Diverse Functions of Tim50, a Component of the Mitochondrial Inner Membrane Protein Translocase

Barth syndrome: cardiolipin, cellular pathophysiology, management, and novel therapeutic targets

(2021) Hana M. Zegallai et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Mitochondrial Ion Channels of the Inner Membrane and Their Regulation in Cell Death Signaling

(2021) Andrea Urbani et al.   Frontiers in Cell and Developmental Biology

Building Better Barrels – β-barrel Biogenesis and Insertion in Bacteria and Mitochondria

(2021) Kathryn A. Diederichs et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural and molecular mechanisms for membrane protein biogenesis by the Oxa1 superfamily

(2021) Melanie A. McDowell et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The mitochondrial intermembrane space: the most constricted mitochondrial sub-compartment with the largest variety of protein import pathways

(2021) Ruairidh Edwards et al.   Open Biology

Carbohydrate metabolism in trypanosomatids: New insights revealing novel complexity, diversity and species-unique features

(2021) Paul A.M. Michels et al.   EXPERIMENTAL PARASITOLOGY

A Leap Into the Unknown – Early Events in African Trypanosome Transmission

(2020) Balázs Szöőr et al.   TRENDS IN PARASITOLOGY

Transmembrane Coordination of Preprotein Recognition and Motor Coupling by the Mitochondrial Presequence Receptor Tim50

(2020) Anne Caumont-Sarcos et al.   Cell Reports

Complete resolution of epileptic spasms with vigabatrin in a patient with 3‐methylglutaconic aciduria caused by TIMM50 gene mutation

(2020) Ali Mir et al.   CLINICAL GENETICS

In Vivo Dissection of the Intrinsically Disordered Receptor Domain of Tim23

(2020) Umut Günsel et al.   JOURNAL OF MOLECULAR BIOLOGY

Mgr2 regulates mitochondrial preprotein import by associating with channel-forming Tim23 subunit

(2020) Srujan Kumar Matta et al.   MOLECULAR BIOLOGY OF THE CELL

Targeting the C-Terminal Domain Small Phosphatase 1

(2020) Harikrishna Reddy Rallabandi et al.   Life-Basel

Mitochondria Are Fundamental for the Emergence of Metazoans: On Metabolism, Genomic Regulation, and the Birth of Complex Organisms

(2020) Hadar Medini et al.   Annual Review of Genetics

Novel IM‐associated protein Tim54 plays a role in the mitochondrial import of internal signal‐containing proteins in Trypanosoma brucei

(2020) Ujjal K Singha et al.   BIOLOGY OF THE CELL

Mitochondrial pathways in human health and aging

(2020) Rebecca Bornstein et al.   MITOCHONDRION

Mitochondrial respiratory supercomplexes in mammalian cells: structural versus functional role

(2020) Sabzali Javadov et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Evolving Differentiation in African Trypanosomes

(2020) Juan F. Quintana et al.   TRENDS IN PARASITOLOGY

The Interplay among Subunit Composition, Cardiolipin Content, and Aggregation State of Bovine Heart Cytochrome c Oxidase

(2020) Erik Sedlák et al.   Cells

Tim17 Updates: A Comprehensive Review of an Ancient Mitochondrial Protein Translocator

(2020) Minu Chaudhuri et al.   Biomolecules

TIMM50 promotes tumor progression via ERK signaling and predicts poor prognosis of non-small cell lung cancer patients

(2019) Xiupeng Zhang et al.   MOLECULAR CARCINOGENESIS

A mutagenesis analysis of Tim50, the major receptor of the TIM23 complex, identifies regions that affect its interaction with Tim23

(2019) Dana Dayan et al.   Scientific Reports

Mutations in TIMM50 cause severe mitochondrial dysfunction by targeting key aspects of mitochondrial physiology

(2019) Frederic Tort et al.   HUMAN MUTATION

Positional Dynamics and Glycosomal Recruitment of Developmental Regulators during Trypanosome Differentiation

(2019) Balázs Szöőr et al.   mBio

Pptc7 is an essential phosphatase for promoting mammalian mitochondrial metabolism and biogenesis

(2019) Natalie M. Niemi et al.   Nature Communications

The Cross Talk between TbTim50 and PIP39, Two Aspartate-Based Protein Phosphatases, Maintains Cellular Homeostasis in Trypanosoma brucei

(2019) Anuj Tripathi et al.   mSphere

Mitochondrial dysfunction, AMPK activation and peroxisomal metabolism: A coherent scenario for non-canonical 3-methylglutaconic acidurias

(2019) Joseph Vamecq et al.   BIOCHIMIE

Dullard deficiency causes hemorrhage in the adult ovarian follicles

(2018) Tadayoshi Hayata et al.   GENES TO CELLS

Fe–S cluster assembly in the supergroup Excavata

(2018) Priscila Peña-Diaz et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

