A rare P2X7 variant Arg307Gln with absent pore formation function protects against neuroinflammation in multiple sclerosis
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Title
A rare P2X7 variant Arg307Gln with absent pore formation function protects against neuroinflammation in multiple sclerosis
Authors
Keywords
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Journal
HUMAN MOLECULAR GENETICS
Volume 24, Issue 19, Pages 5644-5654
Publisher
Oxford University Press (OUP)
Online
2015-07-18
DOI
10.1093/hmg/ddv278
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Note: Only part of the references are listed.- Multiple sclerosis: Insights into pathophysiology and novel therapeutic avenues
- (2014) Ralf Gold et al. EXPERIMENTAL NEUROLOGY
- TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis
- (2014) G. Kleinberger et al. Science Translational Medicine
- P2X7 receptors regulate engulfing activity of non-stimulated resting astrocytes
- (2013) Mina Yamamoto et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- A quantitative method for measuring innate phagocytosis by human monocytes using real-time flow cytometry
- (2013) Ben J. Gu et al. CYTOMETRY PART A
- A rare functional haplotype of the P2RX4 and P2RX7 genes leads to loss of innate phagocytosis and confers increased risk of age-related macular degeneration
- (2013) Ben J. Gu et al. FASEB JOURNAL
- Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis
- (2013) Ashley H Beecham et al. NATURE GENETICS
- P2X7 receptor activation induces inflammatory responses in salivary gland epithelium
- (2012) Lucas T. Woods et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- Clinical evaluation of the efficacy of the P2X7purinergic receptor antagonist AZD9056 on the signs and symptoms of rheumatoid arthritis in patients with active disease despite treatment with methotrexate or sulphasalazine
- (2012) Edward C Keystone et al. ANNALS OF THE RHEUMATIC DISEASES
- Pharmacokinetic and pharmacodynamic profiling of a P2X7 receptor allosteric modulator GSK1482160 in healthy human subjects
- (2012) Zahid Ali et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- Transient P2X 7 Receptor Activation Triggers Macrophage Death Independent of Toll-like Receptors 2 and 4, Caspase-1, and Pannexin-1 Proteins
- (2012) Peter J. Hanley et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- P2X7 receptor-mediated Nlrp3-inflammasome activation is a genetic determinant of macrophage-dependent crescentic glomerulonephritis
- (2012) Simona Deplano et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Efficacy and Safety of CE-224,535, an Antagonist of P2X7 Receptor, in Treatment of Patients with Rheumatoid Arthritis Inadequately Controlled by Methotrexate
- (2012) T. C. STOCK et al. JOURNAL OF RHEUMATOLOGY
- Molecular mechanism of ATP binding and ion channel activation in P2X receptors
- (2012) Motoyuki Hattori et al. NATURE
- Genetically determined P2X7 receptor pore formation regulates variability in chronic pain sensitivity
- (2012) Robert E Sorge et al. NATURE MEDICINE
- Involvement of the cysteine-rich head domain in activation and desensitization of the P2X1 receptor
- (2012) E. Lorinczi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Extracellular ATP mediates mast cell-dependent intestinal inflammation through P2X7 purinoceptors
- (2012) Yosuke Kurashima et al. Nature Communications
- The effect of anions on the human P2X7 receptor
- (2011) Christoph Kubick et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
- Gain-of-function of P2X7 receptor gene variants in multiple sclerosis
- (2011) Olatz Oyanguren-Desez et al. CELL CALCIUM
- A Loss-of-Function Polymorphism in the Human P2X4 Receptor Is Associated With Increased Pulse Pressure
- (2011) Leanne Stokes et al. HYPERTENSION
- P2X7 Is a Scavenger Receptor for Apoptotic Cells in the Absence of Its Ligand, Extracellular ATP
- (2011) B. J. Gu et al. JOURNAL OF IMMUNOLOGY
- Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis
- (2011) Stephen Sawcer et al. NATURE
- Inflammatory Cortical Demyelination in Early Multiple Sclerosis
- (2011) Claudia F. Lucchinetti et al. NEW ENGLAND JOURNAL OF MEDICINE
- Preferential use of unobstructed lateral portals as the access route to the pore of human ATP-gated ion channels (P2X receptors)
- (2011) D. S. K. Samways et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The human P2X7 receptor and its role in innate immunity
- (2011) J. S. Wiley et al. TISSUE ANTIGENS
- A Potential Role for P2X7R in Allergic Airway Inflammation in Mice and Humans
- (2010) Tobias Müller et al. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
- Two haplotypes of the P2X7 receptor containing the Ala-348 to Thr polymorphism exhibit a gain-of-function effect and enhanced interleukin-1β secretion
- (2010) Leanne Stokes et al. FASEB JOURNAL
- Diadenosine Homodinucleotide Products of ADP-ribosyl Cyclases Behave as Modulators of the Purinergic Receptor P2X7
- (2010) Santina Bruzzone et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The P2X7-nonmuscle myosin membrane complex regulates phagocytosis of nonopsonized particles and bacteria by a pathway attenuated by extracellular ATP
- (2009) B. J. Gu et al. BLOOD
- Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20
- (2009) Melanie Bahlo et al. NATURE GENETICS
- CD39 deletion exacerbates experimental murine colitis and human polymorphisms increase susceptibility to inflammatory bowel disease
- (2009) D. J. Friedman et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Multiple sclerosis
- (2008) Alastair Compston et al. LANCET
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