The Synaptic Function of α-Synuclein

Insight into conformational modification of alpha-synuclein in the presence of neuronal whole cells and of their isolated membranes

(2015) Giovanni Smaldone et al.   FEBS LETTERS

 -synuclein and synapsin III cooperatively regulate synaptic function in dopamine neurons

(2015) M. Zaltieri et al.   JOURNAL OF CELL SCIENCE

Definition of a Molecular Pathway Mediating  -Synuclein Neurotoxicity

(2015) J. Burre et al.   JOURNAL OF NEUROSCIENCE

Biophysics of α-synuclein induced membrane remodelling

(2015) Zheng Shi et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Nonaggregated α-Synuclein Influences SNARE-Dependent Vesicle Docking via Membrane Binding

(2014) Ying Lai et al.   BIOCHEMISTRY

Purification of α-Synuclein from Human Brain Reveals an Instability of Endogenous Multimers as the Protein Approaches Purity

(2014) Eric S. Luth et al.   BIOCHEMISTRY

α-Synuclein Multimers Cluster Synaptic Vesicles and Attenuate Recycling

(2014) Lina Wang et al.   CURRENT BIOLOGY

Sequence and Membrane Determinants of the Random Coil–Helix Transition of α-Synuclein

(2014) Sowmya B. Lokappa et al.   JOURNAL OF MOLECULAR BIOLOGY

Concomitant accumulation of α-synuclein and TDP-43 in a patient with corticobasal degeneration

(2014) Satoshi Yamashita et al.   JOURNAL OF NEUROLOGY

Synucleins Regulate the Kinetics of Synaptic Vesicle Endocytosis

(2014) K. J. Vargas et al.   JOURNAL OF NEUROSCIENCE

Neuronal inclusions of α-synuclein contribute to the pathogenesis of Krabbe disease

(2014) Benjamin R Smith et al.   JOURNAL OF PATHOLOGY

α-Synuclein-Induced Membrane Remodeling Is Driven by Binding Affinity, Partition Depth, and Interleaflet Order Asymmetry

(2014) Anthony R. Braun et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Acute increase of α-synuclein inhibits synaptic vesicle recycling evoked during intense stimulation

(2014) David J. Busch et al.   MOLECULAR BIOLOGY OF THE CELL

N-Alpha-Acetylation of α-Synuclein Increases Its Helical Folding Propensity, GM1 Binding Specificity and Resistance to Aggregation

(2014) Tim Bartels et al.   PLoS One

α-Synuclein assembles into higher-order multimers upon membrane binding to promote SNARE complex formation

(2014) Jacqueline Burré et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct observation of the three regions in α-synuclein that determine its membrane-bound behaviour

(2014) Giuliana Fusco et al.   Nature Communications

Gamma-synuclein pathology in amyotrophic lateral sclerosis

(2014) Owen M. Peters et al.   Annals of Clinical and Translational Neurology

Transfer of human α-synuclein from the olfactory bulb to interconnected brain regions in mice

(2013) Nolwen L. Rey et al.   ACTA NEUROPATHOLOGICA

G51D α-synuclein mutation causes a novel Parkinsonian-pyramidal syndrome

(2013) Suzanne Lesage et al.   ANNALS OF NEUROLOGY

Endogenous alpha-synuclein influences the number of dopaminergic neurons in mouse substantia nigra

(2013) Pablo Garcia-Reitboeck et al.   EXPERIMENTAL NEUROLOGY

α-Synuclein coaggregation in familial amyotrophic lateral sclerosis with SOD1 gene mutation

(2013) Yo-ichi Takei et al.   HUMAN PATHOLOGY

α-Synuclein Membrane Association Is Regulated by the Rab3a Recycling Machinery and Presynaptic Activity

(2013) Robert H. C. Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

α-Synuclein Senses Lipid Packing Defects and Induces Lateral Expansion of Lipids Leading to Membrane Remodeling

(2013) Myriam M. Ouberai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

N-terminal Acetylation Stabilizes N-terminal Helicity in Lipid- and Micelle-bound α-Synuclein and Increases Its Affinity for Physiological Membranes

(2013) Igor Dikiy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Membrane Remodeling by α-Synuclein and Effects on Amyloid Formation

(2013) Zhiping Jiang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Alpha-synuclein p.H50Q, a novel pathogenic mutation for Parkinson's disease

(2013) Silke Appel-Cresswell et al.   MOVEMENT DISORDERS

Neuronal vulnerability, pathogenesis, and Parkinson's disease

(2013) David Sulzer et al.   MOVEMENT DISORDERS

Properties of native brain α-synuclein

(2013) Jacqueline Burré et al.   NATURE

A novel  -synuclein missense mutation in Parkinson disease

(2013) C. Proukakis et al.   NEUROLOGY

Age-Dependent Effects of A53T Alpha-Synuclein on Behavior and Dopaminergic Function

(2013) Adam W. Oaks et al.   PLoS One

Large  -synuclein oligomers inhibit neuronal SNARE-mediated vesicle docking

(2013) B.-K. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Native α-synuclein induces clustering of synaptic-vesicle mimics via binding to phospholipids and synaptobrevin-2/VAMP2

(2013) Jiajie Diao et al.   eLife

α-Synuclein knockout mice have cognitive impairments

(2012) V.S. Kokhan et al.   BEHAVIOURAL BRAIN RESEARCH

Bacterial in-cell NMR of human α-synuclein: a disordered monomer by nature?: Figure 1

(2012) Andres Binolfi et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Impact of N-Terminal Acetylation of α-Synuclein on Its Random Coil and Lipid Binding Properties

(2012) Alexander S. Maltsev et al.   BIOCHEMISTRY

Severe olfactory dysfunction is a prodromal symptom of dementia associated with Parkinson's disease: a 3 year longitudinal study

(2012) Toru Baba et al.   BRAIN

O-GlcNAc Modification Prevents Peptide-Dependent Acceleration of α-Synuclein Aggregation

(2012) Nicholas P. Marotta et al.   CHEMBIOCHEM

Contrasting Effects of α-Synuclein and γ-Synuclein on the Phenotype of Cysteine String Protein α (CSPα) Null Mutant Mice Suggest Distinct Function of these Proteins in Neuronal Synapses

(2012) Natalia Ninkina et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Monomeric Synucleins Generate Membrane Curvature

(2012) Christopher H. Westphal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Remodeling of Lipid Vesicles into Cylindrical Micelles by α-Synuclein in an Extended α-Helical Conformation

(2012) Naoko Mizuno et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

α-Synuclein in Central Nervous System and from Erythrocytes, Mammalian Cells, andEscherichia coliExists Predominantly as Disordered Monomer

(2012) Bruno Fauvet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

 -Synuclein Inhibits Intersynaptic Vesicle Mobility and Maintains Recycling-Pool Homeostasis

(2012) D. Scott et al.   JOURNAL OF NEUROSCIENCE

Systematic Mutagenesis of  -Synuclein Reveals Distinct Sequence Requirements for Physiological and Pathological Activities

(2012) J. Burre et al.   JOURNAL OF NEUROSCIENCE

α-Synuclein Induces Both Positive Mean Curvature and Negative Gaussian Curvature in Membranes

(2012) Anthony R. Braun et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Selective pattern of motor system damage in gamma-synuclein transgenic mice mirrors the respective pathology in amyotrophic lateral sclerosis

(2012) Owen M. Peters et al.   NEUROBIOLOGY OF DISEASE

Tandem mass spectrometry identifies many mouse brain O-GlcNAcylated proteins including EGF domain-specific O-GlcNAc transferase targets

(2012) J. F. Alfaro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

N-terminal acetylation is critical for forming α-helical oligomer of α-synuclein

(2012) Adam J. Trexler et al.   PROTEIN SCIENCE

N-terminal acetylation of α-synuclein induces increased transient helical propensity and decreased aggregation rates in the intrinsically disordered monomer

