Transcriptional control mechanisms associated with the nucleotide receptor P2X7, a critical regulator of immunologic, osteogenic, and neurologic functions

P2X7 Receptor Differentially Couples to Distinct Release Pathways for IL-1  in Mouse Macrophage

(2014) P. Pelegrin et al.   JOURNAL OF IMMUNOLOGY

Early Growth Response-1 Induces and Enhances Vascular Endothelial Growth Factor-A Expression in Lung Cancer Cells

(2010) Hiroaki Shimoyamada et al.   AMERICAN JOURNAL OF PATHOLOGY

Extracellular Adenosine Triphosphate and Chronic Obstructive Pulmonary Disease

(2010) Marek Lommatzsch et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Long-term voluntary wheel running is rewarding and produces plasticity in the mesolimbic reward pathway

(2010) Benjamin N. Greenwood et al.   BEHAVIOURAL BRAIN RESEARCH

Mutation of Putative N-Linked Glycosylation Sites on the Human Nucleotide Receptor P2X7Reveals a Key Residue Important for Receptor Function

(2010) Lisa Y. Lenertz et al.   BIOCHEMISTRY

Synthesis and biological activity of a series of tetrasubstituted-imidazoles as P2X7 antagonists

(2010) Robert J. Gleave et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and structure–activity relationships of a series of (1H-pyrazol-4-yl)acetamide antagonists of the P2X7 receptor

(2010) Laura J. Chambers et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of 2-chloro-N-((4,4-difluoro-1-hydroxycyclohexyl)methyl)-5-(5-fluoropyrimidin-2-yl)benzamide as a potent and CNS penetrable P2X7 receptor antagonist

(2010) Xiangyang Chen et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

NF-κB Signaling Pathway, Inflammation and Colorectal Cancer

(2010) Soly Wang et al.   Cellular & Molecular Immunology

Basic Principles of Platelet Biology and Clinical Implications

(2010) Dominick J. Angiolillo et al.   CIRCULATION JOURNAL

Purinergic signalling and bone remodelling☆

(2010) Isabel R Orriss et al.   CURRENT OPINION IN PHARMACOLOGY

P2X purinergic receptor ligands: recently patented compounds

(2010) Hendra Gunosewoyo et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Metaanalysis of P2X7  gene polymorphisms and tuberculosis susceptibility

(2010) Jing Xiao et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

Evidence for associations between the purinergic receptor P2X7 (P2RX7) and toxoplasmosis

(2010) S E Jamieson et al.   GENES AND IMMUNITY

The P2X7-Egr pathway regulates nucleotide-dependent inflammatory gene expression in microglia

(2010) S. A. Friedle et al.   GLIA

Interleukin-2 Receptor Signaling: At the Interface between Tolerance and Immunity

(2010) Thomas R. Malek et al.   IMMUNITY

Activation of the Transcription Factor FosB/Activating Protein-1 (AP-1) Is a Prominent Downstream Signal of the Extracellular Nucleotide Receptor P2RX7 in Monocytic and Osteoblastic Cells

(2010) Monica L. Gavala et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fluid Flow-induced Soluble Vascular Endothelial Growth Factor Isoforms Regulate Actin Adaptation in Osteoblasts

(2010) Mia M. Thi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Extracellular ATP May Contribute to Tissue Repair by Rapidly Stimulating Purinergic Receptor X7-Dependent Vascular Endothelial Growth Factor Release from Primary Human Monocytes

(2010) L. M. Hill et al.   JOURNAL OF IMMUNOLOGY

The Role of the Transcription Factor CREB in Immune Function

(2010) A. Y. Wen et al.   JOURNAL OF IMMUNOLOGY

Hypertonic stress regulates T cell function via pannexin-1 hemichannels and P2X receptors

(2010) Tobias Woehrle et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Involvement of Spinal Microglial P2X7 Receptor in Generation of Tolerance to Morphine Analgesia in Rats

(2010) D. Zhou et al.   JOURNAL OF NEUROSCIENCE

P2X7-Dependent Release of Interleukin-1  and Nociception in the Spinal Cord following Lipopolysaccharide

(2010) A. K. Clark et al.   JOURNAL OF NEUROSCIENCE

Treatment of metastatic renal cell carcinoma

(2010) Maxine Sun et al.   Nature Reviews Urology

POLYMORPHISM IN THE P2X7 GENE INCREASES SUSCEPTIBILITY TO EXTRAPULMONARY TUBERCULOSIS IN TURKISH CHILDREN

(2010) Deniz Tekin et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Intravascular Danger Signals Guide Neutrophils to Sites of Sterile Inflammation

(2010) B. McDonald et al.   SCIENCE

Prostaglandins in bone: bad cop, good cop?

(2010) Katherine A. Blackwell et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Mechanical Factors and Bone Health: Effects of Weightlessness and Neurologic Injury

(2010) Shreyasee Amin   Current Rheumatology Reports

Variation inP2RX7candidate gene (rs2230912) is not associated with bipolar I disorder and unipolar major depression in four European samples

(2009) Maria Grigoroiu-Serbanescu et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Attenuated P2X7Pore Function as a Risk Factor for Virus-induced Loss of Asthma Control

(2009) Loren C. Denlinger et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Early growth response transcription factors and the modulation of immune response

(2009) Diana Gómez-Martín et al.   AUTOIMMUNITY REVIEWS

Synthesis and structure–activity relationships of pyrazolodiazepine derivatives as human P2X7 receptor antagonists

(2009) Ju-Yeon Lee et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Mechanical stress induces Interleukin-11 expression to stimulate osteoblast differentiation

