How Do Post-Translational Modifications Influence the Pathomechanistic Landscape of Huntington’s Disease? A Comprehensive Review

Molecular mechanisms in SUMO conjugation

(2020) Nathalia Varejão et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Much More Than a Scaffold: Cytoskeletal Proteins in Neurological Disorders

(2020) Diana C. Muñoz-Lasso et al.   Cells

SUMOylation in development and neurodegeneration

(2020) Tak-Yu Yau et al.   DEVELOPMENT

Nemo-like kinase reduces mutant huntingtin levels and mitigates Huntington’s disease

(2020) Mali Jiang et al.   HUMAN MOLECULAR GENETICS

Do Post-Translational Modifications Influence Protein Aggregation in Neurodegenerative Diseases: A Systematic Review

(2020) Larissa-Nele Schaffert et al.   Brain Sciences

A protein quality control pathway regulated by linear ubiquitination

(2019) Eva M van Well et al.   EMBO JOURNAL

Metabolic Reprogramming in Astrocytes Distinguishes Region-Specific Neuronal Susceptibility in Huntington Mice

(2019) Aris A. Polyzos et al.   Cell Metabolism

Cdk5 dysfunction contributes to depressive-like behaviors in Huntington´s Disease by altering the phospho-DARPP-32 status in the nucleus accumbens

(2019) Veronica Brito et al.   BIOLOGICAL PSYCHIATRY

New insights of poly(ADP-ribosylation) in neurodegenerative diseases: A focus on protein phase separation and pathologic aggregation

(2019) Cong Liu et al.   BIOCHEMICAL PHARMACOLOGY

Rhes travels from cell to cell and transports Huntington disease protein via TNT-like protrusion

(2019) Manish Sharma et al.   JOURNAL OF CELL BIOLOGY

Global Proteome and Ubiquitinome Changes in the Soluble and Insoluble Fractions of Q175 Huntington Mice Brains

(2019) Karen A. Sap et al.   MOLECULAR & CELLULAR PROTEOMICS

IKKβ slows Huntington’s disease progression in R6/1 mice

(2019) Joseph Ochaba et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Developmental NMDA receptor dysregulation in the infantile neuronal ceroid lipofuscinosis mouse model

(2019) Kevin P Koster et al.   eLife

Mutant huntingtin impairs PNKP and ATXN3, disrupting DNA repair and transcription

(2019) Rui Gao et al.   eLife

Cullin-4B E3 ubiquitin ligase mediates Apaf-1 ubiquitination to regulate caspase-9 activity

(2019) Eri Ohta et al.   PLoS One

A soluble truncated tau species related to cognitive dysfunction and caspase-2 is elevated in the brain of Huntington’s disease patients

(2019) Peng Liu et al.   Acta Neuropathologica Communications

SUMOylation in Neurodegenerative Diseases

(2019) Andrea Princz et al.   GERONTOLOGY

The pathobiology of perturbed mutant huntingtin protein–protein interactions in Huntington's disease

(2019) Erich E. Wanker et al.   JOURNAL OF NEUROCHEMISTRY

Ultrasensitive quantitative measurement of huntingtin phosphorylation at residue S13

(2019) Cristina Cariulo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Bioinformatics analysis of Ras homologue enriched in the striatum, a potential target for Huntington's disease therapy

(2019) Miriam Carbo et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Juvenile Huntington’s Disease Skin Fibroblasts Respond with Elevated Parkin Level and Increased Proteasome Activity as a Potential Mechanism to Counterbalance the Pathological Consequences of Mutant Huntingtin Protein

(2019) Azzam Aladdin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Lowering Mutant Huntingtin Levels and Toxicity: Autophagy-Endolysosome Pathways in Huntington's Disease

(2019) Evelina Valionyte et al.   JOURNAL OF MOLECULAR BIOLOGY

SIRT3 Regulation of Mitochondrial Quality Control in Neurodegenerative Diseases

(2019) Hao Meng et al.   Frontiers in Aging Neuroscience

Autophagic and endo-lysosomal dysfunction in neurodegenerative disease

(2019) Bilal R. Malik et al.   Molecular Brain

SUMOylation Prevents Huntingtin Fibrillization and Localization onto Lipid Membranes

(2019) Faezeh Sedighi et al.   ACS Chemical Neuroscience

TRPC5 channel instability induced by depalmitoylation protects striatal neurons against oxidative stress in Huntington's disease

(2019) Chansik Hong et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Manganese Acts upon Insulin/IGF Receptors to Phosphorylate AKT and Increase Glucose Uptake in Huntington’s Disease Cells

(2019) Miles R. Bryan et al.   MOLECULAR NEUROBIOLOGY

Lercanidipine boosts the efficacy of mesenchymal stem cell therapy in 3-NP-induced Huntington's disease model rats via modulation of the calcium/calcineurin/NFATc4 and Wnt/β-catenin signalling pathways

(2019) Eman M. Elbaz et al.   NEUROCHEMISTRY INTERNATIONAL

Epigenetic mechanisms of neurodegenerative diseases and acute brain injury

(2019) Mario J. Bertogliat et al.   NEUROCHEMISTRY INTERNATIONAL

Huntington’s Disease Pathogenesis Is Modified In Vivo by Alfy/Wdfy3 and Selective Macroautophagy

(2019) Leora M. Fox et al.   NEURON

Structure and Function of the 26S Proteasome

(2018) Jared A.M. Bard et al.   Annual Review of Biochemistry

Drp1 phosphorylation by MAPK1 causes mitochondrial dysfunction in cell culture model of Huntington's disease

(2018) Anne Jessica Roe et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Autophagy in health and disease: A comprehensive review

(2018) Sarbari Saha et al.   BIOMEDICINE & PHARMACOTHERAPY

Synthetic 3',4'-Dihydroxyflavone Exerts Anti-Neuroinflammatory Effects in BV2 Microglia and a Mouse Model

(2018) Namkwon Kim et al.   Biomolecules & Therapeutics

Systematic genetic interaction studies identify histone demethylase Utx as potential target for ameliorating Huntington’s disease

(2018) Wan Song et al.   HUMAN MOLECULAR GENETICS

The role of Cdk5-mediated Drp1 phosphorylation in Aβ1-42 induced mitochondrial fission and neuronal apoptosis

(2018) Miao-Yu Guo et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Aberrant subcellular localization of SQSTM1/p62 contributes to increased vulnerability to proteotoxic stress recovery in Huntington's disease

(2018) Ningjing Huang et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Herp Promotes Degradation of Mutant Huntingtin: Involvement of the Proteasome and Molecular Chaperones

(2018) Huanhuan Luo et al.   MOLECULAR NEUROBIOLOGY

The ubiquitin conjugating enzyme Ube2W regulates solubility of the Huntington's disease protein, huntingtin

(2018) Bo Wang et al.   NEUROBIOLOGY OF DISEASE

YOD1 attenuates neurogenic proteotoxicity through its deubiquitinating activity

(2018) Kunikazu Tanji et al.   NEUROBIOLOGY OF DISEASE

Huntingtin protein: A new option for fixing the Huntington's disease countdown clock

(2018) Marco Caterino et al.   NEUROPHARMACOLOGY

Pharmacological disruption of the MID1/α4 interaction reduces mutant Huntingtin levels in primary neuronal cultures

(2018) Olivia Monteiro et al.   NEUROSCIENCE LETTERS

Amelioration of Huntington's disease phenotypes by Beta-Lapachone is associated with increases in Sirt1 expression, CREB phosphorylation and PGC-1α deacetylation

(2018) Mijung Lee et al.   PLoS One

N6-Furfuryladenine is protective in Huntington’s disease models by signaling huntingtin phosphorylation

