Pathways of cellular proteostasis in aging and disease

ER stress causes widespread protein aggregation and prion formation

(2017) Norfadilah Hamdan et al.   JOURNAL OF CELL BIOLOGY

Shaping proteostasis at the cellular, tissue, and organismal level

(2017) Ambre J. Sala et al.   JOURNAL OF CELL BIOLOGY

Loss-less Nano-fractionator for High Sensitivity, High Coverage Proteomics

(2017) Nils A. Kulak et al.   MOLECULAR & CELLULAR PROTEOMICS

The UPR ER : Sensor and Coordinator of Organismal Homeostasis

(2017) Ashley E. Frakes et al.   MOLECULAR CELL

Regulation of heat shock transcription factors and their roles in physiology and disease

(2017) Rocio Gomez-Pastor et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Biomolecular condensates: organizers of cellular biochemistry

(2017) Salman F. Banani et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Protein homeostasis of a metastable subproteome associated with Alzheimer’s disease

(2017) Rishika Kundra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

UBE2O is a quality control factor for orphans of multiprotein complexes

(2017) Kota Yanagitani et al.   SCIENCE

Hormetic heat stress and HSF-1 induce autophagy to improve survival and proteostasis in C. elegans

(2017) Caroline Kumsta et al.   Nature Communications

HSP90 inhibition enhances cancer immunotherapy by upregulating interferon response genes

(2017) Rina M. Mbofung et al.   Nature Communications

Features of the Chaperone Cellular Network Revealed through Systematic Interaction Mapping

(2017) Kamran Rizzolo et al.   Cell Reports

Evolution of an intricate J-protein network driving protein disaggregation in eukaryotes

(2017) Nadinath B Nillegoda et al.   eLife

Protein Quality Control by Molecular Chaperones in Neurodegeneration

(2017) Aaron Ciechanover et al.   Frontiers in Neuroscience

Are aberrant phase transitions a driver of cellular aging?

(2016) Simon Alberti et al.   BIOESSAYS

UBQLN2 Mediates Autophagy-Independent Protein Aggregate Clearance by the Proteasome

(2016) Roland Hjerpe et al.   CELL

Lipid Biosynthesis Coordinates a Mitochondrial-to-Cytosolic Stress Response

(2016) Hyun-Eui Kim et al.   CELL

Coexisting Liquid Phases Underlie Nucleolar Subcompartments

(2016) Marina Feric et al.   CELL

A current pharmacologic agent versus the promise of next generation therapeutics to ameliorate protein misfolding and/or aggregation diseases

(2016) Aleksandra Baranczak et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Small protein domains fold inside the ribosome exit tunnel

(2016) Jacopo Marino et al.   FEBS LETTERS

The Chaperone Activity and Substrate Spectrum of Human Small Heat Shock Proteins

(2016) Evgeny V. Mymrikov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Trigger Factor Reduces the Force Exerted on the Nascent Chain by a Cotranslationally Folding Protein

(2016) Ola B. Nilsson et al.   JOURNAL OF MOLECULAR BIOLOGY

Ubiquilins Chaperone and Triage Mitochondrial Membrane Proteins for Degradation

(2016) Eisuke Itakura et al.   MOLECULAR CELL

Soluble Oligomers of PolyQ-Expanded Huntingtin Target a Multiplicity of Key Cellular Factors

(2016) Yujin E. Kim et al.   MOLECULAR CELL

Alternative modes of client binding enable functional plasticity of Hsp70

(2016) Alireza Mashaghi et al.   NATURE

An evolutionarily conserved pathway controls proteasome homeostasis

(2016) Adrien Rousseau et al.   NATURE

Autophagy maintains stemness by preventing senescence

(2016) Laura García-Prat et al.   NATURE

A structural ensemble of a ribosome–nascent chain complex during cotranslational protein folding

(2016) Lisa D Cabrita et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Ribosome-associated protein quality control

(2016) Onn Brandman et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Extended survival of misfolded G85R SOD1-linked ALS mice by transgenic expression of chaperone Hsp110

(2016) Maria Nagy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vivo aspects of protein folding and quality control

