P2X1, P2X4, and P2X7 Receptor Knock Out Mice Expose Differential Outcome of Sepsis Induced by α-Haemolysin Producing Escherichia coli

DAMP-Induced Allograft and Tumor Rejection: The Circle Is Closing

(2016) W. G. Land et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Ca2+ signals, cell membrane disintegration, and activation of TMEM16F during necroptosis

(2016) Jiraporn Ousingsawat et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Inhibition of P2X Receptors Protects Human Monocytes against Damage by Leukotoxin from Aggregatibacter actinomycetemcomitans and α-Hemolysin from Escherichia coli

(2016) Steen K. Fagerberg et al.   INFECTION AND IMMUNITY

Human Invariant NKT Cells Induce IL-1β Secretion by Peripheral Blood Monocytes via a P2X7-Independent Pathway

(2016) Laura E. Felley et al.   JOURNAL OF IMMUNOLOGY

Strengths and Limitations of Model Systems for the Study of Urinary Tract Infections and Related Pathologies

(2016) Amelia E. Barber et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Caspase-8 inhibition represses initial human monocyte activation in septic shock model

(2016) Maria Jose Oliva-Martin et al.   Oncotarget

Disseminated intravascular coagulation

(2016) Satoshi Gando et al.   Nature Reviews Disease Primers

Purinergic signaling in the immune system

(2015) Francesco Di Virgilio et al.   AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL

The P2X7/P2X4 interaction shapes the purinergic response in murine macrophages

(2015) Gabriela Pérez-Flores et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Role of P2X7 receptor in Clostridium perfringens beta-toxin-mediated cellular injury

(2015) Masahiro Nagahama et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Thrombocytopenia Impairs Host Defense During Murine Streptococcus pneumoniae Pneumonia

(2015) Florry E. van den Boogaard et al.   CRITICAL CARE MEDICINE

The P2X7 receptor directly interacts with the NLRP3 inflammasome scaffold protein

(2015) Alessia Franceschini et al.   FASEB JOURNAL

Extracellular ATP protects against sepsis through macrophage P2X7 purinergic receptors by enhancing intracellular bacterial killing

(2015) Balázs Csóka et al.   FASEB JOURNAL

Caspase-11 Requires the Pannexin-1 Channel and the Purinergic P2X7 Pore to Mediate Pyroptosis and Endotoxic Shock

(2015) Dahai Yang et al.   IMMUNITY

Caspase-8 as an Effector and Regulator of NLRP3 Inflammasome Signaling

(2015) Christina Antonopoulos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The P2X7 Receptor Contributes to the Development of the Exacerbated Inflammatory Response Associated with Sepsis

(2015) Patricia Texeira Santana et al.   Journal of Innate Immunity

Dysregulation ofEscherichia coliα-hemolysin expression alters the course of acute and persistent urinary tract infection

(2015) Kanna Nagamatsu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interleukin-3 amplifies acute inflammation and is a potential therapeutic target in sepsis

(2015) G. F. Weber et al.   SCIENCE

Mechanisms and Functions of Inflammasomes

(2014) Mohamed Lamkanfi et al.   CELL

P2X7-dependent, but differentially regulated release of IL-6, CCL2, and TNF-α in cultured mouse microglia

(2014) Chu-Hsin Shieh et al.   GLIA

Bacterial RTX Toxins Allow Acute ATP Release from Human Erythrocytes Directly through the Toxin Pore

(2014) Marianne Skals et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

P2X7 Receptor Differentially Couples to Distinct Release Pathways for IL-1  in Mouse Macrophage

(2014) P. Pelegrin et al.   JOURNAL OF IMMUNOLOGY

The P2X1Receptor Is Required for Neutrophil Extravasation during Lipopolysaccharide-Induced Lethal Endotoxemia in Mice

(2014) Blandine Maître et al.   JOURNAL OF IMMUNOLOGY

FADD and Caspase-8 Mediate Priming and Activation of the Canonical and Noncanonical Nlrp3 Inflammasomes

(2014) P. Gurung et al.   JOURNAL OF IMMUNOLOGY

P2X7 receptor is required for neutrophil accumulation in a mouse model of irritant contact dermatitis

