Interactions of amyloidogenic proteins with mitochondrial protein import machinery in aging-related neurodegenerative diseases

Mortalin: Protein partners, biological impacts, pathological roles, and therapeutic opportunities

(2023) Niki Esfahanian et al.   Frontiers in Cell and Developmental Biology

Mitochondrial protein transport: Versatility of translocases and mechanisms

(2023) Jakob D. Busch et al.   MOLECULAR CELL

Structural basis of mitochondrial protein import by the TIM23 complex

(2023) Sue Im Sim et al.   NATURE

Apolipoprotein E in lipid metabolism and neurodegenerative disease

(2023) Linda G. Yang et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

APOE expression and secretion are modulated by mitochondrial dysfunction

(2023) Meghan E Wynne et al.   eLife

The contribution of mitochondria-associated endoplasmic reticulum membranes (MAMs) dysfunction in Alzheimer’s disease and the potential countermeasure

(2023) Zehui Li et al.   Frontiers in Neuroscience

CRMP2 Participates in Regulating Mitochondrial Morphology and Motility in Alzheimer’s Disease

(2023) Tatiana Brustovetsky et al.   Cells

Preservation of mitochondrial membrane potential is necessary for lifespan extension from dietary restriction

(2023) Brandon J. Berry et al.   GeroScience

Cell Rearrangement and Oxidant/Antioxidant Imbalance in Huntington’s Disease

(2023) Francesco D’Egidio et al.   Antioxidants

Central role of Tim17 in mitochondrial presequence protein translocation

(2023) Laura F. Fielden et al.   NATURE

PPAR-gamma agonist pioglitazone recovers mitochondrial quality control in fibroblasts from PITRM1-deficient patients

(2023) Alessia Di Donfrancesco et al.   Frontiers in Pharmacology

Lipid metabolism and Alzheimer's disease: clinical evidence, mechanistic link and therapeutic promise

(2022) Fei Yin   FEBS Journal

Mitochondrial Processing Peptidases—Structure, Function and the Role in Human Diseases

(2022) Nina Kunová et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Coordinated Translocation of Presequence-Containing Precursor Proteins Across Two Mitochondrial Membranes: Knowns and Unknowns of How TOM and TIM23 Complexes Cooperate With Each Other

(2022) Marcel G. Genge et al.   Frontiers in Physiology

Dynamics of huntingtin protein interactions in the striatum identifies candidate modifiers of Huntington disease

(2022) Todd M. Greco et al.   Cell Systems

Neuroprotective Effects of a Small Mitochondrially-Targeted Tetrapeptide Elamipretide in Neurodegeneration

(2022) Nguyen Thanh Nhu et al.   Frontiers in Integrative Neuroscience

The Alzheimer’s disease drug candidate J147 decreases blood plasma fatty acid levels via modulation of AMPK/ACC1 signaling in the liver

(2022) Devin Kepchia et al.   BIOMEDICINE & PHARMACOTHERAPY

Mitochondrial Lipids: From Membrane Organization to Apoptotic Facilitation

(2022) Aikaterini Poulaki et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Role of Intracellular Amyloid β as Pathway Modulator, Biomarker, and Therapy Target

(2022) Lucia Gallego Villarejo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Positively charged amino acids at the N terminus of select mitochondrial proteins mediate early recognition by import proteins αβ′-NAC and Sam37

(2022) Maria Clara Avendaño-Monsalve et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Folding or holding?—Hsp70 and Hsp90 chaperoning of misfolded proteins in neurodegenerative disease

(2022) Benjamin S. Rutledge et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The UPRmt preserves mitochondrial import to extend lifespan

(2022) Nan Xin et al.   JOURNAL OF CELL BIOLOGY

ApoE Cascade Hypothesis in the pathogenesis of Alzheimer’s disease and related dementias

(2022) Yuka A. Martens et al.   NEURON

Ca2+ Dyshomeostasis Links Risk Factors to Neurodegeneration in Parkinson’s Disease

(2022) Jianjun Xu et al.   Frontiers in Cellular Neuroscience

The Unfolded Protein Responses in Health, Aging, and Neurodegeneration: Recent Advances and Future Considerations

(2022) Andrew P. K. Wodrich et al.   Frontiers in Molecular Neuroscience

Mitochondria targeting drugs for neurodegenerative diseases—Design, mechanism and application

(2022) Jiajia Xu et al.   Acta Pharmaceutica Sinica B

Microglial mTOR Activation Upregulates Trem2 and Enhances β-Amyloid Plaque Clearance in the 5XFAD Alzheimer's Disease Model

(2022) Qian Shi et al.   JOURNAL OF NEUROSCIENCE

Structural basis of Tom20 and Tom22 cytosolic domains as the human TOM complex receptors

(2022) Jiayue Su et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure-activity relationships of mitochondria-targeted tetrapeptide pharmacological compounds

(2022) Wayne Mitchell et al.   eLife

Mitochondrial and redox modifications in early stages of Huntington's disease

(2022) Carla Lopes et al.   Redox Biology

ER-mitochondria contact sites; a multifaceted factory for Ca2+ signaling and lipid transport

(2022) Maria Livia Sassano et al.   Frontiers in Cell and Developmental Biology

The Mitochondrial HSP90 Paralog TRAP1: Structural Dynamics, Interactome, Role in Metabolic Regulation, and Inhibitors

(2022) Abhinav Joshi et al.   Biomolecules

Activation of the Mitochondrial Unfolded Protein Response: A New Therapeutic Target?

(2022) Juan M. Suárez-Rivero et al.   Biomedicines

Therapeutic Strategies in Huntington’s Disease: From Genetic Defect to Gene Therapy

(2022) Anamaria Jurcau et al.   Biomedicines

Dysfunctional Glucose Metabolism in Alzheimer’s Disease Onset and Potential Pharmacological Interventions

(2022) Vijay Kumar et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Structures of α-synuclein filaments from human brains with Lewy pathology

(2022) Yang Yang et al.   NATURE

The relationship of alpha-synuclein to mitochondrial dynamics and quality control

(2022) Naomi J. Thorne et al.   Frontiers in Molecular Neuroscience

Rapamycin treatment during development extends life span and health span of male mice and Daphnia magna

(2022) Anastasia V. Shindyapina et al.   Science Advances

Mitochondria in Huntington’s disease: implications in pathogenesis and mitochondrial-targeted therapeutic strategies

(2022) Anamaria Jurcau et al.   Neural Regeneration Research

Lipid Dys-Homeostasis Contributes to APOE4-Associated AD Pathology

(2022) Adina-Nicoleta Lazar et al.   Cells

Urolithin A reduces amyloid-beta load and improves cognitive deficits uncorrelated with plaque burden in a mouse model of Alzheimer’s disease

(2022) Josué Ballesteros-Álvarez et al.   GeroScience

Ubiquitin signalling in neurodegeneration: mechanisms and therapeutic opportunities

(2021) Marlene F. Schmidt et al.   CELL DEATH AND DIFFERENTIATION

Mitochondrial proteases in human diseases

(2021) Maria Gomez‐Fabra Gala et al.   FEBS LETTERS

LONP1 and mtHSP70 cooperate to promote mitochondrial protein folding

(2021) Chun-Shik Shin et al.   Nature Communications

Geroprotective effects of Alzheimer’s disease drug candidates

(2021) Devin Kepchia et al.   Aging-US

Small Non-coding RNAs Are Dysregulated in Huntington’s Disease Transgenic Mice Independently of the Therapeutic Effects of an Environmental Intervention

(2021) Celine Dubois et al.   MOLECULAR NEUROBIOLOGY

Elamipretide (SS-31) Improves Functional Connectivity in Hippocampus and Other Related Regions Following Prolonged Neuroinflammation Induced by Lipopolysaccharide in Aged Rats

(2021) Yang Liu et al.   Frontiers in Aging Neuroscience

Mitochondrial Dysfunction and Oxidative Stress in Alzheimer’s Disease

(2021) Afzal Misrani et al.   Frontiers in Aging Neuroscience

Effects of α-Synuclein-Associated Post-Translational Modifications in Parkinson’s Disease

(2021) Songzhe He et al.   ACS Chemical Neuroscience

Gain of PITRM1 peptidase in cortical neurons affords protection of mitochondrial and synaptic function in an advanced age mouse model of Alzheimer’s disease

(2021) Fang Du et al.   AGING CELL

Crowded organelles, lipid accumulation, and abnormal membrane tubulation in cellular models of enhanced α-synuclein membrane interaction

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Mitochondrial matrix proteases: quality control and beyond

(2021) Karolina Szczepanowska et al.   FEBS Journal

Mitochondrial dynamics in health and disease

(2021) Nethmi M.B. Yapa et al.   FEBS LETTERS

Brain cells derived from Alzheimer’s disease patients have multiple specific innate abnormalities in energy metabolism

(2021) Woo-In Ryu et al.   MOLECULAR PSYCHIATRY

Age-related increase of alpha-synuclein oligomers is associated with motor disturbances in L61 transgenic mice

(2021) Sahar Roshanbin et al.   NEUROBIOLOGY OF AGING

The chaperone-binding activity of the mitochondrial surface receptor Tom70 protects the cytosol against mitoprotein-induced stress

(2021) Sandra Backes et al.   Cell Reports

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(2021) David S. Knopman et al.   Nature Reviews Disease Primers

A Biochemical and Structural Understanding of TOM Complex Interactions and Implications for Human Health and Disease

(2021) Ashley S. Pitt et al.   Cells

Structural insights into assembly of human mitochondrial translocase TOM complex

(2021) Zeyuan Guan et al.   Cell Discovery

An energetics perspective on geroscience: mitochondrial protonmotive force and aging

(2021) Brandon J. Berry et al.   GeroScience

Endoplasmic Reticulum–Mitochondria Contact Sites—Emerging Intracellular Signaling Hubs

(2021) Saeko Aoyama-Ishiwatari et al.   Frontiers in Cell and Developmental Biology

Systemic manifestation and contribution of peripheral tissues to Huntington’s disease pathogenesis

(2021) Chia-Lung Chuang et al.   AGEING RESEARCH REVIEWS

Effect of rapamycin on mitochondria and lysosomes in fibroblasts from patients with mtDNA mutations

(2021) Nashwa J. Cheema et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The role of amyloid oligomers in neurodegenerative pathologies

(2021) Cameron Wells et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Mitochondrial HSP70 Chaperone System—The Influence of Post-Translational Modifications and Involvement in Human Diseases

(2021) Henrieta Havalová et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Diverse Functions of Tim50, a Component of the Mitochondrial Inner Membrane Protein Translocase

(2021) Minu Chaudhuri et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Accelerated expansion of pathogenic mitochondrial DNA heteroplasmies in Huntington’s disease

(2021) Yiqin Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The N terminus of α-synuclein dictates fibril formation

(2021) Ryan P. McGlinchey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impact of the Natural Compound Urolithin A on Health, Disease, and Aging

(2021) Davide D’Amico et al.   TRENDS IN MOLECULAR MEDICINE

Huntingtin and the Synapse

(2021) Jessica C. Barron et al.   Frontiers in Cellular Neuroscience

Spatiotemporally-resolved mapping of RNA binding proteins via functional proximity labeling reveals a mitochondrial mRNA anchor promoting stress recovery

(2021) Wei Qin et al.   Nature Communications

Alpha-Synuclein Post-translational Modifications: Implications for Pathogenesis of Lewy Body Disorders

(2021) Nelson de Oliveira Manzanza et al.   Frontiers in Aging Neuroscience

The amyloid precursor protein is a conserved Wnt receptor

(2021) Tengyuan Liu et al.   eLife

The mitochondrial permeability transition pore activates the mitochondrial unfolded protein response and promotes aging

(2021) Suzanne Angeli et al.   eLife

Roles for α-Synuclein in Gene Expression

(2021) Mahalakshmi Somayaji et al.   Genes

α-Synuclein: An All-Inclusive Trip Around its Structure, Influencing Factors and Applied Techniques

(2021) Nicolò Bisi et al.   Frontiers in Chemistry

Alpha-Synuclein and Lipids: The Elephant in the Room?

(2021) Alessia Sarchione et al.   Cells

Investigating Crosstalk Among PTMs Provides Novel Insight Into the Structural Basis Underlying the Differential Effects of Nt17 PTMs on Mutant Httex1 Aggregation

(2021) Anass Chiki et al.   Frontiers in Molecular Biosciences

Neuronal Trafficking of the Amyloid Precursor Protein—What Do We Really Know?

(2021) Tong Lin et al.   Biomedicines

Role of PITRM1 in Mitochondrial Dysfunction and Neurodegeneration

(2021) Dario Brunetti et al.   Biomedicines

Structural and Functional Alterations in Mitochondria-Associated Membranes (MAMs) and in Mitochondria Activate Stress Response Mechanisms in an In Vitro Model of Alzheimer’s Disease

(2021) Tânia Fernandes et al.   Biomedicines

Mitochondria in Neuronal Health: From Energy Metabolism to Parkinson's Disease

(2021) Hariharan Murali Mahadevan et al.   Advanced Biology

Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context

(2021) Marcel Morgenstern et al.   Cell Metabolism

Cytosolic Quality Control of Mitochondrial Protein Precursors—The Early Stages of the Organelle Biogenesis

(2021) Anna M. Lenkiewicz et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

N-alpha-acetylation of Huntingtin protein increases its propensity to aggregate

(2021) Leah Gottlieb et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multiple variants of the human presequence translocase motor subunit Magmas govern the mitochondrial import

(2021) Tejashree Pradip Waingankar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The receptor subunit Tom20 is dynamically associated with the TOM complex in mitochondria of human cells

(2021) Maniraj Bhagawati et al.   MOLECULAR BIOLOGY OF THE CELL

Mitophagy in Huntington's disease

(2021) I. Šonský et al.   NEUROCHEMISTRY INTERNATIONAL

Nuclear and cytoplasmic huntingtin inclusions exhibit distinct biochemical composition, interactome and ultrastructural properties

(2021) Nathan Riguet et al.   Nature Communications

Urolithin A protects dopaminergic neurons in experimental models of Parkinson's disease by promoting mitochondrial biogenesis through the SIRT1/PGC-1α signaling pathway

(2021) Jia Liu et al.   Food & Function

Alpha-Synuclein Aggregation in Parkinson's Disease

(2021) E. Srinivasan et al.   Frontiers in Medicine

How to get to the other side of the mitochondrial inner membrane – the protein import motor

(2020) Dejana Mokranjac   BIOLOGICAL CHEMISTRY

From cytosol to mitochondria: the beginning of a protein journey

(2020) Maria Clara Avendaño-Monsalve et al.   BIOLOGICAL CHEMISTRY

Mitochondrial fission in Huntington's disease mouse striatum disrupts ER-mitochondria contacts leading to disturbances in Ca2+ efflux and Reactive Oxygen Species (ROS) homeostasis

(2020) Marta Cherubini et al.   NEUROBIOLOGY OF DISEASE

Activation of Mitochondrial Unfolded Protein Response in SHSY5Y Expressing APP Cells and APP/PS1 Mice

(2020) Yang Shen et al.   Frontiers in Cellular Neuroscience

The Challenge of Disease-Modifying Therapies in Parkinson’s Disease: Role of CSF Biomarkers

(2020) Federico Paolini Paoletti et al.   Biomolecules

Investigating the presence of doubly phosphorylated α‐synuclein at tyrosine 125 and serine 129 in idiopathic Lewy body diseases

(2020) Muneera Fayyad et al.   BRAIN PATHOLOGY

Autophagy in Neurodegenerative Diseases: A Hunter for Aggregates

(2020) Hyungsun Park et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The mitochondria-targeted peptide SS-31 binds lipid bilayers and modulates surface electrostatics as a key component of its mechanism of action

(2020) Wayne Mitchell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In Vivo Dissection of the Intrinsically Disordered Receptor Domain of Tim23

(2020) Umut Günsel et al.   JOURNAL OF MOLECULAR BIOLOGY

Mgr2 regulates mitochondrial preprotein import by associating with channel-forming Tim23 subunit

(2020) Srujan Kumar Matta et al.   MOLECULAR BIOLOGY OF THE CELL

PINK1 and Parkin mitochondrial quality control: a source of regional vulnerability in Parkinson’s disease

(2020) Preston Ge et al.   Molecular Neurodegeneration

Mitochondria dysfunction in the pathogenesis of Alzheimer’s disease: recent advances

(2020) Wenzhang Wang et al.   Molecular Neurodegeneration

Structure and Aggregation Mechanisms in Amyloids

(2020) Zaida L. Almeida et al.   MOLECULES

Mitochondrial protein biogenesis in the synapse is supported by local translation

(2020) Bozena Kuzniewska et al.   EMBO REPORTS

Functional coupling of presequence processing and degradation in human mitochondria

(2020) Cansu Kücükköse et al.   FEBS Journal

How Do Post-Translational Modifications Influence the Pathomechanistic Landscape of Huntington’s Disease? A Comprehensive Review

(2020) Beata Lontay et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mitochondrial Respiration Changes in R6/2 Huntington’s Disease Model Mice during Aging in a Brain Region Specific Manner

(2020) Johannes Burtscher et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Glia in neurodegeneration: Drivers of disease or along for the ride?