(2018) Laura E. Bowie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aerobic glycolysis in amyotrophic lateral sclerosis and Huntington’s disease

(2018) Alexandre Vallée et al.   REVIEWS IN THE NEUROSCIENCES

A human huntingtin SNP alters post-translational modification and pathogenic proteolysis of the protein causing Huntington disease

(2018) D. D. O. Martin et al.   Scientific Reports

Dynamic recruitment of ubiquitin to mutant huntingtin inclusion bodies

(2018) Katrin Juenemann et al.   Scientific Reports

Dual Function of USP14 Deubiquitinase in Cellular Proteasomal Activity and Autophagic Flux

(2018) Eunkyoung Kim et al.   Cell Reports

Transcriptional Dysregulation and Post-translational Modifications in Polyglutamine Diseases: From Pathogenesis to Potential Therapeutic Strategies

(2018) Chunchen Xiang et al.   Frontiers in Molecular Neuroscience

Mitochondrial Quality Control in Neurodegenerative Diseases: Focus on Parkinson's Disease and Huntington's Disease

(2018) Sandra Franco-Iborra et al.   Frontiers in Neuroscience

N-terminal Huntingtin (Htt) phosphorylation is a molecular switch regulating Htt aggregation, helical conformation, internalization, and nuclear targeting

(2018) Sean M. Deguire et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT3 Overexpression Inhibits Growth of Kidney Tumor Cells and Enhances Mitochondrial Biogenesis

(2018) Huan Liu et al.   JOURNAL OF PROTEOME RESEARCH

A role for autophagy in Huntington's disease

(2018) Katherine R. Croce et al.   NEUROBIOLOGY OF DISEASE

Mutational analysis implicates the amyloid fibril as the toxic entity in Huntington's disease

(2018) Kenneth W. Drombosky et al.   NEUROBIOLOGY OF DISEASE

Pharmacogenetic modulation of STEP improves motor and cognitive function in a mouse model of Huntington's disease

(2018) Marta García-Forn et al.   NEUROBIOLOGY OF DISEASE

Deubiquitinase Usp12 functions noncatalytically to induce autophagy and confer neuroprotection in models of Huntington’s disease

(2018) Rebecca Aron et al.   Nature Communications

Identification of a novel caspase cleavage site in huntingtin that regulates mutant huntingtin clearance

(2018) Dale D. O. Martin et al.   FASEB JOURNAL

Dynamin-related protein 1: A critical protein in the pathogenesis of neural system dysfunctions and neurodegenerative diseases

(2018) Zhihao Qi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Modulation of AMPA receptor surface diffusion restores hippocampal plasticity and memory in Huntington’s disease models

(2018) Hongyu Zhang et al.   Nature Communications

Simultaneous blockade of NMDA receptors and PARP-1 activity synergistically alleviate immunoexcitotoxicity and bioenergetics in 3-nitropropionic acid intoxicated mice: Evidences from memantine and 3-aminobenzamide interventions

(2017) Saravana Babu Chidambaram et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Protein phosphatase 1 regulates huntingtin exon 1 aggregation and toxicity

(2017) Joana Branco-Santos et al.   HUMAN MOLECULAR GENETICS

Post-translational modifications clustering within proteolytic domains decrease mutant huntingtin toxicity

(2017) Nicolas Arbez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Post-Translational Modifications (PTMs), Identified on Endogenous Huntingtin, Cluster within Proteolytic Domains between HEAT Repeats

(2017) Tamara Ratovitski et al.   JOURNAL OF PROTEOME RESEARCH

Decoding the selectivity of eIF2α holophosphatases and PPP1R15A inhibitors

(2017) Marta Carrara et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

CDK5 inhibitors prevent astroglial apoptosis and reactive astrogliosis by regulating PKA and DRP1 phosphorylations in the rat hippocampus

