Selective vulnerability in neurodegenerative diseases

Striatal neurons directly converted from Huntington’s disease patient fibroblasts recapitulate age-associated disease phenotypes

(2018) Matheus B. Victor et al.   NATURE NEUROSCIENCE

Neuron-Specific Alterations in Signal Transduction Pathways associated with Alzheimer's Disease

(2018) Anne Gerschütz et al.   JOURNAL OF ALZHEIMERS DISEASE

Selective decline of neurotrophin and neurotrophin receptor genes within CA1 pyramidal neurons and hippocampus proper: Correlation with cognitive performance and neuropathology in mild cognitive impairment and Alzheimer's disease

(2017) Stephen D. Ginsberg et al.   HIPPOCAMPUS

Parkinson's Disease Is Not Simply a Prion Disorder

(2017) D. James Surmeier et al.   JOURNAL OF NEUROSCIENCE

Cryo-EM structures of tau filaments from Alzheimer’s disease

(2017) Anthony W. P. Fitzpatrick et al.   NATURE

Generation of pure GABAergic neurons by transcription factor programming

(2017) Nan Yang et al.   NATURE METHODS

Massively parallel single-nucleus RNA-seq with DroNc-seq

(2017) Naomi Habib et al.   NATURE METHODS

Cholinergic neuron gene expression differences captured by translational profiling in a mouse model of Alzheimer's disease

(2017) Paul M. McKeever et al.   NEUROBIOLOGY OF AGING

Tau Pathology Induces Excitatory Neuron Loss, Grid Cell Dysfunction, and Spatial Memory Deficits Reminiscent of Early Alzheimer’s Disease

(2017) Hongjun Fu et al.   NEURON

Evidence for sortilin modulating regional accumulation of human tau prions in transgenic mice

(2017) Noah R. Johnson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spinal motor neuron protein supersaturation patterns are associated with inclusion body formation in ALS

(2017) Prajwal Ciryam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein homeostasis of a metastable subproteome associated with Alzheimer’s disease

(2017) Rishika Kundra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An environment-dependent transcriptional network specifies human microglia identity

(2017) David Gosselin et al.   SCIENCE

Fibril structure of amyloid-β(1–42) by cryo–electron microscopy

(2017) Lothar Gremer et al.   SCIENCE

Major Shifts in Glial Regional Identity Are a Transcriptional Hallmark of Human Brain Aging

(2017) Lilach Soreq et al.   Cell Reports

Neuropathological Staging of Brain Pathology in Sporadic Parkinson’s disease: Separating the Wheat from the Chaff

(2017) Heiko Braak et al.   Journal of Parkinsons Disease

Cell-type Dependent Alzheimer's Disease Phenotypes: Probing the Biology of Selective Neuronal Vulnerability

(2017) Christina R. Muratore et al.   Stem Cell Reports

Scalable Production of iPSC-Derived Human Neurons to Identify Tau-Lowering Compounds by High-Content Screening

(2017) Chao Wang et al.   Stem Cell Reports

What is the evidence that tau pathology spreads through prion-like propagation?

(2017) Amrit Mudher et al.   Acta Neuropathologica Communications

Alzheimer's Disease Selective Vulnerability and Modeling in Transgenic Mice

(2017) Jürgen Götz et al.   JOURNAL OF ALZHEIMERS DISEASE

Proteopathic Strains and the Heterogeneity of Neurodegenerative Diseases

(2016) Lary C. Walker   Annual Review of Genetics

Catastrophic cliffs: a partial suggestion for selective vulnerability in neurodegenerative diseases

(2016) John Hardy   BIOCHEMICAL SOCIETY TRANSACTIONS

Selective vulnerability in neurodegeneration: insights from clinical variants of Alzheimer's disease

(2016) Niklas Mattsson et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Selective Degeneration of Entorhinal-CA1 Synapses in Alzheimer's Disease via Activation of DAPK1

(2016) Shu Shu et al.   JOURNAL OF NEUROSCIENCE

Protein homeostasis gene dysregulation in pretangle-bearing nucleus basalis neurons during the progression of Alzheimer's disease

(2016) Chelsea T. Tiernan et al.   NEUROBIOLOGY OF AGING

Mitochondrial dynamics and quality control in Huntington's disease

(2016) Pedro Guedes-Dias et al.   NEUROBIOLOGY OF DISEASE

A transcriptional signature of Alzheimer’s disease is associated with a metastable subproteome at risk for aggregation

(2016) Prajwal Ciryam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuronal subtypes and diversity revealed by single-nucleus RNA sequencing of the human brain

(2016) B. B. Lake et al.   SCIENCE

Laser capture microscopy coupled with Smart-seq2 for precise spatial transcriptomic profiling

(2016) Susanne Nichterwitz et al.   Nature Communications

Direct Induction and Functional Maturation of Forebrain GABAergic Neurons from Human Pluripotent Stem Cells

(2016) Alfred Xuyang Sun et al.   Cell Reports

Human iPSC-Derived Neuronal Model of Tau-A152T Frontotemporal Dementia Reveals Tau-Mediated Mechanisms of Neuronal Vulnerability

(2016) M. Catarina Silva et al.   Stem Cell Reports

A protein homeostasis signature in healthy brains recapitulates tissue vulnerability to Alzheimers disease

(2016) R. Freer et al.   Science Advances

The Biology of Proteostasis in Aging and Disease

(2015) Johnathan Labbadia et al.   Annual Review of Biochemistry

Neurodegenerative Diseases: Expanding the Prion Concept

(2015) Lary C. Walker et al.   Annual Review of Neuroscience

A gene-based association method for mapping traits using reference transcriptome data

(2015) Eric R Gamazon et al.   NATURE GENETICS

Proteostasis and aging

(2015) Susmita Kaushik et al.   NATURE MEDICINE

Spreading of pathology in neurodegenerative diseases: a focus on human studies

(2015) Johannes Brettschneider et al.   NATURE REVIEWS NEUROSCIENCE

From Intrinsic Firing Properties to Selective Neuronal Vulnerability in Neurodegenerative Diseases

(2015) Francesco Roselli et al.   NEURON

Invited review: Frontotemporal dementia caused bymicrotubule-associated protein taugene (MAPT) mutations: a chameleon for neuropathology and neuroimaging

(2015) Bernardino Ghetti et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Translational profiling identifies a cascade of damage initiated in motor neurons and spreading to glia in mutant SOD1-mediated ALS

(2015) Shuying Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Peptide dimer structure in an Aβ(1–42) fibril visualized with cryo-EM

(2015) Matthias Schmidt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial dysfunction and mitophagy in Parkinson's: from familial to sporadic disease

(2015) Brent J. Ryan et al.   TRENDS IN BIOCHEMICAL SCIENCES

Supersaturation is a major driving force for protein aggregation in neurodegenerative diseases

(2015) Prajwal Ciryam et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

A Genome-wide Gene-Expression Analysis and Database in Transgenic Mice during Development of Amyloid or Tau Pathology

(2015) Mar Matarin et al.   Cell Reports

Highly Multiplexed Subcellular RNA Sequencing in Situ

(2014) J. H. Lee et al.   SCIENCE

Molecular determinants of selective dopaminergic vulnerability in Parkinson’s disease: an update

(2014) Lars Brichta et al.   Frontiers in Neuroanatomy

Staging TDP-43 pathology in Alzheimer’s disease

(2013) Keith A. Josephs et al.   ACTA NEUROPATHOLOGICA

Stages of pTDP-43 pathology in amyotrophic lateral sclerosis

(2013) Johannes Brettschneider et al.   ANNALS OF NEUROLOGY

Human iPSC-Based Modeling of Late-Onset Disease via Progerin-Induced Aging

(2013) Justine D. Miller et al.   Cell Stem Cell

Self-propagation of pathogenic protein aggregates in neurodegenerative diseases

(2013) Mathias Jucker et al.   NATURE

Proteostasis of polyglutamine varies among neurons and predicts neurodegeneration

(2013) Andrey S Tsvetkov et al.   Nature Chemical Biology

Amyotrophic lateral sclerosis—a model of corticofugal axonal spread

(2013) Heiko Braak et al.   Nature Reviews Neurology

L-type Ca2+ currents at CA1 synapses, but not CA3 or dentate granule neuron synapses, are increased in 3xTgAD mice in an age-dependent manner

(2013) Yue Wang et al.   NEUROBIOLOGY OF AGING

Rapid Single-Step Induction of Functional Neurons from Human Pluripotent Stem Cells

(2013) Yingsha Zhang et al.   NEURON

Specific Distribution of the Autophagic Protein GABARAPL1/GEC1 in the Developing and Adult Mouse Brain and Identification of Neuronal Populations Expressing GABARAPL1/GEC1

(2013) Jaclyn Nicole Le Grand et al.   PLoS One

Improved Cell Therapy Protocols for Parkinson's Disease Based on Differentiation Efficiency and Safety of hESC-, hiPSC-, and Non-Human Primate iPSC-Derived Dopaminergic Neurons

