Mitochondrial unfolded protein response: An emerging pathway in human diseases

A Conserved Mito-Cytosolic Translational Balance Links Two Longevity Pathways

(2020) Marte Molenaars et al.   Cell Metabolism

Mitochondrial Quality Control in Age-Related Pulmonary Fibrosis

(2020) Willy Roque et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Activation of Mitochondrial Unfolded Protein Response in SHSY5Y Expressing APP Cells and APP/PS1 Mice

(2020) Yang Shen et al.   Frontiers in Cellular Neuroscience

Role of the mitochondrial stress response in human cancer progression

(2020) Sheng-Fan Wang et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Mitochondrial superoxide/hydrogen peroxide: An emerging therapeutic target for metabolic diseases

(2020) Jialong Yan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Targeting mitochondrial fusion and fission proteins for cardioprotection

(2020) Sauri Hernandez‐Resendiz et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Aerobic Exercise Training Induces the Mitonuclear Imbalance and UPRmt in the Skeletal Muscle of Aged Mice

(2020) André V Cordeiro et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

HSF1 is required for induction of mitochondrial chaperones during the mitochondrial unfolded protein response

(2020) Arpit Katiyar et al.   FEBS Open Bio

Activation of mitochondrial unfolded protein response is associated with Her2-overexpression breast cancer

(2020) Fang-Ming Chen et al.   BREAST CANCER RESEARCH AND TREATMENT

Mitochondria in Alzheimer's disease and their potential role in Alzheimer's proteostasis

(2020) Ian W. Weidling et al.   EXPERIMENTAL NEUROLOGY

Protection against renal ischemia and reperfusion injury by short-term time-restricted feeding involves the mitochondrial unfolded protein response

(2020) Pedro Rojas-Morales et al.   FREE RADICAL BIOLOGY AND MEDICINE

ICAM‐1 and MKL‐1 polymorphisms impose considerable impacts on coronary heart disease occurrence

(2020) Cungang Wu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Regulation of the Golgi apparatus via GOLPH3-mediated new selective autophagy

(2020) Li-qun Lu et al.   LIFE SCIENCES

Mitochondrial unfolded protein-related responses across kingdoms: similar problems, different regulators

(2020) Huy Cuong Tran et al.   MITOCHONDRION

Loss of function of the mitochondrial peptidase PITRM1 induces proteotoxic stress and Alzheimer’s disease-like pathology in human cerebral organoids

(2020) María José Pérez et al.   MOLECULAR PSYCHIATRY

Folding the Mitochondrial UPR into the Integrated Stress Response

(2020) Nadine S. Anderson et al.   TRENDS IN CELL BIOLOGY

Overexpression of PGC-1α influences the mitochondrial unfolded protein response (mtUPR) induced by MPP+ in human SH-SY5Y neuroblastoma cells

(2020) Yousheng Cai et al.   Scientific Reports

Mitochondria, Aging, and Cellular Senescence: Implications for Scleroderma

(2020) Marta Bueno et al.   Current Rheumatology Reports

High-intensity exercise training induces mitonuclear imbalance and activates the mitochondrial unfolded protein response in the skeletal muscle of aged mice

(2020) André Victor Cordeiro et al.   GeroScience

A pathogen branched-chain amino acid catabolic pathway subverts host survival by impairing energy metabolism and the mitochondrial UPR

(2020) Siraje Arif Mahmud et al.   PLoS Pathogens

Stabilization of microtubules improves cognitive functions and axonal transport of mitochondria in Alzheimer's disease model mice

(2020) Baihong Guo et al.   NEUROBIOLOGY OF AGING

Mitochondrial LonP1 protects cardiomyocytes from ischemia/reperfusion injury in vivo

(2019) Sundararajan Venkatesh et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Mitochondrial UPR repression duringPseudomonas aeruginosainfection requires the bZIP protein ZIP-3

(2019) Pan Deng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial unfolded protein response: a stress response with implications for fertility and reproductive aging

(2019) Emre Seli et al.   FERTILITY AND STERILITY

Mutant huntingtin inhibits the mitochondrial unfolded protein response by impairing ABCB10 mRNA stability

(2019) Zixing Fu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Ferritinophagy activation and sideroflexin1-dependent mitochondria iron overload is involved in apelin-13-induced cardiomyocytes hypertrophy

(2019) Mingzhu Tang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cardioprotective Effect of the Mitochondrial Unfolded Protein Response During Chronic Pressure Overload

(2019) Ioannis Smyrnias et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Mitohormesis Primes Tumor Invasion and Metastasis

(2019) Timothy C. Kenny et al.   Cell Reports

TDP-43 induces mitochondrial damage and activates the mitochondrial unfolded protein response

(2019) Peng Wang et al.   PLoS Genetics

Cross talk between SOD1 and the mitochondrial UPR in cancer and neurodegeneration

(2019) Maria Gomez et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Translational Regulation of Non-autonomous Mitochondrial Stress Response Promotes Longevity

(2019) Jianfeng Lan et al.   Cell Reports

Cardioprotection by the mitochondrial unfolded protein response requires ATF5

(2019) Yves T. Wang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Mitohormesis, UPRmt, and the Complexity of Mitochondrial DNA Landscapes in Cancer

(2019) Timothy C. Kenny et al.   CANCER RESEARCH

Mitochondrial Unfolded Protein Response (UPRmt) Activation in Cardiac Diseases

(2019) Luiz H.M. Bozi et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Relationship of single nucleotide polymorphisms and haplotype interaction of mitochondrial unfolded protein response pathway genes with head and neck cancer

(2019) Malik Waqar Ahmed et al.   Future Oncology

Impairment of mitochondrial unfolded protein response contribute to resistance declination of H 2 O 2 ‐induced injury in senescent MRC‐5 cell model

(2019) Tzu‐Ying Lee et al.   KAOHSIUNG JOURNAL OF MEDICAL SCIENCES

Inhibition of LONP1 protects against erastin-induced ferroptosis in Pancreatic ductal adenocarcinoma PANC1 cells

(2019) Hai Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ginseng protein protects against mitochondrial dysfunction and neurodegeneration by inducing mitochondrial unfolded protein response in Drosophila melanogaster PINK1 model of Parkinson's disease

(2019) Meichen Liu et al.   JOURNAL OF ETHNOPHARMACOLOGY

Mitochondrial unfolded protein response gene Clpp is required to maintain ovarian follicular reserve during aging, for oocyte competence, and development of pre-implantation embryos

(2018) Tianren Wang et al.   AGING CELL

Microbial Genetic Composition Tunes Host Longevity

(2018) Bing Han et al.   CELL

Heat shock transcriptional factor mediates mitochondrial unfolded protein response

(2018) Naoki Koike et al.   CURRENT GENETICS

The Mitochondrial Unfolded Protein Response: Role in Cellular Homeostasis and Disease

(2018) I. De et al.   CURRENT MOLECULAR MEDICINE

The role of mitochondria in stem cell fate and aging

(2018) Hongbo Zhang et al.   DEVELOPMENT

The mitochondrial unfolded protein response and mitohormesis: a perspective on metabolic diseases

(2018) Hyon-Seung Yi et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

UPR mt coordinates immunity to maintain mitochondrial homeostasis and animal fitness

(2018) Siyuan Wang et al.   MITOCHONDRION

Mitochondrial function — gatekeeper of intestinal epithelial cell homeostasis

(2018) Eva Rath et al.   Nature Reviews Gastroenterology & Hepatology

Heart Disease in Children

(2018) Richard U. Garcia et al.   PRIMARY CARE

A salicylic acid derivative extends the lifespan of Caenorhabditis elegans by activating autophagy and the mitochondrial unfolded protein response

(2018) Mehrnaz Shamalnasab et al.   AGING CELL

The different axes of the mammalian mitochondrial unfolded protein response

(2018) Christian Münch   BMC BIOLOGY

Choline ameliorates cardiac hypertrophy by regulating metabolic remodelling and UPRmt through SIRT3-AMPK pathway

(2018) Man Xu et al.   CARDIOVASCULAR RESEARCH

Ferritinophagy/ferroptosis: Iron-related newcomers in human diseases

(2018) Mingzhu Tang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

FUS interacts with ATP synthase beta subunit and induces mitochondrial unfolded protein response in cellular and animal models

(2018) Jianwen Deng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial regulation of cardiac aging

(2018) Yuhan Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Mitochondrial unfolded protein response transcription factor ATFS-1 promotes longevity in a long-lived mitochondrial mutant through activation of stress response pathways

(2018) Ziyun Wu et al.   BMC BIOLOGY

PINK1/Parkin-mediated mitophagy promotes apelin-13-induced vascular smooth muscle cell proliferation by AMPKα and exacerbates atherosclerotic lesions

(2018) Lu He et al.   JOURNAL OF CELLULAR PHYSIOLOGY

MicroRNA-382 silencing induces a mitonuclear protein imbalance and activates the mitochondrial unfolded protein response in muscle cells

(2018) Dennis Dahlmans et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Alzheimer's disease

