The Amyloid-β Oligomer Hypothesis: Beginning of the Third Decade

Oligomeric amyloid β preferentially targets neuronal and not glial mitochondrial-encoded mRNAs

(2018) Diego Mastroeni et al.   Alzheimers & Dementia

Discrete Pools of Oligomeric Amyloid-β Track with Spatial Learning Deficits in a Mouse Model of Alzheimer Amyloidosis

(2018) Angie C.A. Chiang et al.   AMERICAN JOURNAL OF PATHOLOGY

Targeting Fyn Kinase in Alzheimer’s Disease

(2018) Haakon B. Nygaard   BIOLOGICAL PSYCHIATRY

Anti-Amyloid-β Monoclonal Antibodies for Alzheimer’s Disease: Pitfalls and Promise

(2018) Christopher H. van Dyck   BIOLOGICAL PSYCHIATRY

Astrocytic glutamatergic transporters are involved in Aβ-induced synaptic dysfunction

(2018) Shuxuan Huang et al.   BRAIN RESEARCH

Neuroprotective effects of a triple GLP-1/GIP/glucagon receptor agonist in the APP/PS1 transgenic mouse model of Alzheimer's disease

(2018) Jingjing Tai et al.   BRAIN RESEARCH

Effect of long-term nutraceutical and dietary supplement use on cognition in the elderly: a 10-year systematic review of randomised controlled trials

(2018) Nathan M. D’Cunha et al.   BRITISH JOURNAL OF NUTRITION

Amyloid-β and Tau Pathology of Alzheimer's Disease Induced by Diabetes in a Rabbit Animal Model

(2018) Claudine L. Bitel et al.   JOURNAL OF ALZHEIMERS DISEASE

Soluble Oligomers of Amyloid-β Cause Changes in Redox State, DNA Methylation, and Gene Transcription by Inhibiting EAAT3 Mediated Cysteine Uptake

(2018) Nathaniel Hodgson et al.   JOURNAL OF ALZHEIMERS DISEASE

Intracellular Localization of Amyloid-β Peptide in SH-SY5Y Neuroblastoma Cells

(2018) Lin Zheng et al.   JOURNAL OF ALZHEIMERS DISEASE

AβPP-Overexpressing Transgenic Rat Model of Alzheimer's Disease Utilizing the Tg2576 Mouse Protocol

(2018) Eugene O'Hare et al.   JOURNAL OF ALZHEIMERS DISEASE

In Vivo and Ex Vivo Imaging of Amyloid-β Cascade Aggregates with a Pronucleon™ Peptide

(2018) Andrew C. Nyborg et al.   JOURNAL OF ALZHEIMERS DISEASE

Brain Transit and Ameliorative Effects of Intranasally Delivered Anti-Amyloid-β Oligomer Antibody in 5XFAD Mice

(2018) Chun Xiao et al.   JOURNAL OF ALZHEIMERS DISEASE

Plasma Membrane Injury Depends on Bilayer Lipid Composition in Alzheimer's Disease

(2018) Elisa Evangelisti et al.   JOURNAL OF ALZHEIMERS DISEASE

Association of Mediterranean Diet with Mild Cognitive Impairment and Alzheimer's Disease: A Systematic Review and Meta-Analysis

(2018) Balwinder Singh et al.   JOURNAL OF ALZHEIMERS DISEASE

Potential of Low Dose Leuco-Methylthioninium Bis(Hydromethanesulphonate) (LMTM) Monotherapy for Treatment of Mild Alzheimer’s Disease: Cohort Analysis as Modified Primary Outcome in a Phase III Clinical Trial

(2017) Gordon K. Wilcock et al.   JOURNAL OF ALZHEIMERS DISEASE

Cerebrospinal Fluid Amyloid-β Levels are Increased in Patients with Insomnia

(2017) Dong-Wan Chen et al.   JOURNAL OF ALZHEIMERS DISEASE

Interaction of amyloid-β (Aβ) oligomers with neurexin 2α and neuroligin 1 mediates synapse damage and memory loss in mice

(2017) Jordano Brito-Moreira et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural and functional analyses of pyroglutamate-amyloid-β-specific antibodies as a basis for Alzheimer immunotherapy

(2017) Anke Piechotta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stabilization of dynamic microtubules by mDia1 drives Tau-dependent Aβ1–42synaptotoxicity

(2017) Xiaoyi Qu et al.   JOURNAL OF CELL BIOLOGY

A human scFv antibody that targets and neutralizes high molecular weight pathogenic amyloid-β oligomers

(2017) Adriano Sebollela et al.   JOURNAL OF NEUROCHEMISTRY

Astrocyte Transforming Growth Factor Beta 1 Protects Synapses against Aβ Oligomers in Alzheimer's Disease Model

(2017) Luan Pereira Diniz et al.   JOURNAL OF NEUROSCIENCE

Insights into Formation and Structure of Aβ Oligomers Cross-Linked via Tyrosines

(2017) Shuting Zhang et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Pathways of Amyloid-β Aggregation Depend on Oligomer Shape

(2017) Bogdan Barz et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Neuroprotective astrocyte-derived insulin/insulin-like growth factor 1 stimulates endocytic processing and extracellular release of neuron-bound Aβ oligomers

(2017) Jason Pitt et al.   MOLECULAR BIOLOGY OF THE CELL

Amyloid β-42 induces neuronal apoptosis by targeting mitochondria

(2017) Xiao-Jian Han et al.   Molecular Medicine Reports

Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer’s disease

(2017) Carmen Venegas et al.   NATURE

Hallmarks of Alzheimer’s Disease in Stem-Cell-Derived Human Neurons Transplanted into Mouse Brain

(2017) Ira Espuny-Camacho et al.   NEURON

Glucose directs amyloid-beta into membrane-active oligomers

(2017) Niraja Kedia et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Aβ seeds and prions: How close the fit?

(2017) Jay Rasmussen et al.   Prion

BACE inhibition-dependent repair of Alzheimer’s pathophysiology

(2017) Aylin D. Keskin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein homeostasis of a metastable subproteome associated with Alzheimer’s disease

(2017) Rishika Kundra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of metformin exposure on neurodegenerative diseases in elderly patients with type 2 diabetes mellitus

(2017) Yi-Chun Kuan et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

The amyloid-β oligomer Aβ*56 induces specific alterations in neuronal signaling that lead to tau phosphorylation and aggregation

(2017) Fatou Amar et al.   Science Signaling

Pyk2 modulates hippocampal excitatory synapses and contributes to cognitive deficits in a Huntington’s disease model

(2017) Albert Giralt et al.   Nature Communications

Neurons derived from sporadic Alzheimer’s disease iPSCs reveal elevated TAU hyperphosphorylation, increased amyloid levels, and GSK3B activation

(2017) Anna Ochalek et al.   Alzheimers Research & Therapy

Oligomeric forms of amyloid-β protein in plasma as a potential blood-based biomarker for Alzheimer’s disease

(2017) Min Jeong Wang et al.   Alzheimers Research & Therapy

Non-canonical soluble amyloid-beta aggregates and plaque buffering: controversies and future directions for target discovery in Alzheimer’s disease

(2017) David L. Brody et al.   Alzheimers Research & Therapy

A Becn1 mutation mediates hyperactive autophagic sequestration of amyloid oligomers and improved cognition in Alzheimer's disease

(2017) Altea Rocchi et al.   PLoS Genetics

Impaired retrograde transport of axonal autophagosomes contributes to autophagic stress in Alzheimer’s disease neurons

(2017) Prasad Tammineni et al.   eLife

Association of Docosahexaenoic Acid Supplementation With Alzheimer Disease Stage in Apolipoprotein E ε4 Carriers

(2017) Hussein N. Yassine et al.   JAMA Neurology

The amyloid-β oligomer Aβ*56 induces specific alterations in neuronal signaling that lead to tau phosphorylation and aggregation

(2017) Fatou Amar et al.   Science Signaling

Tau phosphorylation induced by severe closed head traumatic brain injury is linked to the cellular prion protein

(2017) Richard Rubenstein et al.   Acta Neuropathologica Communications

A Novel Transgenic Rat Model with a Full Alzheimer's-Like Amyloid Pathology Displays Pre-Plaque Intracellular Amyloid-β-Associated Cognitive Impairment

(2017) Wanda Carolina Leon et al.   JOURNAL OF ALZHEIMERS DISEASE

Aβ levels in the jugular vein and high molecular weight Aβ oligomer levels in CSF can be used as biomarkers to indicate the anti-amyloid effect of IVIg for Alzheimer’s disease

(2017) Takashi Kasai et al.   PLoS One

Diversity of Amyloid-beta Proteoforms in the Alzheimer’s Disease Brain

(2017) Norelle C. Wildburger et al.   Scientific Reports

Phosphorylation of the amyloid β-peptide at Ser26 stabilizes oligomeric assembly and increases neurotoxicity

(2016) Sathish Kumar et al.   ACTA NEUROPATHOLOGICA

Presynaptic dystrophic neurites surrounding amyloid plaques are sites of microtubule disruption, BACE1 elevation, and increased Aβ generation in Alzheimer’s disease

(2016) Katherine R. Sadleir et al.   ACTA NEUROPATHOLOGICA

Amyloid β-induced astrogliosis is mediated by β1-integrin via NADPH oxidase 2 in Alzheimer's disease

(2016) Ane Wyssenbach et al.   AGING CELL

Amyloid-beta oligomerization is associated with the generation of a typical peptide fragment fingerprint

(2016) Nikita Rudinskiy et al.   Alzheimers & Dementia

Challenges, solutions, and recommendations for Alzheimer's disease combination therapy

(2016) James A. Hendrix et al.   Alzheimers & Dementia

Phase 3 solanezumab trials: Secondary outcomes in mild Alzheimer's disease patients

(2016) Eric R. Siemers et al.   Alzheimers & Dementia

Synaptic Amyloid-β Oligomers Precede p-Tau and Differentiate High Pathology Control Cases

(2016) Tina Bilousova et al.   AMERICAN JOURNAL OF PATHOLOGY

Structural differences between amyloid beta oligomers

(2016) Leonid Breydo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Eliminating microglia in Alzheimer’s mice prevents neuronal loss without modulating amyloid-β pathology

(2016) Elizabeth E. Spangenberg et al.   BRAIN

Rifampicin is a candidate preventive medicine against amyloid-β and tau oligomers

(2016) Tomohiro Umeda et al.   BRAIN

The Cellular Phase of Alzheimer’s Disease

(2016) Bart De Strooper et al.   CELL

Understanding Amyloid-β Oligomerization at the Molecular Level: The Role of the Fibril Surface

(2016) Bogdan Barz et al.   CHEMISTRY-A EUROPEAN JOURNAL

Imbalanced cholesterol metabolism in Alzheimer's disease

(2016) Zhao Xue-shan et al.   CLINICA CHIMICA ACTA

Tau Biology and Tau-Directed Therapies for Alzheimer’s Disease

(2016) Lidia Bakota et al.   DRUGS

Generation and deposition of Aβ43 by the virtually inactive presenilin‐1 L435F mutant contradicts the presenilin loss‐of‐function hypothesis of Alzheimer's disease

(2016) Benedikt Kretner et al.   EMBO Molecular Medicine

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Human tau increases amyloid β plaque size but not amyloid β-mediated synapse loss in a novel mouse model of Alzheimer's disease

(2016) Rosemary J. Jackson et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

TGF-β1 prevents rat retinal insult induced by amyloid-β (1–42) oligomers

(2016) Vincenzo Fisichella et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Peroxiredoxin 5 prevents amyloid-beta oligomer-induced neuronal cell death by inhibiting ERK–Drp1-mediated mitochondrial fragmentation

(2016) Bokyung Kim et al.   FREE RADICAL BIOLOGY AND MEDICINE

A critical concentration of N-terminal pyroglutamylated amyloid beta drives the misfolding of Ab1-42 into more toxic aggregates

(2016) Denise Galante et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Focus on Extracellular Vesicles: Exosomes and Their Role in Protein Trafficking and Biomarker Potential in Alzheimer’s and Parkinson’s Disease

(2016) Laura Vella et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Alzheimer's disease and diet: a systematic review

(2016) Miryam Yusufov et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Inhibition of Histone Deacetylase 3 Restores Amyloid-β Oligomer-Induced Plasticity Deficit in Hippocampal CA1 Pyramidal Neurons

(2016) Kumar Krishna et al.   JOURNAL OF ALZHEIMERS DISEASE

Shear-Induced Amyloid Formation in the Brain: I. Potential Vascular and Parenchymal Processes

(2016) Conrad N. Trumbore   JOURNAL OF ALZHEIMERS DISEASE

Oligomers of Amyloid β Prevent Physiological Activation of the Cellular Prion Protein-Metabotropic Glutamate Receptor 5 Complex by Glutamate in Alzheimer Disease

(2016) Laura T. Haas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ion Channel Formation by Amyloid-β42Oligomers but Not Amyloid-β40in Cellular Membranes

(2016) David C. Bode et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Amyloid β Oligomer Binding to Neurons and Neurotoxicity by the Prion Protein-mGluR5 Complex

(2016) Flavio H. Beraldo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The amyloid cascade hypothesis: are we poised for success or failure?

