Nucleotide signalling during inflammation

Intestinal Inflammation Increases the Expression of the P2Y6 Receptor on Epithelial Cells and the Release of CXC Chemokine Ligand 8 by UDP

(2014) D. M. Grbic et al.   JOURNAL OF IMMUNOLOGY

CD73+ regulatory T cells contribute to adenosine-mediated resolution of acute lung injury

(2013) Heidi Ehrentraut et al.   FASEB JOURNAL

Crosstalk between the equilibrative nucleoside transporter ENT2 and alveolar Adora2b adenosine receptors dampens acute lung injury

(2013) Tobias Eckle et al.   FASEB JOURNAL

Signaling through Purinergic Receptors for ATP Induces Human Cutaneous Innate and Adaptive Th17 Responses: Implications in the Pathogenesis of Psoriasis

(2013) M. E. Killeen et al.   JOURNAL OF IMMUNOLOGY

Is pannexin the pore associated with the P2X7 receptor?

(2013) A. V. P. Alberto et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Identifying the Origins of Cystic Fibrosis Lung Disease

(2013) Stephanie D. Davis et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mutation of the ATP-gated P2X2 receptor leads to progressive hearing loss and increased susceptibility to noise

(2013) D. Yan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Attenuating myocardial ischemia by targeting A2B adenosine receptors

(2013) Holger K. Eltzschig et al.   TRENDS IN MOLECULAR MEDICINE

Gene deletion of P2Y4 receptor lowers exercise capacity and reduces myocardial hypertrophy with swimming exercise

(2012) Michael Horckmans et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Roles of Purinergic Receptor P2Y, G Protein–Coupled 12 in the Development of Atherosclerosis in Apolipoprotein E–Deficient Mice

(2012) Ding Li et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The split personality of regulatory T cells in HIV infection

(2012) M. F. Chevalier et al.   BLOOD

Purinergic P2Y2 Receptors Promote Neutrophil Infiltration and Hepatocyte Death in Mice With Acute Liver Injury

(2012) Cemil Korcan Ayata et al.   GASTROENTEROLOGY

Protection from asthma in a high-risk birth cohort by attenuated P2X7 function

(2012) David M. Manthei et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Long term effects of denufosol tetrasodium in patients with cystic fibrosis

(2012) Felix Ratjen et al.   Journal of Cystic Fibrosis

Role of extracellular nucleotides in the immune response against intracellular bacteria and protozoan parasites

(2012) Robson Coutinho-Silva et al.   MICROBES AND INFECTION

Adora2b-elicited Per2 stabilization promotes a HIF-dependent metabolic switch crucial for myocardial adaptation to ischemia

(2012) Tobias Eckle et al.   NATURE MEDICINE

Activation of neuronal P2X7 receptor–pannexin-1 mediates death of enteric neurons during colitis

(2012) Brian D Gulbransen et al.   NATURE MEDICINE

Neuromodulation by Extracellular ATP and P2X Receptors in the CNS

(2012) Baljit S. Khakh et al.   NEURON

Purinergic Signaling during Inflammation

(2012) Holger K. Eltzschig et al.   NEW ENGLAND JOURNAL OF MEDICINE

Alternative Splicing of the N-Terminal Cytosolic and Transmembrane Domains of P2X7 Controls Gating of the Ion Channel by ADP-Ribosylation

(2012) Nicole Schwarz et al.   PLoS One

Vesicular and conductive mechanisms of nucleotide release

(2012) Eduardo R. Lazarowski   Purinergic Signalling

Cellular function and molecular structure of ecto-nucleotidases

(2012) Herbert Zimmermann et al.   Purinergic Signalling

G protein-coupled adenosine (P1) and P2Y receptors: ligand design and receptor interactions

(2012) Kenneth A. Jacobson et al.   Purinergic Signalling

Selective Activation of Adenosine A2A Receptors on Immune Cells by a CD73-Dependent Prodrug Suppresses Joint Inflammation in Experimental Rheumatoid Arthritis

(2012) U. Flogel et al.   Science Translational Medicine

Extracellular ATP mediates mast cell-dependent intestinal inflammation through P2X7 purinoceptors

(2012) Yosuke Kurashima et al.   Nature Communications

Purinergic Receptor Type 6 Contributes to Airway Inflammation and Remodeling in Experimental Allergic Airway Inflammation

(2011) Rodolfo Paula Vieira et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Adenosine and Hypoxia-Inducible Factor Signaling in Intestinal Injury and Recovery

(2011) Sean P. Colgan et al.   Annual Review of Physiology

Gene-by-environment effect of house dust mite on purinergic receptor P2Y12 (P2RY12) and lung function in children with asthma

(2011) S. Bunyavanich et al.   CLINICAL AND EXPERIMENTAL ALLERGY

P2Y6 Receptor Contributes to Neutrophil Recruitment to Inflamed Intestinal Mucosa by Increasing Cxc Chemokine Ligand 8 Expression in an AP-1-dependent Manner in Epithelial Cells

(2011) Djordje M. Grbic et al.   INFLAMMATORY BOWEL DISEASES

The Danger Signal, Extracellular ATP, Is a Sensor for an Airborne Allergen and Triggers IL-33 Release and Innate Th2-Type Responses

(2011) Hideaki Kouzaki et al.   JOURNAL OF IMMUNOLOGY

A2B Adenosine Receptor Blockade Enhances Macrophage-Mediated Bacterial Phagocytosis and Improves Polymicrobial Sepsis Survival in Mice

(2011) B. G. Belikoff et al.   JOURNAL OF IMMUNOLOGY

P2Y6 Agonist Uridine 5'-Diphosphate Promotes Host Defense against Bacterial Infection via Monocyte Chemoattractant Protein-1-Mediated Monocytes/Macrophages Recruitment

(2011) Z. Zhang et al.   JOURNAL OF IMMUNOLOGY

Ischemia and reperfusion—from mechanism to translation

(2011) Holger K Eltzschig et al.   NATURE MEDICINE

Nucleotide receptors as targets in the pharmacological enhancement of dermal wound healing

(2011) Edyta Gendaszewska-Darmach et al.   Purinergic Signalling

CD39/Adenosine Pathway Is Involved in AIDS Progression

(2011) Maria Nikolova et al.   PLoS Pathogens

Purines - 80 years and very much alive

(2010) B. Fredholm et al.   Acta Physiologica

Signalling and pharmacological properties of the P2Y14 receptor

(2010) T. K. Harden et al.   Acta Physiologica

The purinergic receptor P2Y2 receptor mediates chemotaxis of dendritic cells and eosinophils in allergic lung inflammation

(2010) T. Müller et al.   ALLERGY

Extracellular Adenosine Triphosphate and Chronic Obstructive Pulmonary Disease

(2010) Marek Lommatzsch et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

P2X7Receptor Signaling in the Pathogenesis of Smoke-Induced Lung Inflammation and Emphysema

(2010) Monica Lucattelli et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

A Potential Role for P2X7R in Allergic Airway Inflammation in Mice and Humans

(2010) Tobias Müller et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Selective induction of endothelial P2Y6 nucleotide receptor promotes vascular inflammation

(2010) A.-K. Riegel et al.   BLOOD

Cysteinyl leukotrienes acting via granule membrane-expressed receptors elicit secretion from within cell-free human eosinophil granules

(2010) Josiane S. Neves et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Lack of the purinergic receptor P2X7results in resistance to contact hypersensitivity

(2010) Felix C. Weber et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Signaling through the A2B Adenosine Receptor Dampens Endotoxin-Induced Acute Lung Injury

(2010) U. Schingnitz et al.   JOURNAL OF IMMUNOLOGY

Purinergic Receptor Inhibition Prevents the Development of Smoke-Induced Lung Injury and Emphysema

(2010) S. Cicko et al.   JOURNAL OF IMMUNOLOGY

Role of the P2Y12 Receptor in the Modulation of Murine Dendritic Cell Function by ADP

(2010) A. Ben Addi et al.   JOURNAL OF IMMUNOLOGY

A2B Adenosine Receptors Protect against Sepsis-Induced Mortality by Dampening Excessive Inflammation

