Lack of a Functioning P2X7 Receptor Leads to Increased Susceptibility to Toxoplasmic Ileitis

Genetic and Pharmacological Inactivation of the Purinergic P2RX7 Receptor Dampens Inflammation but Increases Tumor Incidence in a Mouse Model of Colitis-Associated Cancer

(2015) P. Hofman et al.   CANCER RESEARCH

High Sensitivity of Intestinal CD8+ T Cells to Nucleotides Indicates P2X7 as a Regulator for Intestinal T Cell Responses

(2014) K. Heiss et al.   JOURNAL OF IMMUNOLOGY

Dual Role for Inflammasome Sensors NLRP1 and NLRP3 in Murine Resistance to Toxoplasma gondii

(2014) G. Gorfu et al.   mBio

Replication and Distribution of Toxoplasma gondii in the Small Intestine after Oral Infection with Tissue Cysts

(2013) Beth Gregg et al.   INFECTION AND IMMUNITY

NLRP1 Is an Inflammasome Sensor for Toxoplasma gondii

(2013) Sarah E. Ewald et al.   INFECTION AND IMMUNITY

N-acetylcysteine improves redox status, mitochondrial dysfunction, mucin-depleted crypts and epithelial hyperplasia in dextran sulfate sodium-induced oxidative colitis in mice

(2012) Ilhem Amrouche-Mekkioui et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Extracellular ATP Exerts Opposite Effects on Activated and Regulatory CD4+ T Cells via Purinergic P2 Receptor Activation

(2012) S. Trabanelli et al.   JOURNAL OF IMMUNOLOGY

Plac8-Dependent and Inducible NO Synthase-Dependent Mechanisms Clear Chlamydia muridarum Infections from the Genital Tract

(2012) R. M. Johnson et al.   JOURNAL OF IMMUNOLOGY

Characterizing the Presence and Sensitivity of the P2X7 Receptor in Different Compartments of the Gut

(2012) Nathalia Enes de Campos et al.   Journal of Innate Immunity

Activation of neuronal P2X7 receptor–pannexin-1 mediates death of enteric neurons during colitis

(2012) Brian D Gulbransen et al.   NATURE MEDICINE

Inflammation Drives Dysbiosis and Bacterial Invasion in Murine Models of Ileal Crohn’s Disease

(2012) Melanie Craven et al.   PLoS One

Acute Gastrointestinal Infection Induces Long-Lived Microbiota-Specific T Cell Responses

(2012) T. W. Hand et al.   SCIENCE

Extracellular ATP mediates mast cell-dependent intestinal inflammation through P2X7 purinoceptors

(2012) Yosuke Kurashima et al.   Nature Communications

Insights into inflammatory bowel disease using Toxoplasma gondii as an infectious trigger

(2011) Charlotte E Egan et al.   IMMUNOLOGY AND CELL BIOLOGY

The human P2X7 receptor and its role in innate immunity

(2011) J. S. Wiley et al.   TISSUE ANTIGENS

The Role of the P2X7 Receptor in Infectious Diseases

(2011) Catherine M. Miller et al.   PLoS Pathogens

Amplification loop of the inflammatory process is induced by P2X7R activation in intestinal epithelial cells in response to neutrophil transepithelial migration

(2010) Annabelle Cesaro et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Evidence for associations between the purinergic receptor P2X7 (P2RX7) and toxoplasmosis

(2010) S E Jamieson et al.   GENES AND IMMUNITY

The P2X7-Egr pathway regulates nucleotide-dependent inflammatory gene expression in microglia

(2010) S. A. Friedle et al.   GLIA

Dysregulation of the inflammatory response to the parasite, Toxoplasma gondii, in P2X7 receptor-deficient mice

(2010) Catherine M. Miller et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

The Role of the Transcription Factor CREB in Immune Function

(2010) A. Y. Wen et al.   JOURNAL OF IMMUNOLOGY

P2X7 Receptor-Mediated Killing of an Intracellular Parasite, Toxoplasma gondii, by Human and Murine Macrophages

(2010) M. P. Lees et al.   JOURNAL OF IMMUNOLOGY

Activation of the P2X7 receptor triggers the elimination of Toxoplasma gondii tachyzoites from infected macrophages

(2010) Gladys Corrêa et al.   MICROBES AND INFECTION

Functional aspects of Toll-like receptor/MyD88 signalling during protozoan infection: focus onToxoplasma gondii

(2009) C. E. Egan et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Decrease of Foxp3+ Treg Cell Number and Acquisition of Effector Cell Phenotype during Lethal Infection

(2009) Guillaume Oldenhove et al.   IMMUNITY

Interleukin (IL)-23 mediatesToxoplasma gondii–induced immunopathology in the gut via matrixmetalloproteinase-2 and IL-22 but independent of IL-17

(2009) Melba Muñoz et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cell signaling via the P2X7 nucleotide receptor: linkage to ROS production, gene transcription, and receptor trafficking

(2009) Lisa Y. Lenertz et al.   Purinergic Signalling

The immunobiology of the innate response to Toxoplasma gondii

(2008) Catherine M. Miller et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

The nucleotide receptor P2RX7 mediates ATP-induced CREB activation in human and murine monocytic cells

(2008) Monica L. Gavala et al.   JOURNAL OF LEUKOCYTE BIOLOGY

ATP drives lamina propria TH17 cell differentiation

(2008) Koji Atarashi et al.   NATURE

The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signaling

(2008) Olga Ananieva et al.   NATURE IMMUNOLOGY