(2020) Amy J. Gleichman et al.   NEUROBIOLOGY OF DISEASE

Mitochondrial protein interaction landscape of SS-31

(2020) Juan D. Chavez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting Amyloidogenic Processing of APP in Alzheimer’s Disease

(2020) Jing Zhao et al.   Frontiers in Molecular Neuroscience

Targeting Multiple Mitochondrial Processes by a Metabolic Modulator Prevents Sarcopenia and Cognitive Decline in SAMP8 Mice

(2020) Dario Brunetti et al.   Frontiers in Pharmacology

ATP synthase and Alzheimer’s disease: putting a spin on the mitochondrial hypothesis

(2020) Brad Ebanks et al.   Aging-US

DIBMA nanodiscs keep α-synuclein folded

(2020) Regina Adão et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

NRF2 activation by reversible KEAP1 binding induces the antioxidant response in primary neurons and astrocytes of a Huntington’s disease mouse model

(2020) Daniele Moretti et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mutant huntingtin does not cross the mitochondrial outer membrane

(2020) James Hamilton et al.   HUMAN MOLECULAR GENETICS

Revisiting the Amyloid Cascade Hypothesis: From Anti-Aβ Therapeutics to Auspicious New Ways for Alzheimer’s Disease

(2020) Md. Sahab Uddin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Mitochondrial Unfolded Protein Response: A Hinge Between Healthy and Pathological Aging

(2020) Francisco Muñoz-Carvajal et al.   Frontiers in Aging Neuroscience

Interaction of Alpha-Synuclein With Lipids: Mitochondrial Cardiolipin as a Critical Player in the Pathogenesis of Parkinson’s Disease

(2020) Valentina Gilmozzi et al.   Frontiers in Neuroscience

Atomic structure of human TOM core complex

(2020) Wenhe Wang et al.   Cell Discovery

Interactions of α-synuclein oligomers with lipid membranes

(2020) Greta Musteikytė et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Mitochondrial Dysfunction and Mitophagy in Parkinson’s Disease: From Mechanism to Therapy

(2020) Ana Belen Malpartida et al.   TRENDS IN BIOCHEMICAL SCIENCES

Reduction of elevated proton leak rejuvenates mitochondria in the aged cardiomyocyte

(2020) Huiliang Zhang et al.   eLife

Amyloid β-Peptide Increases Mitochondria-Endoplasmic Reticulum Contact Altering Mitochondrial Function and Autophagosome Formation in Alzheimer’s Disease-Related Models

(2020) Nuno Santos Leal et al.   Cells

Ca2+ Dyshomeostasis Disrupts Neuronal and Synaptic Function in Alzheimer’s Disease

(2020) John McDaid et al.   Cells

Protection from α-Synuclein induced dopaminergic neurodegeneration by overexpression of the mitochondrial import receptor TOM20

(2020) Briana R. De Miranda et al.   npj Parkinsons Disease

Treatment of Alzheimer’s Disease and Blood–Brain Barrier Drug Delivery

(2020) William M. Pardridge   Pharmaceuticals

A lowly populated, transient β-sheet structure in monomeric Aβ1-42 identified by multinuclear NMR of chemical denaturation

(2020) Tayeb Kakeshpour et al.   BIOPHYSICAL CHEMISTRY

Mitochondrial unfolded protein response: An emerging pathway in human diseases

(2020) Li Zhu et al.   FREE RADICAL BIOLOGY AND MEDICINE

ROMO1 is a constituent of the human presequence translocase required for YME1L protease import

(2019) Frank Richter et al.   JOURNAL OF CELL BIOLOGY

Mitochondrial proteins: from biogenesis to functional networks

(2019) Nikolaus Pfanner et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Apolipoprotein E4 Alters Astrocyte Fatty Acid Metabolism and Lipid Droplet Formation

(2019) Brandon Farmer et al.   Cells

Quantitative profiling brain proteomes revealed mitochondrial dysfunction in Alzheimer’s disease

(2019) Sunil S Adav et al.   Molecular Brain

A mutagenesis analysis of Tim50, the major receptor of the TIM23 complex, identifies regions that affect its interaction with Tim23

(2019) Dana Dayan et al.   Scientific Reports

A Quarter Century of APOE and Alzheimer’s Disease: Progress to Date and the Path Forward

(2019) Michaël E. Belloy et al.   NEURON

SignalP 5.0 improves signal peptide predictions using deep neural networks

(2019) José Juan Almagro Armenteros et al.   NATURE BIOTECHNOLOGY

Porin Associates with Tom22 to Regulate the Mitochondrial Protein Gate Assembly

(2019) Haruka Sakaue et al.   MOLECULAR CELL

Mitochondria Bound to Lipid Droplets: Where Mitochondrial Dynamics Regulate Lipid Storage and Utilization

(2019) Ilan Y. Benador et al.   Cell Metabolism

Mutant huntingtin inhibits the mitochondrial unfolded protein response by impairing ABCB10 mRNA stability

(2019) Zixing Fu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Mitochondria in Neuroprotection by Phytochemicals: Bioactive Polyphenols Modulate Mitochondrial Apoptosis System, Function and Structure

(2019) Makoto Naoi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dual Role of Ribosome-Binding Domain of NAC as a Potent Suppressor of Protein Aggregation and Aging-Related Proteinopathies

(2019) Koning Shen et al.   MOLECULAR CELL

Mitochondrial protein translocation-associated degradation

(2019) Christoph U. Mårtensson et al.   NATURE

Molecular structure of an N-terminal phosphorylated β-amyloid fibril

(2019) Zhi-Wen Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Versatility of Preprotein Transfer from the Cytosol to Mitochondria

(2019) Thomas Becker et al.   TRENDS IN CELL BIOLOGY

Dysregulated Lipid Metabolism and Its Role in α-Synucleinopathy in Parkinson’s Disease

(2019) Irina Alecu et al.   Frontiers in Neuroscience

Atlas of Subcellular RNA Localization Revealed by APEX-Seq

(2019) Furqan M. Fazal et al.   CELL

Early Scanning of Nascent Polypeptides inside the Ribosomal Tunnel by NAC

(2019) Martin Gamerdinger et al.   MOLECULAR CELL

Apolipoprotein E4, inhibitory network dysfunction, and Alzheimer’s disease

(2019) Ramsey Najm et al.   Molecular Neurodegeneration

Lewy pathology in Parkinson’s disease consists of crowded organelles and lipid membranes

(2019) Sarah H. Shahmoradian et al.   NATURE NEUROSCIENCE

Mutant huntingtin disrupts mitochondrial proteostasis by interacting with TIM23

(2019) Svitlana Yablonska et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Axonal transport defects and neurodegeneration: Molecular mechanisms and therapeutic implications

(2019) Wenting Guo et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Axonal Transport and Mitochondrial Function in Neurons

(2019) Amrita Mandal et al.   Frontiers in Cellular Neuroscience

Mitochondria as Potential Targets in Alzheimer Disease Therapy: An Update

(2019) Giovanna Cenini et al.   Frontiers in Pharmacology

Elamipretide (SS-31) improves mitochondrial dysfunction, synaptic and memory impairment induced by lipopolysaccharide in mice

(2019) Weixing Zhao et al.   Journal of Neuroinflammation

Structure of the mitochondrial import gate reveals distinct preprotein paths

(2019) Yuhei Araiso et al.   NATURE

Cryo-EM structure of the mitochondrial protein-import channel TOM complex at near-atomic resolution

(2019) Kyle Tucker et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Elevating acetyl-CoA levels reduces aspects of brain aging

(2019) Antonio Currais et al.   eLife

The Beta Amyloid Dysfunction (BAD) Hypothesis for Alzheimer’s Disease

(2019) Heinz Hillen   Frontiers in Neuroscience

Reinvestigating the synthesis and efficacy of small benzimidazole derivatives as presequence protease enhancers

(2019) Nan-Sheng Li et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The Mgr2 subunit of the TIM23 complex regulates membrane insertion of marginal stop‐transfer signals in the mitochondrial inner membrane

(2019) Seoeun Lee et al.   FEBS LETTERS

The mitochondrial ATP synthase is a shared drug target for aging and dementia

(2018) Joshua Goldberg et al.   AGING CELL

The effects of the TOMM40 poly-T alleles on Alzheimer's disease phenotypes

(2018) Ornit Chiba-Falek et al.   Alzheimers & Dementia

Non-vesicular lipid trafficking at the endoplasmic reticulum–mitochondria interface

