Astrocytes mediate HIV-1 Tat-induced neuronal damage via ligand-gated ion channel P2X7R

P2X7-dependent, but differentially regulated release of IL-6, CCL2, and TNF-α in cultured mouse microglia

(2014) Chu-Hsin Shieh et al.   GLIA

Cytochromecdysregulation induced by HIV infection of astrocytes results in bystander apoptosis of uninfected astrocytes by an IP3and calcium-dependent mechanism

(2013) Eliseo A. Eugenin et al.   JOURNAL OF NEUROCHEMISTRY

P2X7 receptor-induced death of motor neurons by a peroxynitrite/FAS-dependent pathway

(2013) Mandi Gandelman et al.   JOURNAL OF NEUROCHEMISTRY

Ligand-Gated Purinergic Receptors Regulate HIV-1 Tat and Morphine Related Neurotoxicity in Primary Mouse Striatal Neuron-Glia Co-Cultures

(2013) Mary E. Sorrell et al.   Journal of Neuroimmune Pharmacology

Adenosine Triphosphate Released from HIV-Infected Macrophages Regulates Glutamatergic Tone and Dendritic Spine Density on Neurons

(2013) Luis B. Tovar-y-Romo et al.   Journal of Neuroimmune Pharmacology

Induction of IL-17 and nonclassical T-cell activation by HIV-Tat protein

(2013) T. P. Johnson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Where does HIV hide? A focus on the central nervous system

(2013) Melissa Churchill et al.   Current Opinion in HIV and AIDS

P2X7 Receptors: Channels, Pores and More

(2012) C. Volonte et al.   CNS & Neurological Disorders-Drug Targets

Monocyte Activation Markers in Cerebrospinal Fluid Associated With Impaired Neurocognitive Testing in Advanced HIV Infection

(2012) Anupa Kamat et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Purinergic Receptors Are Required for HIV-1 Infection of Primary Human Macrophages

(2012) J. E. Hazleton et al.   JOURNAL OF IMMUNOLOGY

Mitochondrial dysfunction is involved in P2X7 receptor-mediated neuronal cell death

(2012) Kentaro Nishida et al.   JOURNAL OF NEUROCHEMISTRY

Activation of neuronal P2X7 receptor–pannexin-1 mediates death of enteric neurons during colitis

(2012) Brian D Gulbransen et al.   NATURE MEDICINE

Extracellular HIV-1 Tat upregulates TNF-α dependent MCP-1/CCL2 production via activation of ERK1/2 pathway in rat hippocampal slice cultures: Inhibition by resveratrol, a polyphenolic phytostilbene

(2011) Eun Ok Lee et al.   EXPERIMENTAL NEUROLOGY

Metabolic abnormalities and viral replication are associated with biomarkers of vascular dysfunction in HIV-infected children

(2011) TL Miller et al.   HIV MEDICINE

Extracellular ATP acts on P2Y2 purinergic receptors to facilitate HIV-1 infection

(2011) Claire Séror et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Neurotoxicity of Human Immunodeficiency Virus-1: Viral Proteins and Axonal Transport

(2011) Italo Mocchetti et al.   NEUROTOXICITY RESEARCH

Astrocytes contacting HIV-1-infected macrophages increase the release of CCL2 in response to the HIV-1-dependent enhancement of membrane-associated TNFα in macrophages

(2010) Claudia Muratori et al.   GLIA

Extensive astrocyte infection is prominent in human immunodeficiency virus-associated dementia

(2009) Melissa J. Churchill et al.   ANNALS OF NEUROLOGY

Altered P2X7-receptor level and function in mouse models of Huntington’s disease and therapeutic efficacy of antagonist administration

(2009) Miguel Díaz-Hernández et al.   FASEB JOURNAL

The P2X7 purinergic receptor: from physiology to neurological disorders

(2009) Stephen D. Skaper et al.   FASEB JOURNAL

Activation of Microglia by Amyloid   Requires P2X7 Receptor Expression

(2009) J. M. Sanz et al.   JOURNAL OF IMMUNOLOGY

Systemic administration of an antagonist of the ATP-sensitive receptor P2X7 improves recovery after spinal cord injury

(2009) W. Peng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clade-specific differences in neurotoxicity of human immunodeficiency virus-1 B and C Tat of human neurons: significance of dicysteine C30C31 motif

(2007) Mamata Mishra et al.   ANNALS OF NEUROLOGY