(2016) Eric Karran et al.   JOURNAL OF NEUROCHEMISTRY

Urban traffic-derived nanoparticulate matter reduces neurite outgrowth via TNFα in vitro

(2016) Hank Cheng et al.   Journal of Neuroinflammation

Large Soluble Oligomers of Amyloid β-Protein from Alzheimer Brain Are Far Less Neuroactive Than the Smaller Oligomers to Which They Dissociate

(2016) Ting Yang et al.   JOURNAL OF NEUROSCIENCE

Cross Talk Between Brain Innate Immunity and Serotonin Signaling Underlies Depressive-Like Behavior Induced by Alzheimer's Amyloid-  Oligomers in Mice

(2016) J. H. Ledo et al.   JOURNAL OF NEUROSCIENCE

Soluble Conformers of A  and Tau Alter Selective Proteins Governing Axonal Transport

(2016) M. A. Sherman et al.   JOURNAL OF NEUROSCIENCE

Amyloid β-Protein Assembly and Alzheimer’s Disease: Dodecamers of Aβ42, but Not of Aβ40, Seed Fibril Formation

(2016) Nicholas J. Economou et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Efficacy and safety of tau-aggregation inhibitor therapy in patients with mild or moderate Alzheimer's disease: a randomised, controlled, double-blind, parallel-arm, phase 3 trial

(2016) Serge Gauthier et al.   LANCET

Failed Alzheimer’s trial does not kill leading theory of disease

(2016) Alison Abbott et al.   NATURE

The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease

(2016) Jeff Sevigny et al.   NATURE

The choroid plexus-cerebrospinal fluid interface in Alzheimer′s disease: more than just a barrier

(2016) RoosmarijnE Vandenbroucke et al.   Neural Regeneration Research

Suppression of glymphatic fluid transport in a mouse model of Alzheimer's disease

(2016) Weiguo Peng et al.   NEUROBIOLOGY OF DISEASE

A Study of Aβ Oligomers in the Temporal Cortex and Cerebellum of Patients with Neuropathologically Confirmed Alzheimer's Disease Compared to Aged Controls

(2016) Armand Savioz et al.   Neurodegenerative Diseases

Aβ42 assembles into specific β-barrel pore-forming oligomers in membrane-mimicking environments

(2016) Montserrat Serra-Batiste et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-speed atomic force microscopy reveals structural dynamics of amyloid β1–42aggregates

(2016) Takahiro Watanabe-Nakayama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nilotinib Effects in Parkinson’s disease and Dementia with Lewy bodies

(2016) Fernando Pagan et al.   Journal of Parkinsons Disease

Amyloid β oligomers elicit mitochondrial transport defects and fragmentation in a time-dependent and pathway-specific manner

(2016) Yanfang Rui et al.   Molecular Brain

Current Research Therapeutic Strategies for Alzheimer’s Disease Treatment

(2016) Jaume Folch et al.   NEURAL PLASTICITY

Identification of approved drugs that inhibit the binding of amyloid β oligomers to ephrin type-B receptor 2

(2016) Koichiro Suzuki et al.   FEBS Open Bio

Key Points Concerning Amyloid Infectivity and Prion-Like Neuronal Invasion

(2016) Alba Espargaró et al.   Frontiers in Molecular Neuroscience

Successful engineering of a highly potent single-chain variable-fragment (scFv) bispecific antibody to target disialoganglioside (GD2) positive tumors

(2016) Ming Cheng et al.   OncoImmunology

The Role of Amyloid-β Oligomers in Toxicity, Propagation, and Immunotherapy

(2016) Urmi Sengupta et al.   EBioMedicine

Humanized Tau Mice with Regionalized Amyloid Exhibit Behavioral Deficits but No Pathological Interaction

(2016) Michael J. Yetman et al.   PLoS One

Highly potent intracellular membrane-associated Aβ seeds

(2016) Anne-Marie Marzesco et al.   Scientific Reports

Individual aggregates of amyloid beta induce temporary calcium influx through the cell membrane of neuronal cells

(2016) Anna Drews et al.   Scientific Reports

Novel Antioxidants Protect Mitochondria from the Effects of Oligomeric Amyloid Beta and Contribute to the Maintenance of Epigenome Function

(2015) Diego Mastroeni et al.   ACS Chemical Neuroscience

Soluble Prion Protein Binds Isolated Low Molecular Weight Amyloid-β Oligomers Causing Cytotoxicity Inhibition

(2015) Thomas L. Williams et al.   ACS Chemical Neuroscience

Beta-amyloid deposition in chronic traumatic encephalopathy

(2015) Thor D. Stein et al.   ACTA NEUROPATHOLOGICA

Amyloid β oligomers in Alzheimer’s disease pathogenesis, treatment, and diagnosis

(2015) Kirsten L. Viola et al.   ACTA NEUROPATHOLOGICA

The aqueous phase of Alzheimer's disease brain contains assemblies built from ∼4 and ∼7 kDa Aβ species

(2015) Jessica M. Mc Donald et al.   Alzheimers & Dementia

Fyn inhibition rescues established memory and synapse loss in Alzheimer mice

(2015) Adam C. Kaufman et al.   ANNALS OF NEUROLOGY

Label-free detection of ApoE4-mediated β-amyloid aggregation on single nanoparticle uncovering Alzheimer's disease

(2015) Min Kyung Kang et al.   BIOSENSORS & BIOELECTRONICS

Progression of Seed-Induced Aβ Deposition within the Limbic Connectome

(2015) Lan Ye et al.   BRAIN PATHOLOGY

Voluntary Running Attenuates Memory Loss, Decreases Neuropathological Changes and Induces Neurogenesis in a Mouse Model of Alzheimer's Disease

(2015) Cheril Tapia-Rojas et al.   BRAIN PATHOLOGY

Insulin Attenuates Beta-Amyloid-Associated Insulin/Akt/EAAT Signaling Perturbations in Human Astrocytes

(2015) Xiaojuan Han et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Targeting Insulin Signaling for the Treatment of Alzheimer's Disease

(2015) Yanxing Chen et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Critical analysis of Alzheimer rsquo s amyloid-beta nbsp toxicity to mitochondria

(2015) Yury G. Kaminsky   Frontiers in Bioscience-Landmark

A Second Pedigree with Amyloid-less Familial Alzheimer's Disease Harboring an Identical Mutation in the Amyloid Precursor Protein Gene (E693delta)

(2015) Yumiko Kutoku et al.   INTERNAL MEDICINE

Amyloid-β Peptide Aβ3pE-42 Induces Lipid Peroxidation, Membrane Permeabilization, and Calcium Influx in Neurons

(2015) Adam P. Gunn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prion-Protein-interacting Amyloid-β Oligomers of High Molecular Weight Are Tightly Correlated with Memory Impairment in Multiple Alzheimer Mouse Models

(2015) Mikhail A. Kostylev et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid-β Receptors: The Good, the Bad, and the Prion Protein

(2015) Heledd H. Jarosz-Griffiths et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dextran sulfate sodium inhibits amyloid-β oligomer binding to cellular prion protein

(2015) Takahiro Aimi et al.   JOURNAL OF NEUROCHEMISTRY

Stabilization of Nontoxic A -Oligomers: Insights into the Mechanism of Action of Hydroxyquinolines in Alzheimer's Disease

(2015) T. M. Ryan et al.   JOURNAL OF NEUROSCIENCE

Amyloid   Oligomers Disrupt Blood-CSF Barrier Integrity by Activating Matrix Metalloproteinases

(2015) M. Brkic et al.   JOURNAL OF NEUROSCIENCE

ApoE4 and A  Oligomers Reduce BDNF Expression via HDAC Nuclear Translocation

(2015) A. Sen et al.   JOURNAL OF NEUROSCIENCE

The Transient Receptor Potential Melastatin 2 (TRPM2) Channel Contributes to  -Amyloid Oligomer-Related Neurotoxicity and Memory Impairment

