Activation of Mitochondrial Unfolded Protein Response in SHSY5Y Expressing APP Cells and APP/PS1 Mice

The UPRmtProtectsCaenorhabditis elegansfrom Mitochondrial Dysfunction by Upregulating Specific Enzymes of the Mevalonate Pathway

(2018) Olga Oks et al.   GENETICS

Early and Selective Activation and Subsequent Alterations to the Unfolded Protein Response in Down Syndrome Mouse Models

(2018) Chiara Lanzillotta et al.   JOURNAL OF ALZHEIMERS DISEASE

The UPRmtProtectsCaenorhabditis elegansfrom Mitochondrial Dysfunction by Upregulating Specific Enzymes of the Mevalonate Pathway

(2018) Olga Oks et al.   GENETICS

Alzheimer’s disease: a molecular mechanism, new hypotheses, and therapeutic strategies

(2018) Milda Plečkaitytė   Medicina-Lithuania

Enhancing mitochondrial proteostasis reduces amyloid-β proteotoxicity

(2017) Vincenzo Sorrentino et al.   NATURE

Evidence for Mitochondrial UPR Gene Activation in Familial and Sporadic Alzheimer's Disease

(2016) John S. Beck et al.   Current Alzheimer Research

Maintenance and propagation of a deleterious mitochondrial genome by the mitochondrial unfolded protein response

(2016) Yi-Fan Lin et al.   NATURE

The impact of mitochondrial endosymbiosis on the evolution of calcium signaling

(2015) Neil W. Blackstone   CELL CALCIUM

The unpredictability of prolonged activation of stress response pathways

(2015) Lilian T. Lamech et al.   JOURNAL OF CELL BIOLOGY

Caenorhabditis elegans pathways that surveil and defend mitochondria

(2014) Ying Liu et al.   NATURE

Loss of HMG-CoA Reductase in C. elegans Causes Defects in Protein Prenylation and Muscle Mitochondria

(2014) Parmida Ranji et al.   PLoS One

Controlled sumoylation of the mevalonate pathway enzyme HMGS-1 regulates metabolism during aging

(2014) Amir Sapir et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of the mitochondrial unfolded protein response does not predict longevity in Caenorhabditis elegans

(2014) Christopher F. Bennett et al.   Nature Communications

Mitonuclear protein imbalance as a conserved longevity mechanism

(2013) Riekelt H. Houtkooper et al.   NATURE

Surveillance-Activated Defenses Block the ROS–Induced Mitochondrial Unfolded Protein Response

(2013) Eva D. Runkel et al.   PLoS Genetics

Signaling the mitochondrial unfolded protein response

(2012) Mark W. Pellegrino et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Could plasma sphingolipids be diagnostic or prognostic biomarkers for Alzheimer’s disease?

(2012) Michelle M Mielke et al.   Clinical Lipidology

Activation of the unfolded protein response pathway causes ceramide accumulation in yeast and INS-1E insulinoma cells

(2012) Sharon Epstein et al.   JOURNAL OF LIPID RESEARCH

Protective Coupling of Mitochondrial Function and Protein Synthesis via the eIF2α Kinase GCN-2

(2012) Brooke M. Baker et al.   PLoS Genetics

The Cell-Non-Autonomous Nature of Electron Transport Chain-Mediated Longevity

(2011) Jenni Durieux et al.   CELL

Estrogen receptor mediates a distinct mitochondrial unfolded protein response

(2011) L. Papa et al.   JOURNAL OF CELL SCIENCE

MicroRNA-137/181c Regulates Serine Palmitoyltransferase and In Turn Amyloid  , Novel Targets in Sporadic Alzheimer's Disease

(2011) H. Geekiyanage et al.   JOURNAL OF NEUROSCIENCE

Structural and mechanistic commonalities of amyloid-β and the prion protein

(2011) Bianca Da Costa Dias et al.   Prion

Sphingosine-1-phosphate phosphohydrolase-1 regulates ER stress-induced autophagy

(2010) S Lépine et al.   CELL DEATH AND DIFFERENTIATION

Altered enzymatic activity and allele frequency of OMI/HTRA2 in Alzheimer's disease

(2010) Marie Westerlund et al.   FASEB JOURNAL

The mitochondrial UPR - protecting organelle protein homeostasis

(2010) C. M. Haynes et al.   JOURNAL OF CELL SCIENCE

The Role of Mitochondria in Apoptosis

(2009) Chunxin Wang et al.   Annual Review of Genetics

Disruption of ceramide synthesis by CerS2 down-regulation leads to autophagy and the unfolded protein response

(2009) Stefka D. Spassieva et al.   BIOCHEMICAL JOURNAL

Quality control of mitochondria: protection against neurodegeneration and ageing

(2008) Takashi Tatsuta et al.   EMBO JOURNAL

Serum sphingomyelins and ceramides are early predictors of memory impairment

(2008) Michelle M. Mielke et al.   NEUROBIOLOGY OF AGING