(2012) Lijuan Kang et al.   PROTEIN SCIENCE

Pathological  -Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice

(2012) K. C. Luk et al.   SCIENCE

Human α-synuclein modulates vesicle trafficking through its interaction with prenylated Rab acceptor protein 1

(2011) Hak Joo Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Decreased reuptake of dopamine in the dorsal striatum in the absence of alpha-synuclein

(2011) Heramb Chadchankar et al.   BRAIN RESEARCH

α-Synuclein Stimulates a Dopamine Transporter-dependent Chloride Current and Modulates the Activity of the Transporter

(2011) Jarod Swant et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sumoylation inhibits α-synuclein aggregation and toxicity

(2011) Petranka Krumova et al.   JOURNAL OF CELL BIOLOGY

Functional Alterations to the Nigrostriatal System in Mice Lacking All Three Members of the Synuclein Family

(2011) S. Anwar et al.   JOURNAL OF NEUROSCIENCE

Allostery in a Disordered Protein: Oxidative Modifications to α-Synuclein Act Distally To Regulate Membrane Binding

(2011) Eva Sevcsik et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation

(2011) Tim Bartels et al.   NATURE

Exogenous α-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron Death

(2011) Laura A. Volpicelli-Daley et al.   NEURON

A soluble  -synuclein construct forms a dynamic tetramer

(2011) W. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Abnormal Neurites Containing C-Terminally Truncated α-Synuclein Are Present in Alzheimer's Disease without Conventional Lewy Body Pathology

(2010) Karen A. Lewis et al.   AMERICAN JOURNAL OF PATHOLOGY

Association of α-, β-, and γ-Synuclein With Diffuse Lewy Body Disease

(2010) Kenya Nishioka et al.   ARCHIVES OF NEUROLOGY

Effects of Curvature and Composition on α-Synuclein Binding to Lipid Vesicles

(2010) Elizabeth R. Middleton et al.   BIOPHYSICAL JOURNAL

SNARE protein redistribution and synaptic failure in a transgenic mouse model of Parkinson’s disease

(2010) Pablo Garcia-Reitböck et al.   BRAIN

The Lipid-binding Domain of Wild Type and Mutant α-Synuclein

(2010) Elka R. Georgieva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Serine 129 Phosphorylation Reduces the Ability of α-Synuclein to Regulate Tyrosine Hydroxylase and Protein Phosphatase 2Ain Vitroandin Vivo

(2010) Haiyan Lou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Membrane Curvature Induction and Tubulation Are Common Features of Synucleins and Apolipoproteins

(2010) Jobin Varkey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylation at S87 Is Enhanced in Synucleinopathies, Inhibits  -Synuclein Oligomerization, and Influences Synuclein-Membrane Interactions

(2010) K. E. Paleologou et al.   JOURNAL OF NEUROSCIENCE

α-Synuclein Delays Endoplasmic Reticulum (ER)-to-Golgi Transport in Mammalian Cells by Antagonizing ER/Golgi SNAREs

(2010) Nandhakumar Thayanidhi et al.   MOLECULAR BIOLOGY OF THE CELL

α-Synuclein Expression in Rat Substantia Nigra Suppresses Phospholipase D2 Toxicity and Nigral Neurodegeneration

(2010) Oleg S Gorbatyuk et al.   MOLECULAR THERAPY

The behavior of α-synuclein in neurons

(2010) Doris L. Fortin et al.   MOVEMENT DISORDERS

Increased Expression of α-Synuclein Reduces Neurotransmitter Release by Inhibiting Synaptic Vesicle Reclustering after Endocytosis

(2010) Venu M. Nemani et al.   NEURON

Neuromuscular pathology in mice lacking alpha-synuclein

(2010) Anssi Pelkonen et al.   NEUROSCIENCE LETTERS

   -Synuclein triple knockout mice reveal age-dependent neuronal dysfunction

(2010) B. Greten-Harrison et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