(2015) V. G. Ostapchenko et al.   JOURNAL OF NEUROSCIENCE

N-Terminal Extensions Retard Aβ42 Fibril Formation but Allow Cross-Seeding and Coaggregation with Aβ42

(2015) Olga Szczepankiewicz et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Small angle X-ray scattering analysis of Cu2+-induced oligomers of the Alzheimer's amyloid β peptide

(2015) Timothy M. Ryan et al.   Metallomics

Persistence of Aβ seeds in APP null mouse brain

(2015) Lan Ye et al.   NATURE NEUROSCIENCE

A 3D human neural cell culture system for modeling Alzheimer's disease

(2015) Young Hye Kim et al.   Nature Protocols

Alzheimer's Aβ interacts with cellular prion protein inducing neuronal membrane damage and synaptotoxicity

(2015) Christian Peters et al.   NEUROBIOLOGY OF AGING

Aβ and NMDAR activation cause mitochondrial dysfunction involving ER calcium release

(2015) Ildete Luísa Ferreira et al.   NEUROBIOLOGY OF AGING

The Glymphatic System: A Beginner’s Guide

(2015) Nadia Aalling Jessen et al.   NEUROCHEMICAL RESEARCH

MRZ-99030 – A novel modulator of Aβ aggregation: I – Mechanism of action (MoA) underlying the potential neuroprotective treatment of Alzheimer's disease, glaucoma and age-related macular degeneration (AMD)

(2015) Christopher G. Parsons et al.   NEUROPHARMACOLOGY

Minocycline attenuates Aβ oligomers-induced pro-inflammatory phenotype in primary microglia while enhancing Aβ fibrils phagocytosis

(2015) Ismail Amr El-Shimy et al.   NEUROSCIENCE LETTERS

Na, K-ATPase α3 is a death target of Alzheimer patient amyloid-β assembly

(2015) Takayuki Ohnishi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Supersaturation is a major driving force for protein aggregation in neurodegenerative diseases

(2015) Prajwal Ciryam et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Amyloid biomarkers in Alzheimer's disease

(2015) Kaj Blennow et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

How the Wnt signaling pathway protects from neurodegeneration: the mitochondrial scenario

(2015) Macarena S. Arrázola et al.   Frontiers in Cellular Neuroscience

Tau Oligomers: The Toxic Player at Synapses in Alzheimer’s Disease

(2015) Marcos J. Guerrero-Muñoz et al.   Frontiers in Cellular Neuroscience

Soluble amyloid-β oligomers as synaptotoxins leading to cognitive impairment in Alzheimer’s disease

(2015) Sergio T. Ferreira et al.   Frontiers in Cellular Neuroscience

A highly sensitive novel immunoassay specifically detects low levels of soluble Aβ oligomers in human cerebrospinal fluid

(2015) Ting Yang et al.   Alzheimers Research & Therapy

Quaternary Structure Defines a Large Class of Amyloid-β Oligomers Neutralized by Sequestration

(2015) Peng Liu et al.   Cell Reports

Brain metabolic stress and neuroinflammation at the basis of cognitive impairment in Alzheimer’s disease

(2015) Fernanda G. De Felice et al.   Frontiers in Aging Neuroscience

Metabolic Risk Factors of Sporadic Alzheimer's Disease: Implications in the Pathology, Pathogenesis and Treatment

(2015) Sasanka Chakrabarti et al.   Aging and Disease

The past and the future of Alzheimer's disease CSF biomarkers—a journey toward validated biochemical tests covering the whole spectrum of molecular events

(2015) Kaj Blennow et al.   Frontiers in Neuroscience

Amyloid accelerates tau propagation and toxicity in a model of early Alzheimer’s disease

(2015) Amy M Pooler et al.   Acta Neuropathologica Communications

Nanoscale Synaptic Membrane Mimetic Allows Unbiased High Throughput Screen That Targets Binding Sites for Alzheimer’s-Associated Aβ Oligomers

(2015) Kyle C. Wilcox et al.   PLoS One

Neurofibrillary tangle formation by introducing wild-type human tau into APP transgenic mice

(2014) Tomohiro Umeda et al.   ACTA NEUROPATHOLOGICA

Tau aggregation and its interplay with amyloid-β

(2014) Rebecca M. Nisbet et al.   ACTA NEUROPATHOLOGICA

Cognitive changes and dementia risk after traumatic brain injury: Implications for aging military personnel

(2014) Andrea S. Vincent et al.   Alzheimers & Dementia

How does brain insulin resistance develop in Alzheimer's disease?

(2014) Fernanda G. De Felice et al.   Alzheimers & Dementia

A critique of the drug discovery and phase 3 clinical programs targeting the amyloid hypothesis for Alzheimer disease

(2014) Eric Karran et al.   ANNALS OF NEUROLOGY

Impairment of paravascular clearance pathways in the aging brain

(2014) Benjamin T. Kress et al.   ANNALS OF NEUROLOGY

Aβ1-42 monomers or oligomers have different effects on autophagy and apoptosis

(2014) Michela Guglielmotto et al.   Autophagy

Aβ dimers differ from monomers in structural propensity, aggregation paths and population of synaptotoxic assemblies

(2014) Tiernan T. O’Malley et al.   BIOCHEMICAL JOURNAL

The C-Terminal Threonine of Aβ43 Nucleates Toxic Aggregation via Structural and Dynamical Changes in Monomers and Protofibrils

(2014) Alexander E. Conicella et al.   BIOCHEMISTRY

Role of the Fast Kinetics of Pyroglutamate-Modified Amyloid-β Oligomers in Membrane Binding and Membrane Permeability

(2014) Joon Lee et al.   BIOCHEMISTRY

Rare Individual Amyloid-β Oligomers Act on Astrocytes to Initiate Neuronal Damage

(2014) Priyanka Narayan et al.   BIOCHEMISTRY

The Binding of Apolipoprotein E to Oligomers and Fibrils of Amyloid-β Alters the Kinetics of Amyloid Aggregation

(2014) Kanchan Garai et al.   BIOCHEMISTRY

Secreted Amyloid β-Proteins in a Cell Culture Model Include N-Terminally Extended Peptides That Impair Synaptic Plasticity

(2014) Alfred T. Welzel et al.   BIOCHEMISTRY

Beta-Amyloid Oligomers Activate Apoptotic BAK Pore for Cytochrome c Release

(2014) Jaewook Kim et al.   BIOPHYSICAL JOURNAL

High molecular mass assemblies of amyloid-β oligomers bind prion protein in patients with Alzheimer’s disease

(2014) Frank Dohler et al.   BRAIN

Biochemical stages of amyloid-β peptide aggregation and accumulation in the human brain and their association with symptomatic and pathologically preclinical Alzheimer’s disease

(2014) Ajeet Rijal Upadhaya et al.   BRAIN

Single-Molecule Imaging Reveals that Small Amyloid-β1-42Oligomers Interact with the Cellular Prion Protein (PrPC)

(2014) Kristina A. Ganzinger et al.   CHEMBIOCHEM

Direct Observations of Amyloid β Self-Assembly in Live Cells Provide Insights into Differences in the Kinetics of Aβ(1–40) and Aβ(1–42) Aggregation

(2014) Elin K. Esbjörner et al.   CHEMISTRY & BIOLOGY

Pan-Amyloid Oligomer Specific scFv Antibody Attenuates Memory Deficits and Brain Amyloid Burden in Mice with Alzheimer’s Disease

(2014) Min Zhao et al.   Current Alzheimer Research

Calcium-Sensing Receptors of Human Astrocyte-Neuron Teams: Amyloid-β-Driven Mediators and Therapeutic Targets of Alzheimer’s Disease

(2014) I. Pra et al.   Current Neuropharmacology

Repurposing Diabetes Drugs for Brain Insulin Resistance in Alzheimer Disease

(2014) M. Yarchoan et al.   DIABETES

Atomic force microscopy to study molecular mechanisms of amyloid fibril formation and toxicity in Alzheimer’s disease

(2014) Elizabeth Drolle et al.   DRUG METABOLISM REVIEWS

Type 3 diabetes is sporadic Alzheimer׳s disease: Mini-review

(2014) Suzanne M. de la Monte   EUROPEAN NEUROPSYCHOPHARMACOLOGY

A Food and Drug Administration-approved Asthma Therapeutic Agent Impacts Amyloid β in the Brain in a Transgenic Model of Alzheimer Disease

(2014) Yukiko Hori et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Mechanisms of Alzheimer Disease Protection by the A673T Allele of Amyloid Precursor Protein

(2014) Janice A. Maloney et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In vivo Activation of Wnt Signaling Pathway Enhances Cognitive Function of Adult Mice and Reverses Cognitive Deficits in an Alzheimer's Disease Model

(2014) J. Y. Vargas et al.   JOURNAL OF NEUROSCIENCE

A Sensitive A  Oligomer Assay Discriminates Alzheimer's and Aged Control Cerebrospinal Fluid

(2014) M. J. Savage et al.   JOURNAL OF NEUROSCIENCE

Activity-Dependent Tau Protein Translocation to Excitatory Synapse Is Disrupted by Exposure to Amyloid-Beta Oligomers

(2014) M. L. Frandemiche et al.   JOURNAL OF NEUROSCIENCE

Alzheimer's Disease-Like Pathology Induced by Amyloid-β Oligomers in Nonhuman Primates

(2014) Leticia Forny-Germano et al.   JOURNAL OF NEUROSCIENCE

Small Aβ1-42oligomer-induced membrane depolarization of neuronal and microglial cells: Role of N-methyl-D-aspartate receptors

(2014) Ramune Morkuniene et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Functional Interaction Between Na/K-ATPase and NMDA Receptor in Cerebellar Neurons

(2014) Evgeny E. Akkuratov et al.   MOLECULAR NEUROBIOLOGY

Altered synaptic structure in the hippocampus in a mouse model of Alzheimer’s disease with soluble amyloid-β oligomers and no plaque pathology

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Towards non-invasive diagnostic imaging of early-stage Alzheimer's disease

(2014) Kirsten L. Viola et al.   Nature Nanotechnology

Spreading of amyloid-β peptides via neuritic cell-to-cell transfer is dependent on insufficient cellular clearance

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Synergistic effects of amyloid-beta and wild-type human tau on dendritic spine loss in a floxed double transgenic model of Alzheimer's disease

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Clinical trial of an inhibitor of RAGE-A  interactions in Alzheimer disease

(2014) D. Galasko et al.   NEUROLOGY

Mitogen-activated protein kinase signaling pathways are involved in regulating α7 nicotinic acetylcholine receptor-mediated amyloid-β uptake in SH-SY5Y cells

(2014) W.N. Yang et al.   NEUROSCIENCE

Do Astrocytes Collaborate with Neurons in Spreading the “Infectious” Aβ and Tau Drivers of Alzheimer’s Disease?

(2014) Ilaria Dal Prà et al.   NEUROSCIENTIST

Antiamyloid Therapy for Alzheimer's Disease — Are We on the Right Road?

(2014) Eric Karran et al.   NEW ENGLAND JOURNAL OF MEDICINE

Relationships between the Circadian System and Alzheimer's Disease-Like Symptoms in Drosophila

(2014) Dani M. Long et al.   PLoS One

Alzheimer's Therapeutics Targeting Amyloid Beta 1–42 Oligomers II: Sigma-2/PGRMC1 Receptors Mediate Abeta 42 Oligomer Binding and Synaptotoxicity

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Alzheimer's Therapeutics Targeting Amyloid Beta 1–42 Oligomers I: Abeta 42 Oligomer Binding to Specific Neuronal Receptors Is Displaced by Drug Candidates That Improve Cognitive Deficits

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Toward a unified therapeutics approach targeting putative amyloid-  oligomer receptors

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Blockade of EphA4 signaling ameliorates hippocampal synaptic dysfunctions in mouse models of Alzheimer’s disease

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Fyn kinase inhibition as a novel therapy for Alzheimer’s disease

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Targeting the proper amyloid-beta neuronal toxins: a path forward for Alzheimer’s disease immunotherapeutics

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BACE1 inhibitor drugs in clinical trials for Alzheimer’s disease

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Alzheimer’s disease drug-development pipeline: few candidates, frequent failures

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Environmental enrichment strengthens corticocortical interactions and reduces amyloid-β oligomers in aged mice

(2014) Marco Mainardi et al.   Frontiers in Aging Neuroscience

Epidemic Spreading Model to Characterize Misfolded Proteins Propagation in Aging and Associated Neurodegenerative Disorders

(2014) Yasser Iturria-Medina et al.   PLoS Computational Biology

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(2014) George S. Bloom   JAMA Neurology

Use of Caenorhabditis elegans as a model to study Alzheimer’s disease and other neurodegenerative diseases

(2014) Adanna G. Alexander et al.   Frontiers in Genetics

Intracellular Aβ pathology and early cognitive impairments in a transgenic rat overexpressing human amyloid precursor protein: a multidimensional study

(2014) M Florencia Iulita et al.   Acta Neuropathologica Communications

Ca2+-dependent endoplasmic reticulum stress correlates with astrogliosis in oligomeric amyloid β-treated astrocytes and in a model of Alzheimer's disease

(2013) Elena Alberdi et al.   AGING CELL

ACU-193: A candidate therapeutic antibody that selectively targets soluble beta-amyloid oligomers

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Aβ43 Is the Earliest-Depositing Aβ Species in APP Transgenic Mouse Brain and Is Converted to Aβ41 by Two Active Domains of ACE

(2013) Kun Zou et al.   AMERICAN JOURNAL OF PATHOLOGY

Site-specific aspartic acid isomerization regulates self-assembly and neurotoxicity of amyloid-β

(2013) Toshihiko Sugiki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Different effects of Alzheimer's peptide Aβ(1–40) oligomers and fibrils on supported lipid membranes

