Mutant huntingtin does not cross the mitochondrial outer membrane

Expression of mutant exon 1 huntingtin fragments in human neural stem cells and neurons causes inclusion formation and mitochondrial dysfunction

(2020) Rhia Ghosh et al.   FASEB JOURNAL

Metabolic Reprogramming in Astrocytes Distinguishes Region-Specific Neuronal Susceptibility in Huntington Mice

(2019) Aris A. Polyzos et al.   Cell Metabolism

Mutant huntingtin disrupts mitochondrial proteostasis by interacting with TIM23

(2019) Svitlana Yablonska et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fractionated mitochondrial magnetic separation for isolation of synaptic mitochondria from brain tissue

(2019) W. Brad Hubbard et al.   Scientific Reports

Energy Metabolism and Mitochondrial Superoxide Anion Production in Pre-symptomatic Striatal Neurons Derived from Human-Induced Pluripotent Stem Cells Expressing Mutant Huntingtin

(2019) James Hamilton et al.   MOLECULAR NEUROBIOLOGY

Mutant huntingtin fails to directly impair brain mitochondria

(2019) James Hamilton et al.   JOURNAL OF NEUROCHEMISTRY

Oxidative metabolism and Ca 2+ handling in striatal mitochondria from YAC128 mice, a model of Huntington's disease

(2017) James Hamilton et al.   NEUROCHEMISTRY INTERNATIONAL

Role of Sex Hormones on Brain Mitochondrial Function, with Special Reference to Aging and Neurodegenerative Diseases

(2017) Pauline Gaignard et al.   Frontiers in Aging Neuroscience

Oxidative metabolism in YAC128 mouse model of Huntington's disease

(2015) James Hamilton et al.   HUMAN MOLECULAR GENETICS

Ca2+handling in isolated brain mitochondria and cultured neurons derived from the YAC128 mouse model of Huntington's disease

(2015) Jessica J. Pellman et al.   JOURNAL OF NEUROCHEMISTRY

Mutant Huntingtin and Elusive Defects in Oxidative Metabolism and Mitochondrial Calcium Handling

(2015) Nickolay Brustovetsky   MOLECULAR NEUROBIOLOGY

Impaired Brain Energy Metabolism in the BACHD Mouse Model of Huntington's Disease: Critical Role of Astrocyte–Neuron Interactions

(2014) Lydie Boussicault et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Inhibition of mitochondrial protein import by mutant huntingtin

(2014) Hiroko Yano et al.   NATURE NEUROSCIENCE

Preservation of mitochondrial functional integrity in mitochondria isolated from small cryopreserved mouse brain areas

(2013) Daniela Valenti et al.   ANALYTICAL BIOCHEMISTRY

A role of mitochondrial complex II defects in genetic models of Huntington's disease expressing N-terminal fragments of mutant huntingtin

(2013) Maria Damiano et al.   HUMAN MOLECULAR GENETICS

Forebrain Striatal-Specific Expression of Mutant Huntingtin Protein in Vivo Induces Cell-Autonomous Age-Dependent Alterations in Sensitivity to Excitotoxicity and Mitochondrial Function

(2011) Soong Ho Kim et al.   ASN Neuro

Abnormal mitochondrial dynamics, mitochondrial loss and mutant huntingtin oligomers in Huntington's disease: implications for selective neuronal damage

(2011) U. Shirendeb et al.   HUMAN MOLECULAR GENETICS

Mutant huntingtin's interaction with mitochondrial protein Drp1 impairs mitochondrial biogenesis and causes defective axonal transport and synaptic degeneration in Huntington's disease

(2011) U. P. Shirendeb et al.   HUMAN MOLECULAR GENETICS

Mitochondria: isolation, structure and function

(2011) Martin Picard et al.   JOURNAL OF PHYSIOLOGY-LONDON

Mutant huntingtin binds the mitochondrial fission GTPase dynamin-related protein-1 and increases its enzymatic activity

(2011) Wenjun Song et al.   NATURE MEDICINE

The many faces of the mitochondrial TIM23 complex

(2010) Dejana Mokranjac et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mitochondrial fission and cristae disruption increase the response of cell models of Huntington's disease to apoptotic stimuli

(2010) Veronica Costa et al.   EMBO Molecular Medicine

Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease

(2010) Marta Martinez-Vicente et al.   NATURE NEUROSCIENCE

Increased glucose metabolism and ATP level in brain tissue of Huntington’s disease transgenic mice

(2008) Judit Oláh et al.   FEBS Journal

N-Terminal Mutant Huntingtin Associates with Mitochondria and Impairs Mitochondrial Trafficking

(2008) A. L. Orr et al.   JOURNAL OF NEUROSCIENCE