(2018) Francesca Giordano   BIOCHEMICAL SOCIETY TRANSACTIONS

Genetic risk factors in Parkinson’s disease

(2018) K. J. Billingsley et al.   CELL AND TISSUE RESEARCH

Secondary nucleation in amyloid formation

(2018) Mattias Törnquist et al.   CHEMICAL COMMUNICATIONS

Striatal synapses, circuits, and Parkinson's disease

(2018) Shenyu Zhai et al.   CURRENT OPINION IN NEUROBIOLOGY

Dihydrofolate reductase and membrane translocation: evolution of a classic experiment

(2018) André Schneider   EMBO REPORTS

The PUF Protein Family: Overview on PUF RNA Targets, Biological Functions, and Post Transcriptional Regulation

(2018) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Synergistic Protective Effects of Mitochondrial Division Inhibitor 1 and Mitochondria-Targeted Small Peptide SS31 in Alzheimer’s Disease

(2018) P. Hemachandra Reddy et al.   JOURNAL OF ALZHEIMERS DISEASE

The Amyloid-β Oligomer Hypothesis: Beginning of the Third Decade

(2018) Erika N. Cline et al.   JOURNAL OF ALZHEIMERS DISEASE

Mitochondrial accumulation of amyloid beta (Aβ) peptides requires TOMM22 as a main Aβ receptor in yeast

(2018) Wenxin Hu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tom70 enhances mitochondrial preprotein import efficiency by binding to internal targeting sequences

(2018) Sandra Backes et al.   JOURNAL OF CELL BIOLOGY

Cytosolic Hsp70 and Hsp40 chaperones enable the biogenesis of mitochondrial β-barrel proteins

(2018) Tobias Jores et al.   JOURNAL OF CELL BIOLOGY

Genome-wide SWAp-Tag yeast libraries for proteome exploration

(2018) Uri Weill et al.   NATURE METHODS

MitoCPR—A surveillance pathway that protects mitochondria in response to protein import stress

(2018) Hilla Weidberg et al.   SCIENCE

A key role for MAM in mediating mitochondrial dysfunction in Alzheimer disease

(2018) Estela Area-Gomez et al.   Cell Death & Disease

α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson’s disease

(2018) Marthe H. R. Ludtmann et al.   Nature Communications

Cardiolipin exposure on the outer mitochondrial membrane modulates α-synuclein

(2018) Tammy Ryan et al.   Nature Communications

Ligustilide Ameliorates Memory Deficiency in APP/PS1 Transgenic Mice via Restoring Mitochondrial Dysfunction

(2018) Yi-Jun Xu et al.   Biomed Research International

The Close Encounter Between Alpha-Synuclein and Mitochondria

(2018) Mattia Vicario et al.   Frontiers in Neuroscience

Polyglutamine Repeats in Neurodegenerative Diseases

(2018) Andrew P. Lieberman et al.   Annual Review of Pathology-Mechanisms of Disease

Decreased Proteolytic Activity of the Mitochondrial Amyloid-β Degrading Enzyme, PreP Peptidasome, in Alzheimer's Disease Brain Mitochondria

(2018) Nyosha Alikhani et al.   JOURNAL OF ALZHEIMERS DISEASE

Biophysical Alterations in Lipid Rafts from Human Cerebral Cortex Associate with Increased BACE1/AβPP Interaction in Early Stages of Alzheimer's Disease

(2018) Mario Díaz et al.   JOURNAL OF ALZHEIMERS DISEASE

The cryo-electron microscopy structure of huntingtin

(2018) Qiang Guo et al.   NATURE

Selective vulnerability in neurodegenerative diseases

(2018) Hongjun Fu et al.   NATURE NEUROSCIENCE

Cyclophilin D deficiency attenuates mitochondrial F1Fo ATP synthase dysfunction via OSCP in Alzheimer's disease

(2018) Esha Gauba et al.   NEUROBIOLOGY OF DISEASE

SS-31 Provides Neuroprotection by Reversing Mitochondrial Dysfunction after Traumatic Brain Injury

(2018) Yihao Zhu et al.   Oxidative Medicine and Cellular Longevity

Regulatory mechanisms of incomplete huntingtin mRNA splicing

(2018) Andreas Neueder et al.   Nature Communications

A mitochondrial FUNDC1/HSC70 interaction organizes the proteostatic stress response at the risk of cell morbidity

(2018) Yanjun Li et al.   EMBO JOURNAL

Identification of a novel caspase cleavage site in huntingtin that regulates mutant huntingtin clearance

(2018) Dale D. O. Martin et al.   FASEB JOURNAL

Reactive oxygen species regulate activity-dependent neuronal plasticity in Drosophila

(2018) Matthew CW Oswald et al.   eLife

AAA Proteases: Guardians of Mitochondrial Function and Homeostasis

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The Hsp70–Hsp90 Chaperone Cascade in Protein Folding

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The hunt for better treatments for Huntington's disease

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αβ′-NAC cooperates with Sam37 to mediate early stages of mitochondrial protein import

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Altered Aconitase 2 Activity in Huntington’s Disease Peripheral Blood Cells and Mouse Model Striatum

(2017) Chiung-Mei Chen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mitochondrial Translocase of the Outer Membrane Alterations May Underlie Dysfunctional Oxidative Phosphorylation in Alzheimer’s Disease

(2017) Yuek Ling Chai et al.   JOURNAL OF ALZHEIMERS DISEASE

Regulation of mitochondrial protein import by the nucleotide exchange factors GrpEL1 and GrpEL2 in human cells

(2017) Shubhi Srivastava et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of the human aminopeptidase XPNPEP3 and comparison of itsin vitroactivity with Icp55 orthologs: Insights into diverse cellular processes

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Pathways of cellular proteostasis in aging and disease

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Sideroflexin 3 is an α-synuclein-dependent mitochondrial protein that regulates synaptic morphology

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Lack of appropriate stoichiometry: Strong evidence against an energetically important astrocyte-neuron lactate shuttle in brain

(2017) Gerald A. Dienel   JOURNAL OF NEUROSCIENCE RESEARCH

Comparative Analysis of Mitochondrial N-Termini from Mouse, Human, and Yeast

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Cytosolic proteostasis through importing of misfolded proteins into mitochondria

(2017) Linhao Ruan et al.   NATURE

Structural variation in amyloid-β fibrils from Alzheimer's disease clinical subtypes

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Enhancing mitochondrial proteostasis reduces amyloid-β proteotoxicity

(2017) Vincenzo Sorrentino et al.   NATURE

Pathology of Neurodegenerative Diseases

(2017) Brittany N. Dugger et al.   Cold Spring Harbor Perspectives in Biology

Fibril polymorphism affects immobilized non-amyloid flanking domains of huntingtin exon1 rather than its polyglutamine core

(2017) Hsiang-Kai Lin et al.   Nature Communications

αSynuclein control of mitochondrial homeostasis in human-derived neurons is disrupted by mutations associated with Parkinson’s disease

(2017) Victorio Martin Pozo Devoto et al.   Scientific Reports

Activation of the mitochondrial unfolded protein response promotes longevity and dopamine neuron survival in Parkinson’s disease models

(2017) Jason F. Cooper et al.   Scientific Reports

Role of Tim17 in coupling the import motor to the translocation channel of the mitochondrial presequence translocase

(2017) Keren Demishtein-Zohary et al.   eLife

Cation selectivity of the presequence translocase channel Tim23 is crucial for efficient protein import

(2017) Niels Denkert et al.   eLife

Mitochondria and α-Synuclein: Friends or Foes in the Pathogenesis of Parkinson’s Disease?

(2017) Gaia Faustini et al.   Genes

Mitophagy in Parkinson’s Disease: Pathogenic and Therapeutic Implications

(2017) Fei Gao et al.   Frontiers in Neurology

Cardiolipin mediates membrane and channel interactions of the mitochondrial TIM23 protein import complex receptor Tim50

(2017) Ketan Malhotra et al.   Science Advances

Mitochondria-Targeted Antioxidants Protect Against Amyloid-β Toxicity in Alzheimer's Disease Neurons

(2017) Maria Manczak et al.   JOURNAL OF ALZHEIMERS DISEASE

The pathogenic exon 1 HTT protein is produced by incomplete splicing in Huntington’s disease patients

(2017) Andreas Neueder et al.   Scientific Reports

Central Nervous System LipoproteinsHighlights

(2016) Robert W. Mahley   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Monomeric Aβ1–40 and Aβ1–42 Peptides in Solution Adopt Very Similar Ramachandran Map Distributions That Closely Resemble Random Coil

(2016) Julien Roche et al.   BIOCHEMISTRY

Mitochondrial Protein Synthesis Adapts to Influx of Nuclear-Encoded Protein

(2016) Ricarda Richter-Dennerlein et al.   CELL

Neuroendocrine Coordination of Mitochondrial Stress Signaling and Proteostasis

(2016) Kristen M. Berendzen et al.   CELL

Evidence for Mitochondrial UPR Gene Activation in Familial and Sporadic Alzheimer's Disease