(2013) Claudio Canale et al.   BIOPHYSICAL CHEMISTRY

Brain amyloid-β oligomers in ageing and Alzheimer’s disease

(2013) Sylvain E. Lesné et al.   BRAIN

TNF-α Mediates PKR-Dependent Memory Impairment and Brain IRS-1 Inhibition Induced by Alzheimer’s β-Amyloid Oligomers in Mice and Monkeys

(2013) Mychael V. Lourenco et al.   Cell Metabolism

Modeling Alzheimer’s Disease with iPSCs Reveals Stress Phenotypes Associated with Intracellular Aβ and Differential Drug Responsiveness

(2013) Takayuki Kondo et al.   Cell Stem Cell

Octodon degus: A Model for the Cognitive Impairment Associated with Alzheimer's Disease

(2013) Ernesto Tarragon et al.   CNS Neuroscience & Therapeutics

Lipid Rafts Mediate Amyloid-Induced Calcium Dyshomeostasis and Oxidative Stress in Alzheimer’s Disease

(2013) Elisa Evangelisti et al.   Current Alzheimer Research

Amyloid-β oligomers induce synaptic damage via Tau-dependent microtubule severing by TTLL6 and spastin

(2013) Hans Zempel et al.   EMBO JOURNAL

Brain interstitial oligomeric amyloid β increases with age and is resistant to clearance from brain in a mouse model of Alzheimer's disease

(2013) Shuko Takeda et al.   FASEB JOURNAL

Prion Protein-mediated Toxicity of Amyloid-β Oligomers Requires Lipid Rafts and the Transmembrane LRP1

(2013) Jo V. Rushworth et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

β-Amyloid (Aβ) Oligomers Impair Brain-derived Neurotrophic Factor Retrograde Trafficking by Down-regulating Ubiquitin C-terminal Hydrolase, UCH-L1

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FcγRIIb mediates amyloid-β neurotoxicity and memory impairment in Alzheimer’s disease

(2013) Tae-In Kam et al.   JOURNAL OF CLINICAL INVESTIGATION

Alzheimer’s disease and insulin resistance: translating basic science into clinical applications

(2013) Fernanda G. De Felice   JOURNAL OF CLINICAL INVESTIGATION

Specific Domains of Aβ Facilitate Aggregation on and Association with Lipid Bilayers

(2013) Elizabeth A. Yates et al.   JOURNAL OF MOLECULAR BIOLOGY

Nilotinib-induced autophagic changes increase endogenous parkin level and ubiquitination, leading to amyloid clearance

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Urban air pollutants reduce synaptic function of CA1 neurons via an NMDA/NȮ pathwayin vitro

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Mechanism of cholesterol-assisted oligomeric channel formation by a short Alzheimer β-amyloid peptide

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Memantine Rescues Transient Cognitive Impairment Caused by High-Molecular-Weight A  Oligomers But Not the Persistent Impairment Induced by Low-Molecular-Weight Oligomers

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A Transgenic Alzheimer Rat with Plaques, Tau Pathology, Behavioral Impairment, Oligomeric A , and Frank Neuronal Loss

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Detection of β-amyloid oligomers as a predictor of neurological outcome after brain injury

(2013) Joshua Wayne Gatson et al.   JOURNAL OF NEUROSURGERY

Experimental Traumatic Brain Injury Induces Rapid Aggregation and Oligomerization of Amyloid-Beta in an Alzheimer's Disease Mouse Model

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Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

(2013) Jean-Charles Lambert et al.   NATURE GENETICS

Inhibition of amyloid beta-induced synaptotoxicity by a pentapeptide derived from the glycine zipper region of the neurotoxic peptide

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Disruption of neocortical histone H3 homeostasis by soluble Aβ: implications for Alzheimer's disease

(2013) Christina Unger Lithner et al.   NEUROBIOLOGY OF AGING

Accelerated tau pathology with synaptic and neuronal loss in a novel triple transgenic mouse model of Alzheimer's disease

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Increased misfolding and truncation of tau in APP/PS1/tau transgenic mice compared to mutant tau mice

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Metabotropic Glutamate Receptor 5 Is a Coreceptor for Alzheimer Aβ Oligomer Bound to Cellular Prion Protein

(2013) Ji Won Um et al.   NEURON

Liraglutide can reverse memory impairment, synaptic loss and reduce plaque load in aged APP/PS1 mice, a model of Alzheimer's disease

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Alzheimer's Disease Related Markers, Cellular Toxicity and Behavioral Deficits Induced Six Weeks after Oligomeric Amyloid-β Peptide Injection in Rats

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Prenatal Exposure to Urban Air Nanoparticles in Mice Causes Altered Neuronal Differentiation and Depression-Like Responses

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Modeling Alzheimer’s Disease in Mouse without Mutant Protein Overexpression: Cooperative and Independent Effects of Aβ and Tau

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Proliferation of amyloid- 42 aggregates occurs through a secondary nucleation mechanism

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Human LilrB2 Is a  -Amyloid Receptor and Its Murine Homolog PirB Regulates Synaptic Plasticity in an Alzheimer's Model

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Propagation of tau pathology in Alzheimer’s disease: identification of novel therapeutic targets

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Autophagic/lysosomal dysfunction in Alzheimer’s disease

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On the subject of rigor in the study of amyloid β-protein assembly

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Amyloid β-protein oligomers and Alzheimer’s disease

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Widespread Aggregation and Neurodegenerative Diseases Are Associated with Supersaturated Proteins

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Thermodynamically stable amyloid-β monomers have much lower membrane affinity than the small oligomers

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A central role for dityrosine crosslinking of Amyloid-β in Alzheimer’s disease

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Synapse-Binding Subpopulations of Aβ Oligomers Sensitive to Peptide Assembly Blockers and scFv Antibodies

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Endoplasmic reticulum stress occurs downstream of GluN2B subunit ofN-methyl-D-aspartate receptor in mature hippocampal cultures treated with amyloid-β oligomers

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Amyloid-beta oligomerization in Alzheimer dementia versus high-pathology controls

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Apolipoprotein E4 effects in Alzheimer’s disease are mediated by synaptotoxic oligomeric amyloid-β

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Na+,K+-ATPase as a docking station: protein–protein complexes of the Na+,K+-ATPase

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Neuronal receptors as targets for the action of amyloid-beta protein (Aβ) in the brain

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Nrf2-regulated phase II enzymes are induced by chronic ambient nanoparticle exposure in young mice with age-related impairments

(2012) Hongqiao Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Abnormal interaction of VDAC1 with amyloid beta and phosphorylated tau causes mitochondrial dysfunction in Alzheimer's disease

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Inhibition of Choline Acetyltransferase as a Mechanism for Cholinergic Dysfunction Induced by Amyloid-β Peptide Oligomers

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Mechanisms for the Insertion of Toxic, Fibril-like β-Amyloid Oligomers into the Membrane

(2012) Hyunbum Jang et al.   Journal of Chemical Theory and Computation

An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer’s disease–associated Aβ oligomers

(2012) Theresa R. Bomfim et al.   JOURNAL OF CLINICAL INVESTIGATION

Soluble A  Promotes Wild-Type Tau Pathology In Vivo

(2012) M. A. Chabrier et al.   JOURNAL OF NEUROSCIENCE

Apolipoprotein E, Especially Apolipoprotein E4, Increases the Oligomerization of Amyloid   Peptide

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The Complex PrPc-Fyn Couples Human Oligomeric A  with Pathological Tau Changes in Alzheimer's Disease

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Hypercholesterolemia accelerates intraneuronal accumulation of Aβ oligomers resulting in memory impairment in Alzheimer's disease model mice

(2012) Tomohiro Umeda et al.   LIFE SCIENCES

Sortilin is required for toxic action of Aβ oligomers (AβOs): Extracellular AβOs trigger apoptosis, and intraneuronal AβOs impair degradation pathways

(2012) Ayumi Takamura et al.   LIFE SCIENCES

Utility of an improved model of amyloid-beta (Aβ1-42) toxicity in Caenorhabditis elegans for drug screening for Alzheimer’s disease

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A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

(2012) Thorlakur Jonsson et al.   NATURE

The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes

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Alzheimer amyloid-β oligomer bound to postsynaptic prion protein activates Fyn to impair neurons

(2012) Ji Won Um et al.   NATURE NEUROSCIENCE

Selective inhibition of the membrane attack complex of complement by low molecular weight components of the aurin tricarboxylic acid synthetic complex

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Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner

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Overexpression of cellular prion protein (PrPC) prevents cognitive dysfunction and apoptotic neuronal cell death induced by amyloid-β (Aβ1–40) administration in mice

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Disruption of the Sleep-Wake Cycle and Diurnal Fluctuation of  -Amyloid in Mice with Alzheimer's Disease Pathology

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Structural dynamics of the ΔE22 (Osaka) familial Alzheimer’s disease-linked amyloid β-protein

(2011) Mohammed Inayathullah et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

Widespread Tau and Amyloid-Beta Pathology Many Years After a Single Traumatic Brain Injury in Humans

(2011) Victoria E. Johnson et al.   BRAIN PATHOLOGY

Clinical Course of Patients with Familial Early-Onset Alzheimer’s Disease Potentially Lacking Senile Plaques Bearing the E693Δ Mutation in Amyloid Precursor Protein

(2011) Hiroyuki Shimada et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

High ability of apolipoprotein E4 to stabilize amyloid-β peptide oligomers, the pathological entities responsible for Alzheimer's disease

(2011) Emilie Cerf et al.   FASEB JOURNAL

Two Distinct Amyloid β-Protein (Aβ) Assembly Pathways Leading to Oligomers and Fibrils Identified by Combined Fluorescence Correlation Spectroscopy, Morphology, and Toxicity Analyses

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High-molecular weight Aβ oligomers and protofibrils are the predominant Aβ species in the native soluble protein fraction of the AD brain

(2011) Ajeet Rijal Upadhaya et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Amyloid-beta oligomers increase the localization of prion protein at the cell surface

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Controlled Cortical Impact Traumatic Brain Injury in 3xTg-AD Mice Causes Acute Intra-Axonal Amyloid-  Accumulation and Independently Accelerates the Development of Tau Abnormalities

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Intraneuronal amyloid β oligomers cause cell death via endoplasmic reticulum stress, endosomal/lysosomal leakage, and mitochondrial dysfunction in vivo

(2011) Tomohiro Umeda et al.   JOURNAL OF NEUROSCIENCE RESEARCH

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Different β-amyloid oligomer assemblies in Alzheimer brains correlate with age of disease onset and impaired cholinergic activity

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Intracellular Aβ-oligomers and early inflammation in a model of Alzheimer's disease

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The Aβ oligomer hypothesis for synapse failure and memory loss in Alzheimer’s disease

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BDNF-, IGF-1- and GDNF-Secreting Human Neural Progenitor Cells Rescue Amyloid β-Induced Toxicity in Cultured Rat Septal Neurons

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Tauopathic Changes in the Striatum of A53T α-Synuclein Mutant Mouse Model of Parkinson's Disease

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C-terminal-truncated apolipoprotein (apo) E4 inefficiently clears amyloid-  (A ) and acts in concert with A  to elicit neuronal and behavioral deficits in mice

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Novel demonstration of amyloid-β oligomers in sporadic inclusion-body myositis muscle fibers

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CX3CR1 Deficiency Alters Microglial Activation and Reduces Beta-Amyloid Deposition in Two Alzheimer's Disease Mouse Models

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Preparation and Characterization of Neurotoxic Tau Oligomers

(2010) Cristian A. Lasagna-Reeves et al.   BIOCHEMISTRY

The presence of sodium dodecyl sulphate-stable Aβ dimers is strongly associated with Alzheimer-type dementia

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Prion protein in Alzheimer's pathogenesis: a hot and controversial issue

(2010) Iryna Benilova et al.   EMBO Molecular Medicine

Binding of amyloid β peptide to β2 adrenergic receptor induces PKA-dependent AMPA receptor hyperactivity

(2010) Dayong Wang et al.   FASEB JOURNAL

Progressive accumulation of amyloid-β oligomers in Alzheimer’s disease and in amyloid precursor protein transgenic mice is accompanied by selective alterations in synaptic scaffold proteins

(2010) Emiley Pham et al.   FEBS Journal

Amyloid-β Protein Oligomer at Low Nanomolar Concentrations Activates Microglia and Induces Microglial Neurotoxicity

(2010) Izumi Maezawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

N-Methyl-d-aspartate receptors are required for synaptic targeting of Alzheimer’s toxic amyloid-β peptide oligomers

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Microglial activation depends on beta-amyloid conformation: role of the formylpeptide receptor 2

(2010) Tony Heurtaux et al.   JOURNAL OF NEUROCHEMISTRY

Liver X Receptor Agonist Treatment Ameliorates Amyloid Pathology and Memory Deficits Caused by High-Fat Diet in APP23 Mice

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Proline-Rich Tyrosine Kinase 2 Regulates Hippocampal Long-Term Depression

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Postsynaptic Clustering and Activation of Pyk2 by PSD-95

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A  Oligomers Cause Localized Ca2+ Elevation, Missorting of Endogenous Tau into Dendrites, Tau Phosphorylation, and Destruction of Microtubules and Spines

(2010) H. Zempel et al.   JOURNAL OF NEUROSCIENCE

A Mouse Model of Amyloid   Oligomers: Their Contribution to Synaptic Alteration, Abnormal Tau Phosphorylation, Glial Activation, and Neuronal Loss In Vivo

(2010) T. Tomiyama et al.   JOURNAL OF NEUROSCIENCE

T cell receptor activation leads to two distinct phases of Pyk2 activation and actin cytoskeletal rearrangement in human T cells

(2010) Michaela Collins et al.   MOLECULAR IMMUNOLOGY

Amyloid-β and tau — a toxic pas de deux in Alzheimer's disease

(2010) Lars M. Ittner et al.   NATURE REVIEWS NEUROSCIENCE

Cognitive effects of cell-derived and synthetically derived Aβ oligomers

(2010) Miranda N. Reed et al.   NEUROBIOLOGY OF AGING

Tetracycline and its analogues protect Caenorhabditis elegans from β amyloid-induced toxicity by targeting oligomers

(2010) Luisa Diomede et al.   NEUROBIOLOGY OF DISEASE

Deleterious Effects of Amyloid β Oligomers Acting as an Extracellular Scaffold for mGluR5

(2010) Marianne Renner et al.   NEURON

Synthetic amyloid-  oligomers impair long-term memory independently of cellular prion protein

(2010) C. Balducci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

‘Too much good news’ – are Alzheimer mouse models trying to tell us how to prevent, not cure, Alzheimer's disease?