(2013) Gabriela L. da Silva et al.   EXPERIMENTAL DERMATOLOGY

K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter

(2013) Raúl Muñoz-Planillo et al.   IMMUNITY

Differences in Purinergic Amplification of Osmotic Cell Lysis by the Pore-Forming RTX Toxins Bordetella pertussis CyaA and Actinobacillus pleuropneumoniae ApxIA: the Role of Pore Size

(2013) Jiri Masin et al.   INFECTION AND IMMUNITY

Expression of P2X7 ATP Receptor Mediating the IL8 and CCL20 Release in Human Periodontal Ligament Stem Cells

(2013) Oriana Trubiani et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Physiological Roles and Potential Therapeutic Applications of the P2X7 Receptor in Inflammation and Pain

(2013) Luiz Alves et al.   MOLECULES

Two independent pathways of regulated necrosis mediate ischemia-reperfusion injury

(2013) A. Linkermann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

P2X Receptor-Dependent Erythrocyte Damage by α-Hemolysin from Escherichia coli Triggers Phagocytosis by THP-1 Cells

(2013) Steen Fagerberg et al.   Toxins

Leukotoxin fromAggregatibacter actinomycetemcomitanscauses shrinkage and P2X receptor-dependent lysis of human erythrocytes

(2012) Peter Svenssen Munksgaard et al.   CELLULAR MICROBIOLOGY

Caspase-8 Blocks Kinase RIPK3-Mediated Activation of the NLRP3 Inflammasome

(2012) Tae-Bong Kang et al.   IMMUNITY

Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1β via a noncanonical caspase-8 inflammasome

(2012) Sonja I Gringhuis et al.   NATURE IMMUNOLOGY

P2X receptor stimulation amplifies complement-induced haemolysis

(2012) J. L. Hejl et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Activation of P2X7 Receptor by ATP Plays an Important Role in Regulating Inflammatory Responses during Acute Viral Infection

(2012) Benjamin H. Lee et al.   PLoS One

Expression, assembly and function of novel C-terminal truncated variants of the mouse P2X7 receptor: re-evaluation of P2X7 knockouts

(2011) Marianela Masin et al.   BRITISH JOURNAL OF PHARMACOLOGY

A potential therapeutic role for P2X7 receptor (P2X7R) antagonists in the treatment of inflammatory diseases

(2011) Nishkantha Arulkumaran et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

ATP-gated P2X1 ion channels protect against endotoxemia by dampening neutrophil activation

(2011) C. LECUT et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

RIP3 mediates the embryonic lethality of caspase-8-deficient mice

(2011) William J. Kaiser et al.   NATURE

Catalytic activity of the caspase-8–FLIPL complex inhibits RIPK3-dependent necrosis

(2011) Andrew Oberst et al.   NATURE

Haemolysis induced by α-toxin from Staphylococcus aureus requires P2X receptor activation

(2011) Marianne Skals et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Lipopolysaccharide-induced lung injury: Role of P2X7 receptor

(2011) Leonardo C. Monção-Ribeiro et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

The human P2X7 receptor and its role in innate immunity

(2011) J. S. Wiley et al.   TISSUE ANTIGENS

P2X7-Dependent Release of Interleukin-1  and Nociception in the Spinal Cord following Lipopolysaccharide

(2010) A. K. Clark et al.   JOURNAL OF NEUROSCIENCE

Targeting Robo4-Dependent Slit Signaling to Survive the Cytokine Storm in Sepsis and Influenza

(2010) N. R. London et al.   Science Translational Medicine

A Central Role for Free Heme in the Pathogenesis of Severe Sepsis

(2010) R. Larsen et al.   Science Translational Medicine

A Functional P2X7 Splice Variant with an Alternative Transmembrane Domain 1 Escapes Gene Inactivation in P2X7 Knock-out Mice

(2009) Annette Nicke et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

 -Hemolysin from Escherichia coli uses endogenous amplification through P2X receptor activation to induce hemolysis

(2009) M. Skals et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Purinergic signalling: past, present and future

(2008) G. Burnstock   BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH

Purinergic regulation of neutrophil chemotaxis

(2008) W. G. Junger   CELLULAR AND MOLECULAR LIFE SCIENCES