Urolithin A protects dopaminergic neurons in experimental models of Parkinson's disease by promoting mitochondrial biogenesis through the SIRT1/PGC-1α signaling pathway

Targeting Mitochondrial Impairment in Parkinson's Disease: Challenges and Opportunities

(2021) Jannik Prasuhn et al.   Frontiers in Cell and Developmental Biology

Urolithin A ameliorates experimental autoimmune encephalomyelitis by targeting aryl hydrocarbon receptor

(2021) Pei-Xin Shen et al.   EBioMedicine

Urolithin A improves muscle function by inducing mitophagy in muscular dystrophy

(2021) Peiling Luan et al.   Science Translational Medicine

Direct supplementation with Urolithin A overcomes limitations of dietary exposure and gut microbiome variability in healthy adults to achieve consistent levels across the population

(2021) Anurag Singh et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Mitochondrial biogenesis: An update

(2020) Lucia‐Doina Popov   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Pharmacological Inhibition of HDAC6 Attenuates NLRP3 Inflammatory Response and Protects Dopaminergic Neurons in Experimental Models of Parkinson’s Disease

(2020) Shaoqi Yan et al.   Frontiers in Aging Neuroscience

Defects in Mitochondrial Biogenesis Drive Mitochondrial Alterations in PARKIN-Deficient Human Dopamine Neurons

(2020) Manoj Kumar et al.   Stem Cell Reports

Impaired autophagy in microglia aggravates dopaminergic neurodegeneration by regulating NLRP3 inflammasome activation in experimental models of Parkinson’s disease

(2020) Yue Qin et al.   BRAIN BEHAVIOR AND IMMUNITY

Mitochondrial Dysfunction and Mitophagy in Parkinson’s Disease: From Mechanism to Therapy

(2020) Ana Belen Malpartida et al.   TRENDS IN BIOCHEMICAL SCIENCES

Natural products targeting mitochondria: emerging therapeutics for age-associated neurological disorders

(2020) Zhibin Liang et al.   PHARMACOLOGY & THERAPEUTICS

Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer’s disease

(2019) Evandro F. Fang et al.   NATURE NEUROSCIENCE

Urolithin A attenuates memory impairment and neuroinflammation in APP/PS1 mice

(2019) Zhuo Gong et al.   Journal of Neuroinflammation

Urolithin A‐activated autophagy but not mitophagy protects against ischemic neuronal injury by inhibiting ER stress in vitro and in vivo

(2019) Anil Ahsan et al.   CNS Neuroscience & Therapeutics

Neuroprotective Effects of Pomegranate Juice against Parkinson’s Disease and Presence of Ellagitannins-Derived Metabolite—Urolithin A—In the Brain

(2019) Małgorzata Kujawska et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mitochondrial Dysfunction and Biogenesis in Neurodegenerative diseases: Pathogenesis and Treatment

(2016) Mojtaba Golpich et al.   CNS Neuroscience & Therapeutics

Urolithins, the rescue of “old” metabolites to understand a “new” concept: Metabotypes as a nexus among phenolic metabolism, microbiota dysbiosis, and host health status

(2016) Francisco A. Tomás-Barberán et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents

(2016) Dongryeol Ryu et al.   NATURE MEDICINE

Promotion of mitochondrial biogenesis by necdin protects neurons against mitochondrial insults

(2016) Koichi Hasegawa et al.   Nature Communications

Mitochondrial Biogenesis: A Therapeutic Target for Neurodevelopmental Disorders and Neurodegenerative Diseases

(2014) Martine Uittenbogaard et al.   CURRENT PHARMACEUTICAL DESIGN

Biological Significance of Urolithins, the Gut Microbial Ellagic Acid-Derived Metabolites: The Evidence So Far

(2013) Juan Carlos Espín et al.   Evidence-based Complementary and Alternative Medicine

In vivo anti-inflammatory and antioxidant properties of ellagitannin metabolite urolithin A

(2011) Hidekazu Ishimoto et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS