The Alzheimer’s disease drug candidate J147 decreases blood plasma fatty acid levels via modulation of AMPK/ACC1 signaling in the liver

Geroprotective effects of Alzheimer’s disease drug candidates

(2021) Devin Kepchia et al.   Aging-US

Intracellular amyloid toxicity induces oxytosis/ferroptosis regulated cell death

(2020) Ling Huang et al.   Cell Death & Disease

The regulation of hepatic fatty acid synthesis and partitioning: the effect of nutritional state

(2019) Leanne Hodson et al.   Nature Reviews Endocrinology

The mitochondrial ATP synthase is a shared drug target for aging and dementia

(2018) Joshua Goldberg et al.   AGING CELL

Aging-associated modifications of collagen affect its degradation by matrix metalloproteinases

(2018) Preety Panwar et al.   MATRIX BIOLOGY

Liver fibrosis: Pathophysiology, pathogenetic targets and clinical issues

(2018) Maurizio Parola et al.   MOLECULAR ASPECTS OF MEDICINE

Geroneuroprotectors: Effective Geroprotectors for the Brain

(2018) David Schubert et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

SAMP8 mice as a neuropathological model of accelerated brain aging and dementia: Toshio Takeda's legacy and future directions

(2017) Ichiro Akiguchi et al.   NEUROPATHOLOGY

A novel Alzheimer’s disease drug candidate targeting inflammation and fatty acid metabolism

(2017) Daniel Daugherty et al.   Alzheimers Research & Therapy

Selecting for neurogenic potential as an alternative for Alzheimer's disease drug discovery

(2016) Marguerite Prior et al.   Alzheimers & Dementia

AMPK: An Energy-Sensing Pathway with Multiple Inputs and Outputs

(2016) D. Grahame Hardie et al.   TRENDS IN CELL BIOLOGY

A comprehensive multiomics approach toward understanding the relationship between aging and dementia

(2015) Antonio Currais et al.   Aging-US

Target Engagement in Lead Generation

(2015) Timothy B. Durham et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Dietary (−)-Epigallocatechin-3-gallate Supplementation Counteracts Aging-Associated Skeletal Muscle Insulin Resistance and Fatty Liver in Senescence-Accelerated Mouse

(2015) Hung-Wen Liu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Back to the Future with Phenotypic Screening

(2014) Marguerite Prior et al.   ACS Chemical Neuroscience

The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR

(2014) Randall M. Chin et al.   NATURE

An atlas of genetic influences on human blood metabolites

(2014) So-Youn Shin et al.   NATURE GENETICS

Nonalcoholic fatty liver disease and aging: Epidemiology to management

(2014) Marco Bertolotti   WORLD JOURNAL OF GASTROENTEROLOGY

Determining target engagement in living systems

(2013) Gabriel M Simon et al.   Nature Chemical Biology

The neurotrophic compound J147 reverses cognitive impairment in aged Alzheimer's disease mice

(2013) Marguerite Prior et al.   Alzheimers Research & Therapy

Diabetes exacerbates amyloid and neurovascular pathology in aging-accelerated mice

(2012) Antonio Currais et al.   AGING CELL

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

A Novel Neurotrophic Drug for Cognitive Enhancement and Alzheimer's Disease

(2011) Qi Chen et al.   PLoS One

Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities

(2010) Sven Heinz et al.   MOLECULAR CELL

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

Senescence-Accelerated Mouse (SAM) with Special References to Neurodegeneration Models, SAMP8 and SAMP10 Mice

(2009) Toshio Takeda   NEUROCHEMICAL RESEARCH

Comparative Studies of Early Liver Dysfunction in Senescence-accelerated Mouse Using Mitochondrial Proteomics Approaches

(2008) Yashu Liu et al.   MOLECULAR & CELLULAR PROTEOMICS

Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists

(2008) Da Wei Huang et al.   NUCLEIC ACIDS RESEARCH