P2X7 receptor-pannexin 1 interaction mediates extracellular alpha-synuclein-induced ATP release in neuroblastoma SH-SY5Y cells

Neurodegenerative disorders share common features of “loss of function” states of a proposed mechanism of nervous system functions

(2016) Kunjumon I. Vadakkan   BIOMEDICINE & PHARMACOTHERAPY

Connexins and pannexins in neuronal development and adult neurogenesis

(2016) Leigh Anne Swayne et al.   BMC CELL BIOLOGY

Aberrant adenosine A2A receptor signaling contributes to neurodegeneration and cognitive impairments in a mouse model of synucleinopathy

(2016) Qidi Hu et al.   EXPERIMENTAL NEUROLOGY

Alzheimer’s amyloid-β peptide disturbs P2X7 receptor-mediated circadian oscillations of intracellular calcium

(2016) Anna Wilkaniec et al.   FOLIA NEUROPATHOLOGICA

An introduction to the roles of purinergic signalling in neurodegeneration, neuroprotection and neuroregeneration

(2016) Geoffrey Burnstock   NEUROPHARMACOLOGY

Adenosine A2AReceptors Modulate α-Synuclein Aggregation and Toxicity

(2015) Diana G. Ferreira et al.   CEREBRAL CORTEX

Cdk5 at crossroads of protein oligomerization in neurodegenerative diseases: facts and hypotheses

(2015) Anna Wilkaniec et al.   JOURNAL OF NEUROCHEMISTRY

Purinergic signalling in neuroregeneration

(2015) Geoffrey Burnstock   Neural Regeneration Research

Extracellular ATP induces intracellular alpha-synuclein accumulation via P2X1 receptor-mediated lysosomal dysfunction

(2015) Ming Gan et al.   NEUROBIOLOGY OF AGING

P2X7 receptor is critical in α-synuclein–mediated microglial NADPH oxidase activation

(2015) Tianfang Jiang et al.   NEUROBIOLOGY OF AGING

Role of Ryanodine and NMDA Receptors in Tetrabromobisphenol A-Induced Calcium Imbalance and Cytotoxicity in Primary Cultures of Rat Cerebellar Granule Cells

(2015) Elzbieta Zieminska et al.   NEUROTOXICITY RESEARCH

The P2X7 receptor is a key modulator of the PI3K/GSK3β/VEGF signaling network: evidence in experimental neuroblastoma

(2015) F Amoroso et al.   ONCOGENE

Cell stress increases ATP release in NLRP3 inflammasome-mediated autoinflammatory diseases, resulting in cytokine imbalance

(2015) Sonia Carta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vesicular expression and release of ATP from dopaminergic neurons of the mouse retina and midbrain

(2015) Tracy Ho et al.   Frontiers in Cellular Neuroscience

Pannexin 1 channels regulate leukocyte emigration through the venous endothelium during acute inflammation

(2015) Alexander W. Lohman et al.   Nature Communications

ATP as a multi-target danger signal in the brain

(2015) Ricardo J. Rodrigues et al.   Frontiers in Neuroscience

Role of P2X7 and P2Y 2 receptors on α-secretase-dependent APP processing: Control of amyloid plaques formation “ in vivo ” by P2X7 receptor

(2015) M. Teresa Miras-Portugal et al.   Computational and Structural Biotechnology Journal

Autocrine activation of P2Y1 receptors couples Ca2+ influx to Ca2+ release in human pancreatic beta cells

(2014) Shara Khan et al.   DIABETOLOGIA

P2X and P2Y Receptors—Role in the Pathophysiology of the Nervous System

(2014) Kamila Puchałowicz et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Extracellular α-synuclein—a novel and crucial factor in Lewy body diseases

(2014) He-Jin Lee et al.   Nature Reviews Neurology

The P2X7 receptor antagonist Brilliant Blue G attenuates contralateral rotations in a rat model of Parkinsonism through a combined control of synaptotoxicity, neurotoxicity and gliosis

(2014) Marta R.S. Carmo et al.   NEUROPHARMACOLOGY

Effect of N-methyl-D-aspartate (NMDA) receptor antagonists on α-synuclein-evoked neuronal nitric oxide synthase activation in the rat brain

(2014) Agata Adamczyk et al.   Pharmacological Reports

Extracellular α-Synuclein Leads to Microtubule Destabilization via GSK-3β-Dependent Tau Phosphorylation in PC12 Cells

(2014) Magdalena Gąssowska et al.   PLoS One

Extracellular alpha-synuclein induces calpain-dependent overactivation of cyclin-dependent kinase 5 in vitro

(2013) Grzegorz A. Czapski et al.   FEBS LETTERS

Ecto-5'-Nucleotidase (CD73)-Mediated Formation of Adenosine Is Critical for the Striatal Adenosine A2A Receptor Functions

(2013) E. Augusto et al.   JOURNAL OF NEUROSCIENCE

Toxicity of extracellular secreted alpha-synuclein: Its role in nitrosative stress and neurodegeneration

(2013) Anna Wilkaniec et al.   NEUROCHEMISTRY INTERNATIONAL

P2X7 Cell Death Receptor Activation and Mitochondrial Impairment in Oxaliplatin-Induced Apoptosis and Neuronal Injury: Cellular Mechanisms and In Vivo Approach

(2013) France Massicot et al.   PLoS One

CD73 Is a Major Regulator of Adenosinergic Signalling in Mouse Brain

(2013) Natalia Kulesskaya et al.   PLoS One

Neurotransmitter signaling in the pathophysiology of microglia

(2013) María Domercq et al.   Frontiers in Cellular Neuroscience

The biochemistry and function of pannexin channels

(2012) Silvia Penuela et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Mitochondrial dysfunction is involved in P2X7 receptor-mediated neuronal cell death

(2012) Kentaro Nishida et al.   JOURNAL OF NEUROCHEMISTRY

Activation of neuronal P2X7 receptor–pannexin-1 mediates death of enteric neurons during colitis

(2012) Brian D Gulbransen et al.   NATURE MEDICINE

Anti-Prion Activity of Brilliant Blue G

(2012) Yoshifumi Iwamaru et al.   PLoS One

Activation of P2X7 Promotes Cerebral Edema and Neurological Injury after Traumatic Brain Injury in Mice

(2012) Donald E. Kimbler et al.   PLoS One

Microglial P2X7receptor expression is accompanied by neuronal damage in the cerebral cortex of the APPswe/PS1dE9 mouse model of Alzheimer's disease

(2011) Hwan Goo Lee et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Seizure suppression and neuroprotection by targeting the purinergic P2X7 receptor during status epilepticus in mice

(2011) Tobias Engel et al.   FASEB JOURNAL

In vivo P2X7 inhibition reduces amyloid plaques in Alzheimer's disease through GSK3β and secretases

(2011) Juan Ignacio Diaz-Hernandez et al.   NEUROBIOLOGY OF AGING

P2X7 receptor blockade prevents ATP excitotoxicity in neurons and reduces brain damage after ischemia

(2011) Joana Arbeloa et al.   NEUROBIOLOGY OF DISEASE

High-Throughput Analysis of Calcium Signalling Kinetics in Astrocytes Stimulated with Different Neurotransmitters

(2011) Laura R. James et al.   PLoS One

Pannexins in ischemia-induced neurodegeneration

(2011) P. Bargiotas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Purinergic modulation of glucose uptake into cultured rat podocytes: Effect of diabetic milieu

(2010) Joanna Karczewska et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

α-Synuclein induced cell death in mouse hippocampal (HT22) cells is mediated by nitric oxide-dependent activation of caspase-3

(2010) Agata Adamczyk et al.   FEBS LETTERS

Extracellular ATP and the P2X7 receptor in astrocyte-mediated motor neuron death: implications for amyotrophic lateral sclerosis

(2010) Mandi Gandelman et al.   Journal of Neuroinflammation

Pannexin 1 channels mediate ‘find-me’ signal release and membrane permeability during apoptosis

(2010) Faraaz B. Chekeni et al.   NATURE

Release of Adenosine and ATP During Ischemia and Epilepsy

(2009) Nicholas Dale et al.   Current Neuropharmacology

Altered P2X7-receptor level and function in mouse models of Huntington’s disease and therapeutic efficacy of antagonist administration

(2009) Miguel Díaz-Hernández et al.   FASEB JOURNAL

The P2X7 purinergic receptor: from physiology to neurological disorders

(2009) Stephen D. Skaper et al.   FASEB JOURNAL

The Pannexin 1 Channel Activates the Inflammasome in Neurons and Astrocytes

(2009) William R. Silverman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increase of intracellular Ca2+by P2Y but not P2X receptors in cultured cortical multipolar neurons of the rat

(2009) Wolfgang Fischer et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Activation of Microglia by Amyloid   Requires P2X7 Receptor Expression

(2009) J. M. Sanz et al.   JOURNAL OF IMMUNOLOGY

Amyloid-β Induces a Caspase-mediated Cleavage of P2X4 to Promote Purinotoxicity

(2009) R. Varma et al.   NEUROMOLECULAR MEDICINE

Systemic administration of an antagonist of the ATP-sensitive receptor P2X7 improves recovery after spinal cord injury

(2009) W. Peng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

P2X7 receptor-Pannexin1 complex: pharmacology and signaling

(2008) R. Iglesias et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

A permeant regulating its permeation pore: inhibition of pannexin 1 channels by ATP

(2008) Feng Qiu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Clearance and deposition of extracellular α-synuclein aggregates in microglia

(2008) He-Jin Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

An Update on Adenosine A2A-Dopamine D2 Receptor Interactions: Implications for the Function of G Protein-Coupled Receptors

(2008) S. Ferre et al.   CURRENT PHARMACEUTICAL DESIGN

α-Synuclein enhances secretion and toxicity of amyloid beta peptides in PC12 cells

(2008) Anna Kazmierczak et al.   NEUROCHEMISTRY INTERNATIONAL

In vitro and in vivo evidence for a role of the P2X7 receptor in the release of IL-1β in the murine brain

(2007) Rozenn Mingam et al.   BRAIN BEHAVIOR AND IMMUNITY