(2010) B. Csoka et al.   JOURNAL OF IMMUNOLOGY

Human Eosinophils Recognize Endogenous Danger Signal Crystalline Uric Acid and Produce Proinflammatory Cytokines Mediated by Autocrine ATP

(2010) T. Kobayashi et al.   JOURNAL OF IMMUNOLOGY

Pannexin 1 channels mediate ‘find-me’ signal release and membrane permeability during apoptosis

(2010) Faraaz B. Chekeni et al.   NATURE

Graft-versus-host disease is enhanced by extracellular ATP activating P2X7R

(2010) Konrad Wilhelm et al.   NATURE MEDICINE

Extracellular adenosine triphosphate and adenosine in cancer

(2010) J Stagg et al.   ONCOGENE

Autocrine Purinergic Receptor Signaling Is Essential for Macrophage Chemotaxis

(2010) M. Kronlage et al.   Science Signaling

P2Y receptors and atherosclerosis in apolipoprotein E-deficient mice

(2009) Pieter-Jan DF Guns et al.   BRITISH JOURNAL OF PHARMACOLOGY

Concomitant activation of P2Y2and P2Y6receptors on monocytes is required for TLR1/2-induced neutrophil migration by regulating IL-8 secretion

(2009) Fethia Ben Yebdri et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Leukotriene E4–induced pulmonary inflammation is mediated by the P2Y12receptor

(2009) Sailaja Paruchuri et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Contribution of Adenosine A2B Receptors to Inflammatory Parameters of Experimental Colitis

(2009) J.-S. Frick et al.   JOURNAL OF IMMUNOLOGY

Crystal structure of the ATP-gated P2X4 ion channel in the closed state

(2009) Toshimitsu Kawate et al.   NATURE

Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance

(2009) Michael R. Elliott et al.   NATURE

Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β–dependent adaptive immunity against tumors

(2009) François Ghiringhelli et al.   NATURE MEDICINE

CD39 deletion exacerbates experimental murine colitis and human polymorphisms increase susceptibility to inflammatory bowel disease

(2009) D. J. Friedman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Double Life of ATP

(2009) Baljit S. Khakh et al.   SCIENTIFIC AMERICAN

Effect of antiplatelet therapy on inflammatory markers in atherothrombotic patients

(2009) J. B. Muhlestein   THROMBOSIS AND HAEMOSTASIS

Involvement of Platelet Activation by P2Y12 Receptor in the Development of Transplant Arteriosclerosis in Mice

(2009) Kenichi Yashiro et al.   TRANSPLANTATION

Signaling at Purinergic P2X Receptors

(2008) Annmarie Surprenant et al.   Annual Review of Physiology

HIF-1-dependent repression of adenosine kinase attenuates hypoxia-induced vascular leak

(2008) J. C. Morote-Garcia et al.   BLOOD

Hypoxia-Inducible Factor–Dependent Repression of Equilibrative Nucleoside Transporter 2 Attenuates Mucosal Inflammation During Intestinal Hypoxia

(2008) Julio C. Morote–Garcia et al.   GASTROENTEROLOGY

Natural killer T cell dysfunction in CD39-null mice protects against concanavalin A-induced hepatitis

(2008) Guido Beldi et al.   HEPATOLOGY

ATP drives lamina propria TH17 cell differentiation

(2008) Koji Atarashi et al.   NATURE

Purinergic signalling and disorders of the central nervous system

(2008) Geoffrey Burnstock   NATURE REVIEWS DRUG DISCOVERY

ATP Release from Vascular Endothelia Occurs Across Cx43 Hemichannels and Is Attenuated during Hypoxia

(2008) Marion Faigle et al.   PLoS One

Denufosol: A review of studies with inhaled P2Y2 agonists that led to Phase 3

(2008) Donald Kellerman et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Neutrophils as Sources of Extracellular Nucleotides: Functional Consequences at the Vascular Interface

(2008) Holger K. Eltzschig et al.   TRENDS IN CARDIOVASCULAR MEDICINE