Upregulated function of mitochondria-associated ER membranes in Alzheimer disease

Effects of Membrane Lipids on the Activity and Processivity of Purified γ-Secretase

(2012) Oliver Holmes et al.   BIOCHEMISTRY

The mechanism of γ-Secretase dysfunction in familial Alzheimer disease

(2012) Lucía Chávez-Gutiérrez et al.   EMBO JOURNAL

Familial Alzheimer Disease Presenilin-1 Mutations Alter the Active Site Conformation of γ-secretase

(2012) De-Ming Chau et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Generation of Alzheimer Disease-associated Amyloid β42/43Peptide by γ-Secretase Can Be Inhibited Directly by Modulation of Membrane Thickness

(2012) Edith Winkler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Changes in cholesterol metabolism-related gene expression in peripheral blood mononuclear cells from Alzheimer patients

(2012) Antonella Mandas et al.   Lipids in Health and Disease

Amyloid Precursor Protein (APP) Mediated Regulation of Ganglioside Homeostasis Linking Alzheimer's Disease Pathology with Ganglioside Metabolism

(2012) Marcus O. W. Grimm et al.   PLoS One

Alzheimer's Disease-Linked Mutations in Presenilin-1 Result in a Drastic Loss of Activity in Purified γ-Secretase Complexes

(2012) Matthias Cacquevel et al.   PLoS One

Alterations in phosphatidylethanolamine levels affect the generation of Aβ

(2011) Iva Nesic et al.   AGING CELL

The role of cholesterol in the association of endoplasmic reticulum membranes with mitochondria

(2011) Michiko Fujimoto et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Comparative Lipidomic Analysis of Mouse and Human Brain with Alzheimer Disease

(2011) Robin B. Chan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reciprocal relationship between APP positioning relative to the membrane and PS1 conformation

(2011) Kengo Uemura et al.   Molecular Neurodegeneration

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease

(2011) Adam C Naj et al.   NATURE GENETICS

Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

(2011) Paul Hollingworth et al.   NATURE GENETICS

Mitochondria: The Next (Neurode)Generation

(2011) Eric A. Schon et al.   NEURON

Presenilin 2 modulates endoplasmic reticulum (ER)-mitochondria interactions and Ca2+ cross-talk

(2011) E. Zampese et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The conserved GTPase Gem1 regulates endoplasmic reticulum-mitochondria connections

(2011) B. Kornmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cholesterol accumulation in Niemann Pick type C (NPC) model cells causes a shift in APP localization to lipid rafts

(2010) Marko Kosicek et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Alzheimer’s disease phenotypes and genotypes associated with mutations in presenilin 2

(2010) Suman Jayadev et al.   BRAIN

A Presenilin-1 Mutation Identified in Familial Alzheimer Disease with Cotton Wool Plaques Causes a Nearly Complete Loss of γ-Secretase Activity

(2010) Elizabeth A. Heilig et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Human Cytomegalovirus Protein UL37 Exon 1 Associates with Internal Lipid Rafts

(2010) C. D. Williamson et al.   JOURNAL OF VIROLOGY

Ca2+ Hot Spots on the Mitochondrial Surface Are Generated by Ca2+ Mobilization from Stores, but Not by Activation of Store-Operated Ca2+ Channels

(2010) Marta Giacomello et al.   MOLECULAR CELL

Imaging Interorganelle Contacts and Local Calcium Dynamics at the ER-Mitochondrial Interface

(2010) György Csordás et al.   MOLECULAR CELL

Abnormal Mitochondrial Dynamics—A Novel Therapeutic Target for Alzheimer's Disease?

