Purinergic signaling in inflammatory cells: P2 receptor expression, functional effects, and modulation of inflammatory responses

Activation of Human Alveolar Macrophages via P2 Receptors: Coupling to Intracellular Ca2+ Increases and Cytokine Secretion

(2014) D. Myrtek et al.   JOURNAL OF IMMUNOLOGY

P2X7 Receptor Differentially Couples to Distinct Release Pathways for IL-1  in Mouse Macrophage

(2014) P. Pelegrin et al.   JOURNAL OF IMMUNOLOGY

Diquafosol Ophthalmic Solution for Dry Eye Treatment

(2012) Masatsugu Nakamura et al.   ADVANCES IN THERAPY

Neutrophil Function: From Mechanisms to Disease

(2012) Borko Amulic et al.   Annual Review of Immunology

Regulation of P2X7-dependent inflammatory functions by P2X4 receptor in mouse macrophages

(2012) Ayumi Kawano et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Involvement of P2X4 receptor in P2X7 receptor-dependent cell death of mouse macrophages

(2012) Ayumi Kawano et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Immunoregulation through extracellular nucleotides

(2012) L. Vitiello et al.   BLOOD

Purines, Purinergic Receptors, and Cancer

(2012) F. Di Virgilio   CANCER RESEARCH

P2X7 receptor-stimulation causes fever via PGE2 and IL-1β release

(2012) Maria Barberà-Cremades et al.   FASEB JOURNAL

Extracellular ATP-stimulated macrophages produce macrophage inflammatory protein-2 which is important for neutrophil migration

(2012) Hiroki Kawamura et al.   IMMUNOLOGY

Protection from asthma in a high-risk birth cohort by attenuated P2X7 function

(2012) David M. Manthei et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

P2 receptors and immunity

(2012) Amel Rayah et al.   MICROBES AND INFECTION

T cell homing to epithelial barriers in allergic disease

(2012) Sabina A Islam et al.   NATURE MEDICINE

A potential therapeutic role for P2X7 receptor (P2X7R) antagonists in the treatment of inflammatory diseases

(2011) Nishkantha Arulkumaran et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Real-time Imaging Reveals That P2Y2and P2Y12Receptor Agonists Are Not Chemoattractants and Macrophage Chemotaxis to Complement C5a Is Phosphatidylinositol 3-Kinase (PI3K)- and p38 Mitogen-activated Protein Kinase (MAPK)-independent

(2011) Katrin Isfort et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

P2Y6 Receptor Signaling Pathway Mediates Inflammatory Responses Induced by Monosodium Urate Crystals

(2011) H. Uratsuji et al.   JOURNAL OF IMMUNOLOGY

NTPDase1 Controls IL-8 Production by Human Neutrophils

(2011) F. Kukulski et al.   JOURNAL OF IMMUNOLOGY

Serum Amyloid A Activates the NLRP3 Inflammasome via P2X7 Receptor and a Cathepsin B-Sensitive Pathway

(2011) K. Niemi et al.   JOURNAL OF IMMUNOLOGY

P2X receptor antagonists for pain management: examination of binding and physicochemical properties

(2011) Rebecca J. Gum et al.   Purinergic Signalling

ATP Inhibits the Generation and Function of Regulatory T Cells Through the Activation of Purinergic P2X Receptors

(2011) U. Schenk et al.   Science Signaling

Neutrophils cascading their way to inflammation

(2011) Christian D. Sadik et al.   TRENDS IN IMMUNOLOGY

The purinergic receptor P2Y2 receptor mediates chemotaxis of dendritic cells and eosinophils in allergic lung inflammation

(2010) T. Müller et al.   ALLERGY

Denufosol Tetrasodium in Patients with Cystic Fibrosis and Normal to Mildly Impaired Lung Function

(2010) Frank J. Accurso et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

ATP secreted by endothelial cells blocks CX3CL1-elicited natural killer cell chemotaxis and cytotoxicity via P2Y11 receptor activation

(2010) S. Gorini et al.   BLOOD

New P2Y 12 Inhibitors

(2010) Marco Cattaneo   CIRCULATION

P2Y nucleotide receptors: promise of therapeutic applications

(2010) Kenneth A. Jacobson et al.   DRUG DISCOVERY TODAY

NTPDase1 governs P2X7-dependent functions in murine macrophages

(2010) Sébastien A. Lévesque et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Purinergic receptor agonists modulate phagocytosis and clearance of apoptotic cells in macrophages

(2010) Camila Marques-da-Silva et al.   IMMUNOBIOLOGY

Lack of the purinergic receptor P2X7results in resistance to contact hypersensitivity

(2010) Felix C. Weber et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Role of the P2Y12 Receptor in the Modulation of Murine Dendritic Cell Function by ADP

(2010) A. Ben Addi et al.   JOURNAL OF IMMUNOLOGY

P2X7 Receptor-Mediated Release of Cathepsins from Macrophages Is a Cytokine-Independent Mechanism Potentially Involved in Joint Diseases

(2010) G. Lopez-Castejon et al.   JOURNAL OF IMMUNOLOGY

P2Y2 Receptor Regulates VCAM-1 Membrane and Soluble Forms and Eosinophil Accumulation during Lung Inflammation

(2010) G. Vanderstocken et al.   JOURNAL OF IMMUNOLOGY

Human Eosinophils Recognize Endogenous Danger Signal Crystalline Uric Acid and Produce Proinflammatory Cytokines Mediated by Autocrine ATP

(2010) T. Kobayashi et al.   JOURNAL OF IMMUNOLOGY

Hypertonic stress regulates T cell function via pannexin-1 hemichannels and P2X receptors

(2010) Tobias Woehrle et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Graft-versus-host disease is enhanced by extracellular ATP activating P2X7R

(2010) Konrad Wilhelm et al.   NATURE MEDICINE

P2Y13 receptor is responsible for ADP-mediated degranulation in RBL-2H3 rat mast cells

(2010) Zhan-Guo Gao et al.   PHARMACOLOGICAL RESEARCH

Human neutrophils do not express purinergic P2X7 receptors

(2010) Guadalupe Martel-Gallegos et al.   Purinergic Signalling

Purinergic Signaling: A Fundamental Mechanism in Neutrophil Activation

(2010) Y. Chen et al.   Science Signaling

Autocrine Purinergic Receptor Signaling Is Essential for Macrophage Chemotaxis

(2010) M. Kronlage et al.   Science Signaling

UDP-glucose acting at P2Y 14 receptors is a mediator of mast cell degranulation

(2009) Zhan-Guo Gao et al.   BIOCHEMICAL PHARMACOLOGY

Functional evidence for the expression of P2X1, P2X4 and P2X7 receptors in human lung mast cells

(2009) K Wareham et al.   BRITISH JOURNAL OF PHARMACOLOGY

Extracellular ATP and P2 receptors are required for IL-8 to induce neutrophil migration

(2009) Filip Kukulski et al.   CYTOKINE

Concomitant activation of P2Y2and P2Y6receptors on monocytes is required for TLR1/2-induced neutrophil migration by regulating IL-8 secretion

(2009) Fethia Ben Yebdri et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Autocrine regulation of T-cell activation by ATP release and P2X7 receptors

(2009) Linda Yip et al.   FASEB JOURNAL

Deletion of CD39 on natural killer cells attenuates hepatic ischemia/reperfusion injury in mice

(2009) Guido Beldi et al.   HEPATOLOGY

Biglycan, a Danger Signal That Activates the NLRP3 Inflammasome via Toll-like and P2X Receptors

(2009) Andrea Babelova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

P2X1 Ion Channels Promote Neutrophil Chemotaxis through Rho Kinase Activation

(2009) C. Lecut et al.   JOURNAL OF IMMUNOLOGY

Endothelial P2Y2 receptor regulates LPS-induced neutrophil transendothelial migration in vitro

(2009) Filip Kukulski et al.   MOLECULAR IMMUNOLOGY

Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance

(2009) Michael R. Elliott et al.   NATURE

The P2X7 receptor and intracellular pathogens: a continuing struggle

(2009) Robson Coutinho-Silva et al.   Purinergic Signalling

P2 receptor-mediated signaling in mast cell biology

(2009) Elena Bulanova et al.   Purinergic Signalling

ATP-induced autophagy is associated with rapid killing of intracellular mycobacteria within human monocytes/macrophages

(2008) Debasis Biswas et al.   BMC IMMUNOLOGY

Purinergic regulation of neutrophil chemotaxis

(2008) W. G. Junger   CELLULAR AND MOLECULAR LIFE SCIENCES

Eosinophils: Biological Properties and Role in Health and Disease

(2008) SIMON P. HOGAN et al.   CLINICAL AND EXPERIMENTAL ALLERGY

The P2X7receptor as a therapeutic target

(2008) Romeo Romagnoli et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Ecto-nucleoside Triphosphate Diphosphohydrolase 1 (E-NTPDase1/CD39) Regulates Neutrophil Chemotaxis by Hydrolyzing Released ATP to Adenosine

(2008) Ross Corriden et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Knockout Mice Reveal a Role for P2Y6 Receptor in Macrophages, Endothelial Cells, and Vascular Smooth Muscle Cells

(2008) I. Bar et al.   MOLECULAR PHARMACOLOGY

ATP-gated P2X cation-channels

(2008) Michael F. Jarvis et al.   NEUROPHARMACOLOGY

Selective P2X7 receptor antagonists for chronic inflammation and pain

(2008) William A. Carroll et al.   Purinergic Signalling

Purinergic Control of T Cell Activation by ATP Released Through Pannexin-1 Hemichannels

(2008) U. Schenk et al.   Science Signaling