Mitochondrial protein interaction landscape of SS-31

The Molecular Mechanism of Transport by the Mitochondrial ADP/ATP Carrier

(2019) Jonathan J. Ruprecht et al.   CELL

Crystal structure of human mitochondrial trifunctional protein, a fatty acid β-oxidation metabolon

(2019) Chuanwu Xia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dimers of mitochondrial ATP synthase induce membrane curvature and self-assemble into rows

(2019) Thorsten B. Blum et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of cardiolipin concentration and acyl chain composition on mitochondrial inner membrane molecular organization and function

(2019) Edward Ross Pennington et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

H+ transport is an integral function of the mitochondrial ADP/ATP carrier

(2019) Ambre M. Bertholet et al.   NATURE

TFPa/HADHA is required for fatty acid beta-oxidation and cardiolipin re-modeling in human cardiomyocytes

(2019) Jason W. Miklas et al.   Nature Communications

Mango: A General Tool for Collision Induced Dissociation-Cleavable Cross-Linked Peptide Identification

(2018) Jared P. Mohr et al.   ANALYTICAL CHEMISTRY

Cross-Linking/Mass Spectrometry for Studying Protein Structures and Protein-Protein Interactions: Where Are We Now and Where Should We Go from Here?

(2018) Andrea Sinz   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structure of the intact 14-subunit human cytochrome c oxidase

(2018) Shuai Zong et al.   CELL RESEARCH

2-Oxoglutarate regulates binding of hydroxylated hypoxia-inducible factor to prolyl hydroxylase domain 2

(2018) Martine I. Abboud et al.   CHEMICAL COMMUNICATIONS

Biogenesis of the bc 1 Complex of the Mitochondrial Respiratory Chain

(2018) Mama Ndi et al.   JOURNAL OF MOLECULAR BIOLOGY

Cryo-EM structure of human mitochondrial trifunctional protein

(2018) Kai Liang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NDUFA4 (Renamed COXFA4) Is a Cytochrome -c Oxidase Subunit

(2018) Robert D.S. Pitceathly et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Chemical Crosslinking Mass Spectrometry Analysis of Protein Conformations and Supercomplexes in Heart Tissue

(2018) Juan D. Chavez et al.   Cell Systems

Cardiolipin-targeted peptides rejuvenate mitochondrial function, remodel mitochondria, and promote tissue regeneration during aging

(2018) Hazel H. Szeto et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Atomistic insights into cardiolipin binding sites of cytochrome c oxidase

(2018) Aapo Malkamäki et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Improving mitochondrial function with SS-31 reverses age-related redox stress and improves exercise tolerance in aged mice

(2018) Matthew D. Campbell et al.   FREE RADICAL BIOLOGY AND MEDICINE

Tools for 3D Interactome Visualization

(2018) Andrew Keller et al.   JOURNAL OF PROTEOME RESEARCH

Stealth Peptides Target Cellular Powerhouses to Fight Rare and Common Age-Related Diseases

(2018) Hazel H. Szeto   PROTEIN AND PEPTIDE LETTERS

Chemical cross-linking with mass spectrometry: a tool for systems structural biology

(2018) Juan D Chavez et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Therapies for mitochondrial diseases and current clinical trials

(2017) Ayman W. El-Hattab et al.   MOLECULAR GENETICS AND METABOLISM

Clarifying the supercomplex: the higher-order organization of the mitochondrial electron transport chain

(2017) James A Letts et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mitochondrial protein interactome elucidated by chemical cross-linking mass spectrometry

(2017) Devin K. Schweppe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clarifying the supercomplex: the higher-order organization of the mitochondrial electron transport chain

(2017) James A Letts et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mitochondrial composition and function under the control of hypoxia

(2017) Dominik C. Fuhrmann et al.   Redox Biology

Studies on the regulatory mechanism of isocitrate dehydrogenase 2 using acetylation mimics

(2017) Yuqun Xu et al.   Scientific Reports

The transport mechanism of the mitochondrial ADP/ATP carrier

(2016) Edmund R.S. Kunji et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Structure of a Complete ATP Synthase Dimer Reveals the Molecular Basis of Inner Mitochondrial Membrane Morphology

(2016) Alexander Hahn et al.   MOLECULAR CELL

Cardiolipin puts the seal on ATP synthase

(2016) Ahmad Reza Mehdipour et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cardiolipin binds selectively but transiently to conserved lysine residues in the rotor of metazoan ATP synthases

(2016) Anna L. Duncan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular mechanism of cardiolipin-mediated assembly of respiratory chain supercomplexes

(2016) C. Arnarez et al.   Chemical Science

Recombinant expression, purification and crystallographic studies of the mature form of human mitochondrial aspartate aminotransferase

