Mgr2 regulates mitochondrial preprotein import by associating with channel-forming Tim23 subunit

ROMO1 is a constituent of the human presequence translocase required for YME1L protease import

(2019) Frank Richter et al.   JOURNAL OF CELL BIOLOGY

Mitochondrial proteins: from biogenesis to functional networks

(2019) Nikolaus Pfanner et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Deletion of Mgr2p Affects the Gating Behavior of the TIM23 Complex

(2019) Oygul Mirzalieva et al.   Frontiers in Physiology

A mutagenesis analysis of Tim50, the major receptor of the TIM23 complex, identifies regions that affect its interaction with Tim23

(2019) Dana Dayan et al.   Scientific Reports

Mitochondrial protein transport in health and disease

(2018) Yilin Kang et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Motor recruitment to the TIM23 channel’s lateral gate restricts polypeptide release into the inner membrane

(2018) Alexander Benjamin Schendzielorz et al.   Nature Communications

Reactive oxygen species modulator-1 (Romo1) predicts unfavorable prognosis in colorectal cancer patients

(2017) Hong Jun Kim et al.   PLoS One

Dual interaction of scaffold protein Tim44 of mitochondrial import motor with channel-forming translocase subunit Tim23

(2017) See-Yeun Ting et al.   eLife

Role of Tim17 in coupling the import motor to the translocation channel of the mitochondrial presequence translocase

(2017) Keren Demishtein-Zohary et al.   eLife

Cation selectivity of the presequence translocase channel Tim23 is crucial for efficient protein import

(2017) Niels Denkert et al.   eLife

Evolution of the Tim17 protein family

(2016) Vojtěch Žárský et al.   Biology Direct

Two distinct membrane potential–dependent steps drive mitochondrial matrix protein translocation

(2016) Alexander Benjamin Schendzielorz et al.   JOURNAL OF CELL BIOLOGY

A disulfide bond in the TIM23 complex is crucial for voltage gating and mitochondrial protein import

(2016) Ajay Ramesh et al.   JOURNAL OF CELL BIOLOGY

Role of Tim17 Transmembrane Regions in Regulating the Architecture of Presequence Translocase and Mitochondrial DNA Stability

(2016) Srujan Kumar Matta et al.   MOLECULAR AND CELLULAR BIOLOGY

GxxxG motifs hold the TIM23 complex together

(2015) Keren Demishtein-Zohary et al.   FEBS Journal

Reactive oxygen species modulator 1 (Romo1) overexpression is an independent predictor of poor survival in NSCLC patients who undergo surgical resection

(2015) Seung Hyeun Lee et al.   LUNG CANCER

Unlocking the presequence import pathway

(2015) Christian Schulz et al.   TRENDS IN CELL BIOLOGY

Protein translocation channel of mitochondrial inner membrane and matrix-exposed import motor communicate via two-domain coupling protein

(2015) Rupa Banerjee et al.   eLife

The structure of Tim50(164–361) suggests the mechanism by which Tim50 receives mitochondrial presequences

(2015) Jingzhi Li et al.   Acta Crystallographica Section F-Structural Biology Communications

Mgr2 Functions as Lateral Gatekeeper for Preprotein Sorting in the Mitochondrial Inner Membrane

(2014) Raffaele Ieva et al.   MOLECULAR CELL

ROMO1 Is an Essential Redox-Dependent Regulator of Mitochondrial Dynamics

(2014) M. Norton et al.   Science Signaling

Molecular Basis of the Dynamic Structure of the TIM23 Complex in the Mitochondrial Intermembrane Space

(2014) Rakhi Bajaj et al.   STRUCTURE

ROMO1 links oxidative stress to mitochondrial integrity

(2014) Sri Swarnabala et al.   Journal of Cell Communication and Signaling

Romo1 expression contributes to oxidative stress-induced death of lung epithelial cells

(2013) Jung Ar Shin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Disturbance of DKK1 level is partly involved in survival of lung cancer cells via regulation of ROMO1 and γ-radiation sensitivity

(2013) In Gyu Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Molecular Insights Revealing Interaction of Tim23 and Channel Subunits of Presequence Translocase

(2013) G. Pareek et al.   MOLECULAR AND CELLULAR BIOLOGY

Overexpression of Romo1 Promotes Production of Reactive Oxygen Species and Invasiveness of Hepatic Tumor Cells

(2012) Jin Sil Chung et al.   GASTROENTEROLOGY

Mgr2 promotes coupling of the mitochondrial presequence translocase to partner complexes

(2012) Michael Gebert et al.   JOURNAL OF CELL BIOLOGY

Direct Interaction of Mitochondrial Targeting Presequences with Purified Components of the TIM23 Protein Complex

(2011) Milit Marom et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

On the mechanism of preprotein import by the mitochondrial presequence translocase

(2010) Martin van der Laan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mitochondrial protein import: from proteomics to functional mechanisms

(2010) Oliver Schmidt et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The intermembrane space domain of Tim23 is intrinsically disordered with a distinct binding region for presequences

(2010) Laura de la Cruz et al.   PROTEIN SCIENCE

Importing Mitochondrial Proteins: Machineries and Mechanisms

(2009) Agnieszka Chacinska et al.   CELL

Pam17 and Tim44 act sequentially in protein import into the mitochondrial matrix

(2009) Dirk Schiller   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Tim23–Tim50 pair coordinates functions of translocators and motor proteins in mitochondrial protein import

(2009) Yasushi Tamura et al.   JOURNAL OF CELL BIOLOGY

A critical role for Romo1-derived ROS in cell proliferation

(2008) Ah Ram Na et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Fluorescence Mapping of Mitochondrial TIM23 Complex Reveals a Water-Facing, Substrate-Interacting Helix Surface

(2008) Nathan N. Alder et al.   CELL

Replicative Senescence Induced by Romo1-derived Reactive Oxygen Species

(2008) Young Min Chung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interaction of the J-Protein Heterodimer Pam18/Pam16 of the Mitochondrial Import Motor with the Translocon of the Inner Membrane

(2007) Patrick R. D'Silva et al.   MOLECULAR BIOLOGY OF THE CELL