(2016) John S. Beck et al.   Current Alzheimer Research

The mitochondrial outer membrane protein MDI promotes local protein synthesis and mtDNA replication

(2016) Yi Zhang et al.   EMBO JOURNAL

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Re-engineering therapeutic antibodies for Alzheimer’s disease as blood-brain barrier penetrating bi-specific antibodies

(2016) William M. Pardridge   EXPERT OPINION ON BIOLOGICAL THERAPY

Mitochondria-targeted molecules MitoQ and SS31 reduce mutant huntingtin-induced mitochondrial toxicity and synaptic damage in Huntington's disease

(2016) Xiangling Yin et al.   HUMAN MOLECULAR GENETICS

Localization and Processing of the Amyloid-β Protein Precursor in Mitochondria-Associated Membranes

(2016) Dolores Del Prete et al.   JOURNAL OF ALZHEIMERS DISEASE

Monomeric Alpha-Synuclein Exerts a Physiological Role on Brain ATP Synthase

(2016) M. H. R. Ludtmann et al.   JOURNAL OF NEUROSCIENCE

APOE genotype and stress response - a mini review

(2016) Janina Dose et al.   Lipids in Health and Disease

Role of Tim17 Transmembrane Regions in Regulating the Architecture of Presequence Translocase and Mitochondrial DNA Stability

(2016) Srujan Kumar Matta et al.   MOLECULAR AND CELLULAR BIOLOGY

Amyloid β-peptides interfere with mitochondrial preprotein import competence by a coaggregation process

(2016) Giovanna Cenini et al.   MOLECULAR BIOLOGY OF THE CELL

Structural disorder of monomeric α-synuclein persists in mammalian cells

(2016) Francois-Xavier Theillet et al.   NATURE

Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents

(2016) Dongryeol Ryu et al.   NATURE MEDICINE

The Biology of Huntingtin

(2016) Frédéric Saudou et al.   NEURON

Mutations associated with familial Parkinson’s disease alter the initiation and amplification steps of α-synuclein aggregation

(2016) Patrick Flagmeier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

α-Synuclein binds to TOM20 and inhibits mitochondrial protein import in Parkinson’s disease

(2016) Roberto Di Maio et al.   Science Translational Medicine

Deregulation of mitochondrial F1FO-ATP synthase via OSCP in Alzheimer’s disease

(2016) Simon J. Beck et al.   Nature Communications

VCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Huntington’s disease

(2016) Xing Guo et al.   Nature Communications

Phosphorylation modifies the molecular stability of β-amyloid deposits

(2016) Nasrollah Rezaei-Ghaleh et al.   Nature Communications

Genetics of β-Amyloid Precursor Protein in Alzheimer's Disease

(2016) Julia TCW et al.   Cold Spring Harbor Perspectives in Medicine

Huntingtin’s spherical solenoid structure enables polyglutamine tract-dependent modulation of its structure and function

(2016) Ravi Vijayvargia et al.   eLife

Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice

(2016) Alessandro Bitto et al.   eLife

Human mitochondrial transcriptional factor A breaks the mitochondria-mediated vicious cycle in Alzheimer’s disease

(2016) Sugako Oka et al.   Scientific Reports

The unfolded protein response in neurodegenerative diseases: a neuropathological perspective

(2015) Wiep Scheper et al.   ACTA NEUROPATHOLOGICA

The Biology of Proteostasis in Aging and Disease

(2015) Johnathan Labbadia et al.   Annual Review of Biochemistry

A presequence-binding groove in Tom70 supports import of Mdl1 into mitochondria

(2015) Jonathan Melin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Defective PITRM1 mitochondrial peptidase is associated with A  amyloidotic neurodegeneration

(2015) D. Brunetti et al.   EMBO Molecular Medicine

ApoE4 upregulates the activity of mitochondria-associated ER membranes

(2015) M. D. Tambini et al.   EMBO REPORTS

Amyloid-β precursor protein: Multiple fragments, numerous transport routes and mechanisms

(2015) Virgil Muresan et al.   EXPERIMENTAL CELL RESEARCH

Potential hippocampal genes and pathways involved in Alzheimer’s disease: a bioinformatic analysis

(2015) L. Zhang et al.   GENETICS AND MOLECULAR RESEARCH

Mitochondrial division inhibitor 1 protects against mutant huntingtin-induced abnormal mitochondrial dynamics and neuronal damage in Huntington's disease

(2015) Maria Manczak et al.   HUMAN MOLECULAR GENETICS

Increased neuronal PreP activity reduces Aβ accumulation, attenuates neuroinflammation and improves mitochondrial and synaptic function in Alzheimer disease's mouse model

(2015) Du Fang et al.   HUMAN MOLECULAR GENETICS

Effects of Serine 129 Phosphorylation on α-Synuclein Aggregation, Membrane Association, and Internalization

(2015) Filsy Samuel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cardiolipin and Its Different Properties in Mitophagy and Apoptosis

(2015) Xiao-Xiao Li et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Cooperation of TOM and TIM23 Complexes during Translocation of Proteins into Mitochondria

(2015) Karin Waegemann et al.   JOURNAL OF MOLECULAR BIOLOGY

A new role for α-synuclein in Parkinson's disease: Alteration of ER-mitochondrial communication

(2015) Cristina Guardia-Laguarta et al.   MOVEMENT DISORDERS

Structure of the toxic core of α-synuclein from invisible crystals

(2015) Jose A. Rodriguez et al.   NATURE

A cytosolic network suppressing mitochondria-mediated proteostatic stress and cell death

(2015) Xiaowen Wang et al.   NATURE

Mistargeted mitochondrial proteins activate a proteostatic response in the cytosol

(2015) Lidia Wrobel et al.   NATURE

The case for rejecting the amyloid cascade hypothesis

(2015) Karl Herrup   NATURE NEUROSCIENCE

Crystal structure of the human mitochondrial chaperonin symmetrical football complex

(2015) Shahar Nisemblat et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular architecture of the active mitochondrial protein gate

(2015) T. Shiota et al.   SCIENCE

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(2015) G. Elif Karagöz et al.   TRENDS IN BIOCHEMICAL SCIENCES

PINK1-induced mitophagy promotes neuroprotection in Huntington’s disease

(2015) B Khalil et al.   Cell Death & Disease

The Synaptic Function of α-Synuclein

(2015) Jacqueline Burré   Journal of Parkinsons Disease

The similarity between N-terminal targeting signals for protein import into different organelles and its evolutionary relevance

(2015) Markus Kunze et al.   Frontiers in Physiology

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(2014) Michael W. Woellhaf et al.   Biochemistry and Cell Biology

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(2014) Catarina Moreira Pinho et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Amyloid-β Peptide Induces Mitochondrial Dysfunction by Inhibition of Preprotein Maturation

(2014) Dirk Mossmann et al.   Cell Metabolism

DNAJC19, a Mitochondrial Cochaperone Associated with Cardiomyopathy, Forms a Complex with Prohibitins to Regulate Cardiolipin Remodeling

(2014) Ricarda Richter-Dennerlein et al.   Cell Metabolism

Alpha-Synuclein Binds to the Inner Membrane of Mitochondria in an α-Helical Conformation

(2014) Marta Robotta et al.   CHEMBIOCHEM

Identification of human presequence protease (hPreP) agonists for the treatment of Alzheimer's disease

(2014) Jhansi Rani Vangavaragu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The mitochondrial unfolded protein response and increased longevity: Cause, consequence, or correlation?