(2016) Xiuping Jiang et al.   BioScience Trends

The Emergence of 2-Oxoglutarate as a Master Regulator Metabolite

(2015) Luciano F. Huergo et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

MitoCarta2.0: an updated inventory of mammalian mitochondrial proteins

(2015) Sarah E. Calvo et al.   NUCLEIC ACIDS RESEARCH

Serendipity and the Discovery of Novel Compounds That Restore Mitochondrial Plasticity

(2014) H H Szeto et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

The 2-Oxoacid Dehydrogenase Complexes in Mitochondria Can Produce Superoxide/Hydrogen Peroxide at Much Higher Rates Than Complex I

(2014) Casey L. Quinlan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR

(2014) Randall M. Chin et al.   NATURE

Structure of Mycobacterial β-Oxidation Trifunctional Enzyme Reveals Its Altered Assembly and Putative Substrate Channeling Pathway

(2013) Rajaram Venkatesan et al.   ACS Chemical Biology

Mitochondrial-targeted peptide rapidly improves mitochondrial energetics and skeletal muscle performance in aged mice

(2013) Michael P. Siegel et al.   AGING CELL

Functional role of cardiolipin in mitochondrial bioenergetics

(2013) Giuseppe Paradies et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

First-in-class cardiolipin-protective compound as a therapeutic agent to restore mitochondrial bioenergetics

(2013) Hazel H Szeto   BRITISH JOURNAL OF PHARMACOLOGY

Targeting mitochondrial cardiolipin and the cytochromec/cardiolipin complex to promote electron transport and optimize mitochondrial ATP synthesis

(2013) A V Birk et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cardiolipin-dependent formation of mitochondrial respiratory supercomplexes

(2013) Eugenia Mileykovskaya et al.   CHEMISTRY AND PHYSICS OF LIPIDS

In Vivo Protein Interaction Network Identified with a Novel Real-Time Cross-Linked Peptide Identification Strategy

(2013) Chad R. Weisbrod et al.   JOURNAL OF PROTEOME RESEARCH

Evidence for Cardiolipin Binding Sites on the Membrane-Exposed Surface of the Cytochrome bc1

(2013) Clement Arnarez et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Mitochondrial-Targeted Compound SS-31 Re-Energizes Ischemic Mitochondria by Interacting with Cardiolipin

(2013) A. V. Birk et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Protein Interactions, Post-translational Modifications and Topologies in Human Cells

(2013) Juan D. Chavez et al.   MOLECULAR & CELLULAR PROTEOMICS

Analysis Tool Web Services from the EMBL-EBI

(2013) Hamish McWilliam et al.   NUCLEIC ACIDS RESEARCH

Dimers of mitochondrial ATP synthase form the permeability transition pore

(2013) V. Giorgio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of cardiolipin binding sites on cytochrome c oxidase at the entrance of proton channels

(2013) C. Arnarez et al.   Scientific Reports

Molecular Dynamics Simulations of Creatine Kinase and Adenine Nucleotide Translocase in Mitochondrial Membrane Patch

(2012) Jaanus Karo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human Trifunctional Protein Alpha Links Cardiolipin Remodeling to Beta-Oxidation

(2012) William A. Taylor et al.   PLoS One

Structure of the yeast F1Fo-ATP synthase dimer and its role in shaping the mitochondrial cristae

(2012) K. M. Davies et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comet: An open-source MS/MS sequence database search tool

(2012) Jimmy K. Eng et al.   PROTEOMICS

The Q cycle of cytochrome bc complexes: A structure perspective

(2011) William A. Cramer et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Cardiolipin Affects the Supramolecular Organization of ATP Synthase in Mitochondria

(2011) Devrim Acehan et al.   BIOPHYSICAL JOURNAL

Molecular Modeling and Functional Confirmation of a Predicted Fatty Acid Binding Site of Mitochondrial Aspartate Aminotransferase

(2011) Michael W. Bradbury et al.   JOURNAL OF MOLECULAR BIOLOGY

Quantitative Proteomic and Interaction Network Analysis of Cisplatin Resistance in HeLa Cells

(2011) Juan D. Chavez et al.   PLoS One

Isocitrate Dehydrogenase 1 and 2 Mutations in Cancer: Alterations at a Crossroads of Cellular Metabolism

(2010) Z. J. Reitman et al.   JNCI-Journal of the National Cancer Institute

Mitochondrial kinases and their molecular interaction with cardiolipin

(2009) Uwe Schlattner et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans

(2009) Ethan J. Anderson et al.   JOURNAL OF CLINICAL INVESTIGATION

The influence of the acyl chain composition of cardiolipin on the stability of mitochondrial complexes; An unexpected effect of cardiolipin in α-ketoglutarate dehydrogenase and prohibitin complexes

(2009) Renske A. van Gestel et al.   Journal of Proteomics

Dimer ribbons of ATP synthase shape the inner mitochondrial membrane

(2008) Mike Strauss et al.   EMBO JOURNAL

Structure of Complex III with Bound Cytochromecin Reduced State and Definition of a Minimal Core Interface for Electron Transfer

(2008) Sozanne R. N. Solmaz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY