Signal Recognition Particle: An Essential Protein-Targeting Machine

Identification of amino acid residues in protein SRP72 required for binding to a kinked 5e motif of the human signal recognition particle RNA

(2012) Elena Iakhiaeva et al.   BMC MOLECULAR BIOLOGY

NAC functions as a modulator of SRP during the early steps of protein targeting to the endoplasmic reticulum

(2012) Ying Zhang et al.   MOLECULAR BIOLOGY OF THE CELL

Fingerloop activates cargo delivery and unloading during cotranslational protein targeting

(2012) Aileen R. Ariosa et al.   MOLECULAR BIOLOGY OF THE CELL

Activated GTPase movement on an RNA scaffold drives co-translational protein targeting

(2012) Kuang Shen et al.   NATURE

Twin-arginine-dependent translocation of folded proteins

(2012) J. Frobel et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Evolution from the Prokaryotic to the Higher Plant Chloroplast Signal Recognition Particle: The Signal Recognition Particle RNA Is Conserved in Plastids of a Wide Range of Photosynthetic Organisms

(2012) C. Trager et al.   PLANT CELL

Staying on message: ensuring fidelity in pre-mRNA splicing

(2012) Daniel R. Semlow et al.   TRENDS IN BIOCHEMICAL SCIENCES

Assembly of Bacterial Inner Membrane Proteins

(2011) Ross E. Dalbey et al.   Annual Review of Biochemistry

Protein Folding at the Exit Tunnel

(2011) Daria V. Fedyukina et al.   Annual Review of Biophysics

Membrane Protein Insertion at the Endoplasmic Reticulum

(2011) Sichen Shao et al.   Annual Review of Cell and Developmental Biology

Interaction Studies between the Chloroplast Signal Recognition Particle Subunit cpSRP43 and the Full-length Translocase Alb3 Reveal a Membrane-embedded Binding Region in Alb3 Protein

(2011) Beatrix Dünschede et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipids Trigger a Conformational Switch That Regulates Signal Recognition Particle (SRP)-mediated Protein Targeting

(2011) Goran Stjepanovic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Site-Specific Fluorescent Labeling of Nascent Proteins on the Translating Ribosome

(2011) Ishu Saraogi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Signal sequence–independent SRP-SR complex formation at the membrane suggests an alternative targeting pathway within the SRP cycle

(2011) David Braig et al.   MOLECULAR BIOLOGY OF THE CELL

SecA Interacts with Ribosomes in Order to Facilitate Posttranslational Translocation in Bacteria

(2011) Damon Huber et al.   MOLECULAR CELL

Tail-anchored membrane protein insertion into the endoplasmic reticulum

(2011) Ramanujan S. Hegde et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structural basis of signal-sequence recognition by the signal recognition particle

(2011) Tobias Hainzl et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis for the molecular evolution of SRP-GTPase activation by protein

(2011) Gert Bange et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cryo-EM structure of the ribosome–SecYE complex in the membrane environment

(2011) Jens Frauenfeld et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Direct visualization reveals dynamics of a transient intermediate during protein assembly

(2011) X. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synergistic actions between the SRP RNA and translating ribosome allow efficient delivery of the correct cargos during cotranslational protein targeting

(2011) K. Shen et al.   RNA

The Crystal Structure of the Signal Recognition Particle in Complex with Its Receptor

(2011) S. F. Ataide et al.   SCIENCE

The Bacterial SRP Receptor, SecA and the Ribosome Use Overlapping Binding Sites on the SecY Translocon

(2011) Patrick Kuhn et al.   TRAFFIC

LTD is a protein required for sorting light-harvesting chlorophyll-binding proteins to the chloroplast SRP pathway

(2011) Min Ouyang et al.   Nature Communications

Defining the Specificity of Cotranslationally Acting Chaperones by Systematic Analysis of mRNAs Associated with Ribosome-Nascent Chain Complexes

(2011) Marta del Alamo et al.   PLOS BIOLOGY

Cryo-electron microscopy of ribosomal complexes in cotranslational folding, targeting, and translocation

(2011) Kèvin Knoops et al.   Wiley Interdisciplinary Reviews-RNA

Biogenesis of the signal recognition particle

(2010) Eileen Leung et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Inserting membrane proteins: The YidC/Oxa1/Alb3 machinery in bacteria, mitochondria, and chloroplasts

