Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents

Urolithin A, C, and D, but not iso-urolithin A and urolithin B, attenuate triglyceride accumulation in human cultures of adipocytes and hepatocytes

(2016) Inhae Kang et al.   MOLECULAR NUTRITION & FOOD RESEARCH

No longer going to waste

(2016) Ken Garber   NATURE BIOTECHNOLOGY

Fate of Microbial Metabolites of Dietary Polyphenols in Rats: Is the Brain Their Target Destination?

(2015) Mattia Gasperotti et al.   ACS Chemical Neuroscience

A rapid and high content assay that measures cyto-ID-stained autophagic compartments and estimates autophagy flux with potential clinical applications

(2015) Sujuan Guo et al.   Autophagy

Urolithins, gut microbiota-derived metabolites of ellagitannins, inhibit LPS-induced inflammation in RAW 264.7 murine macrophages

(2015) Jakub P. Piwowarski et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans

(2015) Konstantinos Palikaras et al.   NATURE

The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

(2015) Michael Lazarou et al.   NATURE

Mitophagy confers resistance to siderophore-mediated killing byPseudomonas aeruginosa

(2015) Natalia V. Kirienko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Parkin-mediated mitophagy directs perinatal cardiac metabolic maturation in mice

(2015) G. Gong et al.   SCIENCE

Controlled-release mitochondrial protonophore reverses diabetes and steatohepatitis in rats

(2015) R. J. Perry et al.   SCIENCE

Ellagic Acid Metabolism by Human Gut Microbiota: Consistent Observation of Three Urolithin Phenotypes in Intervention Trials, Independent of Food Source, Age, and Health Status

(2014) Francisco A. Tomás-Barberán et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Downregulation of E3 Ubiquitin Ligases and Mitophagy-Related Genes in Skeletal Muscle of Physically Inactive, Frail Older Women: A Cross-Sectional Comparison

(2014) M. J. Drummond et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Targeted metabolic profiling of pomegranate polyphenols and urolithins in plasma, urine and colon tissues from colorectal cancer patients

(2014) María A. Nuñez-Sánchez et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Niclosamide ethanolamine–induced mild mitochondrial uncoupling improves diabetic symptoms in mice

(2014) Hanlin Tao et al.   NATURE MEDICINE

Treatment of sporadic inclusion body myositis with bimagrumab

(2014) A. A. Amato et al.   NEUROLOGY

Clinical Effectiveness of Protein and Amino Acid Supplementation on Building Muscle Mass in Elderly People: A Meta-Analysis

(2014) Zhe-rong Xu et al.   PLoS One

The NAD+/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling

(2013) Laurent Mouchiroud et al.   CELL

Metformin Retards Aging in C. elegans by Altering Microbial Folate and Methionine Metabolism

(2013) Filipe Cabreiro et al.   CELL

Reversal of Hypertriglyceridemia, Fatty Liver Disease, and Insulin Resistance by a Liver-Targeted Mitochondrial Uncoupler

(2013) Rachel J. Perry et al.   Cell Metabolism

The role of mitochondria in aging

(2013) Ana Bratic et al.   JOURNAL OF CLINICAL INVESTIGATION

Mitonuclear protein imbalance as a conserved longevity mechanism

(2013) Riekelt H. Houtkooper et al.   NATURE

Architecture of the large subunit of the mammalian mitochondrial ribosome

(2013) Basil J. Greber et al.   NATURE

Pharmacological approaches to restore mitochondrial function

(2013) Pénélope A. Andreux et al.   NATURE REVIEWS DRUG DISCOVERY

CRIF1 Is Essential for the Synthesis and Insertion of Oxidative Phosphorylation Polypeptides in the Mammalian Mitochondrial Membrane

(2012) Soung Jung Kim et al.   Cell Metabolism

Pomegranate as a Functional Food and Nutraceutical Source

(2012) Suzanne D. Johanningsmeier et al.   Annual Review of Food Science and Technology

Fusion and Fission: Interlinked Processes Critical for Mitochondrial Health

(2011) David C. Chan   Annual Review of Genetics

NCoR1 Is a Conserved Physiological Modulator of Muscle Mass and Oxidative Function

(2011) Hiroyasu Yamamoto et al.   CELL

Autophagy and Aging

(2011) David C. Rubinsztein et al.   CELL

Strawberry Processing Does Not Affect the Production and Urinary Excretion of Urolithins, Ellagic Acid Metabolites, in Humans

(2011) Pilar Truchado et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Imaging Intracellular pH in Live Cells with a Genetically Encoded Red Fluorescent Protein Sensor

(2011) Mathew Tantama et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Pyruvate imbalance mediates metabolic reprogramming and mimics lifespan extension by dietary restriction in Caenorhabditis elegans

(2010) Laurent Mouchiroud et al.   AGING CELL

Methods in Mammalian Autophagy Research

(2010) Noboru Mizushima et al.   CELL

Small Molecule Inhibitors of Mitochondrial Division: Tools that Translate Basic Biological Research into Medicine

(2010) Laura L. Lackner et al.   CHEMISTRY & BIOLOGY

Disease-causing mutations in Parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy

(2010) Joo-Yong Lee et al.   JOURNAL OF CELL BIOLOGY

Caenorhabditis elegans as a model system for mtDNA replication defects

(2010) Ivana Bratic et al.   METHODS

The genetics of ageing

(2010) Cynthia J. Kenyon   NATURE

Eaten alive: a history of macroautophagy

(2010) Zhifen Yang et al.   NATURE CELL BIOLOGY

Mechanisms of mitophagy

(2010) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A Role for Ubiquitin in Selective Autophagy

(2009) Vladimir Kirkin et al.   MOLECULAR CELL

Occurrence of urolithins, gut microbiota ellagic acid metabolites and proliferation markers expression response in the human prostate gland upon consumption of walnuts and pomegranate juice

(2009) Antonio González-Sarrías et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Food Ellagitannins–Occurrence, Effects of Processing and Storage

(2008) Emre Bakkalbaşi et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

A Role for Autophagy in the Extension of Lifespan by Dietary Restriction in C. elegans

(2008) Malene Hansen et al.   PLoS Genetics