused rats

(2015) Robert I. Menzies et al.   KIDNEY INTERNATIONAL

The P2X7 receptor regulates cell survival, migration and invasion of pancreatic ductal adenocarcinoma cells

(2015) Andrea Giannuzzo et al.   Molecular Cancer

P2X7 receptor is critical in α-synuclein–mediated microglial NADPH oxidase activation

(2015) Tianfang Jiang et al.   NEUROBIOLOGY OF AGING

The P2X7 receptor is a key modulator of the PI3K/GSK3β/VEGF signaling network: evidence in experimental neuroblastoma

(2015) F Amoroso et al.   ONCOGENE

The Beneficial Effects of P2X7 Antagonism in Rats with Bile Duct Ligation-induced Cirrhosis

(2015) Hung-Chun Tung et al.   PLoS One

Extracellular ATP induces the rapid release of HIV-1 from virus containing compartments of human macrophages

(2015) Francesca Graziano et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of P2X7 receptors in tissue fibrosis: a brief review

(2015) Daniela Gentile et al.   Purinergic Signalling

Expression of P2X7R in breast cancer tissue and the induction of apoptosis by the gene-specific shRNA in MCF-7 cells

(2015) CHAO TAN et al.   Experimental and Therapeutic Medicine

The NLRP3 Inflammasome Is a Pathogen Sensor for Invasive Entamoeba histolytica via Activation of α5β1 Integrin at the Macrophage-Amebae Intercellular Junction

(2015) Leanne Mortimer et al.   PLoS Pathogens

Purinergic Receptors: Key Mediators of HIV-1 Infection and Inflammation

(2015) Talia H. Swartz et al.   Frontiers in Immunology

Role of P2X7 and P2Y 2 receptors on α-secretase-dependent APP processing: Control of amyloid plaques formation “ in vivo ” by P2X7 receptor

(2015) M. Teresa Miras-Portugal et al.   Computational and Structural Biotechnology Journal

NLRP3 Inflammasome Activation in Dialyzed Chronic Kidney Disease Patients

(2015) Simona Granata et al.   PLoS One

Lack of a Functioning P2X7 Receptor Leads to Increased Susceptibility to Toxoplasmic Ileitis

(2015) Catherine M. Miller et al.   PLoS One

Vascular CD39/ENTPD1 Directly Promotes Tumor Cell Growth by Scavenging Extracellular Adenosine Triphosphate

(2015) Lili Feng et al.   NEOPLASIA

Biology of purinergic signalling: Its ancient evolutionary roots, its omnipresence and its multiple functional significance

(2014) Alexei Verkhratsky et al.   BIOESSAYS

Multiple Sclerosis: Autoimmune Disease or Autoimmune Reaction?

(2014) Peter K. Stys   CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES

Accelerated Tumor Progression in Mice Lacking the ATP Receptor P2X7

(2014) E. Adinolfi et al.   CANCER RESEARCH

Atorvastatin prevents ATP-driven invasiveness via P2X7 and EHBP1 signaling in PTEN-expressing prostate cancer cells

(2014) Aram Ghalali et al.   CARCINOGENESIS

ATP Signaling in Brain: Release, Excitotoxicity and Potential Therapeutic Targets

(2014) Abraham Cisneros-Mejorado et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Periodate-oxidized ATP modulates macrophage functions during infection withLeishmania amazonensis

(2014) V. R. Figliuolo et al.   CYTOMETRY PART A

The helminth Trichuris suis suppresses TLR4-induced inflammatory responses in human macrophages

(2014) M K Ottow et al.   GENES AND IMMUNITY

P2X7-dependent, but differentially regulated release of IL-6, CCL2, and TNF-α in cultured mouse microglia

(2014) Chu-Hsin Shieh et al.   GLIA

Tumor-Associated Macrophages: From Mechanisms to Therapy

(2014) Roy Noy et al.   IMMUNITY

ATP-Gated Ionotropic P2X7 Receptor Controls Follicular T Helper Cell Numbers in Peyer’s Patches to Promote Host-Microbiota Mutualism

(2014) Michele Proietti et al.   IMMUNITY

Overexpression of ATP-activated P2X7 Receptors in the Intestinal Mucosa Is Implicated in the Pathogenesis of Crohnʼs Disease

(2014) Adriane R. Neves et al.   INFLAMMATORY BOWEL DISEASES

PARACRINE STIMULATION OF P2X7 RECEPTOR BY ATP ACTIVATES A PROLIFERATIVE PATHWAY IN OVARIAN CARCINOMA CELLS

(2014) Francisco G. Vázquez-Cuevas et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Leukotriene B4 Modulates P2X7 Receptor-Mediated Leishmania amazonensis Elimination in Murine Macrophages

(2014) M. M. Chaves et al.   JOURNAL OF IMMUNOLOGY

Porphyromonas gingivalis Fimbriae Dampen P2X7-Dependent Interleukin-1β Secretion

(2014) Ana Carolina Morandini et al.   Journal of Innate Immunity

Astrocytes mediate HIV-1 Tat-induced neuronal damage via ligand-gated ion channel P2X7R

(2014) Manju Tewari et al.   JOURNAL OF NEUROCHEMISTRY

P2X-Selective Purinergic Antagonists Are Strong Inhibitors of HIV-1 Fusion during both Cell-to-Cell and Cell-Free Infection

(2014) T. H. Swartz et al.   JOURNAL OF VIROLOGY

P2X7Receptor Expression in Coexistence of Papillary Thyroid Carcinoma with Hashimoto's Thyroiditis

(2014) Ji Hyun Kwon et al.   Korean Journal of Pathology

Macrophage P2X7 Receptor Function Is Reduced during Schistosomiasis: Putative Role of TGF-β1

(2014) Suellen D’arc Santos Oliveira et al.   MEDIATORS OF INFLAMMATION

Adenosine uptake is the major effector of extracellular ATP toxicity in human cervical cancer cells

(2014) Paola de Andrade Mello et al.   MOLECULAR BIOLOGY OF THE CELL

Nucleotide signalling during inflammation

(2014) Marco Idzko et al.   NATURE

The P2X7 receptor antagonist Brilliant Blue G attenuates contralateral rotations in a rat model of Parkinsonism through a combined control of synaptotoxicity, neurotoxicity and gliosis

(2014) Marta R.S. Carmo et al.   NEUROPHARMACOLOGY

P2×7 Receptor in the Kidneys of Diabetic Rats Submitted to Aerobic Training or to N-Acetylcysteine Supplementation

(2014) Adelson M. Rodrigues et al.   PLoS One

Trophic Activity of Human P2X7 Receptor Isoforms A and B in Osteosarcoma

(2014) Anna Lisa Giuliani et al.   PLoS One

Involvement of the P2X7 Purinergic Receptor in Colonic Motor Dysfunction Associated with Bowel Inflammation in Rats

(2014) Luca Antonioli et al.   PLoS One

P2X7 Receptor Modulates Inflammatory and Functional Pulmonary Changes Induced by Silica

(2014) Leonardo C. Monção-Ribeiro et al.   PLoS One

P2X7 Mediates ATP-Driven Invasiveness in Prostate Cancer Cells

(2014) Ying Qiu et al.   PLoS One

Plasma ATP is Required for Neutrophil Activation in a Mouse Sepsis Model

(2014) Yuka Sumi et al.   SHOCK

Role of transient receptor potential and pannexin channels in cigarette smoke-triggered ATP release in the lung

(2014) Matthew Baxter et al.   THORAX

P2X7 receptor: an emerging target in central nervous system diseases

(2014) Beáta Sperlágh et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

ATP/P2X7 axis modulates myeloid-derived suppressor cell functions in neuroblastoma microenvironment

(2014) G Bianchi et al.   Cell Death & Disease

Extracellular ATP drives systemic inflammation, tissue damage and mortality

(2014) A Cauwels et al.   Cell Death & Disease

The Global Burden of Disease Study 2010: Interpretation and Implications for the Neglected Tropical Diseases

(2014) Peter J. Hotez et al.   PLoS Neglected Tropical Diseases

Pulmonary Infection with Hypervirulent Mycobacteria Reveals a Crucial Role for the P2X7 Receptor in Aggressive Forms of Tuberculosis

(2014) Eduardo P. Amaral et al.   PLoS Pathogens

The role of p2x7 receptor in infectious inflammatory diseases and the influence of ectonucleotidases

(2014) Robson Coutinho-Silva et al.   Biomedical Journal

Purinergic receptor X7 is a key modulator of metabolic oxidative stress-mediated autophagy and inflammation in experimental nonalcoholic steatohepatitis

(2013) Suvarthi Das et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Silencing of the P2X7 receptor enhances amyloid-β phagocytosis by microglia

(2013) Jiong Ni et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Prophylactic systemic P2X7 receptor blockade prevents experimental colitis

(2013) Carla Caldas Marques et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Purinergic receptor P2X7: A novel target for anti-inflammatory therapy

(2013) Nisha Mehta et al.   BIOORGANIC & MEDICINAL CHEMISTRY

TLR stimulation initiates a CD39-based autoregulatory mechanism that limits macrophage inflammatory responses

(2013) H. B. Cohen et al.   BLOOD

Anthraquinone emodin inhibits human cancer cell invasiveness by antagonizing P2X7 receptors

(2013) Bilel Jelassi et al.   CARCINOGENESIS

Effect of the Purinergic Inhibitor Oxidized ATP in a Model of Islet Allograft Rejection

(2013) A. Vergani et al.   DIABETES

Implication of purinergic P2X7 receptor in M. tuberculosis infection and host interaction mechanisms: A mouse model study

(2013) André A. Santos et al.   IMMUNOBIOLOGY

Activation of NLRP3 and AIM2 Inflammasomes by Porphyromonas gingivalis Infection

(2013) Eunjoo Park et al.   INFECTION AND IMMUNITY

The purinergic 2X7receptor participates in renal inflammation and injury induced by high-fat diet: possible role of NLRP3 inflammasome activation

(2013) Anna Solini et al.   JOURNAL OF PATHOLOGY

P2X7 blockade attenuates mouse liver fibrosis

(2013) CHANGSHAN HUANG et al.   Molecular Medicine Reports

Physiological Roles and Potential Therapeutic Applications of the P2X7 Receptor in Inflammation and Pain

(2013) Luiz Alves et al.   MOLECULES

A role for tau at the synapse in Alzheimer's disease pathogenesis

(2013) Amy M. Pooler et al.   NEUROPHARMACOLOGY

P2X7 Integrates PI3K/AKT and AMPK-PRAS40-mTOR Signaling Pathways to Mediate Tumor Cell Death

(2013) Shu Bian et al.   PLoS One

P2X4 Assembles with P2X7 and Pannexin-1 in Gingival Epithelial Cells and Modulates ATP-induced Reactive Oxygen Species Production and Inflammasome Activation

(2013) Shu-Chen Hung et al.   PLoS One

Purinergic signaling in inflammatory cells: P2 receptor expression, functional effects, and modulation of inflammatory responses

(2013) Fenila Jacob et al.   Purinergic Signalling

Purinergic signalling in the kidney in health and disease

(2013) Geoffrey Burnstock et al.   Purinergic Signalling

Purinergic signalling and diabetes

(2013) Geoffrey Burnstock et al.   Purinergic Signalling

Synthesis and Pharmacological Characterization of Two Novel, Brain Penetrating P2X7 Antagonists

(2013) Michael A. Letavic et al.   ACS Medicinal Chemistry Letters

 -Synuclein in Parkinson's Disease

(2013) L. Stefanis   Cold Spring Harbor Perspectives in Medicine

P2X7 receptor-mediated purinergic signaling promotes liver injury in acetaminophen hepatotoxicity in mice

(2012) Rafaz Hoque et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Clinical evaluation of the efficacy of the P2X7purinergic receptor antagonist AZD9056 on the signs and symptoms of rheumatoid arthritis in patients with active disease despite treatment with methotrexate or sulphasalazine

(2012) Edward C Keystone et al.   ANNALS OF THE RHEUMATIC DISEASES

Apolipoprotein E4 effects in Alzheimer’s disease are mediated by synaptotoxic oligomeric amyloid-β

(2012) Robert M. Koffie et al.   BRAIN

Pharmacokinetic and pharmacodynamic profiling of a P2X7 receptor allosteric modulator GSK1482160 in healthy human subjects

(2012) Zahid Ali et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Expression of P2X7 Receptor Increases In Vivo Tumor Growth

(2012) E. Adinolfi et al.   CANCER RESEARCH

Purines, Purinergic Receptors, and Cancer

(2012) F. Di Virgilio   CANCER RESEARCH

Porphyromonas gingivalis-nucleoside-diphosphate-kinase inhibits ATP-induced reactive-oxygen-species via P2X7receptor/NADPH-oxidase signalling and contributes to persistence

