P2RX7 sensitizes Mac-1/ICAM-1-dependent leukocyte-endothelial adhesion and promotes neurovascular injury during septic encephalopathy

In VivoTwo-photon Fluorescence Microscopy Reveals Disturbed Cerebral Capillary Blood Flow and Increased Susceptibility to Ischemic Insults in Diabetic Mice

(2014) Ji-Yun Huang et al.   CNS Neuroscience & Therapeutics

Decreased Expression of the Fractalkine Receptor CX3CR1 on Circulating Monocytes as New Feature of Sepsis-Induced Immunosuppression

(2014) Alexandre Pachot et al.   JOURNAL OF IMMUNOLOGY

CX3CR1 deficiency suppresses activation and neurotoxicity of microglia/macrophage in experimental ischemic stroke

(2014) Zhiwei Tang et al.   Journal of Neuroinflammation

A Randomized Trial of Protocol-Based Care for Early Septic Shock

(2014)   NEW ENGLAND JOURNAL OF MEDICINE

Love and death: microglia, NLRP3 and the Alzheimer's brain

(2013) Tobias Goldmann et al.   CELL RESEARCH

Nitric oxide suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock

(2013) Kairui Mao et al.   CELL RESEARCH

FBW7 regulates endothelial functions by targeting KLF2 for ubiquitination and degradation

(2013) Rui Wang et al.   CELL RESEARCH

P2X7receptor activation contributes to an initial upstream mechanism of lipopolysaccharide-induced vascular dysfunction

(2013) Chin-Wei Chiao et al.   CLINICAL SCIENCE

Sepsis Is Associated With Altered Cerebral Microcirculation and Tissue Hypoxia in Experimental Peritonitis*

(2013) Fabio Silvio Taccone et al.   CRITICAL CARE MEDICINE

Resistance of the Brain to Escherichia coli K1 Infection Depends on MyD88 Signaling and the Contribution of Neutrophils and Monocytes

(2013) Sandra Ribes et al.   INFECTION AND IMMUNITY

Effect of Eritoran, an Antagonist of MD2-TLR4, on Mortality in Patients With Severe Sepsis

(2013) Steven M. Opal et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The chemokine CX3CL1 promotes trafficking of dendritic cells through inflamed lymphatics

(2013) L. A. Johnson et al.   JOURNAL OF CELL SCIENCE

 2 Integrin-Mediated Crawling on Endothelial ICAM-1 and ICAM-2 Is a Prerequisite for Transcellular Neutrophil Diapedesis across the Inflamed Blood-Brain Barrier

(2013) R. Gorina et al.   JOURNAL OF IMMUNOLOGY

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

(2013) G. M. Tannahill et al.   NATURE

The cortical angiome: an interconnected vascular network with noncolumnar patterns of blood flow

(2013) Pablo Blinder et al.   NATURE NEUROSCIENCE

Microglial migration mediated by ATP-induced ATP release from lysosomes

(2012) Ying Dou et al.   CELL RESEARCH

Microglia and neurodegeneration: The role of systemic inflammation

(2012) Colm Cunningham   GLIA

Two-Photon Microscopy as a Tool to Study Blood Flow and Neurovascular Coupling in the Rodent Brain

(2012) Andy Y Shih et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Sepsis Chronically in MARS: Systemic Cytokine Responses Are Always Mixed Regardless of the Outcome, Magnitude, or Phase of Sepsis

(2012) Marcin F. Osuchowski et al.   JOURNAL OF IMMUNOLOGY

P2X7 signaling promotes microsphere embolism-triggered microglia activation by maintaining elevation of Fas ligand

(2012) Ying-mei Lu et al.   Journal of Neuroinflammation

CXCL1 can be regulated by IL-6 and promotes granulocyte adhesion to brain capillaries during bacterial toxin exposure and encephalomyelitis

(2012) Monica Roy et al.   Journal of Neuroinflammation

Persistent cognitive impairment, hippocampal atrophy and EEG changes in sepsis survivors