(2014) Christopher F. Bennett et al.   EXPERIMENTAL GERONTOLOGY

Insulin and IGF-1 improve mitochondrial function in a PI-3K/Akt-dependent manner and reduce mitochondrial generation of reactive oxygen species in Huntington’s disease knock-in striatal cells

(2014) Márcio Ribeiro et al.   FREE RADICAL BIOLOGY AND MEDICINE

Comparative study of naturally occurring huntingtin fragments in Drosophila points to exon 1 as the most pathogenic species in Huntington's disease

(2014) Brett A. Barbaro et al.   HUMAN MOLECULAR GENETICS

 -Synuclein Is Localized to Mitochondria-Associated ER Membranes

(2014) C. Guardia-Laguarta et al.   JOURNAL OF NEUROSCIENCE

Amyloid Precursor Protein Dimerization and Synaptogenic Function Depend on Copper Binding to the Growth Factor-Like Domain

(2014) F. Baumkotter et al.   JOURNAL OF NEUROSCIENCE

The Regulation of Autophagosome Dynamics by Huntingtin and HAP1 Is Disrupted by Expression of Mutant Huntingtin, Leading to Defective Cargo Degradation

(2014) Y. C. Wong et al.   JOURNAL OF NEUROSCIENCE

Unraveling the Intricate Organization of Mammalian Mitochondrial Presequence Translocases: Existence of Multiple Translocases for Maintenance of Mitochondrial Function

(2014) D. Sinha et al.   MOLECULAR AND CELLULAR BIOLOGY

Mgr2 Functions as Lateral Gatekeeper for Preprotein Sorting in the Mitochondrial Inner Membrane

(2014) Raffaele Ieva et al.   MOLECULAR CELL

Activation of IGF-1 and Insulin Signaling Pathways Ameliorate Mitochondrial Function and Energy Metabolism in Huntington’s Disease Human Lymphoblasts

(2014) Luana Naia et al.   MOLECULAR NEUROBIOLOGY

Inhibition of mitochondrial protein import by mutant huntingtin

(2014) Hiroko Yano et al.   NATURE NEUROSCIENCE

Apolipoprotein E: Structure and function in lipid metabolism, neurobiology, and Alzheimer's diseases

(2014) Yadong Huang et al.   NEUROBIOLOGY OF DISEASE

Activation of mitochondrial protease OMA1 by Bax and Bak promotes cytochrome c release during apoptosis

(2014) X. Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A brief overview of amyloids and Alzheimer's disease

(2014) Sian-Yang Ow et al.   PROTEIN SCIENCE

Targeting and plasticity of mitochondrial proteins revealed by proximity-specific ribosome profiling

(2014) C. C. Williams et al.   SCIENCE

Molecular Basis of the Dynamic Structure of the TIM23 Complex in the Mitochondrial Intermembrane Space

(2014) Rakhi Bajaj et al.   STRUCTURE

Visualizing active membrane protein complexes by electron cryotomography

(2014) Vicki A.M. Gold et al.   Nature Communications

OM14 is a mitochondrial receptor for cytosolic ribosomes that supports co-translational import into mitochondria

(2014) Chen Lesnik et al.   Nature Communications

Targeting the proper amyloid-beta neuronal toxins: a path forward for Alzheimer’s disease immunotherapeutics

(2014) William F Goure et al.   Alzheimers Research & Therapy

Voltage-dependent anion channel involved in the α-synuclein-induced dopaminergic neuron toxicity in rats

(2013) Lingling Lu et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Signal Recognition Particle: An Essential Protein-Targeting Machine

(2013) David Akopian et al.   Annual Review of Biochemistry

The Alzheimer's disease mitochondrial cascade hypothesis: Progress and perspectives

(2013) Russell H. Swerdlow et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Structure and Topology of the Huntingtin 1–17 Membrane Anchor by a Combined Solution and Solid-State NMR Approach

(2013) Matthias Michalek et al.   BIOPHYSICAL JOURNAL

First-in-class cardiolipin-protective compound as a therapeutic agent to restore mitochondrial bioenergetics

(2013) Hazel H Szeto   BRITISH JOURNAL OF PHARMACOLOGY

The Disulfide Relay of the Intermembrane Space Oxidizes the Ribosomal Subunit Mrp10 on Its Transit into the Mitochondrial Matrix

(2013) Sebastian Longen et al.   DEVELOPMENTAL CELL

Signal recognition initiates reorganization of the presequence translocase during protein import

(2013) Oleksandr Lytovchenko et al.   EMBO JOURNAL

Structural and stability studies of the human mtHsp70-escort protein 1: An essential mortalin co-chaperone

(2013) P.R. Dores-Silva et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

α-Synuclein Senses Lipid Packing Defects and Induces Lateral Expansion of Lipids Leading to Membrane Remodeling

(2013) Myriam M. Ouberai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial respiratory chain complex activity and bioenergetic alterations in human platelets derived from pre-symptomatic and symptomatic Huntington's disease carriers

(2013) Ana C. Silva et al.   MITOCHONDRION

The Role of Djp1 in Import of the Mitochondrial Protein Mim1 Demonstrates Specificity between a Cochaperone and Its Substrate Protein

(2013) D. Papic et al.   MOLECULAR AND CELLULAR BIOLOGY

Structural changes in the mitochondrial Tim23 channel are coupled to the proton-motive force

(2013) Ketan Malhotra et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Function of α-Synuclein

(2013) Jacob T. Bendor et al.   NEURON

TOM40 Mediates Mitochondrial Dysfunction Induced by α-Synuclein Accumulation in Parkinson’s Disease

(2013) Andreas Bender et al.   PLoS One

Neuronal Ca2+dyshomeostasis in Huntington disease

(2013) Marta Giacomello et al.   Prion

Aberrant splicing of HTT generates the pathogenic exon 1 protein in Huntington disease

(2013) K. Sathasivam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The neurotrophic compound J147 reverses cognitive impairment in aged Alzheimer's disease mice

(2013) Marguerite Prior et al.   Alzheimers Research & Therapy

 -Synuclein in Parkinson's Disease

(2013) L. Stefanis   Cold Spring Harbor Perspectives in Medicine

Genetics of Parkinson's Disease

(2013) C. Klein et al.   Cold Spring Harbor Perspectives in Medicine

Comparative and meta-analytic insights into life extension via dietary restriction

(2012) Shinichi Nakagawa et al.   AGING CELL

Quantitative proteomic analysis of induced pluripotent stem cells derived from a human Huntington's disease patient

(2012) Jung-Il Chae et al.   BIOCHEMICAL JOURNAL

Processing peptidases in mitochondria and chloroplasts

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MITRAC Links Mitochondrial Protein Translocation to Respiratory-Chain Assembly and Translational Regulation

(2012) David U. Mick et al.   CELL

Huntingtin protein interactions altered by polyglutamine expansion as determined by quantitative proteomic analysis

(2012) Tamara Ratovitski et al.   CELL CYCLE

Upregulated function of mitochondria-associated ER membranes in Alzheimer disease

(2012) Estela Area-Gomez et al.   EMBO JOURNAL

Glutathione redox cycle dysregulation in Huntington’s disease knock-in striatal cells

(2012) Márcio Ribeiro et al.   FREE RADICAL BIOLOGY AND MEDICINE

Abnormal interaction between the mitochondrial fission protein Drp1 and hyperphosphorylated tau in Alzheimer's disease neurons: implications for mitochondrial dysfunction and neuronal damage

(2012) M. Manczak et al.   HUMAN MOLECULAR GENETICS

α-Synuclein Controls Mitochondrial Calcium Homeostasis by Enhancing Endoplasmic Reticulum-Mitochondria Interactions

(2012) Tito Calì et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

α-Synuclein in Central Nervous System and from Erythrocytes, Mammalian Cells, andEscherichia coliExists Predominantly as Disordered Monomer

(2012) Bruno Fauvet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alpha-synuclein impairs normal dynamics of mitochondria in cell and animal models of Parkinson’s disease

(2012) Weilin Xie et al.   JOURNAL OF NEUROCHEMISTRY

Localization of mRNAs encoding human mitochondrial oxidative phosphorylation proteins

(2012) Shinya Matsumoto et al.   MITOCHONDRION

Extracellular signal-regulated kinase is involved in alpha-synuclein-induced mitochondrial dynamic disorders by regulating dynamin-like protein 1

(2012) Ya-Xing Gui et al.   NEUROBIOLOGY OF AGING

Network Organization of the Huntingtin Proteomic Interactome in Mammalian Brain

(2012) Dyna I. Shirasaki et al.   NEURON

Mitochondria-Specific Accumulation of Amyloid β Induces Mitochondrial Dysfunction Leading to Apoptotic Cell Death

(2012) Moon-Yong Cha et al.   PLoS One

Amyloid-β Peptide Binds to Cytochrome C Oxidase Subunit 1

(2012) Luis Fernando Hernandez-Zimbron et al.   PLoS One

Analysis of Proteolytic Processes and Enzymatic Activities in the Generation of Huntingtin N-Terminal Fragments in an HEK293 Cell Model

(2012) Andrew T. N. Tebbenkamp et al.   PLoS One

Structural and Functional Discussion of the Tetra-Trico-Peptide Repeat, a Protein Interaction Module

(2012) Natalie Zeytuni et al.   STRUCTURE

Heterogeneous Amylin Fibril Growth Mechanisms Imaged by Total Internal Reflection Fluorescence Microscopy

(2011) Sharadrao M. Patil et al.   BIOCHEMISTRY

Crystallographic Snapshots of Tom20–Mitochondrial Presequence Interactions with Disulfide-Stabilized Peptides

(2011) Takashi Saitoh et al.   BIOCHEMISTRY

The fusogenic tilted peptide (67–78) of α-synuclein is a cholesterol binding domain

(2011) Jacques Fantini et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Interaction of α-synuclein with vesicles that mimic mitochondrial membranes

(2011) Imola G. Zigoneanu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Biophysics of α-synuclein membrane interactions

(2011) Candace M. Pfefferkorn et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

α-Synuclein misfolding and Parkinson's disease

(2011) Leonid Breydo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Reactivation of protein aggregates by mortalin and Tid1—the human mitochondrial Hsp70 chaperone system

(2011) Ohad Iosefson et al.   CELL STRESS & CHAPERONES

Oxidative stress in synapse development and function

(2011) Valerie J. Milton et al.   Developmental Neurobiology

Exendin-4 increases islet amyloid deposition but offsets the resultant beta cell toxicity in human islet amyloid polypeptide transgenic mouse islets

(2011) K. Aston-Mourney et al.   DIABETOLOGIA

Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage

(2011) Maria Manczak et al.   HUMAN MOLECULAR GENETICS

Impaired mitochondrial biogenesis, defective axonal transport of mitochondria, abnormal mitochondrial dynamics and synaptic degeneration in a mouse model of Alzheimer's disease

(2011) M. J. Calkins et al.   HUMAN MOLECULAR GENETICS

Mutant huntingtin's interaction with mitochondrial protein Drp1 impairs mitochondrial biogenesis and causes defective axonal transport and synaptic degeneration in Huntington's disease

(2011) U. P. Shirendeb et al.   HUMAN MOLECULAR GENETICS

α-Synuclein overexpression impairs mitochondrial function by associating with adenylate translocator

(2011) Yuangang Zhu et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Early Alterations of Brain Cellular Energy Homeostasis in Huntington Disease Models

(2011) Fanny Mochel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Direct Interaction of Mitochondrial Targeting Presequences with Purified Components of the TIM23 Protein Complex

(2011) Milit Marom et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Direct Membrane Association Drives Mitochondrial Fission by the Parkinson Disease-associated Protein α-Synuclein

(2011) Ken Nakamura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tim50’s presequence receptor domain is essential for signal driven transport across the TIM23 complex

(2011) Christian Schulz et al.   JOURNAL OF CELL BIOLOGY

Targeting Capacity and Conservation of PreP Homologues Localization in Mitochondria of Different Species

(2011) Nyosha Alikhani et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural Basis for the Function of Tim50 in the Mitochondrial Presequence Translocase

(2011) Xinguo Qian et al.   JOURNAL OF MOLECULAR BIOLOGY

Soluble Aβ oligomer production and toxicity

(2011) Megan E. Larson et al.   JOURNAL OF NEUROCHEMISTRY

The Aggregation-Enhancing Huntingtin N-Terminus Is Helical in Amyloid Fibrils

(2011) V. N. Sivanandam et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Explaining the Structural Plasticity of α-Synuclein

(2011) Orly Ullman et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mitochondrial protein turnover: role of the precursor intermediate peptidase Oct1 in protein stabilization

(2011) F.-Nora Vögtle et al.   MOLECULAR BIOLOGY OF THE CELL

Biology and pathophysiology of the amyloid precursor protein

(2011) Hui Zheng et al.   Molecular Neurodegeneration

α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation

(2011) Tim Bartels et al.   NATURE

Mutant huntingtin binds the mitochondrial fission GTPase dynamin-related protein-1 and increases its enzymatic activity

(2011) Wenjun Song et al.   NATURE MEDICINE

In vivo protein-interaction mapping of a mitochondrial translocator protein Tom22 at work

(2011) T. Shiota et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A soluble  -synuclein construct forms a dynamic tetramer

(2011) W. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The N-end rule pathway and regulation by proteolysis

(2011) Alexander Varshavsky   PROTEIN SCIENCE

Signal peptidase I: Cleaving the way to mature proteins

(2011) Sarah M. Auclair et al.   PROTEIN SCIENCE

Human apoE Isoforms Differentially Regulate Brain Amyloid-  Peptide Clearance

(2011) J. M. Castellano et al.   Science Translational Medicine

The complexity of cardiolipin in health and disease

(2011) Steven M. Claypool et al.   TRENDS IN BIOCHEMICAL SCIENCES

Aging as an Event of Proteostasis Collapse

(2011) R. C. Taylor et al.   Cold Spring Harbor Perspectives in Biology

The roles of amyloid precursor protein (APP) in neurogenesis

(2011) Zhi-dong Zhou et al.   Cell Adhesion & Migration

Defining the Specificity of Cotranslationally Acting Chaperones by Systematic Analysis of mRNAs Associated with Ribosome-Nascent Chain Complexes

(2011) Marta del Alamo et al.   PLOS BIOLOGY

Understanding the molecular mechanism of protein translocation across the mitochondrial inner membrane: Still a long way to go

(2010) Milit Marom et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The N-Terminus of the Intrinsically Disordered Protein α-Synuclein Triggers Membrane Binding and Helix Folding

(2010) Tim Bartels et al.   BIOPHYSICAL JOURNAL

Effects of Curvature and Composition on α-Synuclein Binding to Lipid Vesicles

(2010) Elizabeth R. Middleton et al.   BIOPHYSICAL JOURNAL

Chaperonin-Catalyzed Rescue of Kinetically Trapped States in Protein Folding

(2010) Kausik Chakraborty et al.   CELL

Iron-Export Ferroxidase Activity of β-Amyloid Precursor Protein Is Inhibited by Zinc in Alzheimer's Disease

(2010) James A. Duce et al.   CELL

The Upside of APP at Synapses

(2010) Hyang-Sook Hoe et al.   CNS Neuroscience & Therapeutics

Medicinal Chemistry of ATP Synthase: A Potential Drug Target of Dietary Polyphenols and Amphibian Antimicrobial Peptides

(2010) Zulfiqar Ahmad et al.   CURRENT MEDICINAL CHEMISTRY

Toxic oligomers and islet beta cell death: guilty by association or convicted by circumstantial evidence?

(2010) S. Zraika et al.   DIABETOLOGIA

Inhibition of mitochondrial fusion by α-synuclein is rescued by PINK1, Parkin and DJ-1

(2010) Frits Kamp et al.   EMBO JOURNAL

Mitochondrial fission and cristae disruption increase the response of cell models of Huntington's disease to apoptotic stimuli

(2010) Veronica Costa et al.   EMBO Molecular Medicine

α-Synuclein induced membrane depolarization and loss of phosphorylation capacity of isolated rat brain mitochondria: Implications in Parkinson's disease

(2010) Kalpita Banerjee et al.   FEBS LETTERS

Role of Magmas in protein transport and human mitochondria biogenesis

(2010) D. Sinha et al.   HUMAN MOLECULAR GENETICS

The interrelationship between mitochondrial dysfunction and transcriptional dysregulation in Huntington disease

(2010) Youngnam N. Jin et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Proteolysis of Mutant Huntingtin Produces an Exon 1 Fragment That Accumulates as an Aggregated Protein in Neuronal Nuclei in Huntington Disease

(2010) Christian Landles et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Understanding the Functional Interplay between Mammalian Mitochondrial Hsp70 Chaperone Machine Components

(2010) Arvind Vittal Goswami et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Transcriptionally Active Amyloid Precursor Protein (APP) Intracellular Domain Is Preferentially Produced from the 695 Isoform of APP in a β-Secretase-dependent Pathway

(2010) Nikolai D. Belyaev et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Review Article: Genetics of Alzheimer Disease

(2010) Lynn M. Bekris et al.   JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY

LILBID-mass spectrometry of the mitochondrial preprotein translocase TOM

(2010) Frauke Mager et al.   JOURNAL OF PHYSICS-CONDENSED MATTER

A Combinatorial NMR and EPR Approach for Evaluating the Structural Ensemble of Partially Folded Proteins

(2010) Jampani Nageswara Rao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The role of parkin in familial and sporadic Parkinson's disease

(2010) Ted M. Dawson et al.   MOVEMENT DISORDERS

The HSP70 chaperone machinery: J proteins as drivers of functional specificity

(2010) Harm H. Kampinga et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanism of amyloid plaque formation suggests an intracellular basis of A  pathogenicity

(2010) R. P. Friedrich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NMR determination of pKa values in α-synuclein

(2010) Robyn L. Croke et al.   PROTEIN SCIENCE

The intermembrane space domain of Tim23 is intrinsically disordered with a distinct binding region for presequences

(2010) Laura de la Cruz et al.   PROTEIN SCIENCE

Genetic variation in the murine lifespan response to dietary restriction: from life extension to life shortening

(2009) Chen-Yu Liao et al.   AGING CELL

Presenilins Are Enriched in Endoplasmic Reticulum Membranes Associated with Mitochondria