(2016) D. Balchin et al.   SCIENCE

The GroEL–GroES Chaperonin Machine: A Nano-Cage for Protein Folding

(2016) Manajit Hayer-Hartl et al.   TRENDS IN BIOCHEMICAL SCIENCES

The harmonizome: a collection of processed datasets gathered to serve and mine knowledge about genes and proteins

(2016) Andrew D. Rouillard et al.   Database-The Journal of Biological Databases and Curation

A structural ensemble of a ribosome–nascent chain complex during cotranslational protein folding

(2016) Lisa D Cabrita et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Ribosome-associated protein quality control

(2016) Onn Brandman et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Dynamic control of Hsf1 during heat shock by a chaperone switch and phosphorylation

(2016) Xu Zheng et al.   eLife

The Biology of Proteostasis in Aging and Disease

(2015) Johnathan Labbadia et al.   Annual Review of Biochemistry

UPRmt-mediated cytoprotection and organismal aging

(2015) Anna M. Schulz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Widespread Proteome Remodeling and Aggregation in Aging C. elegans

(2015) Dirk M. Walther et al.   CELL

RuvbL1 and RuvbL2 enhance aggresome formation and disaggregate amyloid fibrils

(2015) N. Zaarur et al.   EMBO JOURNAL

Compartment-specific aggregases direct distinct nuclear and cytoplasmic aggregate deposition

(2015) S. B. Miller et al.   EMBO JOURNAL

The unpredictability of prolonged activation of stress response pathways

(2015) Lilian T. Lamech et al.   JOURNAL OF CELL BIOLOGY

How Hsp70 Molecular Machines Interact with Their Substrates to Mediate Diverse Physiological Functions

(2015) Eugenia M. Clerico et al.   JOURNAL OF MOLECULAR BIOLOGY

The Mechanism and Function of Group II Chaperonins

(2015) Tom Lopez et al.   JOURNAL OF MOLECULAR BIOLOGY

Repression of the Heat Shock Response Is a Programmed Event at the Onset of Reproduction

(2015) Johnathan Labbadia et al.   MOLECULAR CELL

Compromised autophagy and neurodegenerative diseases

(2015) Fiona M. Menzies et al.   NATURE REVIEWS NEUROSCIENCE

Cytoplasmic protein aggregates interfere with nucleocytoplasmic transport of protein and RNA

(2015) A. C. Woerner et al.   SCIENCE

Cotranslational protein folding on the ribosome monitored in real time

(2015) W. Holtkamp et al.   SCIENCE

Tissue-based map of the human proteome

(2015) M. Uhlen et al.   SCIENCE

Differential Scales of Protein Quality Control

(2014) Suzanne Wolff et al.   CELL

Defining the limits: Protein aggregation and toxicityin vivo

(2014) William M. Holmes et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

How the Nucleus Copes with Proteotoxic Stress

(2014) Yoko Shibata et al.   CURRENT BIOLOGY

Barcoding heat shock proteins to human diseases: looking beyond the heat shock response

(2014) V. Kakkar et al.   Disease Models & Mechanisms

Energy landscapes of functional proteins are inherently risky

(2014) Anne Gershenson et al.   Nature Chemical Biology

Systemic stress signalling: understanding the cell non-autonomous control of proteostasis

(2014) Rebecca C. Taylor et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Protein aggregation can inhibit clathrin-mediated endocytosis by chaperone competition

(2014) A. Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Overexpression of Q-rich prion-like proteins suppresses polyQ cytotoxicity and alters the polyQ interactome

(2014) Leslie Ripaud et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteostasis impairment in protein-misfolding and -aggregation diseases

(2014) Mark S. Hipp et al.   TRENDS IN CELL BIOLOGY

A Chaperome Subnetwork Safeguards Proteostasis in Aging and Neurodegenerative Disease

(2014) Marc Brehme et al.   Cell Reports

Modulation of the Maladaptive Stress Response to Manage Diseases of Protein Folding

(2014) Daniela Martino Roth et al.   PLOS BIOLOGY

Spatial quality control bypasses cell-based limitations on proteostasis to promote prion curing

(2014) Courtney L Klaips et al.   eLife

Molecular Chaperone Functions in Protein Folding and Proteostasis

(2013) Yujin E. Kim et al.   Annual Review of Biochemistry

Orchestration of secretory protein folding by ER chaperones

(2013) Tali Gidalevitz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

PolyQ Proteins Interfere with Nuclear Degradation of Cytosolic Proteins by Sequestering the Sis1p Chaperone

(2013) Sae-Hun Park et al.   CELL

Chaperone-mediated autophagy: roles in disease and aging

(2013) Ana Maria Cuervo et al.   CELL RESEARCH

The mitochondrial unfolded protein response, a conserved stress response pathway with implications in health and disease

(2013) V. Jovaisaite et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

The Hsp70/90 cochaperone, Sti1, suppresses proteotoxicity by regulating spatial quality control of amyloid-like proteins

(2013) Katie J. Wolfe et al.   MOLECULAR BIOLOGY OF THE CELL

Spatial sequestration of misfolded proteins by a dynamic chaperone pathway enhances cellular fitness during stress

(2013) Stéphanie Escusa-Toret et al.   NATURE CELL BIOLOGY

Hsp90 Inhibitors Exhibit Resistance-Free Antiviral Activity against Respiratory Syncytial Virus

(2013) Ron Geller et al.   PLoS One

Soluble forms of polyQ-expanded huntingtin rather than large aggregates cause endoplasmic reticulum stress

(2013) Julia Leitman et al.   Nature Communications

Widespread Aggregation and Neurodegenerative Diseases Are Associated with Supersaturated Proteins

(2013) Prajwal Ciryam et al.   Cell Reports

Identification of a Tissue-Selective Heat Shock Response Regulatory Network

(2013) Eric Guisbert et al.   PLoS Genetics

Pharmacological Tuning of Heat Shock Protein 70 Modulates Polyglutamine Toxicity and Aggregation

(2012) Sidhartha M. Chafekar et al.   ACS Chemical Biology

The Ubiquitin System, an Immense Realm

(2012) Alexander Varshavsky   Annual Review of Biochemistry

Quantitative Analysis of Hsp90-Client Interactions Reveals Principles of Substrate Recognition

(2012) Mikko Taipale et al.   CELL

Metazoan Hsp70 machines use Hsp110 to power protein disaggregation

(2012) Heike Rampelt et al.   EMBO JOURNAL

Hsp70 targets Hsp100 chaperones to substrates for protein disaggregation and prion fragmentation

(2012) Juliane Winkler et al.   JOURNAL OF CELL BIOLOGY

Molecular chaperones and stress-inducible protein-sorting factors coordinate the spatiotemporal distribution of protein aggregates

(2012) Liliana Malinovska et al.   MOLECULAR BIOLOGY OF THE CELL

Ribosome-associated chaperones as key players in proteostasis

(2012) Steffen Preissler et al.   TRENDS IN BIOCHEMICAL SCIENCES

Amyloid-like Aggregates Sequester Numerous Metastable Proteins with Essential Cellular Functions

(2011) Heidi Olzscha et al.   CELL

Autophagy and Aging

(2011) David C. Rubinsztein et al.   CELL

The ribosomal tunnel as a functional environment for nascent polypeptide folding and translational stalling

(2011) Daniel N Wilson et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Suppression of Alzheimer's Disease-Related Phenotypes by Expression of Heat Shock Protein 70 in Mice

(2011) T. Hoshino et al.   JOURNAL OF NEUROSCIENCE

Quantitative Proteomics Reveals That Hsp90 Inhibition Preferentially Targets Kinases and the DNA Damage Response

(2011) Kirti Sharma et al.   MOLECULAR & CELLULAR PROTEOMICS

Molecular chaperones in protein folding and proteostasis

(2011) F. Ulrich Hartl et al.   NATURE

Small-molecule proteostasis regulators for protein conformational diseases

(2011) Barbara Calamini et al.   Nature Chemical Biology

Firefly luciferase mutants as sensors of proteome stress

(2011) Rajat Gupta et al.   NATURE METHODS

In vivo demonstration that  -synuclein oligomers are toxic

(2011) B. Winner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Ribosome Modulates Nascent Protein Folding

(2011) C. M. Kaiser et al.   SCIENCE

Selective Inhibition of a Regulatory Subunit of Protein Phosphatase 1 Restores Proteostasis

(2011) P. Tsaytler et al.   SCIENCE

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

Protein Solubility and Protein Homeostasis: A Generic View of Protein Misfolding Disorders

(2011) M. Vendruscolo et al.   Cold Spring Harbor Perspectives in Biology

Aging as an Event of Proteostasis Collapse

(2011) R. C. Taylor et al.   Cold Spring Harbor Perspectives in Biology

Chaperone-assisted degradation: multiple paths to destruction

(2010) Nadja Kettern et al.   BIOLOGICAL CHEMISTRY

A Nucleus-based Quality Control Mechanism for Cytosolic Proteins

(2010) Rupali Prasad et al.   MOLECULAR BIOLOGY OF THE CELL

Enhancement of proteasome activity by a small-molecule inhibitor of USP14

(2010) Byung-Hoon Lee et al.   NATURE

A photoconvertible reporter of the ubiquitin-proteasome system in vivo

(2010) Geert Hamer et al.   NATURE METHODS

Heat shock factors: integrators of cell stress, development and lifespan

(2010) Malin Åkerfelt et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The HSP70 chaperone machinery: J proteins as drivers of functional specificity

(2010) Harm H. Kampinga et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Widespread Protein Aggregation as an Inherent Part of Aging in C. elegans

(2010) Della C. David et al.   PLOS BIOLOGY

Biological and Chemical Approaches to Diseases of Proteostasis Deficiency

(2009) Evan T. Powers et al.   Annual Review of Biochemistry

The Native 3D Organization of Bacterial Polysomes

(2009) Florian Brandt et al.   CELL

Defining the Human Deubiquitinating Enzyme Interaction Landscape

(2009) Mathew E. Sowa et al.   CELL

Cellular mechanisms of membrane protein folding

(2009) William R Skach   NATURE STRUCTURAL & MOLECULAR BIOLOGY

An expanding arsenal of experimental methods yields an explosion of insights into protein folding mechanisms

(2009) Alice I Bartlett et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cytoplasmic protein quality control degradation mediated by parallel actions of the E3 ubiquitin ligases Ubr1 and San1

(2009) J. W. Heck et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging

(2009) A. Ben-Zvi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial Hsp60 Chaperonopathy Causes an Autosomal-Recessive Neurodegenerative Disorder Linked to Brain Hypomyelination and Leukodystrophy

(2008) Daniella Magen et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Structural and Functional Diversities between Members of the Human HSPB, HSPH, HSPA, and DNAJ Chaperone Families†

(2008) Michel J. Vos et al.   BIOCHEMISTRY

Chemical and Biological Approaches Synergize to Ameliorate Protein-Folding Diseases

(2008) Ting-Wei Mu et al.   CELL

Mistranslation-Induced Protein Misfolding as a Dominant Constraint on Coding-Sequence Evolution

(2008) D. Allan Drummond et al.   CELL

Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies

(2008) S Sarkar et al.   CELL DEATH AND DIFFERENTIATION

Function and structure of inherently disordered proteins

(2008) A Keith Dunker et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Heat shock response relieves ER stress

(2008) Yu Liu et al.   EMBO JOURNAL

Impaired ERAD and ER stress are early and specific events in polyglutamine toxicity

(2008) M. L. Duennwald et al.   GENES & DEVELOPMENT

The Hsp90 Chaperone Machinery

(2008) Sebastian Karl Wandinger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Misfolded proteins partition between two distinct quality control compartments

(2008) Daniel Kaganovich et al.   NATURE

One step at a time: endoplasmic reticulum-associated degradation

(2008) Shruthi S. Vembar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Genome-Wide and Functional Annotation of Human E3 Ubiquitin Ligases Identifies MULAN, a Mitochondrial E3 that Regulates the Organelle's Dynamics and Signaling

(2008) Wei Li et al.   PLoS One

Chaperone-dependent amyloid assembly protects cells from prion toxicity

(2008) P. M. Douglas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adapting Proteostasis for Disease Intervention

(2008) William E. Balch et al.   SCIENCE