(2017) Hye-Won Hyun et al.   NEUROSCIENCE RESEARCH

Huntington’s Disease and Mitochondria

(2017) Mohammad Jodeiri Farshbaf et al.   NEUROTOXICITY RESEARCH

Ubiquitin Accumulation on Disease Associated Protein Aggregates Is Correlated with Nuclear Ubiquitin Depletion, Histone De-Ubiquitination and Impaired DNA Damage Response

(2017) Adi Ben Yehuda et al.   PLoS One

Differential HspBP1 expression accounts for the greater vulnerability of neurons than astrocytes to misfolded proteins

(2017) Ting Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphorylation of huntingtin at residue T3 is decreased in Huntington’s disease and modulates mutant huntingtin protein conformation

(2017) Cristina Cariulo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pyk2 modulates hippocampal excitatory synapses and contributes to cognitive deficits in a Huntington’s disease model

(2017) Albert Giralt et al.   Nature Communications

Decoding the selectivity of eIF2α holophosphatases and PPP1R15A inhibitors

(2017) Marta Carrara et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Dendritic Spine Pathology in Neurodegenerative Diseases

(2016) Jochen Herms et al.   Annual Review of Pathology-Mechanisms of Disease

Acetylation within the First 17 Residues of Huntingtin Exon 1 Alters Aggregation and Lipid Binding

(2016) Maxmore Chaibva et al.   BIOPHYSICAL JOURNAL

Atypical ubiquitination by E3 ligase WWP1 inhibits the proteasome-mediated degradation of mutant huntingtin

(2016) Li Lin et al.   BRAIN RESEARCH

Palmitoylation of caspase-6 by HIP14 regulates its activation

(2016) Niels H Skotte et al.   CELL DEATH AND DIFFERENTIATION

USP14 regulates autophagy by suppressing K63 ubiquitination of Beclin 1

(2016) Daichao Xu et al.   GENES & DEVELOPMENT

Oxygen consumption deficit in Huntington disease mouse brain under metabolic stress

(2016) Song Lou et al.   HUMAN MOLECULAR GENETICS

Huntingtin is a scaffolding protein in the ATM oxidative DNA damage response complex

(2016) Tamara Maiuri et al.   HUMAN MOLECULAR GENETICS

Regulation of TRPP3 Channel Function by N-terminal Domain Palmitoylation and Phosphorylation

(2016) Wang Zheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A high-yield double-purification proteomics strategy for the identification of SUMO sites

(2016) Ivo A Hendriks et al.   Nature Protocols

A comprehensive compilation of SUMO proteomics

(2016) Ivo A. Hendriks et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitochondrial dynamics and quality control in Huntington's disease

(2016) Pedro Guedes-Dias et al.   NEUROBIOLOGY OF DISEASE

PIAS1 Regulates Mutant Huntingtin Accumulation and Huntington’s Disease-Associated Phenotypes In Vivo

(2016) Joseph Ochaba et al.   NEURON

The Biology of Huntingtin

(2016) Frédéric Saudou et al.   NEURON

GSK-3β-induced Tau pathology drives hippocampal neuronal cell death in Huntington’s disease: involvement of astrocyte–neuron interactions

(2016) F L'Episcopo et al.   Cell Death & Disease

VCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Huntington’s disease

(2016) Xing Guo et al.   Nature Communications

Role of Striatal-Enriched Tyrosine Phosphatase in Neuronal Function

(2016) Marija Kamceva et al.   NEURAL PLASTICITY

Blocking the association of HDAC4 with MAP1S accelerates autophagy clearance of mutant Huntingtin

(2015) Fei Yue et al.   Aging-US

Targeting Hsp90/Hsp70-Based Protein Quality Control for Treatment of Adult Onset Neurodegenerative Diseases

(2015) William B. Pratt et al.   Annual Review of Pharmacology and Toxicology

HDAC6 inhibition induces mitochondrial fusion, autophagic flux and reduces diffuse mutant huntingtin in striatal neurons

(2015) Pedro Guedes-Dias et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Increased TRPC5 glutathionylation contributes to striatal neuron loss in Huntington’s disease

(2015) Chansik Hong et al.   BRAIN

The role of tau in the pathological process and clinical expression of Huntington’s disease

(2015) Romina Vuono et al.   BRAIN

PRMT5- mediated symmetric arginine dimethylation is attenuated by mutant huntingtin and is impaired in Huntington's disease (HD)

(2015) Tamara Ratovitski et al.   CELL CYCLE

Tubulin acetylation: responsible enzymes, biological functions and human diseases

(2015) Lin Li et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The JAK/STAT3 Pathway Is a Common Inducer of Astrocyte Reactivity in Alzheimer's and Huntington's Diseases

(2015) L. Ben Haim et al.   JOURNAL OF NEUROSCIENCE

Mutant Huntingtin and Elusive Defects in Oxidative Metabolism and Mitochondrial Calcium Handling

(2015) Nickolay Brustovetsky   MOLECULAR NEUROBIOLOGY

Aberrant protein S-nitrosylation contributes to the pathophysiology of neurodegenerative diseases

(2015) Tomohiro Nakamura et al.   NEUROBIOLOGY OF DISEASE

PARP-1 Inhibition Is Neuroprotective in the R6/2 Mouse Model of Huntington’s Disease

(2015) Antonella Cardinale et al.   PLoS One

Regulation of brain glutamate metabolism by nitric oxide and S-nitrosylation

(2015) Karthik Raju et al.   Science Signaling

DARPP-32 interaction with adducin may mediate rapid environmental effects on striatal neurons

(2015) Olivia Engmann et al.   Nature Communications

Regulation of brain glutamate metabolism by nitric oxide and S-nitrosylation

(2015) Karthik Raju et al.   Science Signaling

Genetic deletion of the Histone Deacetylase 6 exacerbates selected behavioral deficits in the R6/1 mouse model for Huntington's disease

(2015) Alienor Ragot et al.   Brain and Behavior

HTT-lowering reverses Huntington’s disease immune dysfunction caused by NFκB pathway dysregulation

(2014) Ulrike Träger et al.   BRAIN

The Differential Profiling of Ubiquitin-Proteasome and Autophagy Systems in Different Tissues before the Onset of Huntington's Disease Models

(2014) Lu-Shiun Her et al.   BRAIN PATHOLOGY

Spontaneous self-assembly of pathogenic huntingtin exon 1 protein into amyloid structures

(2014) Philipp Trepte et al.   Essays in Biochemistry

Localized changes to glycogen synthase kinase-3 and collapsin response mediator protein-2 in the Huntington's disease affected brain

(2014) N. K. H. Lim et al.   HUMAN MOLECULAR GENETICS

Mutant huntingtin alters Tau phosphorylation and subcellular distribution

(2014) David Blum et al.   HUMAN MOLECULAR GENETICS

Tau hyperphosphorylation and deregulation of calcineurin in mouse models of Huntington's disease

(2014) Maud Gratuze et al.   HUMAN MOLECULAR GENETICS

Ubiquitin-Activating Enzyme Activity Contributes to Differential Accumulation of Mutant Huntingtin in Brain and Peripheral Tissues

(2014) B. E. Wade et al.   JOURNAL OF NEUROSCIENCE

Sirtuin 3 interacts with Lon protease and regulates its acetylation status

(2014) Lara Gibellini et al.   MITOCHONDRION

Transcription, Epigenetics and Ameliorative Strategies in Huntington’s Disease: a Genome-Wide Perspective

(2014) Luis M. Valor   MOLECULAR NEUROBIOLOGY

Activation of IGF-1 and Insulin Signaling Pathways Ameliorate Mitochondrial Function and Energy Metabolism in Huntington’s Disease Human Lymphoblasts

(2014) Luana Naia et al.   MOLECULAR NEUROBIOLOGY

Mitogen-Activated Protein Kinase Phosphatase (MKP)-1 in Nervous System Development and Disease

(2014) Louise M. Collins et al.   MOLECULAR NEUROBIOLOGY

Huntington's disease is a four-repeat tauopathy with tau nuclear rods

(2014) Marta Fernández-Nogales et al.   NATURE MEDICINE

Phosphorylation of Mutant Huntingtin at Serine 116 Modulates Neuronal Toxicity

(2014) Erin E. Watkin et al.   PLoS One

ER Stress-Induced eIF2-alpha Phosphorylation Underlies Sensitivity of Striatal Neurons to Pathogenic Huntingtin

(2014) Julia Leitman et al.   PLoS One

Potential function for the Huntingtin protein as a scaffold for selective autophagy

(2014) Joseph Ochaba et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inputs and outputs of poly(ADP-ribosyl)ation: Relevance to oxidative stress

(2014) Csaba Hegedűs et al.   Redox Biology

S-Nitrosylation of Dynamin-Related Protein 1 Mediates Mutant Huntingtin-Induced Mitochondrial Fragmentation and Neuronal Injury in Huntington's Disease

(2013) Florian Haun et al.   ANTIOXIDANTS & REDOX SIGNALING

PGC-1α, mitochondrial dysfunction, and Huntington's disease

(2013) Ashu Johri et al.   FREE RADICAL BIOLOGY AND MEDICINE

Bidirectional Control of Postsynaptic Density-95 (PSD-95) Clustering by Huntingtin

(2013) Matthew P. Parsons et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dysregulation of voltage-gated sodium channels by ubiquitin ligase NEDD4-2 in neuropathic pain

(2013) Cédric J. Laedermann et al.   JOURNAL OF CLINICAL INVESTIGATION

MAP Kinase Phosphatase 1 (MKP-1/DUSP1) Is Neuroprotective in Huntington's Disease via Additive Effects of JNK and p38 Inhibition

(2013) D. M. Taylor et al.   JOURNAL OF NEUROSCIENCE

Genomic Landscape of Transcriptional and Epigenetic Dysregulation in Early Onset Polyglutamine Disease

(2013) L. M. Valor et al.   JOURNAL OF NEUROSCIENCE

Poly(ADP-ribose) signaling in cell death

(2013) László Virág et al.   MOLECULAR ASPECTS OF MEDICINE

ESET methylates UBF at K232/254 and regulates nucleolar heterochromatin plasticity and rDNA transcription

(2013) Yu Jin Hwang et al.   NUCLEIC ACIDS RESEARCH

Soluble forms of polyQ-expanded huntingtin rather than large aggregates cause endoplasmic reticulum stress

(2013) Julia Leitman et al.   Nature Communications

Translation of HTT mRNA with expanded CAG repeats is regulated by the MID1–PP2A protein complex

(2013) Sybille Krauß et al.   Nature Communications

Activated CaMKII Couples GluN2B and Casein Kinase 2 to Control Synaptic NMDA Receptors

(2013) Antonio Sanz-Clemente et al.   Cell Reports

SUMO-2 and PIAS1 Modulate Insoluble Mutant Huntingtin Protein Accumulation

(2013) Jacqueline Gire O’Rourke et al.   Cell Reports

Recent advances into the understanding of mitochondrial fission

(2012) Kirstin Elgass et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mitochondria: In Sickness and in Health

(2012) Jodi Nunnari et al.   CELL

The Ubiquitin-Proteasome System of Saccharomyces cerevisiae

(2012) D. Finley et al.   GENETICS

Dual-specificity Tyrosine Phosphorylation-regulated Kinase 1A (Dyrk1A) Modulates Serine/Arginine-rich Protein 55 (SRp55)-promoted Tau Exon 10 Inclusion

(2012) Xiaomin Yin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regional vulnerability in Huntington's disease: fMRI-guided molecular analysis in patients and a mouse model of disease