(2013) Maria Sundberg et al.   STEM CELLS

Widespread Aggregation and Neurodegenerative Diseases Are Associated with Supersaturated Proteins

(2013) Prajwal Ciryam et al.   Cell Reports

Otx2 selectively controls the neurogenesis of specific neuronal subtypes of the ventral tegmental area and compensates En1-dependent neuronal loss and MPTP vulnerability

(2012) Luca Giovanni Di Giovannantonio et al.   DEVELOPMENTAL BIOLOGY

Changes in properties of serine 129 phosphorylated α-synuclein with progression of Lewy-type histopathology in human brains

(2012) Douglas G. Walker et al.   EXPERIMENTAL NEUROLOGY

Pathogenesis of Parkinson's disease

(2012) Etienne C. Hirsch et al.   MOVEMENT DISORDERS

Living on the edge with too many mouths to feed: Why dopamine neurons die

(2012) J. Paul Bolam et al.   MOVEMENT DISORDERS

Induced Pluripotent Stem Cell Technology and Direct Conversion: New Possibilities to Study and Treat Parkinson’s Disease

(2012) Reinhard Roessler et al.   Stem Cell Reviews and Reports

Rac1b Increases with Progressive Tau Pathology within Cholinergic Nucleus Basalis Neurons in Alzheimer's Disease

(2011) Sylvia E. Perez et al.   AMERICAN JOURNAL OF PATHOLOGY

Neuropathology of Frontotemporal Lobar Degeneration-Tau (FTLD-Tau)

(2011) Dennis W. Dickson et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Selective Neuronal Vulnerability in Neurodegenerative Diseases: from Stressor Thresholds to Degeneration

(2011) Smita Saxena et al.   NEURON

Neuronal vulnerability in Parkinson's disease

(2011) Kay L Double   PARKINSONISM & RELATED DISORDERS

Aging as an Event of Proteostasis Collapse

(2011) R. C. Taylor et al.   Cold Spring Harbor Perspectives in Biology

Motor Neuron Diversity in Development and Disease

(2010) Kevin C. Kanning et al.   Annual Review of Neuroscience

Calcium, cellular aging, and selective neuronal vulnerability in Parkinson's disease

(2010) D. James Surmeier et al.   CELL CALCIUM

Brain stem pathology in Parkinson's disease: An evaluation of the Braak staging model

(2010) Ann E. Kingsbury et al.   MOVEMENT DISORDERS

Early Increase in Extrasynaptic NMDA Receptor Signaling and Expression Contributes to Phenotype Onset in Huntington's Disease Mice

(2010) Austen J. Milnerwood et al.   NEURON

Efficient Generation of Functional Dopaminergic Neurons from Human Induced Pluripotent Stem Cells Under Defined Conditions

(2010) Andrzej Swistowski et al.   STEM CELLS

Selective Vulnerability of Neurons in Layer II of the Entorhinal Cortex during Aging and Alzheimer's Disease

(2010) Alexis M. Stranahan et al.   NEURAL PLASTICITY

Selective vulnerability in Alzheimer's disease: Amyloid precursor protein and p75NTRinteraction

(2009) Joanna Fombonne et al.   ANNALS OF NEUROLOGY

Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin

(2009) Shu-ichi Okamoto et al.   NATURE MEDICINE

Calcium homeostasis, selective vulnerability and Parkinson's disease

(2009) C. Savio Chan et al.   TRENDS IN NEUROSCIENCES

Distinct MRI Atrophy Patterns in Autopsy-Proven Alzheimer's Disease and Frontotemporal Lobar Degeneration

(2008) G.D. Rabinovici et al.   American Journal of Alzheimers Disease and Other Dementias

WGCNA: an R package for weighted correlation network analysis

(2008) Peter Langfelder et al.   BMC BIOINFORMATICS

Selective functional, regional, and neuronal vulnerability in frontotemporal dementia

(2008) William W Seeley   CURRENT OPINION IN NEUROLOGY

Calcium ions in neuronal degeneration

(2008) Urszula Wojda et al.   IUBMB LIFE

Dopaminergic midbrain neurons are the prime target for mitochondrial DNA deletions

(2008) A. Bender et al.   JOURNAL OF NEUROLOGY

Altered neuronal gene expression in brain regions differentially affected by Alzheimer's disease: a reference data set

(2008) Winnie S. Liang et al.   PHYSIOLOGICAL GENOMICS