(2010) Kathleen R. Zahs et al.   TRENDS IN NEUROSCIENCES

The E693Δ Mutation in Amyloid Precursor Protein Increases Intracellular Accumulation of Amyloid β Oligomers and Causes Endoplasmic Reticulum Stress-Induced Apoptosis in Cultured Cells

(2009) Kazuchika Nishitsuji et al.   AMERICAN JOURNAL OF PATHOLOGY

Alzheimer-type tau pathology in advanced aged nonhuman primate brains harboring substantial amyloid deposition

(2009) Naoto Oikawa et al.   BRAIN RESEARCH

Soluble oligomeric forms of beta-amyloid (Aβ) peptide stimulate Aβ production via astrogliosis in the rat brain

(2009) J.L. Perez et al.   EXPERIMENTAL NEUROLOGY

Membrane protein assembly into Nanodiscs

(2009) Timothy H. Bayburt et al.   FEBS LETTERS

Isolation and Characterization of Patient-derived, Toxic, High Mass Amyloid β-Protein (Aβ) Assembly from Alzheimer Disease Brains

(2009) Akihiko Noguchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insulin Receptor Dysfunction Impairs Cellular Clearance of Neurotoxic Oligomeric Aβ

(2009) Wei-Qin Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of Calcineurin-mediated Endocytosis and α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors Prevents Amyloid β Oligomer-induced Synaptic Disruption

(2009) Wei-Qin Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NSAIDs prevent, but do not reverse, neuronal cell cycle reentry in a mouse model of Alzheimer disease

(2009) Nicholas H. Varvel et al.   JOURNAL OF CLINICAL INVESTIGATION

Diffuse neuronal perikaryal amyloid precursor protein immunoreactivity in an ovine model of non-accidental head injury (the shaken baby syndrome)

(2009) John W. Finnie et al.   JOURNAL OF CLINICAL NEUROSCIENCE

The T cell receptor-mediated phosphorylation of Pyk2 tyrosines 402 and 580 occurs via a distinct mechanism than other receptor systems

(2009) Michaela Collins et al.   JOURNAL OF LEUKOCYTE BIOLOGY

 -Amyloid Oligomers Induce Phosphorylation of Tau and Inactivation of Insulin Receptor Substrate via c-Jun N-Terminal Kinase Signaling: Suppression by Omega-3 Fatty Acids and Curcumin

(2009) Q.-L. Ma et al.   JOURNAL OF NEUROSCIENCE

Dietary composition modulates brain mass and solubilizable Aβ levels in a mouse model of aggressive Alzheimer's amyloid pathology

(2009) Steve Pedrini et al.   Molecular Neurodegeneration

The PI3K-Akt-mTOR pathway regulates Aβ oligomer induced neuronal cell cycle events

(2009) Kiran Bhaskar et al.   Molecular Neurodegeneration

Cellular prion protein mediates impairment of synaptic plasticity by amyloid-β oligomers

(2009) Juha Laurén et al.   NATURE

β-Amyloid impairs axonal BDNF retrograde trafficking

(2009) Wayne W. Poon et al.   NEUROBIOLOGY OF AGING

Microglia activation mediates fibrillar amyloid-β toxicity in the aged primate cortex

(2009) Elaine Leung et al.   NEUROBIOLOGY OF AGING

Disruption of fast axonal transport is a pathogenic mechanism for intraneuronal amyloid beta

(2009) G. Pigino et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure-neurotoxicity relationships of amyloid  -protein oligomers

(2009) K. Ono et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oligomeric amyloid   associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques

(2009) R. M. Koffie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protection of synapses against Alzheimer's-linked toxins: Insulin signaling prevents the pathogenic binding of Aβ oligomers

(2009) Fernanda G. De Felice et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A new amyloid β variant favoring oligomerization in Alzheimer's-type dementia

(2008) Takami Tomiyama et al.   ANNALS OF NEUROLOGY

Is Covalently Crosslinked Aβ Responsible for Synaptotoxicity in Alzheimers Disease?

(2008) R. Naylor et al.   Current Alzheimer Research

Diet-induced insulin resistance impairs hippocampal synaptic plasticity and cognition in middle-aged rats

(2008) Alexis M. Stranahan et al.   HIPPOCAMPUS

Amyloid-β Binds to the Extracellular Cysteine-rich Domain of Frizzled and Inhibits Wnt/β-Catenin Signaling

(2008) Margaret H. Magdesian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Anti-oligomeric Aβ Single-chain Variable Domain Antibody Blocks Aβ-induced Toxicity Against Human Neuroblastoma Cells

(2008) Andleeb Zameer et al.   JOURNAL OF MOLECULAR BIOLOGY

Exercise alters the immune profile in Tg2576 Alzheimer mice toward a response coincident with improved cognitive performance and decreased amyloid

(2008) Kathryn E Nichol et al.   Journal of Neuroinflammation

Amyloid   Oligomers (A 1-42 Globulomer) Suppress Spontaneous Synaptic Activity by Inhibition of P/Q-Type Calcium Currents

(2008) V. Nimmrich et al.   JOURNAL OF NEUROSCIENCE

Inflammatory Response in the Hippocampus of PS1M146L/APP751SL Mouse Model of Alzheimer's Disease: Age-Dependent Switch in the Microglial Phenotype from Alternative to Classic

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A  Oligomers Induce Neuronal Cell Cycle Events in Alzheimer's Disease

(2008) N. H. Varvel et al.   JOURNAL OF NEUROSCIENCE

Amyloid   Protein Dimer-Containing Human CSF Disrupts Synaptic Plasticity: Prevention by Systemic Passive Immunization

(2008) I. Klyubin et al.   JOURNAL OF NEUROSCIENCE

ER stress is involved in Aβ‐induced GSK‐3β activation and tau phosphorylation

(2008) Rosa Resende et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Soluble amyloid β oligomers may contribute to apoptosis of retinal ganglion cells in glaucoma

(2008) Hongbo Yin et al.   MEDICAL HYPOTHESES

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

(2008) Ganesh M Shankar et al.   NATURE MEDICINE

Heat shock treatment reduces beta amyloid toxicity in vivo by diminishing oligomers

(2008) Yanjue Wu et al.   NEUROBIOLOGY OF AGING

Amyloid beta oligomers induce impairment of neuronal insulin receptors

(2007) Wei-Qin Zhao et al.   FASEB JOURNAL

Alzheimer's disease-type neuronal tau hyperphosphorylation induced by Aβ oligomers

(2007) Fernanda G. De Felice et al.   NEUROBIOLOGY OF AGING