(2012) Nicole M. Lewandowski et al.   NEUROBIOLOGY OF DISEASE

Ganglioside GM1 induces phosphorylation of mutant huntingtin and restores normal motor behavior in Huntington disease mice

(2012) A. Di Pardo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SAP102 Mediates Synaptic Clearance of NMDA Receptors

(2012) Bo-Shiun Chen et al.   Cell Reports

PARP-1 cleavage fragments: signatures of cell-death proteases in neurodegeneration

(2011) Ganta Chaitanya et al.   Cell Communication and Signaling

Dysregulation of upstream binding factor-1 acetylation at K352 is linked to impaired ribosomal DNA transcription in Huntington's disease

(2011) J Lee et al.   CELL DEATH AND DIFFERENTIATION

Long-term memory deficits in Huntington's disease are associated with reduced CBP histone acetylase activity

(2011) A. Giralt et al.   HUMAN MOLECULAR GENETICS

Wild-type HTT modulates the enzymatic activity of the neuronal palmitoyl transferase HIP14

(2011) Kun Huang et al.   HUMAN MOLECULAR GENETICS

Minocycline inhibits cell death and decreases mutant Huntingtin aggregation by targeting Apaf-1

(2011) Mónica Sancho et al.   HUMAN MOLECULAR GENETICS

Mutant huntingtin's interaction with mitochondrial protein Drp1 impairs mitochondrial biogenesis and causes defective axonal transport and synaptic degeneration in Huntington's disease

(2011) U. P. Shirendeb et al.   HUMAN MOLECULAR GENETICS

Modifications of p53 and the DNA Damage Response in Cells Expressing Mutant Form of the Protein Huntingtin

(2011) Jennifer L. Illuzzi et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Microglial p38α MAPK is a key regulator of proinflammatory cytokine up-regulation induced by toll-like receptor (TLR) ligands or beta-amyloid (Aβ)

(2011) Adam D Bachstetter et al.   Journal of Neuroinflammation

The Aggregation-Enhancing Huntingtin N-Terminus Is Helical in Amyloid Fibrils

(2011) V. N. Sivanandam et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mass Spectrometric Identification of Novel Lysine Acetylation Sites in Huntingtin

(2011) Xin Cong et al.   MOLECULAR & CELLULAR PROTEOMICS

Kinase inhibitors modulate huntingtin cell localization and toxicity

(2011) Randy Singh Atwal et al.   Nature Chemical Biology

Mutant huntingtin binds the mitochondrial fission GTPase dynamin-related protein-1 and increases its enzymatic activity

(2011) Wenjun Song et al.   NATURE MEDICINE

The role of IκB kinase complex in the neurobiology of Huntington's disease

(2011) Ali Khoshnan et al.   NEUROBIOLOGY OF DISEASE

Post-translational modifications of tau protein: Implications for Alzheimer's disease

(2011) Ludovic Martin et al.   NEUROCHEMISTRY INTERNATIONAL

Hdac6 Knock-Out Increases Tubulin Acetylation but Does Not Modify Disease Progression in the R6/2 Mouse Model of Huntington's Disease

(2011) Anna Bobrowska et al.   PLoS One

Ser46 phosphorylation and prolyl-isomerase Pin1-mediated isomerization of p53 are key events in p53-dependent apoptosis induced by mutant huntingtin

(2011) A. Grison et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Toll-like receptor signaling in neural plasticity and disease

(2011) Eitan Okun et al.   TRENDS IN NEUROSCIENCES

DARPP-32, Jack of All Trades? Master of Which?