(2012) Alexander Semmler et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Activation of Cannabinoid Receptor 2 Attenuates Leukocyte-Endothelial Cell Interactions and Blood-Brain Barrier Dysfunction under Inflammatory Conditions

(2012) S. H. Ramirez et al.   JOURNAL OF NEUROSCIENCE

Rodent models of sepsis found shockingly lacking

(2012) Kathleen Raven   NATURE MEDICINE

The pulmonary endothelial glycocalyx regulates neutrophil adhesion and lung injury during experimental sepsis

(2012) Eric P Schmidt et al.   NATURE MEDICINE

After Xigris, researchers look to new targets to combat sepsis

(2012) Sarah C P Williams   NATURE MEDICINE

An Automated Method to Quantify Microglia Morphology and Application to Monitor Activation State Longitudinally In Vivo

(2012) Cleopatra Kozlowski et al.   PLoS One

A novel role for P2X7 receptor signalling in the survival of mouse embryonic stem cells

(2011) Belinda A.N. Thompson et al.   CELLULAR SIGNALLING

P2RX7 genotype association in severe sepsis identified by a novel Multi-Individual Array for rapid screening and replication of risk SNPs

(2011) J. Geistlinger et al.   CLINICA CHIMICA ACTA

Traffic of leukocytes and cytokine up-regulation in the central nervous system in sepsis

(2011) Clarissa M. Comim et al.   INTENSIVE CARE MEDICINE

Clemastine Potentiates the Human P2X7 Receptor by Sensitizing It to Lower ATP Concentrations

(2011) Wolfgang Nörenberg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased expression of the chemokines CXCL1 and MIP-1α by resident brain cells precedes neutrophil infiltration in the brain following prolonged soman-induced status epilepticus in rats

(2011) Erik A Johnson et al.   Journal of Neuroinflammation

Long-term Cognitive Impairment and Functional Disability Among Survivors of Severe Sepsis

(2010) Theodore J. Iwashyna et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

ICAM-1 Clustering on Endothelial Cells Recruits VCAM-1

(2010) Jaap D. van Buul et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

P2X7-Dependent Release of Interleukin-1  and Nociception in the Spinal Cord following Lipopolysaccharide

(2010) A. K. Clark et al.   JOURNAL OF NEUROSCIENCE

Melatonin ameliorates ischemic-like injury-evoked nitrosative stress: Involvement of HtrA2/PED pathways in endothelial cells

(2010) Feng Han et al.   JOURNAL OF PINEAL RESEARCH

IκBβ acts to inhibit and activate gene expression during the inflammatory response

(2010) Ping Rao et al.   NATURE

MicroRNA-124 promotes microglia quiescence and suppresses EAE by deactivating macrophages via the C/EBP-α–PU.1 pathway

(2010) Eugene D Ponomarev et al.   NATURE MEDICINE

Pathogenesis of septic encephalopathy

(2009) Peter Pytel et al.   CURRENT OPINION IN NEUROLOGY

Biglycan, a Danger Signal That Activates the NLRP3 Inflammasome via Toll-like and P2X Receptors

(2009) Andrea Babelova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Immunodesign of experimental sepsis by cecal ligation and puncture

(2009) Daniel Rittirsch et al.   Nature Protocols

Determinants of survival in progressive multifocal leukoencephalopathy

(2009) A. Marzocchetti et al.   NEUROLOGY

L-selectin shedding in sepsis limits leukocyte mediated microvascular injury at remote sites

(2009) Lorenzo E. Ferri et al.   SURGERY

Nonmuscle myosin light-chain kinase mediates neutrophil transmigration in sepsis-induced lung inflammation by activating β2 integrins

(2008) Jingsong Xu et al.   NATURE IMMUNOLOGY

Del-1, an Endogenous Leukocyte-Endothelial Adhesion Inhibitor, Limits Inflammatory Cell Recruitment

(2008) E. Y. Choi et al.   SCIENCE