(2012) Chul Hee Choi et al.   CELLULAR MICROBIOLOGY

Long-Term Heart Transplant Survival by Targeting the Ionotropic Purinergic Receptor P2X7

(2012) Andrea Vergani et al.   CIRCULATION

P2X7 receptor-NADPH oxidase axis mediates protein radical formation and Kupffer cell activation in carbon tetrachloride-mediated steatohepatitis in obese mice

(2012) Saurabh Chatterjee et al.   FREE RADICAL BIOLOGY AND MEDICINE

Purinergic signalling in the pancreas in health and disease

(2012) G Burnstock et al.   JOURNAL OF ENDOCRINOLOGY

Pathological roles of purinergic signaling in the liver

(2012) Byron P. Vaughn et al.   JOURNAL OF HEPATOLOGY

Significant Role of IL-1 Signaling, but Limited Role of Inflammasome Activation, in Oviduct Pathology during Chlamydia muridarum Genital Infection

(2012) U. M. Nagarajan et al.   JOURNAL OF IMMUNOLOGY

Purinergic Receptors Are Required for HIV-1 Infection of Primary Human Macrophages

(2012) J. E. Hazleton et al.   JOURNAL OF IMMUNOLOGY

Characterizing the Presence and Sensitivity of the P2X7 Receptor in Different Compartments of the Gut

(2012) Nathalia Enes de Campos et al.   Journal of Innate Immunity

P2X7 receptor-mediated Nlrp3-inflammasome activation is a genetic determinant of macrophage-dependent crescentic glomerulonephritis

(2012) Simona Deplano et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Efficacy and Safety of CE-224,535, an Antagonist of P2X7 Receptor, in Treatment of Patients with Rheumatoid Arthritis Inadequately Controlled by Methotrexate

(2012) T. C. STOCK et al.   JOURNAL OF RHEUMATOLOGY

Role of extracellular nucleotides in the immune response against intracellular bacteria and protozoan parasites

(2012) Robson Coutinho-Silva et al.   MICROBES AND INFECTION

Cell cooperation and role of the P2X7receptor in pulmonary inflammation induced by nanoparticles

(2012) Samir Dekali et al.   Nanotoxicology

Molecular mechanism of ATP binding and ion channel activation in P2X receptors

(2012) Motoyuki Hattori et al.   NATURE

Activation of neuronal P2X7 receptor–pannexin-1 mediates death of enteric neurons during colitis

(2012) Brian D Gulbransen et al.   NATURE MEDICINE

Activation of P2X7 Receptor by ATP Plays an Important Role in Regulating Inflammatory Responses during Acute Viral Infection

(2012) Benjamin H. Lee et al.   PLoS One

Leishmaniasis Worldwide and Global Estimates of Its Incidence

(2012) Jorge Alvar et al.   PLoS One

P2X7 receptor activation leads to increased cell death in a radiosensitive human glioma cell line

(2012) Marina Petersen Gehring et al.   Purinergic Signalling

Endothelial P2X7 receptors’ expression is reduced by schistosomiasis

(2012) Suellen D’Arc dos Santos Oliveira et al.   Purinergic Signalling

Molecular and functional properties of P2X receptors—recent progress and persisting challenges

(2012) Karina Kaczmarek-Hájek et al.   Purinergic Signalling

The P2X7 receptor is a key modulator of aerobic glycolysis

(2012) F Amoroso et al.   Cell Death & Disease

Extracellular ATP mediates mast cell-dependent intestinal inflammation through P2X7 purinoceptors

(2012) Yosuke Kurashima et al.   Nature Communications

Inflammatory Pathways in Parkinson’s Disease; A BNE Microarray Study

(2012) Pascal. F. Durrenberger et al.   Parkinsons Disease

Mast Cell Function and Death in Trypanosoma cruzi Infection

(2011) Marcelo Meuser-Batista et al.   AMERICAN JOURNAL OF PATHOLOGY

Expression, assembly and function of novel C-terminal truncated variants of the mouse P2X7 receptor: re-evaluation of P2X7 knockouts

(2011) Marianela Masin et al.   BRITISH JOURNAL OF PHARMACOLOGY

Hypoxia-increased RAGE and P2X7R expression regulates tumor cell invasion through phosphorylation of Erk1/2 and Akt and nuclear translocation of NF-κB

(2011) Marco Tafani et al.   CARCINOGENESIS

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Gain-of-function of P2X7 receptor gene variants in multiple sclerosis

(2011) Olatz Oyanguren-Desez et al.   CELL CALCIUM

P2RX7 genotype association in severe sepsis identified by a novel Multi-Individual Array for rapid screening and replication of risk SNPs

(2011) J. Geistlinger et al.   CLINICA CHIMICA ACTA

P2X7 receptor positively regulates MyD88-dependent NF-κB activation

(2011) Yanhui Liu et al.   CYTOKINE

Endotoxin-induced effects on nucleotide catabolism in mouse kidney

(2011) Fernanda C. Vuaden et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

A potential therapeutic role for P2X7 receptor (P2X7R) antagonists in the treatment of inflammatory diseases

(2011) Nishkantha Arulkumaran et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Opposite effects of P2X7 and P2Y2nucleotide receptors on α-secretase-dependent APP processing in Neuro-2a cells

(2011) Miriam León-Otegui et al.   FEBS LETTERS

Contribution of theP2X71513A/C loss-of-function polymorphism to extrapulmonary tuberculosis susceptibility in Tunisian populations

(2011) Walid Ben-Selma et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

P2X7 receptor antagonism attenuates the hypertension and renal injury in Dahl salt-sensitive rats

(2011) Xu Ji et al.   HYPERTENSION RESEARCH

Transcriptional control mechanisms associated with the nucleotide receptor P2X7, a critical regulator of immunologic, osteogenic, and neurologic functions

(2011) Lisa Y. Lenertz et al.   IMMUNOLOGIC RESEARCH

Genetic polymorphisms in the P2X7 gene and its association with susceptibility to tuberculosis

(2011) N. Singla et al.   INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE

Purinergic P2X7 receptor regulates lung surfactant secretion in a paracrine manner

(2011) A. Mishra et al.   JOURNAL OF CELL SCIENCE

Testing the Role of P2X 7 Receptors in the Development of Type 1 Diabetes in Nonobese Diabetic Mice

(2011) Yi-Guang Chen et al.   JOURNAL OF IMMUNOLOGY

Ecto-5′-Nucleotidase (CD73) Decreases Mortality and Organ Injury in Sepsis

(2011) György Haskó et al.   JOURNAL OF IMMUNOLOGY

Lack of neuroprotection in the absence of P2X7 receptors in toxin-induced animal models of Parkinson's disease

(2011) Zsuzsanna Hracskó et al.   Molecular Neurodegeneration

Inhibition of Neuronal Voltage-Gated Sodium Channels by Brilliant Blue G

(2011) S. Jo et al.   MOLECULAR PHARMACOLOGY

In vivo P2X7 inhibition reduces amyloid plaques in Alzheimer's disease through GSK3β and secretases

(2011) Juan Ignacio Diaz-Hernandez et al.   NEUROBIOLOGY OF AGING

Resilience and reduced c-Fos expression in P2X7 receptor knockout mice exposed to repeated forced swim test

(2011) A.A. Boucher et al.   NEUROSCIENCE

Inflammatory Cortical Demyelination in Early Multiple Sclerosis

(2011) Claudia F. Lucchinetti et al.   NEW ENGLAND JOURNAL OF MEDICINE

P2X7 receptor activation enhances SK3 channels- and cystein cathepsin-dependent cancer cells invasiveness

(2011) B Jelassi et al.   ONCOGENE

Caspase-1 Dependent IL-1β Secretion Is Critical for Host Defense in a Mouse Model of Chlamydia pneumoniae Lung Infection

(2011) Kenichi Shimada et al.   PLoS One

Differential Modulation of ATP-Induced P2X7-Associated Permeabilities to Cations and Anions of Macrophages by Infection with Leishmania amazonensis

(2011) Camila Marques-da-Silva et al.   PLoS One

Lipid metabolism modulation by the P2X7 receptor in the immune system and during the course of infection: new insights into the old view

(2011) Helio Miranda Costa-Junior et al.   Purinergic Signalling

Lipopolysaccharide-induced lung injury: Role of P2X7 receptor

(2011) Leonardo C. Monção-Ribeiro et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

ATP Inhibits the Generation and Function of Regulatory T Cells Through the Activation of Purinergic P2X Receptors

(2011) U. Schenk et al.   Science Signaling

Extracellular ATP Is a Danger Signal Activating P2X7Receptor in Lung Inflammation and Fibrosis