 -Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro

(2010) J. Burre et al.   SCIENCE

A β-synuclein mutation linked to dementia produces neurodegeneration when expressed in mouse brain

(2010) Masayo Fujita et al.   Nature Communications

Phosphorylation of α-synuclein upregulates tyrosine hydroxylase activity in MN9D cells

(2009) Bo Wu et al.   ACTA HISTOCHEMICA

Evidence That α-Synuclein Does Not Inhibit Phospholipase D†

(2009) Irit Rappley et al.   BIOCHEMISTRY

α-Synuclein Binds Large Unilamellar Vesicles as an Extended Helix†

(2009) Adam J. Trexler et al.   BIOCHEMISTRY

γ-Synucleinopathy: neurodegeneration associated with overexpression of the mouse protein

(2009) Natalia Ninkina et al.   HUMAN MOLECULAR GENETICS

Multiple Tight Phospholipid-Binding Modes of α-Synuclein Revealed by Solution NMR Spectroscopy

(2009) Christina R. Bodner et al.   JOURNAL OF MOLECULAR BIOLOGY

Lipidomic profiling in mouse brain reveals differences between ages and genders, with smaller changes associated with α-synuclein genotype

(2009) Irit Rappley et al.   JOURNAL OF NEUROCHEMISTRY

Genome-wide association study reveals genetic risk underlying Parkinson's disease

(2009) Javier Simón-Sánchez et al.   NATURE GENETICS

Alterations in corticostriatal synaptic plasticity in mice overexpressing human α-synuclein

(2009) J.B. Watson et al.   NEUROSCIENCE

Inclusion formation and neuronal cell death through neuron-to-neuron transmission of  -synuclein

(2009) P. Desplats et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Increased striatal dopamine release and hyperdopaminergic-like behaviour in mice lacking both alpha-synuclein and gamma-synuclein

(2008) Steven L. Senior et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Mitochondrial Import and Accumulation of α-Synuclein Impair Complex I in Human Dopaminergic Neuronal Cultures and Parkinson Disease Brain

(2008) Latha Devi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylation at Ser-129 but Not the Phosphomimics S129E/D Inhibits the Fibrillation of α-Synuclein

(2008) Katerina E. Paleologou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Aging and α-synuclein affect synaptic plasticity in the dentate gyrus

(2008) Irina Gureviciene et al.   JOURNAL OF NEURAL TRANSMISSION

Optical Reporters for the Conformation of  -Synuclein Reveal a Specific Interaction with Mitochondria

(2008) K. Nakamura et al.   JOURNAL OF NEUROSCIENCE

Advanced glycation end products induce in vitro cross‐linking of α‐synuclein and accelerate the process of intracellular inclusion body formation

(2008) Shamim Shaikh et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Antiparallel Arrangement of the Helices of Vesicle-Bound α-Synuclein

(2008) Malte Drescher et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Membrane-Bound α-Synuclein Forms an Extended Helix: Long-Distance Pulsed ESR Measurements Using Vesicles, Bicelles, and Rodlike Micelles

(2008) Elka R. Georgieva et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Proteomics Analysis Identifies Phosphorylation-dependent α-Synuclein Protein Interactions

(2008) Melinda A. McFarland et al.   MOLECULAR & CELLULAR PROTEOMICS

α-Synuclein–induced Aggregation of Cytoplasmic Vesicles in Saccharomyces cerevisiae

(2008) James H. Soper et al.   MOLECULAR BIOLOGY OF THE CELL

Absence of α-synuclein affects dopamine metabolism and synaptic markers in the striatum of aging mice

(2008) Abdelmojib Al-Wandi et al.   NEUROBIOLOGY OF AGING

Structure of membrane-bound  -synuclein from site-directed spin labeling and computational refinement

(2008) C. C. Jao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

α-Synuclein and Polyunsaturated Fatty Acids Promote Clathrin-Mediated Endocytosis and Synaptic Vesicle Recycling

(2008) Tziona Ben Gedalya et al.   TRAFFIC