Targeting of the P2X7 receptor in pancreatic cancer and stellate cells

The P2X7 receptor regulates cell survival, migration and invasion of pancreatic ductal adenocarcinoma cells

(2015) Andrea Giannuzzo et al.   Molecular Cancer

Pancreatic cancer: from state-of-the-art treatments to promising novel therapies

(2015) Ignacio Garrido-Laguna et al.   Nature Reviews Clinical Oncology

P2X7 receptor stimulates breast cancer cell invasion and migration via the AKT pathway

(2015) JIYI XIA et al.   ONCOLOGY REPORTS

A Novel NHE1-Centered Signaling Cassette Drives Epidermal Growth Factor Receptor–Dependent Pancreatic Tumor Metastasis and Is a Target for Combination Therapy

(2015) Rosa Angela Cardone et al.   NEOPLASIA

Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival

(2014) Berna C. Özdemir et al.   CANCER CELL

Stromal Elements Act to Restrain, Rather Than Support, Pancreatic Ductal Adenocarcinoma

(2014) Andrew D. Rhim et al.   CANCER CELL

Accelerated Tumor Progression in Mice Lacking the ATP Receptor P2X7

(2014) E. Adinolfi et al.   CANCER RESEARCH

P2X7 Mediates ATP-Driven Invasiveness in Prostate Cancer Cells

(2014) Ying Qiu et al.   PLoS One

Autocrine signaling via release of ATP and activation of P2X7 receptor influences motile activity of human lung cancer cells

(2014) Erina Takai et al.   Purinergic Signalling

Role of pancreatic stellate cells in chemoresistance in pancreatic cancer

(2014) Joshua A. McCarroll et al.   Frontiers in Physiology

Molecular imaging in pancreatic cancer – A roadmap for therapeutic decisions

(2013) Gabriela Kramer-Marek et al.   CANCER LETTERS

Anthraquinone emodin inhibits human cancer cell invasiveness by antagonizing P2X7 receptors

(2013) Bilel Jelassi et al.   CARCINOGENESIS

Toward a Better Understanding of Pancreatic Ductal Adenocarcinoma

(2013) Christian Partensky   PANCREAS

Insights into the Molecular Mechanisms Underlying Mammalian P2X7 Receptor Functions and Contributions in Diseases, Revealed by Structural Modeling and Single Nucleotide Polymorphisms

(2013) Lin-Hua Jiang et al.   Frontiers in Pharmacology

The participation of plasma membrane hemichannels to purinergic signaling

(2012) Alberto Baroja-Mazo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Enzymatic Targeting of the Stroma Ablates Physical Barriers to Treatment of Pancreatic Ductal Adenocarcinoma

(2012) Paolo P. Provenzano et al.   CANCER CELL

Expression of P2X7 Receptor Increases In Vivo Tumor Growth

(2012) E. Adinolfi et al.   CANCER RESEARCH

EMT and Dissemination Precede Pancreatic Tumor Formation

(2012) Andrew D. Rhim et al.   CELL

Feasibility study of B16 melanoma therapy using oxidized ATP to target purinergic receptor P2X7

(2012) Fumie Hattori et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Persistent activation of pancreatic stellate cells creates a microenvironment favorable for the malignant behavior of pancreatic ductal adenocarcinoma

(2012) Dong Tang et al.   INTERNATIONAL JOURNAL OF CANCER

The P2X7 Receptor Supports Both Life and Death in Fibrogenic Pancreatic Stellate Cells

(2012) Kristian A. Haanes et al.   PLoS One

A potential therapeutic role for P2X7 receptor (P2X7R) antagonists in the treatment of inflammatory diseases

(2011) Nishkantha Arulkumaran et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

P2X7 receptor antagonism in the treatment of cancers

(2011) Sébastien Roger et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Origin of pancreatic ductal adenocarcinoma from atypical flat lesions: a comparative study in transgenic mice and human tissues

(2011) Michaela Aichler et al.   JOURNAL OF PATHOLOGY

P2X7 receptor activation enhances SK3 channels- and cystein cathepsin-dependent cancer cells invasiveness

(2011) B Jelassi et al.   ONCOGENE

P2X7 receptor-deficient mice are susceptible to bone cancer pain

(2011) Rikke Rie Hansen et al.   PAIN

Trophic activity of a naturally occurring truncated isoform of the P2X7 receptor

(2010) Elena Adinolfi et al.   FASEB JOURNAL

Effect of P2X7receptor knockout on exocrine secretion of pancreas, salivary glands and lacrimal glands

(2010) Ivana Novak et al.   JOURNAL OF PHYSIOLOGY-LONDON

Graft-versus-host disease is enhanced by extracellular ATP activating P2X7R

(2010) Konrad Wilhelm et al.   NATURE MEDICINE

Context-Dependent Transformation of Adult Pancreatic Cells by Oncogenic K-Ras

(2009) Sharon Y. Gidekel Friedlander et al.   CANCER CELL

Up-regulation of the inflammatory-reparative phenotype in human prostate carcinoma

(2009) Linda Ravenna et al.   PROSTATE

An in vivo model of melanoma: treatment with ATP

(2009) Nicholas White et al.   Purinergic Signalling

Pancreatic Stellate Cells: Partners in Crime with Pancreatic Cancer Cells

(2008) A. Vonlaufen et al.   CANCER RESEARCH

Increased Level of Extracellular ATP at Tumor Sites: In Vivo Imaging with Plasma Membrane Luciferase

(2008) Patrizia Pellegatti et al.   PLoS One

Increased P2X7Receptor Expression and Function in Thyroid Papillary Cancer: A New Potential Marker of the Disease?

(2007) Anna Solini et al.   ENDOCRINOLOGY

Disordered Pancreatic Inflammatory Responses and Inhibition of Fibrosis in CD39-Null Mice

(2007) Beat M. Künzli et al.   GASTROENTEROLOGY