Physiological Roles and Potential Therapeutic Applications of the P2X7 Receptor in Inflammation and Pain

Anthraquinone emodin inhibits human cancer cell invasiveness by antagonizing P2X7 receptors

(2013) Bilel Jelassi et al.   CARCINOGENESIS

Tuberculosis

(2013) Alimuddin Zumla et al.   NEW ENGLAND JOURNAL OF MEDICINE

Purinergic signaling in inflammatory cells: P2 receptor expression, functional effects, and modulation of inflammatory responses

(2013) Fenila Jacob et al.   Purinergic Signalling

Clinical evaluation of the efficacy of the P2X7purinergic receptor antagonist AZD9056 on the signs and symptoms of rheumatoid arthritis in patients with active disease despite treatment with methotrexate or sulphasalazine

(2012) Edward C Keystone et al.   ANNALS OF THE RHEUMATIC DISEASES

Purinergic signalling: Its unpopular beginning, its acceptance and its exciting future

(2012) Geoffrey Burnstock   BIOESSAYS

The His155Tyr (489C>T) single nucleotide polymorphism of P2RX7 gene confers an enhanced function of P2X7 receptor in immune cells from patients with rheumatoid arthritis

(2012) Liliana Portales-Cervantes et al.   CELLULAR IMMUNOLOGY

P2X7 Receptors: Channels, Pores and More

(2012) C. Volonte et al.   CNS & Neurological Disorders-Drug Targets

P2X7 receptor-stimulation causes fever via PGE2 and IL-1β release

(2012) Maria Barberà-Cremades et al.   FASEB JOURNAL

Efficacy and Safety of CE-224,535, an Antagonist of P2X7 Receptor, in Treatment of Patients with Rheumatoid Arthritis Inadequately Controlled by Methotrexate

(2012) T. C. STOCK et al.   JOURNAL OF RHEUMATOLOGY

P2 Receptors for Extracellular Nucleotides in the Central Nervous System: Role of P2X7 and P2Y2 Receptor Interactions in Neuroinflammation

(2012) Gary A. Weisman et al.   MOLECULAR NEUROBIOLOGY

Action of Natural Products on P2 Receptors: A Reinvented Era for Drug Discovery

(2012) Robson Faria et al.   MOLECULES

Genetically determined P2X7 receptor pore formation regulates variability in chronic pain sensitivity

(2012) Robert E Sorge et al.   NATURE MEDICINE

Tests and models of nociception and pain in rodents

(2012) M. Barrot   NEUROSCIENCE

Contribution of the spinal P2X7 receptors to bee venom-induced nociception and inflammation in conscious rats

(2012) Zhong-He Zhou et al.   NEUROSCIENCE LETTERS

Association of P2X7 receptor polymorphisms with bone mineral density and osteoporosis risk in a cohort of Dutch fracture patients

(2012) A. Wesselius et al.   OSTEOPOROSIS INTERNATIONAL

Colchicine inhibits cationic dye uptake induced by ATP in P2X2 and P2X7 receptor-expressing cells: implications for its therapeutic action

(2011) C Marques-da-Silva et al.   BRITISH JOURNAL OF PHARMACOLOGY

A potential therapeutic role for P2X7 receptor (P2X7R) antagonists in the treatment of inflammatory diseases

(2011) Nishkantha Arulkumaran et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Cross-talk between P2X4 and γ-Aminobutyric Acid, Type A Receptors Determines Synaptic Efficacy at a Central Synapse

(2011) Young-Hwan Jo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

P2X7 receptor signaling contributes to tissue factor–dependent thrombosis in mice

(2011) Christian Furlan-Freguia et al.   JOURNAL OF CLINICAL INVESTIGATION

Effect of Rheedia longifolia Leaf Extract and Fractions on the P2X7 Receptor In Vitro: Novel Antagonists?

(2011) José A.A. Santos et al.   JOURNAL OF MEDICINAL FOOD

Peripheral inflammation upregulates P2X receptor expression in satellite glial cells of mouse trigeminal ganglia: A calcium imaging study

(2011) Raya Kushnir et al.   NEUROPHARMACOLOGY

Central sensitization of nociceptive neurons in rat medullary dorsal horn involves purinergic P2X7 receptors