(2017) C. A. Lane et al.   EUROPEAN JOURNAL OF NEUROLOGY

Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals

(2017) Pedro M. Quirós et al.   JOURNAL OF CELL BIOLOGY

Dysregulation of the Mitochondrial Unfolded Protein Response Induces Non-Apoptotic Dopaminergic Neurodegeneration inC. elegansModels of Parkinson's Disease

(2017) Bryan A. Martinez et al.   JOURNAL OF NEUROSCIENCE

Cytosolic proteostasis through importing of misfolded proteins into mitochondria

(2017) Linhao Ruan et al.   NATURE

Enhancing mitochondrial proteostasis reduces amyloid-β proteotoxicity

(2017) Vincenzo Sorrentino et al.   NATURE

Selected mitochondrial DNA landscapes activate the SIRT3 axis of the UPRmt to promote metastasis

(2017) T C Kenny et al.   ONCOGENE

Mitochondrial dysfunction in cancer: Potential roles of ATF5 and the mitochondrial UPR

(2017) Pan Deng et al.   SEMINARS IN CANCER BIOLOGY

Effect of follicular aging on ATP content and mitochondria distribution in bovine oocytes

(2017) Dinesh Dadarwal et al.   THERIOGENOLOGY

Activation of the mitochondrial unfolded protein response promotes longevity and dopamine neuron survival in Parkinson’s disease models

(2017) Jason F. Cooper et al.   Scientific Reports

Role of ATF5 in the invasive potential of diverse human cancer cell lines

(2016) Akihiro Nukuda et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Neuroendocrine Coordination of Mitochondrial Stress Signaling and Proteostasis

(2016) Kristen M. Berendzen et al.   CELL

Evidence for Mitochondrial UPR Gene Activation in Familial and Sporadic Alzheimer's Disease

(2016) John S. Beck et al.   Current Alzheimer Research

The Transcription Factor ATF5 Mediates a Mammalian Mitochondrial UPR

(2016) Christopher J. Fiorese et al.   CURRENT BIOLOGY

Loss of CLPP alleviates mitochondrial cardiomyopathy without affecting the mammalian UPRmt

(2016) Dominic Seiferling et al.   EMBO REPORTS

Metabolism and the UPR mt

(2016) Yi-Fan Lin et al.   MOLECULAR CELL

Joint mouse–human phenome-wide association to test gene function and disease risk

(2016) Xusheng Wang et al.   Nature Communications

Mitochondrial dysfunction enhances cisplatin resistance in human gastric cancer cells via the ROS-activated GCN2-eIF2α-ATF4-xCT pathway

(2016) Sheng-Fan Wang et al.   Oncotarget

Ablation of the mitochondrial complex IV assembly protein Surf1 leads to increased expression of the UPRMT and increased resistance to oxidative stress in primary cultures of fibroblasts

(2016) Gavin Pharaoh et al.   Redox Biology

Down-regulation of HSP60 Suppresses the Proliferation of Glioblastoma Cells via the ROS/AMPK/mTOR Pathway

(2016) Haiping Tang et al.   Scientific Reports

The loss of LRPPRC function induces the mitochondrial unfolded protein response

(2015) Fabian Köhler et al.   Aging-US

HSP60 overexpression increases the protein levels of the p110α subunit of  phosphoinositide 3-kinase and c-Myc

(2015) Feng-Qin Yan et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Exposure to arginine analog canavanine induces aberrant mitochondrial translation products, mitoribosome stalling, and instability of the mitochondrial proteome

(2015) Svetlana Konovalova et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Mitochondrial Lon protease controls ROS-dependent apoptosis in cardiomyocyte under hypoxia

(2015) Chan-Yen Kuo et al.   MITOCHONDRION

Mitochondrial and Nuclear Accumulation of the Transcription Factor ATFS-1 Promotes OXPHOS Recovery during the UPRmt

(2015) Amrita M. Nargund et al.   MOLECULAR CELL

A mitochondrial UPR-mediated metabolic checkpoint regulates hematopoietic stem cell aging

(2015) M. Mohrin et al.   SCIENCE

Mitochondrial SSBP1 protects cells from proteotoxic stresses by potentiating stress-induced HSF1 transcriptional activity

(2015) Ke Tan et al.   Nature Communications

A Mutation in Caenorhabditis elegans NDUF-7 Activates the Mitochondrial Stress Response and Prolongs Lifespan via ROS and CED-4

(2015) Manish Rauthan et al.   G3-Genes Genomes Genetics

Pharmacological Inhibition of Poly(ADP-Ribose) Polymerases Improves Fitness and Mitochondrial Function in Skeletal Muscle

(2014) Eija Pirinen et al.   Cell Metabolism

Oxidative Post-Translational Modifications Develop LONP1 Dysfunction in Pressure Overload Heart Failure

(2014) Atsushi Hoshino et al.   Circulation-Heart Failure

FGF21 is an endocrine signal of protein restriction

(2014) Thomas Laeger et al.   JOURNAL OF CLINICAL INVESTIGATION

Mitochondrial UPR-regulated innate immunity provides resistance to pathogen infection

(2014) Mark W. Pellegrino et al.   NATURE

Mitochondrial form and function

(2014) Jonathan R. Friedman et al.   NATURE

The NAD+/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling

(2013) Laurent Mouchiroud et al.   CELL

Muscle Mitohormesis Promotes Longevity via Systemic Repression of Insulin Signaling

(2013) Edward Owusu-Ansah et al.   CELL

Stress-Regulated Translational Attenuation Adapts Mitochondrial Protein Import through Tim17A Degradation

(2013) T. Kelly Rainbolt et al.   Cell Metabolism

Leptin regulation of Hsp60 impacts hypothalamic insulin signaling

(2013) André Kleinridders et al.   JOURNAL OF CLINICAL INVESTIGATION

SirT3 Regulates the Mitochondrial Unfolded Protein Response

(2013) L. Papa et al.   MOLECULAR AND CELLULAR BIOLOGY

CHOP induces activating transcription factor 5 (ATF5) to trigger apoptosis in response to perturbations in protein homeostasis

(2013) Brian F. Teske et al.   MOLECULAR BIOLOGY OF THE CELL

Pravastatin slows the progression of heart failure by inhibiting the c-Jun N-terminal kinase-mediated intrinsic apoptotic signaling pathway

(2013) SHIPING CAO et al.   Molecular Medicine Reports

Mitonuclear protein imbalance as a conserved longevity mechanism

(2013) Riekelt H. Houtkooper et al.   NATURE

Evaluating and responding to mitochondrial dysfunction: the mitochondrial unfolded-protein response and beyond

(2013) Cole M. Haynes et al.   TRENDS IN CELL BIOLOGY

Surveillance-Activated Defenses Block the ROS–Induced Mitochondrial Unfolded Protein Response

(2013) Eva D. Runkel et al.   PLoS Genetics

Signaling the mitochondrial unfolded protein response

(2012) Mark W. Pellegrino et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Genetic analysis of mitochondrial protein misfolding in Drosophila melanogaster

(2012) I Pimenta de Castro et al.   CELL DEATH AND DIFFERENTIATION

Sirtuins as regulators of metabolism and healthspan

(2012) Riekelt H. Houtkooper et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Role of mitochondrial homeostasis and dynamics in Alzheimer's disease

(2012) J. Eva Selfridge et al.   NEUROBIOLOGY OF DISEASE

Mitochondrial Import Efficiency of ATFS-1 Regulates Mitochondrial UPR Activation

(2012) A. M. Nargund et al.   SCIENCE

Protective Coupling of Mitochondrial Function and Protein Synthesis via the eIF2α Kinase GCN-2

(2012) Brooke M. Baker et al.   PLoS Genetics

Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks

(2011) Brian Magnuson et al.   BIOCHEMICAL JOURNAL

The Cell-Non-Autonomous Nature of Electron Transport Chain-Mediated Longevity

(2011) Jenni Durieux et al.   CELL

BCL-2 Is a Downstream Target of ATF5 That Mediates the Prosurvival Function of ATF5 in a Cell Type-dependent Manner

(2011) Douglas Dluzen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Estrogen receptor mediates a distinct mitochondrial unfolded protein response

(2011) L. Papa et al.   JOURNAL OF CELL SCIENCE

The Matrix Peptide Exporter HAF-1 Signals a Mitochondrial UPR by Activating the Transcription Factor ZC376.7 in C. elegans

(2010) Cole M. Haynes et al.   MOLECULAR CELL

A double-blind, placebo-controlled study to assess the mitochondria-targeted antioxidant MitoQ as a disease-modifying therapy in Parkinson's disease

(2010) Barry J. Snow et al.   MOVEMENT DISORDERS

Interaction between HSP60 and β-catenin promotes metastasis

(2009) Ya-Ping Tsai et al.   CARCINOGENESIS

PGC-1α, SIRT1 and AMPK, an energy sensing network that controls energy expenditure

(2009) Carles Cantó et al.   CURRENT OPINION IN LIPIDOLOGY