P2X7 Integrates PI3K/AKT and AMPK-PRAS40-mTOR Signaling Pathways to Mediate Tumor Cell Death

Vascular CD39/ENTPD1 Directly Promotes Tumor Cell Growth by Scavenging Extracellular Adenosine Triphosphate

(2015) Lili Feng et al.   NEOPLASIA

P2X7 Receptor Differentially Couples to Distinct Release Pathways for IL-1  in Mouse Macrophage

(2014) P. Pelegrin et al.   JOURNAL OF IMMUNOLOGY

Extracellular ATP induces cell death in human intestinal epithelial cells

(2012) Carolina O. Souza et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Immunoregulation through extracellular nucleotides

(2012) L. Vitiello et al.   BLOOD

Expression of P2X7 Receptor Increases In Vivo Tumor Growth

(2012) E. Adinolfi et al.   CANCER RESEARCH

Concomitant Targeting of Tumor Cells and Induction of T-cell Response Synergizes to Effectively Inhibit Trastuzumab-Resistant Breast Cancer

(2012) Q. Wang et al.   CANCER RESEARCH

Disordered purinergic signaling and abnormal cellular metabolism are associated with development of liver cancer inCd39/Entpd1null Mice

(2012) Xiaofeng Sun et al.   HEPATOLOGY

Stat3 and Gfi-1 Transcription Factors Control Th17 Cell Immunosuppressive Activity via the Regulation of Ectonucleotidase Expression

(2012) Fanny Chalmin et al.   IMMUNITY

Autophagy modulation as a potential therapeutic target for diverse diseases

(2012) David C. Rubinsztein et al.   NATURE REVIEWS DRUG DISCOVERY

Purinergic Signaling during Inflammation

(2012) Holger K. Eltzschig et al.   NEW ENGLAND JOURNAL OF MEDICINE

Protocadherin-18 Is a Novel Differentiation Marker and an Inhibitory Signaling Receptor for CD8+ Effector Memory T Cells

(2012) Edwin J. Vazquez-Cintron et al.   PLoS One

Subversion of the chemotherapy-induced anticancer immune response by the ecto-ATPase CD39

(2012) Mickaël Michaud et al.   OncoImmunology

CD26 expression and adenosine deaminase activity in regulatory T cells (Treg) and CD4+T effector cells in patients with head and neck squamous cell carcinoma

(2012) Magis Mandapathil et al.   OncoImmunology

ATP Inhibits the Generation and Function of Regulatory T Cells Through the Activation of Purinergic P2X Receptors

(2011) U. Schenk et al.   Science Signaling

CD73 on Tumor Cells Impairs Antitumor T-Cell Responses: A Novel Mechanism of Tumor-Induced Immune Suppression

(2010) D. Jin et al.   CANCER RESEARCH

Tumor Cell Death and ATP Release Prime Dendritic Cells and Efficient Anticancer Immunity

(2010) L. Aymeric et al.   CANCER RESEARCH

Interaction and interrelation of P2X7 and P2X4 receptor complexes in mouse lung epithelial cells

(2010) Karina Weinhold et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

NTPDase1 governs P2X7-dependent functions in murine macrophages

(2010) Sébastien A. Lévesque et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

mTOR regulation of autophagy

(2010) Chang Hwa Jung et al.   FEBS LETTERS

CD39/ENTPD1 Expression by CD4+Foxp3+ Regulatory T Cells Promotes Hepatic Metastatic Tumor Growth in Mice

(2010) Xiaofeng Sun et al.   GASTROENTEROLOGY

Purinergic Receptor-mediated Rapid Depletion of Nuclear Phosphorylated Akt Depends on Pleckstrin Homology Domain Leucine-rich Repeat Phosphatase, Calcineurin, Protein Phosphatase 2A, and PTEN Phosphatases

(2010) Oras Mistafa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The role of P2X7 receptor in ATP-mediated human leukemia cell death: calcium influx-independent

(2009) Xiujun Zhang et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Extracellular nucleotides as negative modulators of immunity

(2009) Francesco Di Virgilio et al.   CURRENT OPINION IN PHARMACOLOGY

A Functional P2X7 Splice Variant with an Alternative Transmembrane Domain 1 Escapes Gene Inactivation in P2X7 Knock-out Mice

(2009) Annette Nicke et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Activation of P2X7 Receptor Impairs Lysosomal Functions and Stimulates the Release of Autophagolysosomes in Microglial Cells

(2009) T. Takenouchi et al.   JOURNAL OF IMMUNOLOGY

Functional interactions between P2X4and P2X7receptors from mouse salivary epithelia

(2009) Griselda Casas-Pruneda et al.   JOURNAL OF PHYSIOLOGY-LONDON

Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance

(2009) Michael R. Elliott et al.   NATURE

Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β–dependent adaptive immunity against tumors

(2009) François Ghiringhelli et al.   NATURE MEDICINE

Extracellular ATP in the Immune System: More Than Just a "Danger Signal"

(2009) A. Trautmann   Science Signaling

Natural killer T cell dysfunction in CD39-null mice protects against concanavalin A-induced hepatitis

(2008) Guido Beldi et al.   HEPATOLOGY

Ecto-nucleoside Triphosphate Diphosphohydrolase 1 (E-NTPDase1/CD39) Regulates Neutrophil Chemotaxis by Hydrolyzing Released ATP to Adenosine

(2008) Ross Corriden et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

(2008) Dana M. Gwinn et al.   MOLECULAR CELL

ATP drives lamina propria TH17 cell differentiation

(2008) Koji Atarashi et al.   NATURE

Increased Level of Extracellular ATP at Tumor Sites: In Vivo Imaging with Plasma Membrane Luciferase

(2008) Patrizia Pellegatti et al.   PLoS One