Purinergic receptor X7 is a key modulator of metabolic oxidative stress-mediated autophagy and inflammation in experimental nonalcoholic steatohepatitis

Coordination of autophagy with other cellular activities

(2013) Yan Wang et al.   ACTA PHARMACOLOGICA SINICA

Focus

(2013) Scott L. Friedman   JOURNAL OF HEPATOLOGY

Pharmacological promotion of autophagy alleviates steatosis and injury in alcoholic and non-alcoholic fatty liver conditions in mice

(2013) Chih-Wen Lin et al.   JOURNAL OF HEPATOLOGY

Environmental Toxin–Linked Nonalcoholic Steatohepatitis and Hepatic Metabolic Reprogramming in Obese Mice

(2013) Ratanesh Kumar Seth et al.   TOXICOLOGICAL SCIENCES

Proinflammatory adipokine leptin mediates disinfection byproduct bromodichloromethane-induced early steatohepatitic injury in obesity

(2013) Suvarthi Das et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

HMGB1: The Central Cytokine for All Lymphoid Cells

(2013) Guanqiao Li et al.   Frontiers in Immunology

Regulation of P2X7-dependent inflammatory functions by P2X4 receptor in mouse macrophages

(2012) Ayumi Kawano et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Vitamin E and nonalcoholic fatty liver disease

(2012) Tommy Pacana et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

P2X7 receptor-NADPH oxidase axis mediates protein radical formation and Kupffer cell activation in carbon tetrachloride-mediated steatohepatitis in obese mice

(2012) Saurabh Chatterjee et al.   FREE RADICAL BIOLOGY AND MEDICINE

NASH is an Infl ammatory Disorder: Pathogenic, Prognostic and Therapeutic Implications

(2012) Geoffrey C. Farrell et al.   Gut and Liver

Mutually exclusive redox forms of HMGB1 promote cell recruitment or proinflammatory cytokine release

(2012) Emilie Venereau et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Critical role of cytochrome P450 2E1 (CYP2E1) in the development of high fat-induced non-alcoholic steatohepatitis

(2012) Mohamed A. Abdelmegeed et al.   JOURNAL OF HEPATOLOGY

CYP2E1 and oxidant stress in alcoholic and non-alcoholic fatty liver disease

(2012) Tung-Ming Leung et al.   JOURNAL OF HEPATOLOGY

Autophagy: An Emerging Immunological Paradigm

(2012) V. Deretic   JOURNAL OF IMMUNOLOGY

Chaperone-mediated autophagy: a unique way to enter the lysosome world

(2012) Susmita Kaushik et al.   TRENDS IN CELL BIOLOGY

A potential therapeutic role for P2X7 receptor (P2X7R) antagonists in the treatment of inflammatory diseases

(2011) Nishkantha Arulkumaran et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Autophagy in nonalcoholic steatohepatitis

(2011) Muhammad Amir et al.   Expert Review of Gastroenterology & Hepatology

Autophagy in health and disease. 1. Regulation and significance of autophagy: an overview

(2010) Maryam Mehrpour et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Chronic Exposure to a High-Fat Diet Induces Hepatic Steatosis, Impairs Nitric Oxide Bioavailability, and Modifies the Mitochondrial Proteome in Mice

(2010) Heather B. Eccleston et al.   ANTIOXIDANTS & REDOX SIGNALING

Chaperone-mediated autophagy: machinery, regulation and biological consequences

(2010) Wenming Li et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Protection from olanzapine-induced metabolic toxicity in mice by acetaminophen and tetrahydroindenoindole

(2010) H G Shertzer et al.   INTERNATIONAL JOURNAL OF OBESITY

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

Chaperone-mediated autophagy: Molecular mechanisms and physiological relevance

(2010) Samantha J. Orenstein et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Impaired Autolysosome Formation Correlates With Lamp-2 Depletion: Role of Apoptosis, Autophagy, and Necrosis in Pancreatitis

(2009) Franco Fortunato et al.   GASTROENTEROLOGY

Pan-caspase inhibitor VX-166 reduces fibrosis in an animal model of nonalcoholic steatohepatitis

(2009) Rafal P. Witek et al.   HEPATOLOGY

The Activation of P2X7 Receptor Impairs Lysosomal Functions and Stimulates the Release of Autophagolysosomes in Microglial Cells

(2009) T. Takenouchi et al.   JOURNAL OF IMMUNOLOGY

P2X7 receptors regulate multiple types of membrane trafficking responses and non-classical secretion pathways

(2009) Yan Qu et al.   Purinergic Signalling

High fat diet induces dysregulation of hepatic oxygen gradients and mitochondrial functionin vivo

(2008) Sudheer K. Mantena et al.   BIOCHEMICAL JOURNAL

Immuno-spin trapping of a post-translational carboxypeptidase B1 radical formed by a dual role of xanthine oxidase and endothelial nitric oxide synthase in acute septic mice

(2008) Saurabh Chatterjee et al.   FREE RADICAL BIOLOGY AND MEDICINE