TbLpn, a key enzyme in lipid droplet formation and phospholipid metabolism, is essential for mitochondrial integrity and growth of Trypanosoma brucei

(2018) Ladan Dawoody Nejad et al.   MOLECULAR MICROBIOLOGY

Divergent Small Tim Homologues Are Associated with TbTim17 and Critical for the Biogenesis of TbTim17 Protein Complexes in Trypanosoma brucei

(2018) Joseph T. Smith et al.   mSphere

The role of mitochondrial cardiolipin in heart function and its implication in cardiac disease

(2018) Jan Dudek et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Mutations in TIMM50 compromise cell survival in OxPhos‐dependent metabolic conditions

(2018) Aurelio Reyes et al.   EMBO Molecular Medicine

Structural Basis of Membrane Protein Chaperoning through the Mitochondrial Intermembrane Space

(2018) Katharina Weinhäupl et al.   CELL

Inner Mitochondrial Translocase Tim50 Is Central in Adrenal and Testicular Steroid Synthesis

(2018) Himangshu S. Bose et al.   MOLECULAR AND CELLULAR BIOLOGY

Proteomics of human mitochondria

(2017) Johan Palmfeldt et al.   MITOCHONDRION

The proteome of higher plant mitochondria

(2017) R.S.P. Rao et al.   MITOCHONDRION

Mitochondrial protein import in trypanosomes: Expect the unexpected

(2017) Anke Harsman et al.   TRAFFIC

Phosphatase UBLCP1 controls proteasome assembly

(2017) Shuangwu Sun et al.   Open Biology

A trypanosomal orthologue of an intermembrane space chaperone has a non-canonical function in biogenesis of the single mitochondrial inner membrane protein translocase

(2017) Christoph Wenger et al.   PLoS Pathogens

Translocase of Inner Membrane 50 Functions as a Novel Protective Regulator of Pathological Cardiac Hypertrophy

(2017) Kai Tang et al.   Journal of the American Heart Association

Cardiolipin mediates membrane and channel interactions of the mitochondrial TIM23 protein import complex receptor Tim50

(2017) Ketan Malhotra et al.   Science Advances

Targeting pathogen metabolism without collateral damage to the host

(2017) Jurgen R. Haanstra et al.   Scientific Reports

Mitochondrial epileptic encephalopathy, 3-methylglutaconic aciduria and variable complex V deficiency associated withTIMM50mutations

(2016) M.A. Shahrour et al.   CLINICAL GENETICS

Cajal bodies and snRNPs - friends with benefits

(2016) David Staněk   RNA Biology

The non-canonical mitochondrial inner membrane presequence translocase of trypanosomatids contains two essential rhomboid-like proteins

(2016) Anke Harsman et al.   Nature Communications

Functional Complementation Analyses Reveal that the Single PRAT Family Protein of Trypanosoma brucei Is a Divergent Homolog of Tim17 in Saccharomyces cerevisiae

(2015) Ebony Weems et al.   EUKARYOTIC CELL

Tim62, a Novel Mitochondrial Protein inTrypanosoma brucei, Is Essential for Assembly and Stability of the TbTim17 Protein Complex

(2015) Ujjal K. Singha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cooperation of TOM and TIM23 Complexes during Translocation of Proteins into Mitochondria

(2015) Karin Waegemann et al.   JOURNAL OF MOLECULAR BIOLOGY

Regulation of human 3-beta-hydroxysteroid dehydrogenase type-2 (3βHSD2) by molecular chaperones and the mitochondrial environment affects steroidogenesis

(2015) James L. Thomas et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Down regulation of Tim50 in Trypanosoma brucei increases tolerance to oxidative stress

(2015) Marjorie Fullerton et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Loss of TIM50 suppresses proliferation and induces apoptosis in breast cancer

(2015) Shui-Ping Gao et al.   TUMOR BIOLOGY

The structure of Tim50(164–361) suggests the mechanism by which Tim50 receives mitochondrial presequences

(2015) Jingzhi Li et al.   Acta Crystallographica Section F-Structural Biology Communications

Architecture of the TIM23 Inner Mitochondrial Translocon and Interactions with the Matrix Import Motor

(2014) See-Yeun Ting et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Barth syndrome: Cellular compensation of mitochondrial dysfunction and apoptosis inhibition due to changes in cardiolipin remodeling linked to tafazzin (TAZ) gene mutation

(2013) François Gonzalvez et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Signal recognition initiates reorganization of the presequence translocase during protein import

(2013) Oleksandr Lytovchenko et al.   EMBO JOURNAL

Single point mutations in ATP synthase compensate for mitochondrial genome loss in trypanosomes

(2013) Samuel Dean et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lack of the Mitochondrial Protein Acylglycerol Kinase Causes Sengers Syndrome

(2012) Johannes A. Mayr et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Network News: The Replication of Kinetoplast DNA

(2012) Robert E. Jensen et al.   Annual Review of Microbiology

Human HAD phosphatases: structure, mechanism, and roles in health and disease

(2012) Annegrit Seifried et al.   FEBS Journal

Genetic Analysis of Complex Interactions Among Components of the Mitochondrial Import Motor and Translocon in Saccharomyces cerevisiae

(2012) B. A. Schilke et al.   GENETICS

Protein Translocase of Mitochondrial Inner Membrane inTrypanosoma brucei

(2012) Ujjal K. Singha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tim50 inTrypanosoma bruceiPossesses a Dual Specificity Phosphatase Activity and Is Critical for Mitochondrial Protein Import

(2012) Melanie R. Duncan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bacterial Origin of a Mitochondrial Outer Membrane Protein Translocase

(2012) Anke Harsman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Upregulation of the mitochondrial transport protein, Tim50, by mutant p53 contributes to cell growth and chemoresistance

(2011) Heidi Sankala et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Mitochondrial Preprotein Translocase of Trypanosomatids Has a Bacterial Origin

(2011) Mascha Pusnik et al.   CURRENT BIOLOGY

The Molecular Biology, Biochemistry, and Physiology of Human Steroidogenesis and Its Disorders

(2011) Walter L. Miller et al.   ENDOCRINE REVIEWS

Inner Mitochondrial Translocase Tim50 Interacts with 3β-Hydroxysteroid Dehydrogenase Type 2 to Regulate Adrenal and Gonadal Steroidogenesis

(2011) Kevin J. Pawlak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Early steps in steroidogenesis: intracellular cholesterol trafficking

(2011) Walter L. Miller et al.   JOURNAL OF LIPID RESEARCH

Structural Basis for the Function of Tim50 in the Mitochondrial Presequence Translocase

(2011) Xinguo Qian et al.   JOURNAL OF MOLECULAR BIOLOGY

Arabidopsis mitochondrial protein TIM50 affects hypocotyl cell elongation through intracellular ATP level

(2011) Shailesh Kumar et al.   PLANT SCIENCE

The Core Components of Organelle Biogenesis and Membrane Transport in the Hydrogenosomes of Trichomonas vaginalis

(2011) Petr Rada et al.   PLoS One

Expression and structural characterization of human translocase of inner membrane of mitochondria Tim50

(2011) Yongqiang Zhang et al.   PROTEIN EXPRESSION AND PURIFICATION

On the mechanism of preprotein import by the mitochondrial presequence translocase

(2010) Martin van der Laan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mitochondrial protein import: from proteomics to functional mechanisms

(2010) Oliver Schmidt et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Trypanosoma brucei MitoCarta and its regulation and splicing pattern during development

(2010) Xiaobai Zhang et al.   NUCLEIC ACIDS RESEARCH

A spectrum of disease in Human African trypanosomiasis: the host and parasite genetics of virulence

(2010) JEREMY M. STERNBERG et al.   PARASITOLOGY

The Essentials of Protein Import in the Degenerate Mitochondrion of Entamoeba histolytica

(2010) Pavel Dolezal et al.   PLoS Pathogens

Cardiolipin, a critical determinant of mitochondrial carrier protein assembly and function

(2009) Steven M. Claypool   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Tim23–Tim50 pair coordinates functions of translocators and motor proteins in mitochondrial protein import

(2009) Yasushi Tamura et al.   JOURNAL OF CELL BIOLOGY

Role of Tim50 in the Transfer of Precursor Proteins from the Outer to the Inner Membrane of Mitochondria

(2009) Dejana Mokranjac et al.   MOLECULAR BIOLOGY OF THE CELL

Protein composition of Trypanosoma brucei mitochondrial membranes

(2009) Nathalie Acestor et al.   PROTEOMICS

Fluorescence Mapping of Mitochondrial TIM23 Complex Reveals a Water-Facing, Substrate-Interacting Helix Surface

(2008) Nathan N. Alder et al.   CELL

Assembly of the three small Tim proteins precedes docking to the mitochondrial carrier translocase

(2008) Natalia Gebert et al.   EMBO REPORTS

Interaction of Tim23 with Tim50 Is Essential for Protein Translocation by the Mitochondrial TIM23 Complex

(2008) Lada Gevorkyan-Airapetov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural and Functional Requirements for Activity of the Tim9–Tim10 Complex in Mitochondrial Protein Import

(2008) Michael J. Baker et al.   MOLECULAR BIOLOGY OF THE CELL

The Structure of Fcp1, an Essential RNA Polymerase II CTD Phosphatase

(2008) Agnidipta Ghosh et al.   MOLECULAR CELL