(2010) Nicolas Riteau et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Discovery of 2-chloro-N-((4,4-difluoro-1-hydroxycyclohexyl)methyl)-5-(5-fluoropyrimidin-2-yl)benzamide as a potent and CNS penetrable P2X7 receptor antagonist

(2010) Xiangyang Chen et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Tumor Cell Death and ATP Release Prime Dendritic Cells and Efficient Anticancer Immunity

(2010) L. Aymeric et al.   CANCER RESEARCH

Targeting P2X7receptor inhibits the metastasis of murine P388D1 lymphoid neoplasm cells to lymph nodes

(2010) Shuangyi Ren et al.   CELL BIOLOGY INTERNATIONAL

Adenosine A2A receptor agonist (CGS-21680) prevents endotoxin-induced effects on nucleotidase activities in mouse lymphocytes

(2010) Fernanda Cenci Vuaden et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Evidence for associations between the purinergic receptor P2X7 (P2RX7) and toxoplasmosis

(2010) S E Jamieson et al.   GENES AND IMMUNITY

Dysregulation of the inflammatory response to the parasite, Toxoplasma gondii, in P2X7 receptor-deficient mice

(2010) Catherine M. Miller et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

The Purinergic Receptor P2X7 Triggers α-Secretase-dependent Processing of the Amyloid Precursor Protein

(2010) Cécile Delarasse et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of ATP-induced cell death in the GL261 mouse glioma

(2010) Alessandra S.K. Tamajusuku et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Extracellular ATP May Contribute to Tissue Repair by Rapidly Stimulating Purinergic Receptor X7-Dependent Vascular Endothelial Growth Factor Release from Primary Human Monocytes

(2010) L. M. Hill et al.   JOURNAL OF IMMUNOLOGY

Inflammation and Fibrosis during Chlamydia pneumoniae Infection Is Regulated by IL-1 and the NLRP3/ASC Inflammasome

(2010) X. He et al.   JOURNAL OF IMMUNOLOGY

P2X7 Receptor-Mediated Killing of an Intracellular Parasite, Toxoplasma gondii, by Human and Murine Macrophages

(2010) M. P. Lees et al.   JOURNAL OF IMMUNOLOGY

On the role of P2X7 receptors in dopamine nerve cell degeneration in a rat model of Parkinson’s disease: studies with the P2X7 receptor antagonist A-438079

(2010) Daniel Marcellino et al.   JOURNAL OF NEURAL TRANSMISSION

Block of Purinergic P2X7R Inhibits Tumor Growth in a C6 Glioma Brain Tumor Animal Model

(2010) Jae K. Ryu et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Randomized Clinical Trial on the Effects of Adenosine 5'-Triphosphate Infusions on Quality of Life, Functional Status, and Fatigue in Preterminal Cancer Patients

(2010) Sandra Beijer et al.   JOURNAL OF PAIN AND SYMPTOM MANAGEMENT

Chlamydial infection of monocytes stimulates IL-1β secretion through activation of the NLRP3 inflammasome

(2010) Ali A. Abdul-Sater et al.   MICROBES AND INFECTION

Activation of the P2X7 receptor triggers the elimination of Toxoplasma gondii tachyzoites from infected macrophages

(2010) Gladys Corrêa et al.   MICROBES AND INFECTION

Graft-versus-host disease is enhanced by extracellular ATP activating P2X7R

(2010) Konrad Wilhelm et al.   NATURE MEDICINE

Temporal expression of P2X7 purinergic receptor during the course of experimental autoimmune encephalomyelitis

(2010) Tomasz Grygorowicz et al.   NEUROCHEMISTRY INTERNATIONAL

Purinergic signalling is involved in the malaria parasite Plasmodium falciparum invasion to red blood cells

(2010) Julio Levano-Garcia et al.   Purinergic Signalling

Evolutionary origins of the purinergic signalling system

(2009) G. Burnstock et al.   Acta Physiologica

Effect of adenosine 5′-triphosphate infusions on the nutritional status and survival of preterminal cancer patients

(2009) Sandra Beijer et al.   ANTI-CANCER DRUGS

The antihyperalgesic activity of a selective P2X7 receptor antagonist, A-839977, is lost in IL-1αβ knockout mice

(2009) Prisca Honore et al.   BEHAVIOURAL BRAIN RESEARCH

Abnormal expression of P2X family receptors in Chinese pediatric acute leukemias

(2009) Jing-Hui Chong et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mammalian P2X7 receptor pharmacology: comparison of recombinant mouse, rat and human P2X7 receptors

(2009) Diana L Donnelly-Roberts et al.   BRITISH JOURNAL OF PHARMACOLOGY

An Essential Role for the NLRP3 Inflammasome in Host Defense against the Human Fungal Pathogen Candida albicans

(2009) Amy G. Hise et al.   Cell Host & Microbe

Purinergic P2X7 receptors regulate secretion of interleukin-1 receptor antagonist and beta cell function and survival

(2009) R. Glas et al.   DIABETOLOGIA

Altered P2X7-receptor level and function in mouse models of Huntington’s disease and therapeutic efficacy of antagonist administration

(2009) Miguel Díaz-Hernández et al.   FASEB JOURNAL

Autocrine regulation of T-cell activation by ATP release and P2X7 receptors

(2009) Linda Yip et al.   FASEB JOURNAL

The P2X7 purinergic receptor: from physiology to neurological disorders

(2009) Stephen D. Skaper et al.   FASEB JOURNAL

Expression of the P2X7Receptor Increases the Ca2+Content of the Endoplasmic Reticulum, Activates NFATc1, and Protects from Apoptosis

(2009) Elena Adinolfi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of Microglia by Amyloid   Requires P2X7 Receptor Expression

(2009) J. M. Sanz et al.   JOURNAL OF IMMUNOLOGY

Lymphocytes from P2X7 -deficient mice exhibit enhanced P2X7 responses

(2009) Simon R. J. Taylor et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Antagonists of the P2X7Receptor. From Lead Identification to Drug Development

(2009) Simon D. Guile et al.   JOURNAL OF MEDICINAL CHEMISTRY

Interleukin-1β enhances nucleotide-induced and α-secretase-dependent amyloid precursor protein processing in rat primary cortical neurons via up-regulation of the P2Y2receptor

(2009) Qiongman Kong et al.   JOURNAL OF NEUROCHEMISTRY

Modulation of P2X7 purinergic receptor in macrophages by Leishmania amazonensis and its role in parasite elimination

(2009) Suzana Passos Chaves et al.   MICROBES AND INFECTION

Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β–dependent adaptive immunity against tumors

(2009) François Ghiringhelli et al.   NATURE MEDICINE

Extracellular ATP and Cancer—An Overview with Special Reference to P2 Purinergic Receptors

(2009) Tamás Deli et al.   PATHOLOGY & ONCOLOGY RESEARCH

An in vivo model of melanoma: treatment with ATP

(2009) Nicholas White et al.   Purinergic Signalling

Synthesis and in vitro activity of 1-(2,3-dichlorophenyl)-N-(pyridin-3-ylmethyl)-1H-1,2,4-triazol-5-amine and 4-(2,3-dichlorophenyl)-N-(pyridin-3-ylmethyl)-4H-1,2,4-triazol-3-amine P2X7 antagonists

(2008) Alan S. Florjancic et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Effect of extracellular ATP on the growth of hormone-refractory prostate cancer in vivo

(2008) Majid Shabbir et al.   BJU INTERNATIONAL

Cellular localization of P2X7 receptor mRNA in the rat brain

(2008) Yong Yu et al.   BRAIN RESEARCH

ATP scavenging by the intracellular pathogen Porphyromonas gingivalis inhibits P2X7-mediated host-cell apoptosis

(2008) Özlem Yilmaz et al.   CELLULAR MICROBIOLOGY

Functional evidence for presynaptic P2X7receptors in adult rat cerebrocortical nerve terminals

(2008) Susanna Alloisio et al.   FEBS LETTERS

Block of purinergic P2X7 receptor is neuroprotective in an animal model of Alzheimerʼs disease

(2008) Jae K. Ryu et al.   NEUROREPORT

P2X7 modulatory web in Trypanosoma cruzi infection

(2008) C. M. Cascabulho et al.   PARASITOLOGY RESEARCH

The Plasmodium falciparum-induced anion channel of human erythrocytes is an ATP-release pathway

(2008) Canan Akkaya et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Increased Level of Extracellular ATP at Tumor Sites: In Vivo Imaging with Plasma Membrane Luciferase

(2008) Patrizia Pellegatti et al.   PLoS One

Extracellular ATP reduces HIV-1 transfer from immature dendritic cells to CD4+ T lymphocytes

(2008) Corinne Barat et al.   Retrovirology