(2009) Shinsuke Kido et al.   BONE

Autocrine regulation of T-cell activation by ATP release and P2X7 receptors

(2009) Linda Yip et al.   FASEB JOURNAL

Analysis of Assembly and Trafficking of Native P2X4 and P2X7 Receptor Complexes in Rodent Immune Cells

(2009) Miyyada Boumechache et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expression of the P2X7Receptor Increases the Ca2+Content of the Endoplasmic Reticulum, Activates NFATc1, and Protects from Apoptosis

(2009) Elena Adinolfi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quantitative AP-1 gene regulation by oxidative stress in the human retinal pigment epithelium

(2009) Edward Chaum et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Antagonists of the P2X7Receptor. From Lead Identification to Drug Development

(2009) Simon D. Guile et al.   JOURNAL OF MEDICINAL CHEMISTRY

Single nucleotide polymorphisms that were identified in affective mood disorders affect ATP-activated P2X7 receptor functions

(2009) Sébastien Roger et al.   JOURNAL OF PSYCHIATRIC RESEARCH

P2X7 Deficiency Attenuates Renal Injury in Experimental Glomerulonephritis

(2009) S. R.J. Taylor et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Noninjurious mechanical ventilation activates a proinflammatory transcriptional program in the lung

(2009) Sina A. Gharib et al.   PHYSIOLOGICAL GENOMICS

Systemic administration of an antagonist of the ATP-sensitive receptor P2X7 improves recovery after spinal cord injury

(2009) W. Peng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Different properties of P2X7 receptor in hippocampal and cortical astrocytes

(2009) Fabio Bianco et al.   Purinergic Signalling

Expression, signaling, and function of P2X7 receptors in bone

(2009) Matthew W. Grol et al.   Purinergic Signalling

Genetics of the P2X7 receptor and human disease

(2009) Stephen J. Fuller et al.   Purinergic Signalling

Cell signaling via the P2X7 nucleotide receptor: linkage to ROS production, gene transcription, and receptor trafficking

(2009) Lisa Y. Lenertz et al.   Purinergic Signalling

Direct Observation of ATP-Induced Conformational Changes in Single P2X4 Receptors

(2009) Youichi Shinozaki et al.   PLOS BIOLOGY

Association between depression and the Gln460Arg polymorphism of P2RX7 Gene: A dimensional approach

(2008) Krisztina Hejjas et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Behavioral profile of P2X7 receptor knockout mice in animal models of depression and anxiety: Relevance for neuropsychiatric disorders

(2008) Ana M. Basso et al.   BEHAVIOURAL BRAIN RESEARCH

Vascular Endothelial Growth Factor Receptor 2 Mediates Macrophage Infiltration into Orthotopic Pancreatic Tumors in Mice

(2008) S. P. Dineen et al.   CANCER RESEARCH

Palmitoylation of the P2X7 receptor, an ATP-gated channel, controls its expression and association with lipid rafts

(2008) P. Gonnord et al.   FASEB JOURNAL

P2X7 receptors on osteoblasts couple to production of lysophosphatidic acid: a signaling axis promoting osteogenesis

(2008) Nattapon Panupinthu et al.   JOURNAL OF CELL BIOLOGY

1513A>C Polymorphism in the P2X7Receptor Gene in Patients with Papillary Thyroid Cancer: Correlation with Histological Variants and Clinical Parameters

(2008) Angela Dardano et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The nucleotide receptor P2RX7 mediates ATP-induced CREB activation in human and murine monocytic cells

(2008) Monica L. Gavala et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Inflammatory events in hippocampal slice cultures prime neuronal susceptibility to excitotoxic injury: a crucial role of P2X7receptor-mediated IL-1β release

(2008) Liliana Bernardino et al.   JOURNAL OF NEUROCHEMISTRY

Activation of P2X7receptors induces CCL3 production in microglial cells through transcription factor NFAT

(2008) Ayako Kataoka et al.   JOURNAL OF NEUROCHEMISTRY

The Influence of  FosB in the Nucleus Accumbens on Natural Reward-Related Behavior

(2008) D. L Wallace et al.   JOURNAL OF NEUROSCIENCE

Characterization of N-(Adamantan-1-ylmethyl)-5-[(3R-aminopyrrolidin-1-yl)methyl]-2-chloro-benzamide, a P2X7 Antagonist in Animal Models of Pain and Inflammation

(2008) D. C. Broom et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Case–control studies show that a non-conservative amino-acid change from a glutamine to arginine in the P2RX7 purinergic receptor protein is associated with both bipolar- and unipolar-affective disorders

(2008) A McQuillin et al.   MOLECULAR PSYCHIATRY

Selective P2X7 receptor antagonists for chronic inflammation and pain

(2008) William A. Carroll et al.   Purinergic Signalling

Synthesis and structure–activity relationship studies of tyrosine-based antagonists at the human P2X7 receptor

(2007) Ga Eun Lee et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

In vitro and in vivo evidence for a role of the P2X7 receptor in the release of IL-1β in the murine brain

(2007) Rozenn Mingam et al.   BRAIN BEHAVIOR AND IMMUNITY

Expression and function of the P2X7 receptor in rat C6 glioma cells

(2007) Wei Wei et al.   CANCER LETTERS

Increased P2X7Receptor Expression and Function in Thyroid Papillary Cancer: A New Potential Marker of the Disease?

(2007) Anna Solini et al.   ENDOCRINOLOGY

The role of chemokines in neutrophil biology

(2007) Yoshiro Kobayashi   Frontiers in Bioscience-Landmark