(2009) Estela Area-Gomez et al.   AMERICAN JOURNAL OF PATHOLOGY

Evidence for Proteotoxicity in β Cells in Type 2 Diabetes

(2009) Tatyana Gurlo et al.   AMERICAN JOURNAL OF PATHOLOGY

Mitochondria Targeted Peptides Protect Against 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Neurotoxicity

(2009) Lichuan Yang et al.   ANTIOXIDANTS & REDOX SIGNALING

PGC-1α Expression Decreases in the Alzheimer Disease Brain as a Function of Dementia

(2009) Weiping Qin et al.   ARCHIVES OF NEUROLOGY

Differential Phospholipid Binding of α-Synuclein Variants Implicated in Parkinson’s Disease Revealed by Solution NMR Spectroscopy

(2009) Christina R. Bodner et al.   BIOCHEMISTRY

Mitochondrial trafficking of APP and alpha synuclein: Relevance to mitochondrial dysfunction in Alzheimer's and Parkinson's diseases

(2009) Latha Devi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Mitochondrial ATP-Synthase in the Entorhinal Cortex Is a Target of Oxidative Stress at Stages I/II of Alzheimer's Disease Pathology

(2009) Beatrice Terni et al.   BRAIN PATHOLOGY

Global Analysis of the Mitochondrial N-Proteome Identifies a Processing Peptidase Critical for Protein Stability

(2009) F.-Nora Vögtle et al.   CELL

Amyloid precursor protein and its homologues: a family of proteolysis-dependent receptors

(2009) Kristin T. Jacobsen et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Membrane permeabilization by Islet Amyloid Polypeptide

(2009) Maarten F.M. Engel   CHEMISTRY AND PHYSICS OF LIPIDS

The Mitochondrial Protein Translocation Motor: Structural Conservation between the Human and Yeast Tim14/Pam18-Tim16/Pam16 co-Chaperones

(2009) Shira Elsner et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Parkinson’s disease and mitochondrial complex I: a perspective on the Ndi1 therapy

(2009) Mathieu Marella et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Roles of Tom70 in Import of Presequence-containing Mitochondrial Proteins

(2009) Hayashi Yamamoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tim23–Tim50 pair coordinates functions of translocators and motor proteins in mitochondrial protein import

(2009) Yasushi Tamura et al.   JOURNAL OF CELL BIOLOGY

Altered cholesterol and fatty acid metabolism in Huntington disease

(2009) Robert C. Block et al.   Journal of Clinical Lipidology

Impaired Balance of Mitochondrial Fission and Fusion in Alzheimer's Disease

(2009) X. Wang et al.   JOURNAL OF NEUROSCIENCE

Distinct Forms of Mitochondrial TOM-TIM Supercomplexes Define Signal-Dependent States of Preprotein Sorting

(2009) A. Chacinska et al.   MOLECULAR AND CELLULAR BIOLOGY

Role of Tim50 in the Transfer of Precursor Proteins from the Outer to the Inner Membrane of Mitochondria

(2009) Dejana Mokranjac et al.   MOLECULAR BIOLOGY OF THE CELL

The chaperonin TRiC blocks a huntingtin sequence element that promotes the conformational switch to aggregation

(2009) Stephen Tam et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Polyglutamine disruption of the huntingtin exon 1 N terminus triggers a complex aggregation mechanism

(2009) Ashwani K Thakur et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

An Overview of APP Processing Enzymes and Products

(2009) Vivian W. Chow et al.   NEUROMOLECULAR MEDICINE

Calcium hypothesis of Alzheimer’s disease

(2009) Michael J. Berridge   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

A TOMM40 variable-length polymorphism predicts the age of late-onset Alzheimer's disease

(2009) A D Roses et al.   PHARMACOGENOMICS JOURNAL

Structural characterization of α-synuclein in an aggregation prone state

(2009) Min-Kyu Cho et al.   PROTEIN SCIENCE

Secondary Structure of Huntingtin Amino-Terminal Region

(2009) Mee Whi Kim et al.   STRUCTURE

HELIQUEST: a web server to screen sequences with specific  -helical properties

(2008) R. Gautier et al.   BIOINFORMATICS

APOE ε4 lowers age at onset and is a high risk factor for Alzheimer's disease; A case control study from central Norway

(2008) Sigrid B Sando et al.   BMC Neurology

Semi-quantitative analysis of α-synuclein in subcellular pools of rat brain neurons: An immunogold electron microscopic study using a C-terminal specific monoclonal antibody

(2008) Ling Zhang et al.   BRAIN RESEARCH

Fluorescence Mapping of Mitochondrial TIM23 Complex Reveals a Water-Facing, Substrate-Interacting Helix Surface

(2008) Nathan N. Alder et al.   CELL

The mitochondrial serine protease HtrA2/Omi: an overview

(2008) L Vande Walle et al.   CELL DEATH AND DIFFERENTIATION

Active remodelling of the TIM23 complex during translocation of preproteins into mitochondria

(2008) Du\[sbreve]an Popov-Čeleketić et al.   EMBO JOURNAL

Mitochondrial translocation of α-synuclein is promoted by intracellular acidification

(2008) Nelson B. Cole et al.   EXPERIMENTAL CELL RESEARCH

Proteomic and oxidative stress analysis in human brain samples of Huntington disease

(2008) M Alba Sorolla et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Human Escort Protein Hep Binds to the ATPase Domain of Mitochondrial Hsp70 and Regulates ATP Hydrolysis

(2008) Peng Zhai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interaction of Tim23 with Tim50 Is Essential for Protein Translocation by the Mitochondrial TIM23 Complex

(2008) Lada Gevorkyan-Airapetov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial Import and Accumulation of α-Synuclein Impair Complex I in Human Dopaminergic Neuronal Cultures and Parkinson Disease Brain

(2008) Latha Devi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Efficient mitochondrial targeting relies on co-operation of multiple protein signals in plants

(2008) Laurent Chatre et al.   JOURNAL OF EXPERIMENTAL BOTANY

Cryo-Electron Microscopy Structure of a Yeast Mitochondrial Preprotein Translocase

(2008) Kirstin Model et al.   JOURNAL OF MOLECULAR BIOLOGY

N-Terminal Mutant Huntingtin Associates with Mitochondria and Impairs Mitochondrial Trafficking

(2008) A. L. Orr et al.   JOURNAL OF NEUROSCIENCE

Optical Reporters for the Conformation of  -Synuclein Reveal a Specific Interaction with Mitochondria

(2008) K. Nakamura et al.   JOURNAL OF NEUROSCIENCE

Inhibitors of Cytochrome c Release with Therapeutic Potential for Huntington's Disease

(2008) X. Wang et al.   JOURNAL OF NEUROSCIENCE

Membrane-Bound α-Synuclein Forms an Extended Helix: Long-Distance Pulsed ESR Measurements Using Vesicles, Bicelles, and Rodlike Micelles

(2008) Elka R. Georgieva et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Proteomics Analysis Identifies Phosphorylation-dependent α-Synuclein Protein Interactions

(2008) Melinda A. McFarland et al.   MOLECULAR & CELLULAR PROTEOMICS

Bimodal Protein Targeting through Activation of Cryptic Mitochondrial Targeting Signals by an Inducible Cytosolic Endoprotease

(2008) Ettickan Boopathi et al.   MOLECULAR CELL

Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease

(2008) Heng Du et al.   NATURE MEDICINE

Chaperonin chamber accelerates protein folding through passive action of preventing aggregation

(2008) A. C. Apetri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alzheimer's disease is associated with reduced expression of energy metabolism genes in posterior cingulate neurons

(2008) W. S. Liang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of membrane-bound  -synuclein from site-directed spin labeling and computational refinement

(2008) C. C. Jao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid-  overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins

(2008) X. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The amyloid  -peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristae

(2008) C. A. Hansson Petersen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hydrogen exchange of monomeric α-synuclein shows unfolded structure persists at physiological temperature and is independent of molecular crowding inEscherichia coli

(2008) Robyn L. Croke et al.   PROTEIN SCIENCE

Mutant huntingtin and mitochondrial dysfunction

(2008) Ella Bossy-Wetzel et al.   TRENDS IN NEUROSCIENCES

α-Synuclein Selectively Binds to Anionic Phospholipids Embedded in Liquid-Disordered Domains

(2007) Martin Stöckl et al.   JOURNAL OF MOLECULAR BIOLOGY

Quaternary Structure of the Mitochondrial TIM23 Complex Reveals Dynamic Association between Tim23p and Other Subunits

(2007) Nathan N. Alder et al.   MOLECULAR BIOLOGY OF THE CELL

Amyloid accomplices and enforcers

(2004) Andrei T. Alexandrescu   PROTEIN SCIENCE