(2011) K. Itoh et al.   NEUROSCIENCE

Induction of the P2X7 receptor in spinal microglia in a neuropathic pain model

(2011) Kimiko Kobayashi et al.   NEUROSCIENCE LETTERS

P2X7 receptor-deficient mice are susceptible to bone cancer pain

(2011) Rikke Rie Hansen et al.   PAIN

A new definition of neuropathic pain

(2011) Troels S. Jensen et al.   PAIN

Activation and Regulation of Purinergic P2X Receptor Channels

(2011) C. Coddou et al.   PHARMACOLOGICAL REVIEWS

A Potential Role for P2X7R in Allergic Airway Inflammation in Mice and Humans

(2010) Tobias Müller et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Synthesis and structure–activity relationships of a series of (1H-pyrazol-4-yl)acetamide antagonists of the P2X7 receptor

(2010) Laura J. Chambers et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of 2-chloro-N-((4,4-difluoro-1-hydroxycyclohexyl)methyl)-5-(5-fluoropyrimidin-2-yl)benzamide as a potent and CNS penetrable P2X7 receptor antagonist

(2010) Xiangyang Chen et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Inhibition of ATP-induced macrophage death by emodin via antagonizing P2X7 receptor

(2010) Lijun Liu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

P2X purinergic receptor ligands: recently patented compounds

(2010) Hendra Gunosewoyo et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

The P2X7-Egr pathway regulates nucleotide-dependent inflammatory gene expression in microglia

(2010) S. A. Friedle et al.   GLIA

Expression and function of the P2X7 purinergic receptor in patients with systemic lupus erythematosus and rheumatoid arthritis

(2010) Liliana Portales-Cervantes et al.   HUMAN IMMUNOLOGY

Experimental Characterization and Mathematical Modeling of P2X7 Receptor Channel Gating

(2010) Z. Yan et al.   JOURNAL OF NEUROSCIENCE

Minocycline Attenuates Mechanical Allodynia and Central Sensitization Following Peripheral Second-Degree Burn Injury

(2010) Yu-Wen Chang et al.   JOURNAL OF PAIN

Pain channelopathies

(2010) Roman Cregg et al.   JOURNAL OF PHYSIOLOGY-LONDON

Potentiation of the glutamatergic synaptic input to rat locus coeruleus neurons by P2X7 receptors

(2010) Roghayeh Khakpay et al.   Purinergic Signalling

Autocrine Purinergic Receptor Signaling Is Essential for Macrophage Chemotaxis

(2010) M. Kronlage et al.   Science Signaling

The antihyperalgesic activity of a selective P2X7 receptor antagonist, A-839977, is lost in IL-1αβ knockout mice

(2009) Prisca Honore et al.   BEHAVIOURAL BRAIN RESEARCH

Synthesis and evaluation of 3-amino-6-aryl-pyridazines as selective CB2 agonists for the treatment of inflammatory pain

(2009) Robert J. Gleave et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Mammalian P2X7 receptor pharmacology: comparison of recombinant mouse, rat and human P2X7 receptors

(2009) Diana L Donnelly-Roberts et al.   BRITISH JOURNAL OF PHARMACOLOGY

P2X1 Ion Channels Promote Neutrophil Chemotaxis through Rho Kinase Activation

(2009) C. Lecut et al.   JOURNAL OF IMMUNOLOGY

Peripheral origin of IL-1β production in the rodent hippocampus under in vivo systemic bacterial lipopolysaccharide (LPS) challenge and its regulation by P2X7 receptors

(2009) C. Csölle et al.   JOURNAL OF NEUROIMMUNOLOGY

Behavioral Phenotypes of Mice Lacking Purinergic P2X4 Receptors in Acute and Chronic Pain Assays

(2009) Makoto Tsuda et al.   Molecular Pain

Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance

(2009) Michael R. Elliott et al.   NATURE

Hemodynamic Regulation of Inflammation at the Endothelial–Neutrophil Interface

(2008) Julie Y. Ji et al.   ANNALS OF BIOMEDICAL ENGINEERING

Modulation of P2X7 receptor expression in macrophages from mineral oil-injected mice

(2008) Camila Marques da Silva et al.   IMMUNOBIOLOGY

P2X7 Receptor Activation Amplifies Lipopolysaccharide-Induced Vascular Hyporeactivity via Interleukin-1  Release

(2008) C.-W. Chiao et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Block of purinergic P2X7 receptor is neuroprotective in an animal model of Alzheimerʼs disease

(2008) Jae K. Ryu et al.   NEUROREPORT

Selective P2X7 receptor antagonists for chronic inflammation and pain

(2008) William A. Carroll et al.   Purinergic Signalling

In vitro and in vivo evidence for a role of the P2X7 receptor in the release of IL-1β in the murine brain

(2007) Rozenn Mingam et al.   BRAIN BEHAVIOR AND IMMUNITY