Effect of rapamycin on mitochondria and lysosomes in fibroblasts from patients with mtDNA mutations

Mitochondrial Dynamics Regulation in Skin Fibroblasts from Mitochondrial Disease Patients

(2020) Takeshi Tokuyama et al.   Biomolecules

Rapamycin activates mammalian microautophagy

(2019) Masahiro Sato et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Rapamycin directly activates lysosomal mucolipin TRP channels independent of mTOR

(2019) Xiaoli Zhang et al.   PLOS BIOLOGY

Health Care for Mitochondrial Disorders in Canada: A Survey of Physicians

(2019) Karen Paik et al.   CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES

Emerging Developments in Targeting Proteotoxicity in Neurodegenerative Diseases

(2019) Luke McAlary et al.   CNS DRUGS

Rapamycin rescues mitochondrial myopathy via coordinated activation of autophagy and lysosomal biogenesis

(2018) Gabriele Civiletto et al.   EMBO Molecular Medicine

mTOR inhibitors may benefit kidney transplant recipients with mitochondrial diseases

(2018) Simon C. Johnson et al.   KIDNEY INTERNATIONAL

MTORC1 Regulates both General Autophagy and Mitophagy Induction after Oxidative Phosphorylation Uncoupling

(2017) Alberto Bartolomé et al.   MOLECULAR AND CELLULAR BIOLOGY

The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging

(2016) Brian K. Kennedy et al.   Cell Metabolism

Loss of Mitochondrial Function Impairs Lysosomes

(2016) Julie Demers-Lamarche et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Critical role of AMP-activated protein kinase in the balance between mitophagy and mitochondrial biogenesis in MELAS disease

(2015) Juan Garrido-Maraver et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

MELAS syndrome: Clinical manifestations, pathogenesis, and treatment options

(2015) Ayman W. El-Hattab et al.   MOLECULAR GENETICS AND METABOLISM

Oxidative stress-induced mitochondrial fragmentation and movement in skeletal muscle myoblasts

(2014) Sobia Iqbal et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Bulk autophagy, but not mitophagy, is increased in cellular model of mitochondrial disease

(2014) María Morán et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Rapamycin increases mitochondrial efficiency by mtDNA-dependent reprogramming of mitochondrial metabolism inDrosophila

(2014) Eugenia Villa-Cuesta et al.   JOURNAL OF CELL SCIENCE

Mitochondrial Encephalopathy With Lactic Acidosis and Stroke-like Episodes (MELAS) May Respond to Adjunctive Ketogenic Diet

(2014) Claude Steriade et al.   PEDIATRIC NEUROLOGY

Rapamycin drives selection against a pathogenic heteroplasmic mitochondrial DNA mutation

(2013) Ying Dai et al.   HUMAN MOLECULAR GENETICS

Rapamycin Reduces Reactive Oxygen Species in Cultured Human Corneal Endothelial Cells

(2012) Young Joo Shin et al.   CURRENT EYE RESEARCH

Secondary coenzyme Q10 deficiency triggers mitochondria degradation by mitophagy in MELAS fibroblasts

(2011) David Cotán et al.   FASEB JOURNAL

Mitochondrial autophagy in cells with mtDNA mutations results from synergistic loss of transmembrane potential and mTORC1 inhibition

(2011) Robert W. Gilkerson et al.   HUMAN MOLECULAR GENETICS

MELAS syndrome, cardiomyopathy, rhabdomyolysis, and autism associated with the A3260G mitochondrial DNA mutation

(2010) Barbara S. Connolly et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

What does the commonly used DCF test for oxidative stress really show?

(2010) Markus Karlsson et al.   BIOCHEMICAL JOURNAL

Mitochondrial Encephalopathy, Lactic Acidosis, and Strokelike Episodes

(2009) Douglas M. Sproule et al.   Annals of the New York Academy of Sciences

Effect of thyroid hormone on mitochondrial properties and oxidative stress in cells from patients with mtDNA defects

(2008) Keir J. Menzies et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY