A brief overview of amyloids and Alzheimer's disease

How Type II Diabetes-Related Islet Amyloid Polypeptide Damages Lipid Bilayers

(2012) Chang-Chun Lee et al.   BIOPHYSICAL JOURNAL

The Amyloid Beta Peptide: A Chemist’s Perspective. Role in Alzheimer’s and Fibrillization

(2012) I. W. Hamley   CHEMICAL REVIEWS

APP transgenic mice for modelling behavioural and psychological symptoms of dementia (BPSD)

(2012) R. Lalonde et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Distinguishing crystal-like amyloid fibrils and glass-like amorphous aggregates from their kinetics of formation

(2012) Y. Yoshimura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Membrane and surface interactions of Alzheimer’s Aβ peptide - insights into the mechanism of cytotoxicity

(2011) Thomas L. Williams et al.   FEBS Journal

The Alzheimer's amyloid β-peptide (Aβ) binds a specific DNA Aβ-interacting domain (AβID) in the APP, BACE1, and APOE promoters in a sequence-specific manner: Characterizing a new regulatory motif

(2011) Bryan Maloney et al.   GENE

Lysine-Specific Molecular Tweezers Are Broad-Spectrum Inhibitors of Assembly and Toxicity of Amyloid Proteins

(2011) Sharmistha Sinha et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Proteins Fibrils from a Polymer Physics Perspective

(2011) Jozef Adamcik et al.   MACROMOLECULES

Microglial phagocytosis induced by fibrillar β-amyloid is attenuated by oligomeric β-amyloid: implications for Alzheimer's disease

(2011) Xiao-dong Pan et al.   Molecular Neurodegeneration

Spatial Extent of Charge Repulsion Regulates Assembly Pathways for Lysozyme Amyloid Fibrils

(2011) Shannon E. Hill et al.   PLoS One

Amyloidogenic Protein-Membrane Interactions: Mechanistic Insight from Model Systems

(2010) Sara M. Butterfield et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Lipid raft disruption protects mature neurons against amyloid oligomer toxicity

(2010) Fiorella Malchiodi-Albedi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Characterization of β-Lactoglobulin Fibrillar Assembly Using Atomic Force Microscopy, Polyacrylamide Gel Electrophoresis, andin SituFourier Transform Infrared Spectroscopy

(2010) Daniela Oboroceanu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Alpha-secretase in Alzheimer’s disease: molecular identity, regulation and therapeutic potential

(2010) Stefan F. Lichtenthaler   JOURNAL OF NEUROCHEMISTRY

Distinct modulation of microglial amyloid beta phagocytosis and migration by neuropeptides

(2010) Sigal Fleisher-Berkovich et al.   Journal of Neuroinflammation

Protein Aggregation in Crowded Environments

(2010) Duncan A. White et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Alzheimer's disease: clinical trials and drug development

(2010) Francesca Mangialasche et al.   LANCET NEUROLOGY

Probing aromatic, hydrophobic, and steric effects on the self-assembly of an amyloid-β fragment peptide

(2010) F. Timur Senguen et al.   Molecular BioSystems

Clarifying the influence of core amino acid hydrophobicity, secondary structure propensity, and molecular volume on amyloid-β 16–22 self-assembly

(2010) F. Timur Senguen et al.   Molecular BioSystems

Natural products as a source of Alzheimer's drug leads

(2010) Philip Williams et al.   NATURAL PRODUCT REPORTS

Understanding amyloid aggregation by statistical analysis of atomic force microscopy images

(2010) Jozef Adamcik et al.   Nature Nanotechnology

UV-light-induced conversion and aggregation of prion proteins

(2009) Lars Redecke et al.   FREE RADICAL BIOLOGY AND MEDICINE

Shear-Induced Deformation of Bovine Insulin in Couette Flow

(2009) Innocent B. Bekard et al.   JOURNAL OF PHYSICAL CHEMISTRY B

 -Helix targeting reduces amyloid-  peptide toxicity

(2009) C. Nerelius et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Integration of amyloid nanowires in organic solar cells

(2008) S. Barrau et al.   APPLIED PHYSICS LETTERS

Phase 2 Safety Trial Targeting Amyloid β Production With a γ-Secretase Inhibitor in Alzheimer Disease

(2008) Adam S. Fleisher et al.   ARCHIVES OF NEUROLOGY

Fitting Neurological Protein Aggregation Kinetic Data via a 2-Step, Minimal/“Ockham's Razor” Model:  The Finke−Watzky Mechanism of Nucleation Followed by Autocatalytic Surface Growth†

(2008) Aimee M. Morris et al.   BIOCHEMISTRY

Temperature-Induced Dissociation of Aβ Monomers from Amyloid Fibril

(2008) Takako Takeda et al.   BIOPHYSICAL JOURNAL

How Metal Ions Affect Amyloid Formation: Cu2+- and Zn2+-Sensitive Peptides

(2008) Kevin Pagel et al.   CHEMBIOCHEM

The new approach in development of anti-Alzheimer's disease drugs via the cholinergic hypothesis

(2008) Hachiro Sugimoto   CHEMICO-BIOLOGICAL INTERACTIONS

Effects of Flow on Hen Egg White Lysozyme (HEWL) Fibril Formation: Length Distribution, Flexibility, and Kinetics

(2008) Nam-Phuong Humblet-Hua et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Sulfated Polysaccharides Promote the Assembly of Amyloid β1–42 Peptide into Stable Fibrils of Reduced Cytotoxicity

(2008) Ramona Bravo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

How Does Shear Affect Aβ Fibrillogenesis?

(2008) Paul Hamilton-Brown et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Systematic analysis of nucleation-dependent polymerization reveals new insights into the mechanism of amyloid self-assembly

(2008) Wei-Feng Xue et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stabilization of a β-hairpin in monomeric Alzheimer's amyloid-β peptide inhibits amyloid formation

(2008) Wolfgang Hoyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Potential roles of abundant extracellular chaperones in the control of amyloid formation and toxicity

(2007) Mark R. Wilson et al.   Molecular BioSystems

FTIR reveals structural differences between native β-sheet proteins and amyloid fibrils

(2004) Giorgia Zandomeneghi et al.   PROTEIN SCIENCE