(2010) Peng Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The Sec translocase

(2010) David J.F. du Plessis et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Component interactions, regulation and mechanisms of chloroplast signal recognition particle-dependent protein transport

(2010) Christine V. Richter et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Interplay between the cpSRP pathway components, the substrate LHCP and the translocase Alb3: An in vivo and in vitro study

(2010) Thomas Bals et al.   FEBS LETTERS

cpSRP43 Is a Novel Chaperone Specific for Light-harvesting Chlorophylla,b-binding Proteins

(2010) Sebastian Falk et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genetic Evidence for Functional Interaction of theEscherichia coliSignal Recognition Particle Receptor with Acidic Lipidsin Vivo

(2010) Elinor Erez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Dynamic cpSRP43-Albino3 Interaction Mediates Translocase Regulation of Chloroplast Signal Recognition Particle (cpSRP)-targeting Components

(2010) Nathaniel E. Lewis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipid activation of the signal recognition particle receptor provides spatial coordination of protein targeting

(2010) Vinh Q. Lam et al.   JOURNAL OF CELL BIOLOGY

Evolutionary Gain of Function for the ER Membrane Protein Sec62 from Yeast to Humans

(2010) Linda Müller et al.   MOLECULAR BIOLOGY OF THE CELL

G domain dimerization controls dynamin's assembly-stimulated GTPase activity

(2010) Joshua S. Chappie et al.   NATURE

Recognition of a signal peptide by the signal recognition particle

(2010) Claudia Y. Janda et al.   NATURE

A ribosome-associating factor chaperones tail-anchored membrane proteins

(2010) Malaiyalam Mariappan et al.   NATURE

ATP-independent reversal of a membrane protein aggregate by a chloroplast SRP subunit

(2010) Peera Jaru-Ampornpan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cryo-EM structure of the E. coli translating ribosome in complex with SRP and its receptor

(2010) Leandro F Estrozi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Transient tether between the SRP RNA and SRP receptor ensures efficient cargo delivery during cotranslational protein targeting

(2010) Kuang Shen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The action of cardiolipin on the bacterial translocon

(2010) V. A. M. Gold et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Residues in SRP9/14 essential for elongation arrest activity of the signal recognition particle define a positively charged functional domain on one side of the protein

(2010) C. Mary et al.   RNA

Sequential Checkpoints Govern Substrate Selection During Cotranslational Protein Targeting

(2010) X. Zhang et al.   SCIENCE

Signal Recognition Particle (SRP) and SRP Receptor: A New Paradigm for Multistate Regulatory GTPases

(2009) Shu-ou Shan et al.   BIOCHEMISTRY

Predominant membrane localization is an essential feature of the bacterial signal recognition particle receptor

(2009) Miryana Mircheva et al.   BMC BIOLOGY

Protein transport in organelles: Protein transport into and across the thylakoid membrane

(2009) Cassie Aldridge et al.   FEBS Journal

YidC is required for the assembly of the MscL homopentameric pore

(2009) Ovidiu I. Pop et al.   FEBS Journal

The C Terminus of the Alb3 Membrane Insertase Recruits cpSRP43 to the Thylakoid Membrane

(2009) Sebastian Falk et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Membrane-binding Motif of the Chloroplast Signal Recognition Particle Receptor (cpFtsY) Regulates GTPase Activity

(2009) Naomi J. Marty et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A trans-membrane segment inside the ribosome exit tunnel triggers RAMP4 recruitment to the Sec61p translocase

(2009) Martin R. Pool   JOURNAL OF CELL BIOLOGY

A Distinct Mechanism to Achieve Efficient Signal Recognition Particle (SRP)–SRP Receptor Interaction by the Chloroplast SRP Pathway

(2009) Peera Jaru-Ampornpan et al.   MOLECULAR BIOLOGY OF THE CELL

It takes two to tango: regulation of G proteins by dimerization

(2009) Raphael Gasper et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Delivering proteins for export from the cytosol

(2009) Benedict C. S. Cross et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The ribosome as a platform for co-translational processing, folding and targeting of newly synthesized proteins

(2009) Günter Kramer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Studying membrane proteins through the eyes of the genetic code revealed a strong uracil bias in their coding mRNAs

(2009) J. Prilusky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multiple conformational switches in a GTPase complex control co-translational protein targeting

(2009) Xin Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A signal-anchor sequence stimulates signal recognition particle binding to ribosomes from inside the exit tunnel

(2009) U. Berndt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization of the SRP68/72 interface of human signal recognition particle by systematic site-directed mutagenesis

(2009) Elena Iakhiaeva et al.   PROTEIN SCIENCE

Signal Sequences Activate the Catalytic Switch of SRP RNA

(2009) N. Bradshaw et al.   SCIENCE

Structure of Monomeric Yeast and Mammalian Sec61 Complexes Interacting with the Translating Ribosome

(2009) T. Becker et al.   SCIENCE

Anti-cooperative assembly of the SRP19 and SRP68/72 components of the signal recognition particle

(2008) Tuhin Subhra Maity et al.   BIOCHEMICAL JOURNAL

SRP Keeps Polypeptides Translocation-Competent by Slowing Translation to Match Limiting ER-Targeting Sites

(2008) Asvin K.K. Lakkaraju et al.   CELL

Evolutionary substitution of two amino acids in chloroplast SRP54 of higher plants cause its inability to bind SRP RNA

(2008) Christine V. Richter et al.   FEBS LETTERS

Role of Protein Translocation Pathways across the Endoplasmic Reticulum inTrypanosoma brucei

(2008) Hanoch Goldshmidt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Crystal Structure of the Periplasmic Domain of theEscherichia coliMembrane Protein Insertase YidC Contains a Substrate Binding Cleft

(2008) Stephanie Ravaud et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanisms of YidC-mediated Insertion and Assembly of Multimeric Membrane Protein Complexes

(2008) Stefan Kol et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An interaction between the SRP receptor and the translocon is critical during cotranslational protein translocation

(2008) Ying Jiang et al.   JOURNAL OF CELL BIOLOGY

Assembly of Chloroplast Signal Recognition Particle Involves Structural Rearrangement in cpSRP43

(2008) Karuppanan Muthusamy Kathir et al.   JOURNAL OF MOLECULAR BIOLOGY

Demonstration of a Multistep Mechanism for Assembly of the SRP·SRP Receptor Complex: Implications for the Catalytic Role of SRP RNA

(2008) Xin Zhang et al.   JOURNAL OF MOLECULAR BIOLOGY

A Cleavable N-Terminal Membrane Anchor is Involved in Membrane Binding of the Escherichia coli SRP Receptor

(2008) Benjamin Weiche et al.   JOURNAL OF MOLECULAR BIOLOGY

Mathematical models of infectious disease transmission

(2008) Nicholas C. Grassly et al.   NATURE REVIEWS MICROBIOLOGY

SRP RNA controls a conformational switch regulating the SRP–SRP receptor interaction

(2008) Saskia B Neher et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Signal sequence–independent membrane targeting of ribosomes containing short nascent peptides within the exit tunnel

(2008) Thomas Bornemann et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structures of SRP54 and SRP19, the Two Proteins that Organize the Ribonucleic Core of the Signal Recognition Particle from Pyrococcus furiosus

(2008) Pascal F. Egea et al.   PLoS One

The 5e motif of eukaryotic signal recognition particle RNA contains a conserved adenosine for the binding of SRP72

(2008) E. Iakhiaeva et al.   RNA

Conformation of the signal recognition particle in ribosomal targeting complexes

(2008) I. A. Buskiewicz et al.   RNA

Structural Basis for Specific Substrate Recognition by the Chloroplast Signal Recognition Particle Protein cpSRP43

(2008) K. F. Stengel et al.   SCIENCE

Hsp104 and ClpB: protein disaggregating machines

(2008) Shannon M. Doyle et al.   TRENDS IN BIOCHEMICAL SCIENCES

Protein Translocation Across the Bacterial Cytoplasmic Membrane

(2007) Arnold J.M. Driessen et al.   Annual Review of Biochemistry

Sec- and Tat-mediated protein secretion across the bacterial cytoplasmic membrane—Distinct translocases and mechanisms

(2007) Paolo Natale et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Structure of the Chloroplast Signal Recognition Particle (SRP) Receptor: Domain Arrangement Modulates SRP–Receptor Interaction

(2007) Sowmya Chandrasekar et al.   JOURNAL OF MOLECULAR BIOLOGY