(2010) Bo Su et al.   MOLECULAR NEUROBIOLOGY

Detergent-Resistant Microdomains Determine the Localization of  -1 Receptors to the Endoplasmic Reticulum-Mitochondria Junction

(2010) T. Hayashi et al.   MOLECULAR PHARMACOLOGY

Sphingomyelin accumulation provides a favorable milieu for GM1 ganglioside-induced assembly of amyloid β-protein

(2010) Kohei Yuyama et al.   NEUROSCIENCE LETTERS

Fusion of the Endoplasmic Reticulum and Mitochondrial Outer Membrane in Rats Brown Adipose Tissue: Activation of Thermogenesis by Ca2+

(2010) Leopoldo de Meis et al.   PLoS One

FAD Mutations in Amyloid Precursor Protein Do Not Directly Perturb Intracellular Calcium Homeostasis

(2010) Emily Stieren et al.   PLoS One

ACAT1 gene ablation increases 24(S)-hydroxycholesterol content in the brain and ameliorates amyloid pathology in mice with AD

(2010) E. Y. Bryleva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipid Rafts As a Membrane-Organizing Principle

(2010) D. Lingwood et al.   SCIENCE

ER Calcium and Alzheimer's Disease: In a State of Flux

(2010) M. P. Mattson   Science Signaling

Gain-of-Function Enhancement of IP3 Receptor Modal Gating by Familial Alzheimer's Disease-Linked Presenilin Mutants in Human Cells and Mouse Neurons

(2010) K.-H. Cheung et al.   Science Signaling

Presenilins Are Enriched in Endoplasmic Reticulum Membranes Associated with Mitochondria

(2009) Estela Area-Gomez et al.   AMERICAN JOURNAL OF PATHOLOGY

Accumulation of neutral lipids in peripheral blood mononuclear cells as a distinctive trait of Alzheimer patients and asymptomatic subjects at risk of disease

(2009) Alessandra Pani et al.   BMC Medicine

Cholesterol in Alzheimers Disease: Unresolved Questions

(2009) Massimo Stefani et al.   Current Alzheimer Research

Inhibition of acyl-coenzyme A: cholesterol acyl transferase modulates amyloid precursor protein trafficking in the early secretory pathway

(2009) Henri J. Huttunen et al.   FASEB JOURNAL

Cardiolipin-enriched raft-like microdomains are essential activating platforms for apoptotic signals on mitochondria

(2009) Maurizio Sorice et al.   FEBS LETTERS

Mitochondria do not contain lipid rafts, and lipid rafts do not contain mitochondrial proteins

(2009) Yu Zi Zheng et al.   JOURNAL OF LIPID RESEARCH

The role of abnormal mitochondrial dynamics in the pathogenesis of Alzheimer’s disease

(2009) Xinglong Wang et al.   JOURNAL OF NEUROCHEMISTRY

GM1-Ganglioside Accumulation at the Mitochondria-Associated ER Membranes Links ER Stress to Ca2+-Dependent Mitochondrial Apoptosis

(2009) Renata Sano et al.   MOLECULAR CELL

MAM: more than just a housekeeper

(2009) Teruo Hayashi et al.   TRENDS IN CELL BIOLOGY

The life of lipid droplets

(2008) Tobias C. Walther et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Reassessing the amyloid cascade hypothesis of Alzheimer's disease

(2008) Sanjay W. Pimplikar   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Physical Coupling Supports the Local Ca2+Transfer between Sarcoplasmic Reticulum Subdomains and the Mitochondria in Heart Muscle

(2008) Cecilia García-Pérez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Thematic Review Series: Glycerolipids.Phosphatidylserine and phosphatidylethanolamine in mammalian cells: two metabolically related aminophospholipids

(2008) Jean E. Vance   JOURNAL OF LIPID RESEARCH

Novel N-terminal Cleavage of APP Precludes Aβ Generation in ACAT-Defective AC29 Cells

(2008) Henri J. Huttunen et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

The Subcellular Distribution of Calnexin Is Mediated by PACS-2

(2008) Nathan Myhill et al.   MOLECULAR BIOLOGY OF THE CELL

Mitofusin 2 tethers endoplasmic reticulum to mitochondria

(2008) Olga Martins de Brito et al.   NATURE

Mechanism of Ca2+ Disruption in Alzheimer's Disease by Presenilin Regulation of InsP3 Receptor Channel Gating

(2008) King-Ho Cheung et al.   NEURON

The molecular face of lipid rafts in model membranes

(2008) H. J. Risselada et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease

(2008) Ilya Bezprozvanny et al.   TRENDS IN NEUROSCIENCES