(2011) Marion Yger et al.   Frontiers in Behavioral Neuroscience

Dynamic regulation of mitochondrial fission through modification of the dynamin-related protein Drp1

(2010) Chuang-Rung Chang et al.   Annals of the New York Academy of Sciences

The Interplay Between Mitochondrial Dynamics and Mitophagy

(2010) Gilad Twig et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondrial fission and cristae disruption increase the response of cell models of Huntington's disease to apoptotic stimuli

(2010) Veronica Costa et al.   EMBO Molecular Medicine

Phosphorylation of Huntingtin at Ser421 in YAC128 Neurons Is Associated with Protection of YAC128 Neurons from NMDA-Mediated Excitotoxicity and Is Modulated by PP1 and PP2A

(2010) M. Metzler et al.   JOURNAL OF NEUROSCIENCE

Huntington's disease: from molecular pathogenesis to clinical treatment

(2010) Christopher A Ross et al.   LANCET NEUROLOGY

Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease

(2010) Marta Martinez-Vicente et al.   NATURE NEUROSCIENCE

p75NTR-dependent, myelin-mediated axonal degeneration regulates neural connectivity in the adult brain

(2010) Katya J Park et al.   NATURE NEUROSCIENCE

Prion-like transmission of protein aggregates in neurodegenerative diseases

(2010) Patrik Brundin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Protein palmitoylation in neuronal development and synaptic plasticity

(2010) Yuko Fukata et al.   NATURE REVIEWS NEUROSCIENCE

Palmitoylation and function of glial glutamate transporter-1 is reduced in the YAC128 mouse model of Huntington disease

(2010) Kun Huang et al.   NEUROBIOLOGY OF DISEASE

Casein Kinase 2 Regulates the NR2 Subunit Composition of Synaptic NMDA Receptors

(2010) Antonio Sanz-Clemente et al.   NEURON

Mechanism of PP2A-mediated IKKβ dephosphorylation: a systems biological approach

(2009) Johannes Witt et al.   BMC Systems Biology

Acetylation Targets Mutant Huntingtin to Autophagosomes for Degradation

(2009) Hyunkyung Jeong et al.   CELL

PH domain leucine-rich repeat protein phosphatase 1 contributes to maintain the activation of the PI3K/Akt pro-survival pathway in Huntington's disease striatum

(2009) A Saavedra et al.   CELL DEATH AND DIFFERENTIATION

Phosphorylation of Threonine 3

(2009) Charity T. Aiken et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome

(2009) Leslie Michels Thompson et al.   JOURNAL OF CELL BIOLOGY

Glutamate toxicity in the striatum of the R6/2 Huntington's disease transgenic mice is age-dependent and correlates with decreased levels of glutamate transporters

(2009) Ana María Estrada-Sánchez et al.   NEUROBIOLOGY OF DISEASE

CREB is a key regulator of striatal vulnerability in chemical and genetic models of Huntington's disease

(2009) Yun-Sik Choi et al.   NEUROBIOLOGY OF DISEASE

Serines 13 and 16 Are Critical Determinants of Full-Length Human Mutant Huntingtin Induced Disease Pathogenesis in HD Mice

(2009) Xiaofeng Gu et al.   NEURON

Distinct neuroinflammatory profile in post-mortem human Huntingtonʼs disease

(2009) Aurelio Silvestroni et al.   NEUROREPORT

Secondary Structure of Huntingtin Amino-Terminal Region

(2009) Mee Whi Kim et al.   STRUCTURE

Huntingtin phosphorylation acts as a molecular switch for anterograde/retrograde transport in neurons

(2008) Emilie Colin et al.   EMBO JOURNAL

Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

(2008) Gilad Twig et al.   EMBO JOURNAL

Immune markers for Huntington’s disease?

(2008) Edward Wild et al.   Expert Review of Neurotherapeutics

Phosphorylation of mutant huntingtin at S421 restores anterograde and retrograde transport in neurons

(2008) Diana Zala et al.   HUMAN MOLECULAR GENETICS

Effects of overexpression of Huntingtin proteins on mitochondrial integrity

(2008) Hongmin Wang et al.   HUMAN MOLECULAR GENETICS

Calcineurin is involved in the early activation of NMDA-mediated cell death in mutant huntingtin knock-in striatal cells

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